2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction

Name: Work Video:
Duration: 3 min 30 s
Elliott M. Antman; Mary M. Hand; Paul W. Armstrong; Eric Bates; Lee A. Green; Lakshmi Halasyamani; Judith S. Hochman; Harlan M. Krumholz; Gervasio A. Lamas; Charles J. Mullany; David L. Pearle; Michael A. Sloan; Sidney C. Smith; Elliott M. Antman; Daniel T. Anbe; Paul W. Armstrong; Eric Bates; Lee A. Green; Mary M. Hand; Judith S. Hochman; Harlan M. Krumholz; Frederick G. Kushner; Gervasio A. Lamas; Charles J. Mullany; Joseph P. Ornato; David L. Pearle; Michael A. Sloan; Sidney C. Smith; Sidney C. Smith; Alice K. Jacobs; Cynthia D. Adams; Jeffrey L. Anderson; Christopher E. Buller; Mark A. Creager; Steven M. Ettinger; Jonathan L. Halperin; Sharon A. Hunt; Harlan M. Krumholz; Frederick G. Kushner; Bruce W. Lytle; Rick A. Nishimura; Richard L. Page; Bárbara Riegel; Lynn G. Tarkington; Clyde W. Yancy
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2577, 2598, 2604, 2615, 2621, 2648, 2653, 2662, 2739, 2771, 2896, 2940, 2966, 3000, 3037, 3079, 3088, 3134, 3141, 3221, 3243, 3346, 3502, 3630, 3694, 3725, 3770, 3842, 3912, 3955, 4045, 4072, 4133, 4248, 4272], 'Infarction,': [104], 'Behalf': [107], 'Committee': [112, 189, 457, 681, 2446], 'Elliott': [113, 191, 379, 460], 'M.': [114, 154, 192, 233, 319, 336, 380, 382, 420, 422, 461, 463, 501, 503, 585, 587, 603, 605], 'Antman,': [115, 193], 'MD,': [116, 129, 135, 141, 146, 150, 156, 162, 173, 179, 184, 194, 201, 207, 213, 219, 229, 235, 241, 247, 258, 264, 270, 275, 284, 291, 304, 310, 315, 321, 326, 332, 338, 344, 350, 355, 361, 377, 2006, 2017], 'FACC,': [117, 130, 136, 151, 157, 163, 169, 174, 180, 185, 195, 202, 208, 214, 230, 236, 242, 248, 254, 259, 265, 271, 276, 285, 292, 305, 311, 316, 322, 327, 333, 339, 345, 351, 356, 362, 2007, 2018], 'FAHA,': [118, 124, 131, 137, 152, 158, 175, 186, 196, 203, 209, 215, 225, 231, 237, 243, 260, 266, 277, 286, 293, 300, 306, 317, 328, 334, 340, 346, 352, 357, 363, 368], 'Co-Chair,': [119, 125], 'Mary': [120, 221, 385, 490], 'Hand,': [121, 222], 'MSPH,': [122, 223], 'RN,': [123, 224, 367], 'Paul': [126, 204, 389, 472], 'W.': [127, 205, 348, 375, 390, 392, 473, 475, 615, 617, 641, 643], 'Armstrong,': [128, 206], 'Eric': [132, 210, 395, 478], 'R.': [133, 211, 396, 398, 479, 481], 'Bates,': [134, 212], 'Lee': [138, 216, 401, 484], 'A.': [139, 160, 177, 217, 245, 268, 313, 330, 402, 404, 426, 428, 444, 446, 485, 487, 513, 515, 537, 539, 579, 581, 597, 599], 'Green,': [140, 218], 'MPH,': [142, 220], 'Lakshmi': [143, 407], 'K.': [144, 289, 408, 410, 555, 557, 2015], 'Halasyamani,': [145], 'Judith': [147, 226, 413, 494], 'S.': [148, 227, 414, 416, 495, 497], 'Hochman,': [149, 228], 'Harlan': [153, 232, 335, 419, 500, 602], 'Krumholz,': [155, 234, 337], 'Gervasio': [159, 244, 425, 512], 'Lamas,': [161, 246], 'Charles': [164, 249, 431, 518], 'J.': [165, 250, 432, 434, 519, 521], 'Mullany,': [166, 251], 'MB,': [167, 252], 'MS,': [168, 253], 'David': [170, 261, 437, 530], 'L.': [171, 262, 302, 324, 359, 438, 440, 531, 533, 567, 569, 591, 593, 625, 627], 'Pearle,': [172, 263], 'Michael': [176, 267, 443, 536], 'Sloan,': [178, 269], 'Sidney': [181, 272, 278, 449, 542, 548], 'C.': [182, 273, 279, 450, 452, 543, 545, 549, 551, 2003], 'SmithJr,': [183, 274, 280], 'Members': [190, 458], 'Chair,': [197, 287], 'Daniel': [198, 466], 'T.': [199, 467, 469], 'Anbe,': [200], 'Frederick': [238, 341, 506, 608], 'G.': [239, 342, 370, 507, 509, 609, 611, 635, 637], 'Kushner,': [240, 343], 'Joseph': [255, 524], 'P.': [256, 525, 527], 'Ornato,': [257], 'Members:,': [283], 'Alice': [288, 554], 'Jacobs,': [290, 2016], 'Vice-Chair,': [294], 'Cynthia': [295, 560], 'D.': [296, 561, 563], 'Adams,': [297], 'MSN,': [298], 'PhD,': [299], 'Jeffrey': [301, 566], 'Anderson,': [303], 'Christopher': [307, 572], 'E.': [308, 573, 575], 'Buller,': [309], 'Mark': [312, 578], 'Creager,': [314], 'Steven': [318, 584], 'Ettinger,': [320], 'Jonathan': [323, 590], 'Halperin,': [325], 'Sharon': [329, 596], 'Hunt,': [331], 'Bruce': [347, 614], 'Lytle,': [349], 'Rick': [353, 620], 'Nishimura,': [354], 'Richard': [358, 624], 'Page,': [360], 'Barbara': [364, 630], 'Riegel,': [365], 'DNSc,': [366], 'Lynn': [369, 634], 'Tarkington,': [371], 'RN': [372], 'Clyde': [374, 640], 'Yancy,': [376], 'FACC': [378], 'AntmanElliott': [381, 462], 'Antman': [383, 464, 2134], ',': [384, 388, 394, 400, 406, 412, 418, 424, 430, 436, 442, 448, 454, 459, 465, 471, 477, 483, 489, 493, 499, 505, 511, 517, 523, 529, 535, 541, 547, 553, 559, 565, 571, 577, 583, 589, 595, 601, 607, 613, 619, 623, 629, 633], 'HandMary': [386, 491], 'Hand': [387, 492], 'ArmstrongPaul': [391, 474], 'Armstrong': [393, 476], 'BatesEric': [397, 480], 'Bates': [399, 482], 'GreenLee': [403, 486], 'Green': [405, 488], 'HalasyamaniLakshmi': [409], 'Halasyamani': [411], 'HochmanJudith': [415, 496], 'Hochman': [417, 