Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2614019591', 'doi': 'https://doi.org/10.1038/emm.2017.41', 'title': 'Upregulation and biological function of transmembrane protein 119 in osteosarcoma', 'display_name': 'Upregulation and biological function of transmembrane protein 119 in osteosarcoma', 'publication_year': 2017, 'publication_date': '2017-05-01', 'ids': {'openalex': 'https://openalex.org/W2614019591', 'doi': 'https://doi.org/10.1038/emm.2017.41', 'mag': '2614019591', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28496199', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5454443'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2017.41', 'pdf_url': 'https://www.nature.com/articles/emm201741.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/emm201741.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5030219358', 'display_name': 'Zhenhuan Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139780', 'display_name': "Yixing People's Hospital", 'ror': 'https://ror.org/049avne82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139780']}, {'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhen-Huan Jiang', 'raw_affiliation_strings': ["Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210139780', 'https://openalex.org/I115592961']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101534951', 'display_name': 'Jun Peng', 'orcid': 'https://orcid.org/0000-0003-2401-731X'}, 'institutions': [{'id': 'https://openalex.org/I4210139780', 'display_name': "Yixing People's Hospital", 'ror': 'https://ror.org/049avne82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139780']}, {'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Peng', 'raw_affiliation_strings': ["Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210139780', 'https://openalex.org/I115592961']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100786522', 'display_name': 'Huilin Yang', 'orcid': 'https://orcid.org/0000-0003-4483-5109'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}, {'id': 'https://openalex.org/I4210153519', 'display_name': 'First Affiliated Hospital of Soochow University', 'ror': 'https://ror.org/051jg5p78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153519']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui-Lin Yang', 'raw_affiliation_strings': ["Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China", 'institution_ids': ['https://openalex.org/I3923682', 'https://openalex.org/I4210153519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046896857', 'display_name': 'Xingli Fu', 'orcid': 'https://orcid.org/0000-0002-9199-7525'}, 'institutions': [{'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xing-Li Fu', 'raw_affiliation_strings': ["Health Science Center of Jiangsu University, Zhenjiang, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Health Science Center of Jiangsu University, Zhenjiang, People's Republic of China", 'institution_ids': ['https://openalex.org/I115592961']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115592037', 'display_name': 'Jinzhi Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin-Zhi Wang', 'raw_affiliation_strings': ["Department of Cell Biology, School of Medicine, Soochow University, Suzhou, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Cell Biology, School of Medicine, Soochow University, Suzhou, People's Republic of China", 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089272863', 'display_name': 'Lei Liu', 'orcid': 'https://orcid.org/0000-0003-4898-5665'}, 'institutions': [{'id': 'https://openalex.org/I4210139780', 'display_name': "Yixing People's Hospital", 'ror': 'https://ror.org/049avne82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139780']}, {'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lei Liu', 'raw_affiliation_strings': ["Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210139780', 'https://openalex.org/I115592961']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079165223', 'display_name': 'Jiannong Jiang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139780', 'display_name': "Yixing People's Hospital", 'ror': 'https://ror.org/049avne82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139780']}, {'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian-Nong Jiang', 'raw_affiliation_strings': ["Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Orthopedics, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210139780', 'https://openalex.org/I115592961']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066497348', 'display_name': 'Yongfei Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139780', 'display_name': "Yixing People's Hospital", 'ror': 'https://ror.org/049avne82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139780']}, {'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong-Fei Tan', 