Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2613758819', 'doi': 'https://doi.org/10.1016/j.kint.2017.03.008', 'title': 'Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor', 'display_name': 'Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor', 'publication_year': 2017, 'publication_date': '2017-05-12', 'ids': {'openalex': 'https://openalex.org/W2613758819', 'doi': 'https://doi.org/10.1016/j.kint.2017.03.008', 'mag': '2613758819', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28506759', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5612014'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.kint.2017.03.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S97303050', 'display_name': 'Kidney International', 'issn_l': '0085-2538', 'issn': ['0085-2538', '1523-1755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.kint.2017.03.008', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5052179348', 'display_name': 'Serafim Kiriakidis', 'orcid': 'https://orcid.org/0000-0003-3273-401X'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Serafim Kiriakidis', 'raw_affiliation_strings': ['Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091310776', 'display_name': 'Simon Hoer', 'orcid': 'https://orcid.org/0000-0002-6071-967X'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simon S. Hoer', 'raw_affiliation_strings': ['School of Clinical Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK'], 'affiliations': [{'raw_affiliation_string': 'School of Clinical Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016397586', 'display_name': 'Natalie Burrows', 'orcid': 'https://orcid.org/0000-0001-6591-5971'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Natalie Burrows', 'raw_affiliation_strings': ['School of Clinical Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK'], 'affiliations': [{'raw_affiliation_string': 'School of Clinical Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039840345', 'display_name': 'Gloria Biddlecome', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gloria Biddlecome', 'raw_affiliation_strings': ['Oncology Research, AMGEN, Thousand Oaks, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Oncology Research, AMGEN, Thousand Oaks, California, USA', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077088448', 'display_name': 'Moddasar N. Khan', 'orcid': None}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Moddasar N. Khan', 'raw_affiliation_strings': ['Cobra Biologics, Keele, UK'], 'affiliations': [{'raw_affiliation_string': 'Cobra Biologics, Keele, UK', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046373817', 'display_name': 'Cyrille C. Thinnes', 'orcid': 'https://orcid.org/0000-0002-8619-9537'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Cyrille C. Thinnes', 'raw_affiliation_strings': ['Department of Chemistry, University of Oxford, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Oxford, Oxford, UK', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042398293', 'display_name': 'Christopher J. Schofield', 'orcid': 'https://orcid.org/0000-0002-0290-6565'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Schofield', 'raw_affiliation_strings': ['Department of Chemistry, University of Oxford, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of Oxford, Oxford, UK', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030064991', 'display_name': 'Norma Rogers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320553840', 'display_name': 'Amgen (United States)', 'ror': 'https://ror.org/03g03ge92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320553840']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Norma Rogers', 'raw_affiliation_strings': ['Oncology Research, AMGEN, Thousand Oaks, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Oncology Research, AMGEN, Thousand Oaks, California, USA', 'institution_ids': ['https://openalex.org/I1320553840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027333125', 'display_name': 'Marina Botto', 'orcid': 'https://orcid.org/0000-0002-1458-3791'}, 'institutions': [{'id': 'https://openalex.org/I4210151647', 'display_name': 'Centre for Inflammation Research', 'ror': 'https://ror.org/05wcr1b38', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210151647', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Marina Botto', 'raw_affiliation_strings': ['Centre for Complement and Inflammation Research (CCIR), Imperial College London, London, UK'], 'affiliations': [{'raw_affiliation_string': 'Centre for Complement and Inflammation Research (CCIR), Imperial College London, London, UK', 'institution_ids': ['https://openalex.org/I4210151647', 'https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007539244', 'display_name': 'Ewa Paleolog', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ewa Paleolog', 