498], 'KrumholzHarlan': [421, 502, 604], 'Krumholz': [423, 504, 606], 'LamasGervasio': [427, 514], 'Lamas': [429, 516], 'MullanyCharles': [433, 520], 'Mullany': [435, 522], 'PearleDavid': [439, 532], 'Pearle': [441, 534], 'SloanMichael': [445, 538], 'Sloan': [447, 540], 'SmithJrSidney': [451, 544, 550], 'SmithJr': [453, 546, 552], 'AnbeDaniel': [468], 'Anbe': [470], 'KushnerFrederick': [508, 610], 'Kushner': [510, 612], 'OrnatoJoseph': [526], 'Ornato': [528], 'JacobsAlice': [556], 'Jacobs': [558], 'AdamsCynthia': [562], 'Adams': [564], 'AndersonJeffrey': [568], 'Anderson': [570], 'BullerChristopher': [574], 'Buller': [576], 'CreagerMark': [580], 'Creager': [582], 'EttingerSteven': [586], 'Ettinger': [588], 'HalperinJonathan': [592], 'Halperin': [594], 'HuntSharon': [598], 'Hunt': [600], 'LytleBruce': [616], 'Lytle': [618], 'NishimuraRick': [621], 'Nishimura': [622], 'PageRichard': [626], 'Page': [628], 'RiegelBarbara': [631], 'Riegel': [632], 'TarkingtonLynn': [636], 'Tarkington': [638], 'YancyClyde': [642], 'Yancy': [644], 'Originally': [645], 'published10': [646], 'Dec': [647], '2007https://doi.org/10.1161/CIRCULATIONAHA.107.188209Circulation.': [648], '2008;117:296–329is': [649], 'corrected': [650], 'byCorrectionOther': [651], 'version(s)': [652], 'this': [654, 663, 828, 974, 983, 1452, 1843, 1872, 1924, 2167, 2243, 2429, 2451, 2625, 4290], 'articleYou': [655], 'are': [656, 778, 817, 1129, 1241, 1280, 1363, 1487, 1494, 1557, 1634, 1698, 1703, 1837, 1869, 1889, 1900, 1919, 1933, 1943, 1998, 2348, 2372, 2734, 3049, 3194, 3500, 4021, 4048, 4136, 4158, 4342], 'viewing': [657], 'most': [659, 1598, 1601], 'recent': [660, 2093], 'version': [661, 2396], 'article.': [664], 'Previous': [665, 670], 'versions:': [666], 'December': [667], '10,': [668], '2007:': [669], 'Version': [671], '1': [672, 1794, 1913, 2588, 3703, 3834, 4063], 'Preamble…2971.': [673], 'Introduction…299': [674], '1.1.': [675], 'Review…299': [677], '1.2.': [678], 'Organization': [679, 2444], 'Relationships': [683, 2448], 'Industry…299': [685], '1.3.': [686], 'Approval…3002.': [689], 'Analgesia…3003.': [690], 'Beta': [691, 3059, 3165], 'Blockers…300': [692], '3.1.': [693], 'COMMIT/CCS-2': [694, 3626, 3628], '(Metoprolol)…300': [695], '3.2.': [696], 'Conclusion…3014.': [697], 'Reperfusion…302': [698], '4.1.': [699], 'Logistics': [700], 'Care…3025.': [702], 'Facilitated': [703], 'PCI…3046.': [704], 'Immediate': [705], 'or': [706, 716, 822, 1083, 1098, 1178, 1221, 1299, 1334, 1378, 1382, 1585, 1673, 1749, 1758, 1902, 1939, 2365, 2382, 2397, 2733, 3021, 3214, 3266, 3314, 3329, 3335, 3407, 3430, 3474, 3529, 3544, 3550, 3596, 3611, 3617, 3675, 3689, 3715, 3739, 3767, 3873, 3883, 3892, 3943, 3963, 4017, 4097, 4189, 4231], 'Emergency': [707], 'Invasive': [708, 749], 'Strategy': [709], 'Rescue': [711], 'PCI…3057.': [712], 'PCI': [713], 'After': [714], 'Fibrinolysis': [715], 'Not': [719], 'Undergoing': [720], 'Primary': [721], 'Reperfusion…307': [722], '7.1.': [723], 'The': [724, 732, 1587, 1603, 2240, 3756, 3822, 4286, 4317], 'Late': [725, 733], 'Open': [726, 734], 'Artery': [727, 735], 'Hypothesis:': [728, 736], 'Clinical': [729, 1645], 'Outcomes…307': [730], '7.2.': [731], 'Angiographic': [737], 'Outcomes…308': [738], '7.3.': [739], 'Conclusion…3088.': [740], 'Ancillary': [741], 'Therapy…308': [742], '8.1.': [743], 'Conclusion…3129.': [744], 'Thienopyridines…313': [745], '9.1.': [746], 'Conclusion…31410.': [747], 'Anticoagulants…31511.': [748], 'Evaluation…31512.': [750], 'Secondary': [751], 'Prevention…31513.': [752], 'Antiplatelet': [753], 'Therapy…320References…321Appendix': [754], '1…324Appendix': [755], '2…326PreambleA': [756], 'primary': [757, 3269], 'challenge': [758], 'development': [761], 'clinical': [763, 940, 1190, 1200, 1215, 1297, 1346, 1357, 1372, 1565, 2029, 2098, 2318, 2346, 2417], 'practice': [764, 1071, 1470, 1526, 1555, 2192], 'guidelines': [765, 837, 1097, 1194, 1254, 1351, 1459, 1471, 1556, 1588, 1641, 1664, 1855, 1868, 1884, 1918, 1942, 1979, 2083], 'is': [766, 978, 986, 1141, 1186, 1223, 1342, 1380, 1449, 1661, 1680, 1948, 1981, 2622, 2797, 2834, 3457, 3476, 3483, 3722, 4052, 4070, 4075, 4163, 4205], 'keeping': [767], 'pace': [768], 'with': [769, 1081, 1095, 1173, 1329, 1695, 1732, 1809, 1817, 1891, 2064, 2271, 2307, 2329, 2542, 2550, 2684, 2722, 2783, 2807, 2820, 2844, 2883, 2900, 2944, 3045, 3348, 3374, 3405, 3418, 3428, 3441, 3803, 3862, 3874, 3884, 3893, 3950, 4013, 4094, 4155, 4225, 4237], 'stream': [771], 'new': [773, 788, 806, 847, 958, 1012, 1060, 2164], 'data': [774, 821, 959, 1013, 1023, 1103, 2079, 2095, 2165, 2199, 2223, 2487], 'upon': [775], 'which': [776, 1128, 1146, 1637, 3982, 4025], 'recommendations': [777, 815, 924, 1107, 1271, 1405, 1697, 1798, 1850, 1860, 1879, 1909, 1922, 2229, 2426, 3064], 'based.': [779], 'In': [780, 4349], 'an': [781, 853, 894, 963, 991, 1974, 2297, 3013, 3487, 