'raw_affiliation_strings': ["Department of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210139780', 'https://openalex.org/I115592961']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100295999', 'display_name': 'Zhijun Ge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210139780', 'display_name': "Yixing People's Hospital", 'ror': 'https://ror.org/049avne82', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210139780']}, {'id': 'https://openalex.org/I115592961', 'display_name': 'Jiangsu University', 'ror': 'https://ror.org/03jc41j30', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I115592961']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Jun Ge', 'raw_affiliation_strings': ["Department of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Critical Care Medicine, The Affiliated Yixing Hospital of Jiangsu University, Yixing, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210139780', 'https://openalex.org/I115592961']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2690, 'currency': 'GBP', 'value_usd': 3299, 'provenance': 'doaj'}, 'apc_paid': {'value': 2690, 'currency': 'GBP', 'value_usd': 3299, 'provenance': 'doaj'}, 'fwci': 1.426, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.799125, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '49', 'issue': '5', 'first_page': 'e329', 'last_page': 'e329'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9832, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9796, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777760704', 'wikidata': 'https://www.wikidata.org/wiki/Q549534', 'display_name': 'Osteosarcoma', 'level': 2, 'score': 0.89454496}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.80817544}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.69113547}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.67224026}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6342991}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5668303}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5437717}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.5308738}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.4928496}, {'id': 'https://openalex.org/C30352789', 'wikidata': 'https://www.wikidata.org/wiki/Q14903153', 'display_name': 'Bone morphogenetic protein 2', 'level': 3, 'score': 0.46845838}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43844047}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.4324999}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.4143933}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.29151475}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20215276}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.13375038}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09086475}], 'mesh': [{'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009362', 'descriptor_name': 'Neoplasm Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2017.41', 'pdf_url': 'https://www.nature.com/articles/emm201741.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454443', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28496199', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2017.41', 'pdf_url': 'https://www.nature.com/articles/emm201741.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W141167630', 'https://openalex.org/W1561757020', 'https://openalex.org/W1682458758', 'https://openalex.org/W181426613', 'https://openalex.org/W1850687807', 'https://openalex.org/W1876443470', 'https://openalex.org/W1935862113', 'https://openalex.org/W1936583519', 'https://openalex.org/W1942214720', 'https://openalex.org/W1979995768', 'https://openalex.org/W1986629515', 'https://openalex.org/W1987997281', 'https://openalex.org/W1992018116', 'https://openalex.org/W2004471876', 'https://openalex.org/W2004676972', 'https://openalex.org/W2009991266', 'https://openalex.org/W2024945571', 'https://openalex.org/W2032919896', 'https://openalex.org/W2034681029', 'https://openalex.org/W2042488089', 'https://openalex.org/W2045624605', 'https://openalex.org/W2047724495', 'https://openalex.org/W2052592414', 'https://openalex.org/W2057698298', 'https://openalex.org/W2061390323', 'https://openalex.org/W2063011414', 'https://openalex.org/W2089439379', 'https://openalex.org/W2122844744', 'https://openalex.org/W2130410032', 'https://openalex.org/W2138585583', 'https://openalex.org/W2141567682', 'https://openalex.org/W2151680511', 'https://openalex.org/W2160462120', 'https://openalex.org/W2171172582', 'https://openalex.org/W262238300', 'https://openalex.org/W4254730040'], 'related_works': ['https://openalex.org/W4242486335', 'https://openalex.org/W3176933524', 'https://openalex.org/W3046968286', 'https://openalex.org/W2743186002', 'https://openalex.org/W2418133988', 'https://openalex.org/W2353576099', 'https://openalex.org/W2349036090', 'https://openalex.org/W2126015323', 