'raw_affiliation_strings': ['Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Oxford, UK', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036848232', 'display_name': 'Patrick H. Maxwell', 'orcid': 'https://orcid.org/0000-0002-0338-2679'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Patrick H. Maxwell', 'raw_affiliation_strings': ['School of Clinical Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK'], 'affiliations': [{'raw_affiliation_string': 'School of Clinical Medicine, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK', 'institution_ids': ['https://openalex.org/I241749']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3200, 'currency': 'USD', 'value_usd': 3200, 'provenance': 'doaj'}, 'apc_paid': {'value': 3450, 'currency': 'EUR', 'value_usd': 3720, 'provenance': 'openapc'}, 'fwci': 0.541, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.999897, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '92', 'issue': '4', 'first_page': '900', 'last_page': '908'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11968', 'display_name': 'High Altitude and Hypoxia', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hydroxylation', 'display_name': 'Hydroxylation', 'score': 0.89730453}, {'id': 'https://openalex.org/keywords/hypoxia-inducible-factors', 'display_name': 'Hypoxia-Inducible Factors', 'score': 0.6473638}], 'concepts': [{'id': 'https://openalex.org/C2781109383', 'wikidata': 'https://www.wikidata.org/wiki/Q898497', 'display_name': 'Hydroxylation', 'level': 3, 'score': 0.89730453}, {'id': 'https://openalex.org/C160450060', 'wikidata': 'https://www.wikidata.org/wiki/Q104598479', 'display_name': 'Hypoxia-inducible factors', 'level': 3, 'score': 0.6473638}, {'id': 'https://openalex.org/C111684460', 'wikidata': 'https://www.wikidata.org/wiki/Q334848', 'display_name': 'Complement system', 'level': 3, 'score': 0.6378529}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.57812536}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5134412}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.5094674}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33961374}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.22660008}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14971945}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.11635202}], 'mesh': [{'descriptor_ui': 'D015922', 'descriptor_name': 'Complement C1q', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064799', 'descriptor_name': 'Hypoxia-Inducible Factor-Proline Dioxygenases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011393', 'descriptor_name': 'Procollagen-Proline Dioxygenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D064800', 'descriptor_name': 'Prolyl-Hydroxylase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000740', 'descriptor_name': 'Anemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000740', 'descriptor_name': 'Anemia', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D000740', 'descriptor_name': 'Anemia', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015922', 'descriptor_name': 'Complement C1q', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015922', 'descriptor_name': 'Complement C1q', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D003171', 'descriptor_name': 'Complement Pathway, Classical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006900', 'descriptor_name': 'Hydroxylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064799', 'descriptor_name': 'Hypoxia-Inducible Factor-Proline Dioxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011393', 'descriptor_name': 'Procollagen-Proline Dioxygenase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D011393', 'descriptor_name': 'Procollagen-Proline Dioxygenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064800', 'descriptor_name': 'Prolyl-Hydroxylase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064800', 'descriptor_name': 'Prolyl-Hydroxylase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.kint.2017.03.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S97303050', 'display_name': 'Kidney International', 'issn_l': '0085-2538', 'issn': ['0085-2538', '1523-1755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5612014', 'pdf_url': 'https://europepmc.org/articles/pmc5612014?