3853, 4034, 4078, 4312], 'effort': [782, 1724, 1743], 'respond': [784, 859], 'more': [785, 857, 916, 1911, 3817, 3952, 3956, 4294], 'quickly': [786, 899], 'evidence,': [789], '(ACC/AHA)': [797], 'has': [803, 2671, 2700, 3108, 4368], 'created': [804], 'a': [805, 869, 886, 926, 932, 944, 995, 1017, 1171, 1212, 1218, 1369, 1375, 1393, 1414, 1419, 1500, 1551, 1570, 1609, 1762, 1887, 1892, 2106, 2215, 2248, 2330, 2524, 2543, 2673, 2692, 2704, 2716, 3038, 3073, 3119, 3142, 3259, 3304, 3419, 3442, 3472, 3519, 3586, 3684, 3742, 4040, 4167, 4180, 4300, 4356], '"focused': [807], 'update"': [808], 'process': [809, 947], 'revise': [811], 'existing': [813, 836], 'guideline': [814, 923, 1005, 1099, 1404, 2060], 'that': [816, 866, 907, 935, 982, 1031, 1170, 1183, 1217, 1268, 1339, 1374, 1412, 1418, 1451, 1486, 1593, 1630, 1828, 2080, 2191, 2246, 2300, 2561, 2709, 3071, 3152, 3972, 4198, 4303, 4358], 'affected': [818, 1863], 'evolving': [820], 'opinion.': [823], 'Before': [824], 'initiation': [826], 'focused': [829, 975, 984, 1112, 1239, 1259, 1844, 1873, 1925, 1937, 1946, 1996, 2107, 2168, 2423, 2430, 2452, 2474, 2507, 3990], 'approach,': [830], 'periodic': [831], 'updates': [832, 889, 1240, 2439], 'revisions': [834, 2437], 'required': [838, 1774, 1821, 2479, 2523], 'up': [839, 3740], '3': [841, 2570, 2578, 3657], 'years': [842, 919, 3870, 4297], 'complete.': [844], 'Now,': [845], 'however,': [846, 2724, 4321], 'evidence': [848, 1140, 1235, 1247, 1789, 1907, 2178, 3302, 3517, 3584, 4281, 4287], 'will': [849, 880, 890, 1453, 1461, 1927, 2432], 'be': [850, 881, 891, 1207, 1211, 1368, 1613, 1643, 1666, 1928, 2320, 2433, 2923, 2975, 3252, 3279, 3359, 3385, 3567, 3967, 4028, 4149, 4196], 'reviewed': [851, 882, 1248, 2056, 2513, 2568], 'ongoing': [854], 'fashion': [855], 'efficiently': [858], 'important': [861, 949, 979, 1025, 1189, 1345, 2102], 'science': [862], 'treatment': [864, 1160, 1167, 1533, 1692, 1716, 2216, 2343, 2370, 3778, 3932, 4301], 'trends': [865], 'could': [867, 3966], 'have': [868, 912, 962, 1269, 1273, 1406, 1903, 2730, 2874, 3291, 3506, 3573, 4101, 4235], 'major': [870], 'impact': [871, 964, 1032, 1523, 2082], 'patient': [873, 953, 966, 1473, 1529, 1611, 1621, 1711, 1728, 2710, 4042, 4074], 'outcomes': [874, 3760], 'quality': [876, 1651, 1681], 'care.': [878], 'at': [883, 1464, 2032, 2323, 2792, 2829, 2878, 2978, 3491, 3961, 4077, 4219, 4344], 'least': [884], 'twice': [885], 'year,': [887], 'initiated': [892, 3280], 'as': [895, 898, 900, 948, 1255, 1257, 1308, 1668, 1840, 1894, 1973, 2049, 2051, 2201, 2203, 2375, 2471, 2585, 2587, 2865, 2867, 2915, 2917, 3366, 3392, 3415, 3438, 4119, 4223], 'needed': [896, 2309, 2361], 'basis': [897, 1028, 1670, 2087, 4086], 'possible,': [901], 'while': [902], 'maintaining': [903], 'rigorous': [905], 'methodology': [906, 1040], 'ACC': [909, 1986, 2576], 'AHA': [911, 1989], 'developed': [913, 1119, 1392, 4293], 'during': [914, 2925, 3699, 3775], 'their': [915, 2901, 2945], 'than': [917, 1812, 1912, 2546, 3197, 3204, 3211, 3218, 3325, 3540, 3607, 3868, 3879, 3889, 3897, 4295], '20': [918], 'partnership.These': [921], 'updated': [922, 1106, 1920, 2427], 'reflect': [925], 'consensus': [927, 1216, 1373], 'expert': [929], 'opinion': [930], 'following': [931, 3110], 'thorough': [933], 'review': [934, 998, 1066, 2534, 3143], 'consisted': [936], 'primarily': [937], 'late-breaking': [939], 'trials': [941, 1089, 1204, 1298, 1362, 1786, 2030, 2075, 2319, 2347, 3114], 'identified': [942], 'through': [943], 'broad-based': [945], 'vetting': [946], 'relevant': [952, 1815, 2225, 2484, 2499, 2552], 'population': [954, 1543], 'other': [957, 1076, 1084, 1096, 1788, 2053, 2070, 2077, 2097, 2967, 3316, 3531, 3598, 3936, 4115], 'deemed': [960, 1024], 'care': [967, 1477, 1562, 1607, 1618, 1660, 1683, 1719], '(see': [968, 1792, 2627, 2983, 4241], 'Section': [969, 2753, 2987, 3052, 3163], '1.1': [970], 'details': [972], 'update).': [976], 'It': [977, 1448, 3482, 4051, 4162, 4194], 'note': [981], 'update': [985, 992, 1068, 1113, 1926, 1938, 1947, 1975, 1997, 2108, 2431, 2475, 2491, 3991], 'not': [987, 1181, 1196, 1206, 1274, 1337, 1353, 1364, 1488, 1835, 1838, 2419, 2735, 2922, 3154, 3290, 3505, 3566, 3975, 4076, 4323, 4343], 'intended': [988, 1558], 'represent': [990], 'based': [993, 1242, 3068], 'full': [996, 1410, 1443, 1854, 1867, 2518], 'literature': [997], 'from': [999, 1069, 1296, 1427, 1639, 1755, 1825, 1861, 1880, 2000, 2179, 2558, 2591, 2995, 3736, 3772, 3830, 3846, 4305, 4371], 'date': [1001], 'previous': [1004, 1088, 1250], 'publication.': [1006], 'Specific': [1007], 'criteria/considerations': [1008, 2090], 'inclusion': [1010], 'include:': [1014], '•Publication': [1015], 'peer-reviewed': [1018], 'journal•Large,': [1019], 'randomized,': [1020], 'placebo-controlled': [1021], 'trial(s)•Nonrandomized': [1022], 'results': [1030, 4250], 'current': [1033, 1047, 1050, 