'https://openalex.org/W2030857804', 'https://openalex.org/W2028656779'], 'abstract_inverted_index': {'Osteosarcoma': [0], 'is': [1, 259], 'suggested': [2, 211], 'to': [3, 25, 58, 109, 234, 346], 'be': [4, 59, 110], 'caused': [5], 'by': [6, 149], 'genetic': [7], 'and': [8, 28, 37, 53, 85, 118, 129, 157, 169, 171, 181, 196, 218, 238, 243, 289, 330, 352, 354, 376], 'molecular': [9], 'alterations': [10], 'that': [11, 19, 138, 162, 212, 231, 294], 'disrupt': [12], 'osteoblast': [13, 26], 'differentiation.': [14], 'Recent': [15], 'studies': [16], 'have': [17, 42, 291], 'reported': [18], 'transmembrane': [20, 254], 'protein': [21, 54, 73, 255, 315], '119': [22, 256], '(TMEM119)': [23, 257], 'contributes': [24, 233], 'differentiation': [27], 'bone': [29, 66, 268, 276, 302, 318, 341], 'development.': [30, 277], 'However,': [31], 'the': [32, 48, 96, 144, 173, 186, 229, 235, 253, 263, 281, 299, 321, 334, 337, 356, 365], 'level': [33, 70], 'of': [34, 71, 95, 140, 146, 175, 189, 240, 252, 267, 285, 301, 313, 323, 336, 358, 364], 'TMEM119': [35, 51, 72, 104, 125, 141, 163, 190, 213, 232, 270, 295, 314, 324, 338, 371], 'expression': [36, 55, 74, 105, 126, 174, 251, 335], 'its': [38], 'roles': [39], 'in': [40, 61, 106, 127, 154, 199, 248, 275, 340, 349, 360, 384], 'osteosarcoma': [41, 62, 107, 147, 193, 241, 308], 'not': [43], 'yet': [44], 'been': [45], 'elucidated.': [46], 'In': [47, 224], 'present': [49], 'study,': [50], 'mRNA': [52], 'was': [56, 75], 'found': [57, 161], 'up-regulated': [60], 'compared': [63], 'with': [64, 78, 113, 202, 261, 326], 'normal': [65], 'cyst': [67], 'tissues.': [68], 'The': [69], 'strongly': [76], 'associated': [77, 260], 'tumor': [79, 327], 'size,': [80, 328], 'clinical': [81], 'stage,': [82], 'distant': [83], 'metastasis': [84, 117, 329], 'overall': [86], 'survival': [87], 'time.': [88], 'Moreover,': [89], 'gene': [90, 258, 339, 382], 'set': [91], 'enrichment': [92], 'analysis': [93], '(GSEA)': [94], 'Gene': [97], 'Expression': [98], 'Omnibus': [99], '(GEO)': [100], 'GSE42352': [101], 'dataset': [102], 'revealed': [103, 137], 'tissues': [108], 'positively': [111], 'correlated': [112, 325], 'cell': [114, 151, 167, 194, 216, 343, 350], 'cycle,': [115], 'apoptosis,': [116], 'TGF-β': [119, 176, 183, 204], 'signaling.': [120, 223], 'We': [121, 159], 'then': [122], 'knocked': [123], 'down': [124], 'U2OS': [128], 'MG63': [130], 'cells': [131, 148], 'using': [132], 'small': [133], 'interfering': [134], 'RNA,': [135], 'which': [136], 'downregulation': [139], 'could': [142], 'inhibit': [143], 'proliferation': [145, 351], 'inducing': [150], 'cycle': [152], 'arrest': [153], 'G0/G1': [155], 'phase': [156], 'apoptosis.': [158], 'also': [160, 297], 'knockdown': [164, 191], 'significantly': [165, 214], 'inhibited': [166], 'migration': [168, 195, 217, 237], 'invasion,': [170, 219], 'decreased': [172], 'pathway-related': [177], 'factors': [178], '(BMP2,': [179], 'BMP7': [180], 'TGF-β).': [182], 'application': [184], 'rescued': [185], 'inhibitory': [187], 'effects': [188], 'on': [192], 'invasion.': [197], 'Further': [198], 'vitro': [200], 'experiments': [201], 'a': [203, 272, 347, 361, 373, 378], 'inhibitor': [205, 209], '(SB431542)': [206], 'or': [207], 'BMP': [208], '(dorsomorphin)': [210], 'promotes': [215], 'partly': [220], 'through': [221], 'TGF-β/BMP': [222], 'conclusion,': [225], 'our': [226], 'data': [227], 'support': [228], 'notion': [230], 'proliferation,': [236], 'invasion': [239], 'cells,': [242], 'functions': [244], 'as': [245, 372, 377], 'an': [246], 'oncogene': [247], 'osteosarcoma.': [249, 385], 'Increased': [250], 'osteosarcoma,': [262], 'most': [264], 'common': [265], 'type': [266], 'cancer.': [269], 'has': [271], 'well-established': [273], 'role': [274], 'Zhi-Jun': [278], 'Ge': [279], 'at': [280], 'Affiliated': [282], 'Yixing': [283], 'Hospital': [284], 'Jiangsu': [286], 'University,': [287], 'China,': [288], 'colleagues': [290], 'now': [292], 'shown': [293], 'can': [296], 'drive': [298], 'formation': [300, 357], 'tumors.': [303], 'Not': [304], 'only': [305], 'did': [306], 'human': [307], 'tissue': [309], 'contain': [310], 'higher': [311], 'levels': [312, 322], 'than': [316], 'control': [317], 'tissue,': [319], 'but': [320], 'patient': [331], 'survival.': [332], 'Blocking': [333], 'cancer': [342], 'lines': [344], 'led': [345], 'reduction': [348], 'migration,': [353], 'suppressed': [355], 'tumors': [359], 'mouse': [362], 'model': [363], 'disease.': [366], 'Together,': [367], 'these': [368], 'findings': [369], 'highlight': [370], 'prognostic': [374], 'factor': [375], 'potential': [379], 'target': [380], 'for': [381], 'therapy': [383]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2614019591', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 7}], 'updated_date': '2025-01-12T17:01:49.667920', 'created_date': '2017-05-19'}