Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2126015323', 'doi': 'https://doi.org/10.1016/j.archoralbio.2010.06.010', 'title': 'Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation', 'display_name': 'Epidermal growth factor and bone morphogenetic proteins upregulate osteoblast proliferation and osteoblastic markers and inhibit bone nodule formation', 'publication_year': 2010, 'publication_date': '2010-07-12', 'ids': {'openalex': 'https://openalex.org/W2126015323', 'doi': 'https://doi.org/10.1016/j.archoralbio.2010.06.010', 'mag': '2126015323', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20627196'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.archoralbio.2010.06.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44717366', 'display_name': 'Archives of Oral Biology', 'issn_l': '0003-9969', 'issn': ['0003-9969', '1879-1506'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073859486', 'display_name': 'Claude Laflamme', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Claude Laflamme', 'raw_affiliation_strings': ['Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Pavillon de médecine dentaire, Université Laval, Québec, Canada G1K 7P4.'], 'affiliations': [{'raw_affiliation_string': 'Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Pavillon de médecine dentaire, Université Laval, Québec, Canada G1K 7P4.', 'institution_ids': ['https://openalex.org/I43406934']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080861792', 'display_name': 'Sèverine Curt', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sèverine Curt', 'raw_affiliation_strings': ['Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Pavillon de médecine dentaire, Université Laval, Québec, Canada G1K 7P4.'], 'affiliations': [{'raw_affiliation_string': 'Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Pavillon de médecine dentaire, Université Laval, Québec, Canada G1K 7P4.', 'institution_ids': ['https://openalex.org/I43406934']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017099324', 'display_name': 'Mahmoud Rouabhia', 'orcid': 'https://orcid.org/0000-0003-2205-8281'}, 'institutions': [{'id': 'https://openalex.org/I43406934', 'display_name': 'Université Laval', 'ror': 'https://ror.org/04sjchr03', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I43406934']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Mahmoud Rouabhia', 'raw_affiliation_strings': ['Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Pavillon de médecine dentaire, Université Laval, Québec, Canada G1K 7P4.'], 'affiliations': [{'raw_affiliation_string': 'Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Pavillon de médecine dentaire, Université Laval, Québec, Canada G1K 7P4.', 'institution_ids': ['https://openalex.org/I43406934']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'USD', 'value_usd': 3920, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.865, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.797047, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '55', 'issue': '9', 'first_page': '689', 'last_page': '701'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11221', 'display_name': 'Bone health and treatments', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bone-formation', 'display_name': 'Bone Formation', 'score': 0.45217684}], 'concepts': [{'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.7963059}, {'id': 'https://openalex.org/C30352789', 'wikidata': 'https://www.wikidata.org/wiki/Q14903153', 'display_name': 'Bone morphogenetic protein 2', 'level': 3, 'score': 0.6398426}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.5792858}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.57839376}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.52201945}, {'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.5073442}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49939656}, {'id': 'https://openalex.org/C125349252', 'wikidata': 'https://www.wikidata.org/wiki/Q14903102', 'display_name': 'Bone morphogenetic protein 7', 'level': 4, 'score': 0.48603565}, {'id': 'https://openalex.org/C2993291840', 'wikidata': 'https://www.wikidata.org/wiki/Q1121544', 'display_name': 'Bone formation', 'level': 2, 'score': 0.45217684}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.42607835}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35675716}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.30329394}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28879684}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.15278053}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13924965}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.051335156}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.047528297}], 'mesh': [{'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D015675', 'descriptor_name': 'Osteocalcin', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000704', 'descriptor_name': 'Analysis of Variance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055396', 'descriptor_name': 'Bone Morphogenetic Protein 2', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D055419', 'descriptor_name': 'Bone Morphogenetic Protein 7', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002113', 'descriptor_name': 'Calcification, Physiologic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002113', 'descriptor_name': 'Calcification, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015675', 'descriptor_name': 'Osteocalcin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018709', 'descriptor_name': 'Statistics, Nonparametric', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.archoralbio.2010.06.010', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44717366', 'display_name': 'Archives of Oral Biology', 'issn_l': '0003-9969', 'issn': ['0003-9969', '1879-1506'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20627196', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1600272283', 'https://openalex.org/W1609684706', 'https://openalex.org/W1962351050', 'https://openalex.org/W1962377023', 'https://openalex.org/W1963528166', 'https://openalex.org/W1963712887', 'https://openalex.org/W1972070722', 'https://openalex.org/W1973461515', 'https://openalex.org/W1974223809', 'https://openalex.org/W1975828859', 'https://openalex.org/W1976878696', 'https://openalex.org/W1982941157', 'https://openalex.org/W1984678678', 'https://openalex.org/W1989314203', 'https://openalex.org/W1995801858', 'https://openalex.org/W1997812904', 'https://openalex.org/W2000122480', 'https://openalex.org/W2000336408', 'https://openalex.org/W2013341058', 'https://openalex.org/W2015115352', 'https://openalex.org/W2026275149', 'https://openalex.org/W2027116665', 'https://openalex.org/W2027337609', 'https://openalex.org/W2027872372', 'https://openalex.org/W2034996179', 'https://openalex.org/W2036416554', 'https://openalex.org/W2042074752', 'https://openalex.org/W2044864383', 'https://openalex.org/W2051165362', 'https://openalex.org/W2058104849', 'https://openalex.org/W2058152354', 'https://openalex.org/W2059756533', 'https://openalex.org/W2063474343', 'https://openalex.org/W2075576056', 'https://openalex.org/W2078637826', 'https://openalex.org/W2082385204', 'https://openalex.org/W2087736493', 'https://openalex.org/W2090789303', 'https://openalex.org/W2092113319', 'https://openalex.org/W2110696242', 'https://openalex.org/W2113078334', 'https://openalex.org/W2116668498', 'https://openalex.org/W2128742818', 'https://openalex.org/W2136922954', 'https://openalex.org/W2139457077', 'https://openalex.org/W2139586508', 'https://openalex.org/W2146194163', 'https://openalex.org/W2171495416', 'https://openalex.org/W2293780251', 'https://openalex.org/W2403854640', 'https://openalex.org/W3000473592', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4242486335', 'https://openalex.org/W4230801422', 'https://openalex.org/W3101550007', 'https://openalex.org/W2919616119', 'https://openalex.org/W2752589608', 'https://openalex.org/W2606517225', 'https://openalex.org/W2587076878', 'https://openalex.org/W2495905015', 'https://openalex.org/W2165658291', 'https://openalex.org/W2091413202'], 'abstract_inverted_index': None, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126015323', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2025-01-21T15:21:39.057814', 'created_date': '2016-06-24'}