Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2940577902', 'doi': 'https://doi.org/10.3390/cells8050384', 'title': 'Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?', 'display_name': 'Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?', 'publication_year': 2019, 'publication_date': '2019-04-26', 'ids': {'openalex': 'https://openalex.org/W2940577902', 'doi': 'https://doi.org/10.3390/cells8050384', 'mag': '2940577902', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31035491', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6562979'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells8050384', 'pdf_url': 'https://www.mdpi.com/2073-4409/8/5/384/pdf?version=1556528286', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2073-4409/8/5/384/pdf?version=1556528286', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083197965', 'display_name': 'Moritz J. Strowitzki', 'orcid': 'https://orcid.org/0000-0001-6967-9283'}, 'institutions': [{'id': 'https://openalex.org/I100930933', 'display_name': 'University College Dublin', 'ror': 'https://ror.org/05m7pjf47', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I100930933']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Moritz Strowitzki', 'raw_affiliation_strings': ['School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland', 'UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland'], 'affiliations': [{'raw_affiliation_string': 'UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}, {'raw_affiliation_string': 'School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080945110', 'display_name': 'Eoin P. Cummins', 'orcid': 'https://orcid.org/0000-0002-9346-8299'}, 'institutions': [{'id': 'https://openalex.org/I100930933', 'display_name': 'University College Dublin', 'ror': 'https://ror.org/05m7pjf47', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I100930933']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Eoin Cummins', 'raw_affiliation_strings': ['School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland', 'UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland'], 'affiliations': [{'raw_affiliation_string': 'UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}, {'raw_affiliation_string': 'School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5076392736', 'display_name': 'Carson Key Taylor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I100930933', 'display_name': 'University College Dublin', 'ror': 'https://ror.org/05m7pjf47', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I100930933']}], 'countries': ['IE'], 'is_corresponding': True, 'raw_author_name': 'Cormac Taylor', 'raw_affiliation_strings': ['School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland', 'Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland', 'UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}, {'raw_affiliation_string': 'UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}, {'raw_affiliation_string': 'Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland', 'institution_ids': ['https://openalex.org/I100930933']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5076392736'], 'corresponding_institution_ids': ['https://openalex.org/I100930933'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 2.657, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 170, 'citation_normalized_percentile': {'value': 0.998517, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '8', 'issue': '5', 'first_page': '384', 'last_page': '384'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Metabolism and Function of Arachidonic Acid Derivatives', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11968', 'display_name': 'Genetic and Physiological Adaptations to High-Altitude Environments', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hydroxylation', 'display_name': 'Hydroxylation', 'score': 0.91651654}, {'id': 'https://openalex.org/keywords/hypoxia-inducible-factors', 'display_name': 'Hypoxia-inducible factors', 'score': 0.7269609}, {'id': 'https://openalex.org/keywords/hypoxia', 'display_name': 'Hypoxia', 'score': 0.543802}], 'concepts': [{'id': 'https://openalex.org/C2781109383', 'wikidata': 'https://www.wikidata.org/wiki/Q898497', 'display_name': 'Hydroxylation', 'level': 3, 