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/264388', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/d6250c75-a8cb-4ed8-abcf-2d846f35f862/download', 'source': {'id': 'https://openalex.org/S4306401777', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612014', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28506759', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.kint.2017.03.008', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S97303050', 'display_name': 'Kidney International', 'issn_l': '0085-2538', 'issn': ['0085-2538', '1523-1755'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1521036527', 'https://openalex.org/W1607422228', 'https://openalex.org/W1630743007', 'https://openalex.org/W1776416624', 'https://openalex.org/W181708339', 'https://openalex.org/W1844723954', 'https://openalex.org/W1965845267', 'https://openalex.org/W1969463979', 'https://openalex.org/W1969640384', 'https://openalex.org/W1970718615', 'https://openalex.org/W1979862380', 'https://openalex.org/W1999357965', 'https://openalex.org/W2003305541', 'https://openalex.org/W2005729255', 'https://openalex.org/W2005868568', 'https://openalex.org/W2015684766', 'https://openalex.org/W2017575850', 'https://openalex.org/W2021932335', 'https://openalex.org/W2026647479', 'https://openalex.org/W2042832398', 'https://openalex.org/W2055453684', 'https://openalex.org/W2058157062', 'https://openalex.org/W2067217824', 'https://openalex.org/W2076464105', 'https://openalex.org/W2079844104', 'https://openalex.org/W2092330145', 'https://openalex.org/W2096895041', 'https://openalex.org/W2098921416', 'https://openalex.org/W2104429032', 'https://openalex.org/W2105230781', 'https://openalex.org/W2115785123', 'https://openalex.org/W2146103737', 'https://openalex.org/W2149117196', 'https://openalex.org/W2156426667', 'https://openalex.org/W2158006372', 'https://openalex.org/W2191103386', 'https://openalex.org/W2225590536', 'https://openalex.org/W2319894206', 'https://openalex.org/W2403166380', 'https://openalex.org/W2599748763', 'https://openalex.org/W33499302', 'https://openalex.org/W808221841'], 'related_works': ['https://openalex.org/W4391598491', 'https://openalex.org/W3142983916', 'https://openalex.org/W2940577902', 'https://openalex.org/W2593147304', 'https://openalex.org/W2370045143', 'https://openalex.org/W2365080244', 'https://openalex.org/W2143857507', 'https://openalex.org/W2104333948', 'https://openalex.org/W2099667514', 'https://openalex.org/W1965456255'], 'abstract_inverted_index': {'Complement': [0], 'C1q': [1, 23, 57, 103, 120, 128, 147, 170, 185], 'is': [2, 24, 132, 139, 171], 'part': [3], 'of': [4, 19, 26, 37, 46, 146, 184, 194], 'the': [5, 11, 44, 47, 71, 177], 'C1': [6], 'macromolecular': [7], 'complex': [8], 'that': [9, 32, 55, 80, 91, 97, 114, 126], 'mediates': [10], 'classical': [12], 'complement': [13], 'activation': [14], 'pathway:': [15], 'a': [16, 112, 127, 134, 140], 'major': [17], 'arm': [18], 'innate': [20], 'immune': [21], 'defense.': [22], 'composed': [25], 'A,': [27], 'B,': [28], 'and': [29, 70], 'C': [30], 'chains': [31], 'require': [33], 'post-translational': [34], 'prolyl': [35, 53, 64, 75, 94, 166], '4-hydroxylation': [36], 'their': [38], 'N-terminal': [39], 'collagen-like': [40], 'domain': [41, 77], 'to': [42, 111], 'enable': [43], 'formation': [45], 'functional': [48], 'triple': [49], 'helical': [50], 'multimers.': [51], 'The': [52], '4-hydroxylase(s)': [54], 'hydroxylate': [56], 'have': [58], 'not': [59, 118, 133, 149, 176], 'previously': [60], 'been': [61], 'identified.': [62], 'Recognized': [63], '4-hydroxylases': [65], 'include': [66], 'collagen': [67], 'prolyl-4-hydroxylases': [68], '(CP4H)': [69], 'more': [72], 'recently': [73], 'described': [74], 'hydroxylase': [76, 95, 167], '(PHD)': [78], 'enzymes': [79], 'act': [81], 'as': [82, 200], 'oxygen': [83], 'sensors': [84], 'regulating': [85], 'hypoxia-inducible': [86], 'factor': [87], '(HIF).': [88], 'We': [89], 'show': [90], 'several': [92], 'small-molecule': [93], 'inhibitors': [96, 198], 'activate': [98], 'HIF': [99, 116], 'also': [100], 'potently': [101], 'suppress': [102], 'secretion': [104], 'by': [105, 165, 173], 'human': [106], 'macrophages.': [107], 'However,': [108], 'reducing': [109], 'oxygenation': [110], 'level': [113], 'activates': [115], 'does': [117], 'compromise': [119], 'hydroxylation.': [121], 'In': [122], 'vitro': [123], 'studies': [124], 'showed': [125], 'A': [129], 'chain': [130], 'peptide': [131], 'substrate': [135, 141], 'for': [136, 142, 202], 'PHD2': [137], 'but': [138, 162, 175], 'CP4H1.': [143], 'Circulating': [144], 'levels': [145, 186], 'did': [148], 'differ': [150], 'between': [151], 'wild-type': [152], 'mice': [153, 155], 'or': [154], 'with': [156], 'genetic': [157], 'deficits': [158], 'in': [159], 'PHD': [160, 180, 197], 'enzymes,': [161], 'were': [163], 'reduced': [164], 'inhibitors.': [168], 'Thus,': [169], 'hydroxylated': [172], 'CP4H,': [174], 'structurally': [178], 'related': [179], 'hydroxylases.': [181], 'Hence,': [182], 'reduction': [183], 'may': [187], 'be': [188], 'an': [189], 'important': [190], 'off-target': [191], 'side': [192], 'effect': [193], 'small': [195], 'molecule': [196], 'developed': [199], 'treatments': [201], 'renal': [203], 'anemia.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2613758819', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2025-01-04T05:49:26.740837', 'created_date': '2017-05-19'}