1930, 2852, 3401, 3452, 4330], 'safety': [1034, 4260], 'efficacy': [1036, 2273], 'assumptions•Strengths/weakness': [1037], 'research': [1039], 'findings•Likelihood': [1042], 'additional': [1044, 2990], 'studies': [1045, 1267, 1506, 2180, 3070], 'influencing': [1046], 'findings•Impact': [1048], 'performance': [1051, 1061, 3267], 'measure(s)': [1052], 'and/or': [1053, 2438], 'likelihood': [1054], 'need': [1057], 'develop': [1059], 'measure(s)•Requests': [1062], 'requirements': [1064], 'community,': [1072], 'key': [1073, 2078], 'stakeholders,': [1074], 'sources': [1077], 'free': [1078, 4159], 'relationships': [1080, 1757, 1782, 1816], 'industry': [1082, 1756, 1818, 2551], 'potential': [1085, 1522, 4004], 'bias•Number': [1086], 'showing': [1090], 'consistent': [1091], 'results•Need': [1092], 'consistency': [1094], 'revisionsIn': [1100], 'analyzing': [1101], 'developing': [1105, 3191], 'supporting': [1109], 'text,': [1110], 'writing': [1114, 1401, 1518, 1763, 1767, 1803, 2061, 2171, 2219, 2460, 2476, 2492, 2519, 2529, 2539, 2619, 4275, 4318], 'group': [1115, 2172, 2220, 2493, 2530, 4276, 4319], 'used': [1116, 1667, 2286], 'evidence-based': [1117], 'methodologies': [1118], 'Guidelines,': [1127, 2986, 4001, 4245], 'described': [1130, 2373], 'elsewhere.1,2The': [1131], 'schema': [1132], 'class': [1134, 1229, 1502, 3895], 'recommendation': [1136, 1172, 1185, 1231, 1328, 1341, 1467, 2522, 2555, 2695, 2707, 2719, 2850, 3343, 3399, 3450, 3558, 4334], 'level': [1138, 1233, 3233], 'summarized': [1142], 'Table': [1144, 2749], '1,': [1145], 'also': [1147, 1982], 'illustrates': [1148], 'how': [1149], 'grading': [1151], 'system': [1152], 'provides': [1153], 'estimates': [1154], 'size': [1157, 2315], 'effect': [1161, 1534], 'certainty': [1164], 'effect.': [1168], 'Note': [1169], 'Level': [1174, 1292, 1330, 4210, 4365], 'B': [1177, 1333], 'C': [1179, 1335], 'does': [1180, 1336], 'imply': [1182, 1338], 'weak.': [1187, 1343], 'Many': [1188, 1344], 'questions': [1191, 1347, 4257], 'addressed': [1192, 1348], 'do': [1195, 1352, 3289, 3504], 'lend': [1197, 1354], 'themselves': [1198, 1355, 1824], 'trials.': [1201, 1358], 'Although': [1202, 2189], 'randomized': [1203, 1361, 3113, 3640], 'may': [1205, 1210, 1367, 1642, 1665, 1713], 'available,': [1208, 1365], 'there': [1209, 1366, 1633], 'very': [1213, 1370], 'clear': [1214, 1371], 'particular': [1219, 1376, 1610], 'test': [1220, 1377], 'therapy': [1222, 1379, 3087, 3107, 3147, 3250, 3265, 3277, 3365, 3391, 3414, 3437, 4058, 4291, 4362, 4382], 'useful': [1224, 1381, 4029], 'effective.': [1226], 'Both': [1227], 'listed': [1236, 1839], 'consideration': [1244, 1791], 'iterations': [1251], 'well': [1256, 2050, 2202, 2586, 2866, 2916], 'update.': [1260, 1874, 2424], 'Of': [1261], 'note,': [1262], 'implications': [1264], 'older': [1266], 'informed': [1270], 'but': [1272, 1676, 3815, 4335], 'been': [1275, 1407, 1904, 2701, 4369], 'repeated': [1276, 2791, 2828, 3695], 'contemporary': [1278, 2317, 4306], 'settings': [1279], 'carefully': [1281], 'considered.': [1282], 'Download': [1283], 'figureDownload': [1284], 'PowerPointTable': [1285], '1.': [1286, 3898], 'Applying': [1287], 'Classification': [1288], 'Recommendations': [1290], 'Evidence†*Data': [1294], 'available': [1295, 1490, 1999], 'registries': [1300], 'about': [1301, 2675, 3095, 4258], 'usefulness/efficacy': [1303], 'different': [1305, 1525], 'subpopulations,': [1306], 'such': [1307, 1417, 1781, 4118, 4222], 'gender,': [1309], 'age,': [1310, 3872], 'history': [1311, 1314, 1319], 'diabetes,': [1313], 'prior': [1316, 1324], 'myocardial': [1317, 2234, 2688, 2774, 2897, 2941, 3149, 3246], 'infarction,': [1318], 'heart': [1321, 2894, 2938, 3019, 3215, 3299, 3331, 3514, 3546, 3581, 3613, 3886, 4015, 4229], 'failure,': [1322, 2895, 2939, 3020, 3300, 3515, 3582, 4230], 'aspirin': [1325], 'use.': [1326, 2902, 2946], 'A': [1327, 2992, 4372], 'Even': [1359], 'though': [1360], 'effective.†In': [1383], '2003,': [1384], 'list': [1394], 'suggested': [1396], 'phrases': [1397], 'use': [1399, 3097, 3124, 4200, 4263], 'when': [1400, 4068, 4128], 'recommendations.': [1402, 2084], 'All': [1403, 1766, 2609], 'written': [1408], 'sentences': [1411], 'express': [1413], 'complete': [1415], 'thought,': [1416], 'recommendation,': [1420], 'even': [1421], 'if': [1422, 1701, 3471], 'separated': [1423], 'presented': [1425, 1628, 1851, 1890, 2031, 2349], 'apart': [1426], 'rest': [1429], 'document': [1432, 2566, 2626, 2632], '(including': [1433], 'headings': [1434], 'above': [1435], 'sets': [1436], 'recommendations),': [1438], 'would': [1439], 'still': [1440], 'convey': [1441], 'intent': [1444], 'recommendation.': [1447, 1504, 1829], 'hoped': [1450], 'increase': [1454, 3856, 3915], "readers'": [1455], 'comprehension': [1456], 'allow': [1462], 'queries': [1463], 'individual': [1466, 2606], 'level.The': [1468], 'address': [1472], 'populations': [1474, 