'score': 0.91651654}, {'id': 'https://openalex.org/C160450060', 'wikidata': 'https://www.wikidata.org/wiki/Q104598479', 'display_name': 'Hypoxia-inducible factors', 'level': 3, 'score': 0.7269609}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.48927113}, {'id': 'https://openalex.org/C1292079', 'wikidata': 'https://www.wikidata.org/wiki/Q3817769', 'display_name': 'Transactivation', 'level': 4, 'score': 0.48602468}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.4797605}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.44912836}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.43710324}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41514012}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39610356}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37594762}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2888047}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.26816136}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.22292143}], 'mesh': [{'descriptor_ui': 'D064799', 'descriptor_name': 'Hypoxia-Inducible Factor-Proline Dioxygenases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D064800', 'descriptor_name': 'Prolyl-Hydroxylase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006900', 'descriptor_name': 'Hydroxylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000860', 'descriptor_name': 'Hypoxia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051795', 'descriptor_name': 'Hypoxia-Inducible Factor 1, alpha Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064799', 'descriptor_name': 'Hypoxia-Inducible Factor-Proline Dioxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064800', 'descriptor_name': 'Prolyl-Hydroxylase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells8050384', 'pdf_url': 'https://www.mdpi.com/2073-4409/8/5/384/pdf?version=1556528286', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6562979', 'pdf_url': 'https://europepmc.org/articles/pmc6562979?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562979', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31035491', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells8050384', 'pdf_url': 'https://www.mdpi.com/2073-4409/8/5/384/pdf?version=1556528286', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': 'DFG; STR 1570/1-1'}], 'datasets': [], 'versions': [], 'referenced_works_count': 150, 'referenced_works': ['https://openalex.org/W1492654684', 'https://openalex.org/W1572512950', 'https://openalex.org/W1603781996', 'https://openalex.org/W1619977460', 'https://openalex.org/W1727368590', 'https://openalex.org/W1775891333', 'https://openalex.org/W1822565500', 'https://openalex.org/W1869391303', 'https://openalex.org/W1903984126', 'https://openalex.org/W1965390897', 'https://openalex.org/W1970971661', 'https://openalex.org/W1972514933', 'https://openalex.org/W1973092951', 'https://openalex.org/W1975070474', 'https://openalex.org/W1980476482', 'https://openalex.org/W1984604224', 'https://openalex.org/W1988363595', 'https://openalex.org/W1988377666', 'https://openalex.org/W1991330040', 'https://openalex.org/W1991346678', 'https://openalex.org/W1991443411', 'https://openalex.org/W1991494214', 'https://openalex.org/W1992454850', 'https://openalex.org/W1994313430', 'https://openalex.org/W2000272522', 'https://openalex.org/W2001450136', 'https://openalex.org/W2001604240', 'https://openalex.org/W2001666774', 'https://openalex.org/W2003440707', 'https://openalex.org/W2005539293', 'https://openalex.org/W2005729255', 'https://openalex.org/W2005868568', 'https://openalex.org/W2007429348', 'https://openalex.org/W2012520088', 'https://openalex.org/W2013883770', 'https://openalex.org/W2015519364', 'https://openalex.org/W2018008610', 'https://openalex.org/W2019521269', 'https://openalex.org/W2020471728', 'https://openalex.org/W2021529165', 'https://openalex.org/W2021932335', 'https://openalex.org/W2022126917', 'https://openalex.org/W2023898808', 'https://openalex.org/W2025443699', 'https://openalex.org/W2026281043', 'https://openalex.org/W2030262660', 'https://openalex.org/W2036493597', 'https://openalex.org/W2038139095', 'https://openalex.org/W2038197749', 'https://openalex.org/W2039099639', 'https://openalex.org/W2040031153', 'https://openalex.org/W2042721691', 