1530], '(and': [1475], 'health': [1476, 1561, 1617, 1718], 'providers)': [1478], 'residing': [1479], 'North': [1481, 1492, 1515, 2187, 2238, 2324], 'America.': [1482, 2188, 2239], 'As': [1483, 2691], 'such,': [1484], 'drugs': [1485, 2970, 2973], 'currently': [1489], 'America': [1493], 'discussed': [1495, 4049], 'text': [1498], 'without': [1499, 3258, 3468], 'specific': [1501, 1552, 1583], 'For': [1505, 1875, 3793], 'performed': [1507], 'large': [1509, 2182], 'numbers': [1510, 2183], 'subjects': [1512, 2185, 2260], 'outside': [1513, 2186, 2571, 2579], 'America,': [1516], 'each': [1517, 2590, 3663], 'committee': [1519, 1764, 1768, 1804, 1807, 1831, 2062, 2461, 2540, 2620], 'reviews': [1520], 'patterns': [1527, 2193], 'relevance': [1538], 'target': [1542], 'determine': [1545], 'whether': [1546, 1896], 'findings': [1548], 'should': [1549, 1648, 1721, 2728, 2873, 2921, 2974, 3251, 3278, 3358, 3384, 3411, 3434, 3565, 4100, 4195], 'inform': [1550], 'recommendation.The': [1553], 'assist': [1560], 'providers': [1563, 1720], 'decision': [1566, 1646, 2244], 'making': [1567, 1647], 'describing': [1569], 'range': [1571], 'generally': [1573], 'acceptable': [1574], 'approaches': [1575], 'diagnosis,': [1578], 'management,': [1579], 'prevention': [1581, 3417, 3440, 4216], 'diseases': [1584], 'conditions.': [1586], 'attempt': [1589], 'define': [1591], 'practices': [1592], 'meet': [1594, 2311], 'needs': [1596], 'patients': [1599, 2306, 2683, 2721, 2727, 2961, 3024, 3083, 3257, 3287, 3467, 3498, 3571, 3643, 3796, 3960, 4012, 4154, 4218, 4340], 'circumstances.': [1602], 'ultimate': [1604, 1678], 'judgment': [1605], 'regarding': [1606], 'must': [1612], 'made': [1614], 'provider': [1619], 'light': [1623], 'all': [1625, 1780, 1802, 1878, 2454, 2482], 'circumstances': [1627, 1635, 4023], 'patient.': [1631, 1707], 'Thus,': [1632], 'deviations': [1638], 'these': [1640, 1696, 2972, 4046], 'appropriate.': [1644], 'consider': [1649], 'availability': [1653], 'expertise': [1655], 'area': [1658], 'where': [1659], 'provided.': [1662], 'These': [1663], 'regulatory': [1672], 'payer': [1674], 'decisions,': [1675], 'goal': [1679], 'serving': [1685], "patient's": [1687], 'best': [1688], 'interests.Prescribed': [1689], 'courses': [1690], 'accordance': [1694], 'only': [1699], 'effective': [1700], 'they': [1702, 1897, 1932, 3973, 4234], 'followed': [1704, 3669], 'Because': [1708], 'lack': [1709], 'adherence': [1712], 'adversely': [1714], 'affect': [1715], 'outcomes,': [1717], 'make': [1722], 'every': [1723, 1742, 3696, 3794, 4175], 'engage': [1726], 'active': [1730, 3333, 3548, 3615], 'participation': [1731], 'prescribed': [1733], 'treatment.The': [1734], 'makes': [1741], 'avoid': [1745], 'any': [1746, 1881, 3292, 3507, 3574, 3773, 3979], 'actual,': [1747], 'potential,': [1748], 'perceived': [1750], 'conflict': [1751], 'interest': [1753], 'arising': [1754], 'personal': [1759], 'interests': [1760], 'member.': [1765], 'members': [1769, 1808, 1832, 2455, 2494, 2531], 'peer': [1771], 'reviewers': [1772, 2572, 2580], 'were': [1773, 1799, 1820, 2055, 2100, 2224, 2285, 2462, 2478, 3026, 3067, 3761, 3920, 3974], 'provide': [1776, 2327], 'disclosure': [1777], 'statements': [1778], 'pertaining': [1783], 'under': [1790, 2488], 'Appendixes': [1793], '2).': [1796, 2748], 'Final': [1797], 'balloted': [1800], 'members.': [1805], 'significant': [1810, 2498, 2544, 3156], '(greater': [1811, 2545], '$10': [1813, 2547], '000)': [1814, 2548], '(RWI)': [1819], 'recuse': [1823], 'voting': [1826, 2559], 'who': [1833, 2261, 2467, 2495, 3025, 3288, 3499, 3503, 3572, 4157, 4341], 'did': [1834, 3153], 'participate': [1836], 'authors': [1841, 3970], 'update.With': [1845], 'exception': [1847], 'here,': [1852], 'remain': [1856, 1898], 'current.': [1857], 'Only': [1858], 'section(s)': [1864], 'included': [1870, 4311], 'easy': [1876], 'reference,': [1877], 'section': [1882], 'impacted': [1885], 'change': [1888, 4325], 'notation': [1893], 'current,': [1899], 'new,': [1901], 'modified.': [1905], 'When': [1906], 'impacts': [1908], 'set': [1914, 2332], 'guidelines,': [1916], 'those': [1917, 2074, 2466, 2875, 3256, 3866, 4224], 'concurrently.The': [1921], 'considered': [1929, 2101, 2296], 'until': [1931, 3734], 'superseded': [1934], 'another': [1936], 'full-text': [1941, 1978, 2395, 2442], 'revised.': [1944], 'This': [1945], 'published': [1949, 2623], 'January': [1952, 1967], '15,': [1953, 1968], '2008,': [1954, 1969], 'issue': [1955, 1970], 'Journal': [1958], 'Cardiology': [1964, 2646], 'Circulation': [1972], 'posted': [1983], '(www.acc.org)': [1987], '(www.americanheart.org)': [1990], 'Web': [1991], 'sites.': [1992], 'Copies': [1993], 'both': [2001, 2863, 2913, 3085], 'organizations.Sidney': [2002], 'Smith,': [2004], 'Jr.,': [2005], 'FAHAChair,': [2008], 'GuidelinesAlice': [2014], 'FAHAVice-Chair,': [2019], 'Guidelines1.': [2025], 'Introduction1.1.': [2026], 'ReviewLate-breaking': [2028], '2005': [2034], '2006': [2036], 'annual': [2037], 'scientific': [2038], 'meetings': [2039], 'ACC,': [2042], 'AHA,': [2043, 2584], 'European': [2045], 'Cardiology,': [2048], 'selected': [2052], 'data,': [2054, 2334], 'standing': [2059], 'along': [2063], 'parent': [2066], 'experts': [2071], 'identify': [2073, 3978], 'might': [2081, 2209], 'On': [2085, 3899], 'noted': [2091, 3928, 3971, 4197], 'above,': [2092], 'trial': [2094, 4255], 'information': [2099, 2612], 'enough': [2103], 'prompt': [2105], '[see': [2123], 'Chen': [2124, 2128], 'ZM': [2125, 2129], 'et': [2126, 2130, 2136, 2140, 2144, 2148, 2152, 2157], 'al.3;': [2127], 'al.4;': [2131], 'ASSENT-4': [2132], 'PCI5;': [2133], 'EM': [2135], 'al.6;': [2137], 'Yusuf': [2138], 'S': [2139], 'al.7;': [2141], 'Bhatt': [2142], 'DL': [2143], 'al.8;': [2145], 'Sabatine': [2146], 'MS': [2147], 'al.9;': [2149], 'Bennett': [2150], 'JS': [2151], 'al.10;': [2153], 'Smith': [2154], 'SC': [2155], 'Jr': [2156], 'al.11;': [2158], 'OAT12,13': [2159], 'TOSCA14].When': [2161], 'considering': [2162], 'update,': [2169, 2453], 'faced': [2173], 'task': [2175], 'weighing': [2177], 'enrolling': [2181], 'noting': [2190], 'rigor': [2196], 'applied': [2197], 'collection,': [2200], 'genetic': [2205], 'makeup': [2206], 'subjects,': [2208], 'influence': [2210], 'observed': [2212], 'magnitude': [2213], 'effect,': [2217], 'believed': [2221], 'formulation': [2227], 'management': [2231, 2252, 2803, 2840, 3035], 'ST-elevation': [2233, 2773, 3245], 'infarction': [2235, 2689, 3150], '(STEMI)': [2236], 'reasons': [2241], 'include': [2245], '1)': [2247, 3296, 3511, 3578], 'broad': [2249], 'array': [2250], 'strategies': [2253], 'was': [2254, 2295, 2511, 2556, 2567, 2613, 2633, 3691, 3717, 3753, 3786, 3801, 3827, 3927, 3948, 4292, 4322], 'represented,': [2255], 'including': [2256], 'substantial': [2257], 'proportions': [2258], 'received': [2262, 2731], 'some': [2263], 'form': [2264], 'reperfusion': [2266, 2732], 'therapy,': [2267], '2)': [2268, 3301, 3516, 3583], 'concomitant': [2269, 3263], 'treatments': [2270], 'proven': [2272], '(e.g.,': [2274], 'aspirin,': [2275], 'beta': [2276, 3091, 3100, 3117, 3320, 3462, 3489, 3535, 3563, 3602, 4009, 4036, 4112, 4203, 4266, 4314], 'blockers,': [2277, 4267], 'inhibitors': [2278, 2965], 'renin-angiotensin-aldosterone': [2281], 'system,': [2282], 'statins)': [2284], 'majority': [2289], 'patients,': [2291], '3)': [2293, 3066, 3308, 3523, 3590], 'it': [2294, 4026, 4338], 'impractical': [2298], 'expectation': [2299], 'tens': [2302], 'thousands': [2304], 'STEMI': [2308, 2459, 2726, 2756, 2759, 2872, 2884, 2928, 2982, 2985, 3057, 3062, 3167, 3170, 3357, 3383, 3466, 3497, 3570, 4000, 4041, 4067, 4156, 4244], 'estimated': [2313], 'sample': [2314], 'enrolled': [2321], 'exclusively': [2322], 'sites.To': [2326], 'clinicians': [2328], 'comprehensive': [2331], 'whenever': [2335], 'possible': [2336], 'exact': [2338], 'event': [2339], 'rates': [2340, 3864], 'various': [2342, 3047], 'arms': [2344], 'permit': [2351], 'calculation': [2352], 'absolute': [2355, 3907, 3914], 'risk': [2356, 2380, 2889, 2933, 2956, 3015, 3044, 3183, 3189, 3965, 4005, 4080, 4089, 4346], 'difference': [2357, 3926], '(ARD)': [2358], 'number': [2360, 3181], 'treat': [2363], '(NNT)': [2364], 'harm': [2366], '(NNH);': [2367], 'relative': [2369, 2379, 3317, 3532, 3599, 3855], 'effects': [2371, 2679, 4130], 'either': [2374, 2729, 2745, 3941], 'odds': [2376], 'ratio': [2377, 2384], '(OR),': [2378], '(RR),': [2381], 'hazard': [2383], '(HR),': [2385], 'depending': [2386], 'format': [2389], 'original': [2392], 'publication.Consult': [2393], 'executive': [2398], 'summary': [2399], 'Infarction15': [2413], 'policy': [2415], 'areas': [2418], 'covered': [2420], 'Individual': [2425], 'incorporated': [2434], 'into': [2435], 'future': [2436], 'guidelines.1.2.': [2443], 'IndustryFor': [2450], 'invited': [2463], 'participate;': [2465], 'agreed': [2468], '(referred': [2469], 'group)': [2477], 'disclose': [2481], 'RWI': [2483, 2500, 2611], 'consideration.2': [2489], 'had': [2496], 'no': [2497, 4309], 'wrote': [2501], 'first': [2503, 3283, 3353, 3379, 3666], 'draft': [2504, 2510], 'update;': [2508], 'then': [2512], 'revised': [2515], 'group.': [2520], 'Each': [2521], 'confidential': [2525], 'vote': [2526], 'before': [2532, 2871, 4108], 'external': [2533], 'document.': [2537], 'Any': [2538], 'member': [2541], 'relationship': [2549], 'recused': [2557], 'recommendation.1.3.': [2562], 'ApprovalThis': [2565], 'nominated': [2573, 2581], 'reviewer': [2589, 2610], 'Physicians': [2597, 2661], '(CCS)': [2603], '58': [2605], 'content': [2607], 'reviewers.': [2608], 'collected': [2614], 'distributed': [2616], 'Appendix': [2628], '2': [2629, 2786, 2823, 3111, 3708, 3757, 3848, 3931, 4126, 4254], 'details).This': [2631], 'approved': [2634], 'publication': [2636], 'governing': [2639], 'bodies': [2640], 'Foundation': [2647], 'endorsed': [2654], 'Society.2.': [2666], 'AnalgesiaAnalysis': [2667], 'retrospective': [2669], 'data16': [2670], 'raised': [2672], 'question': [2674], 'potentially': [2677], 'adverse': [2678], 'morphine': [2681, 2697, 2714], 'unstable': [2685], 'angina': [2686], '(UA)/non–ST-elevation': [2687], '(NSTEMI).': [2690], 'result,': [2693], 'pain': [2698, 2741, 2805, 2842], 'relief': [2699, 2743], 'reduced': [2702, 3074, 3788], 'Class': [2705, 2717], 'IIa': [2706], 'population.': [2711], 'Use': [2712], 'remains': [2715, 2851, 3400, 3451, 4383], 'I': [2718], 'STEMI,': [2723, 2772, 3244], 'because': [2725, 2885, 2929, 4351], 'candidates': [2736], 'reperfusion,': [2738], 'continuing': [2740], 'requires': [2742], 'case': [2746], '(Table': [2747, 3065, 4043], '2.': [2750], 'Updates': [2751, 3161], '6.3.1.3:': [2754], 'Analgesia2004': [2755], 'Guideline': [2757, 3168], 'Recommendation2007': [2758, 3169], 'RecommendationCommentsCOX-2': [2762], 'indicates': [2763, 3230], 'cyclooxygenase-2;': [2764], 'IV,': [2765], 'intravenous/intravenously;': [2766], 'NSAIDs,': [2767], 'nonsteroidal': [2768, 2968], 'anti-inflammatory': [2769, 2969], 'drugs;': [2770], 'infarction.Class': [2775, 3247], 'IMorphine': [2776], 'sulfate': [2777, 2814], '(2': [2778, 2815], '4': [2780, 2817, 3745], 'mg': [2781, 2789, 2818, 2826, 3661, 3672, 3711, 4141, 4171, 4185], 'IV': [2782, 2790, 2819, 2827, 3099, 3116, 3461, 3488, 3562, 3662, 3682, 4008, 4035, 4056, 4111, 4265], 'increments': [2784, 2821], '8': [2788, 2825], '5-': [2793, 2830], '15-minute': [2795, 2832], 'intervals)': [2796, 2833], 'analgesic': [2799, 2836], 'choice': [2801, 2838], 'associated': [2806, 2843, 2899, 2943, 3802, 3949], 'STEMI.': [2808, 2845], '(Level': [2809, 2846, 2903, 2947, 3271, 3339, 3369, 3395, 3423, 3446, 3478, 3554, 3621], 'Evidence:': [2811, 2848, 2905, 2949, 3273, 3341, 3371, 3397, 3425, 3448, 3480, 3556, 3623, 4212], 'C)1.': [2812], 'Morphine': [2813], 'C)2004': [2849, 3398], 'Update2.': [2855], 'routinely': [2857], 'taking': [2858, 2962, 3027], 'NSAIDs': [2859, 2909, 3028], '(except': [2860, 2910], 'aspirin),': [2862, 2912], 'nonselective': [2864, 2914], 'COX-2': [2868, 2918], 'selective': [2869, 2919], 'agents,': [2870, 2920], 'agents': [2876], 'discontinued': [2877, 2976], 'time': [2880, 2980, 3223, 3493], 'presentation': [2882, 3495], 'increased': [2888, 2932, 2955, 3014, 3109, 3222, 3309, 3524, 3591, 4079], 'mortality,': [2891, 2935], 'reinfarction,': [2892, 2936, 3018, 3766, 3808], 'hypertension,': [2893, 2937], 'rupture': [2898, 2942], 'C)New': [2906, 2950], 'recommendationClass': [2907], 'III1.': [2908, 3561], 'administered': [2924, 3253, 3568, 3692, 3718], 'hospitalization': [2926, 4065], 'recommendationBecause': [2951], 'known': [2954], 'cardiovascular': [2958], 'events': [2959], 'among': [2960, 3023], 'cyclooxygenase-2': [2963], '(COX-2)': [2964], '(NSAIDs),17–19': [2971], 'immediately': [2977], '7.12.5,': [2988], 'discussion).3,15,20,21': [2991], 'substudy': [2993], 'analysis': [2994, 3121], 'ExTRACT': [2997], 'TIMI-25': [2998], '(Enoxaparin': [2999], 'Thrombolysis': [3001], 'Reperfusion': [3002], 'Acute': [3004], 'Treatment–Thrombolysis': [3007], 'Infarction)': [3010], 'trial22': [3011], 'demonstrated': [3012], 'death,': [3017, 3765, 3940], 'shock': [3022, 3177, 3826, 3859, 4083], 'within': [3029, 3351, 3377, 3644], '7': [3030], 'days': [3031], 'enrollment.': [3033], 'Longer-term': [3034], 'considerations': [3036], 'discussion': [3039], 'gradient': [3042], 'NSAIDS': [3048], 'found': [3050], '7.12.5': [3053], 'Guidelines.153.': [3058], 'BlockersThe': [3060], 'showed': [3072], 'incidence': [3075], 'subsequent': [3077], 'reinfarction': [3078, 3841, 4132], 'recurrent': [3080], 'ischemia': [3081], 'receiving': [3084], 'fibrinolytic': [3086, 3106, 3264], 'intravenous': [3089], '(IV)': [3090], 'blockers.': [3092], 'However,': [3093], 'uncertainty': [3094], 'blockers': [3101, 3463, 3564, 4010, 4113, 4204], 'setting': [3104], 'later': [3112], 'blockade,23,24': [3118], 'post-hoc': [3120], 'atenolol': [3126], 'GUSTO-I': [3129], '(Global': [3130], 'Utilization': [3131], 'Streptokinase': [3133], 'TPA': [3135], 'Occluded': [3137], 'Coronary': [3138], 'Arteries)': [3139], 'trial,25': [3140], 'early': [3145, 3349, 3375, 4262, 4331, 4376], 'beta-blocker': [3146, 3249, 3276, 3364, 3390, 3413, 3436, 4057, 4284, 4333, 4381], '(MI)26': [3151], 'find': [3155], 'reductions': [3157, 3839], 'mortality.15Table': [3159], '3.': [3160], '6.3.1.5:': [3164], 'Blockers2004': [3166], 'RecommendationComments*Risk': [3173], 'factors': [3174, 3184, 4090], 'cardiogenic': [3176, 3192, 3312, 3527, 3594, 3820, 3825, 3858, 3917, 4018, 4082], '(the': [3178], 'greater': [3179, 3196, 3210, 3324, 3539, 3606, 3867, 3888, 3896], 'present,': [3185], 'higher': [3187, 3863], 'shock)': [3193], 'age': [3195], '70': [3198, 3869], 'years,': [3199], 'systolic': [3200, 3875], 'blood': [3201, 3876], 'pressure': [3202, 3877], 'less': [3203, 3217, 3878], '120': [3205, 3880], 'mm': [3206, 3881], 'Hg,': [3207, 3882], 'sinus': [3208, 4095], 'tachycardia': [3209, 4096], '110': [3212, 3890], 'bpm': [3213], 'rate': [3216, 3887], '60': [3219], 'bpm,': [3220, 3891], 'since': [3224], 'onset': [3225, 3648], 'symptoms': [3227], 'STEMI.IV': [3229], 'intravenous;': [3231], 'LOE,': [3232], 'evidence;': [3235], 'LV,': [3236], 'left': [3237, 4102], 'ventricular;': [3238], 'PCI,': [3239], 'percutaneous': [3240], 'coronary': [3241], 'intervention;': [3242], 'IOral': [3248], 'promptly': [3254, 3464], 'contraindication,': [3260], 'irrespective': [3261], 'PCI.': [3270], 'A)1.': [3274], 'Oral': [3275], '24': [3284, 3354, 3380, 3645, 4378], 'hours': [3285, 3355, 3381, 3646, 3698], 'following:': [3295, 3510, 3577], 'signs': [3297, 3512, 3579], 'low': [3305, 3520, 3587, 3964, 4226], 'output': [3306, 3521, 3588], 'state,': [3307, 3522, 3589], 'risk*': [3310, 3525, 3592], 'shock,': [3313, 3528, 3595], '4)': [3315, 3530, 3597], 'contraindications': [3318, 3350, 3376, 3533, 3600], 'blockade': [3321, 3536, 3603], '(PR': [3322, 3537, 3604], 'interval': [3323, 3538, 3605], '0.24': [3326, 3541, 3608], 'seconds,': [3327, 3542, 3609], 'second-': [3328, 3543, 3610], 'third-degree': [3330, 3545, 3612], 'block,': [3332, 3547, 3614], 'asthma,': [3334, 3549, 3616], 'reactive': [3336, 3551, 3618], 'airway': [3337, 3552, 3619], 'disease).': [3338, 3553, 3620], 'B)Modified': [3342, 3557], '(changed': [3344, 3559], 'LOE': [3345], 'text)Patients': [3347], 'reevaluated': [3360, 3386], 'candidacy': [3362, 3388], 'secondary': [3367, 3393, 3416, 3439, 4215], 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4173], '(up': [3655], 'doses': [3658], '5': [3660, 3804, 3809], '15': [3667, 3754], 'minutes,': [3668], '200': [3671, 3710, 4140, 4184], 'orally': [3673, 3693, 3719, 4174, 4188], 'daily)': [3674], 'matching': [3676], 'placebo.': [3677], 'Fifteen': [3678], 'minutes': [3679], 'after': [3680, 3835], 'doses,': [3683], '50-mg': [3685], 'tablet': [3686], 'placebo': [3690, 3716], '6': [3697, 4176], 'Days': [3700, 3831, 4060], '0': [3701, 3832, 4061], 'hospitalization.': [3705], 'From': [3706, 4124], 'Day': [3707, 3847, 4125], 'onward,': [3709, 4127], 'controlled-release': [3713, 4143], 'daily': [3720, 4146], '(this': [3721], 'Food': [3724], 'Drug': [3726], 'Administration': [3727], '[FDA]-approved': [3728], 'regimen': [3729], 'MI)': [3733], 'discharge': [3735], 'hospital': [3738, 3748], 'maximum': [3743, 4191], 'weeks': [3746], '(in': [3749], 'survivors,': [3750], 'mean': [3752], 'days).': [3755], 'prespecified': [3758], 'co-primary': [3759, 3782], 'composite': [3763], 'cardiac': [3768], 'arrest': [3769], 'death': [3771], 'cause': [3774], 'scheduled': [3777], 'period.Neither': [3779], 'study': [3783, 3904, 4310, 4357], 'end': [3784], 'points': [3785], 'significantly': [3787, 3951], 'allocation': [3790, 3798, 3947], 'metoprolol.': [3792], '1000': [3795], 'treated,': [3797], 'fewer': [3805, 3810], 'episodes': [3806, 3811, 3818], 'ventricular': [3813, 3843, 4103, 4134], 'defibrillation,': [3814], '11': [3816], 'shock.': [3821, 4019], 'excess': [3823], 'seen': [3828], 'chiefly': [3829], 'hospitalization,': [3836], 'whereas': [3837], 'fibrillation': [3844, 4099, 4135], 'appeared': [3845], 'onward.Allocation': [3849], 'produced': [3852], 'average': [3854, 3900], '30%,': [3861], 'presenting': [3885], 'Killip': [3894], 'across': [3901], 'whole': [3903], 'population,': [3905], 'reduction': [3908], 'arrhythmia-related': [3910], 'deaths': [3911, 3919], 'shock–related': [3918], 'similar': [3922], 'magnitude.': [3923], 'No': [3924], 'apparent': [3925], 'between': [3929], 'groups': [3933], 'attributed': [3937], 'causes': [3938], 'individually': [3942], 'aggregate.': [3945], 'persistent': [3953], 'hypotension': [3954], 'cases': [3957], 'bradycardia.Though': [3959], 'high': [3962, 4345], 'identified,': [3968], 'able': [3976], 'subgroups': [3980], 'benefits': [3984], 'clearly': [3985], 'outweighed': [3986], 'risks.3.2.': [3988], 'ConclusionThis': [3989], 'expands': [3992], 'concepts': [3995], 'introduced': [3996], 'underscoring': [4002], 'administering': [4007], 'There': [4020], 'several': [4022], 'can': [4027], '(Class': [4030, 4208], 'IIa)': [4031], 'acutely': [4038], '3),': [4044], 'situations': [4047], 'below.': [4050], 'present': [4071], 'defined': [4091], 'above.': [4092], 'atrial': [4098], '(LV)': [4104], 'function': [4105], 'rapidly': [4106], 'evaluated': [4107, 4360], 'administration': [4109, 4138], '(or': [4114], 'negative': [4116], 'inotropes,': [4117], 'non-dihydropyridine': [4120], 'calcium': [4121], 'channel': [4122], 'blockers).': [4123], 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'created_date': '2017-05-26'}
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