'https://openalex.org/W2046031903', 'https://openalex.org/W2047519730', 'https://openalex.org/W2047816152', 'https://openalex.org/W2048004132', 'https://openalex.org/W2051068162', 'https://openalex.org/W2051531582', 'https://openalex.org/W2058045672', 'https://openalex.org/W2064696266', 'https://openalex.org/W2066077682', 'https://openalex.org/W2067704394', 'https://openalex.org/W2067704515', 'https://openalex.org/W2069437598', 'https://openalex.org/W2069679898', 'https://openalex.org/W2072929297', 'https://openalex.org/W2075394689', 'https://openalex.org/W2078825950', 'https://openalex.org/W2079849140', 'https://openalex.org/W2080785218', 'https://openalex.org/W2080823011', 'https://openalex.org/W2086812941', 'https://openalex.org/W2088442622', 'https://openalex.org/W2089141914', 'https://openalex.org/W2089692551', 'https://openalex.org/W2091525053', 'https://openalex.org/W2093598492', 'https://openalex.org/W2096190389', 'https://openalex.org/W2098902167', 'https://openalex.org/W2098972920', 'https://openalex.org/W2099219058', 'https://openalex.org/W2103214055', 'https://openalex.org/W2104014368', 'https://openalex.org/W2104551938', 'https://openalex.org/W2105230781', 'https://openalex.org/W2106969933', 'https://openalex.org/W2108237056', 'https://openalex.org/W2109492293', 'https://openalex.org/W2110272715', 'https://openalex.org/W2112337731', 'https://openalex.org/W2116715687', 'https://openalex.org/W2117236885', 'https://openalex.org/W2120329137', 'https://openalex.org/W2122535638', 'https://openalex.org/W2122978965', 'https://openalex.org/W2123891308', 'https://openalex.org/W2124903372', 'https://openalex.org/W2127562514', 'https://openalex.org/W2130895038', 'https://openalex.org/W2132261610', 'https://openalex.org/W2135994263', 'https://openalex.org/W2137035181', 'https://openalex.org/W2137465719', 'https://openalex.org/W2139326129', 'https://openalex.org/W2142619483', 'https://openalex.org/W2143778153', 'https://openalex.org/W2144625075', 'https://openalex.org/W2145023430', 'https://openalex.org/W2146153138', 'https://openalex.org/W2146904400', 'https://openalex.org/W2147703815', 'https://openalex.org/W2148119611', 'https://openalex.org/W2150126834', 'https://openalex.org/W2150456795', 'https://openalex.org/W2157507072', 'https://openalex.org/W2157920299', 'https://openalex.org/W2161105936', 'https://openalex.org/W2163045670', 'https://openalex.org/W2166898507', 'https://openalex.org/W2167479466', 'https://openalex.org/W2169533924', 'https://openalex.org/W2191615533', 'https://openalex.org/W2225466805', 'https://openalex.org/W2232997241', 'https://openalex.org/W2293983889', 'https://openalex.org/W2334934303', 'https://openalex.org/W2344123412', 'https://openalex.org/W2485589748', 'https://openalex.org/W2521911213', 'https://openalex.org/W2525561749', 'https://openalex.org/W2540751197', 'https://openalex.org/W2599499085', 'https://openalex.org/W2599748763', 'https://openalex.org/W2608519211', 'https://openalex.org/W2734802699', 'https://openalex.org/W2751237807', 'https://openalex.org/W2756198750', 'https://openalex.org/W2775824694', 'https://openalex.org/W2789871802', 'https://openalex.org/W2793118931', 'https://openalex.org/W2797027795', 'https://openalex.org/W2883676103', 'https://openalex.org/W2886859416', 'https://openalex.org/W2891020602', 'https://openalex.org/W2897557441', 'https://openalex.org/W2915638677', 'https://openalex.org/W2923585401', 'https://openalex.org/W4210414581', 'https://openalex.org/W4242075931', 'https://openalex.org/W4246575879'], 'related_works': ['https://openalex.org/W4243232297', 'https://openalex.org/W3083246029', 'https://openalex.org/W2972038063', 'https://openalex.org/W2940577902', 'https://openalex.org/W2143857507', 'https://openalex.org/W2121895466', 'https://openalex.org/W2115920214', 'https://openalex.org/W2114920820', 'https://openalex.org/W2099667514', 'https://openalex.org/W1550036480'], 'abstract_inverted_index': {'All': [0], 'metazoans': [1], 'that': [2, 19, 134, 154], 'utilize': [3], 'molecular': [4], 'oxygen': [5, 39], '(O2)': [6], 'for': [7, 125, 163, 186, 229, 244], 'metabolic': [8], 'purposes': [9], 'have': [10, 139, 182], 'the': [11, 17, 32, 59, 83, 89, 111, 122, 187, 211, 253], 'capacity': [12], 'to': [13, 15, 52, 79, 113, 144, 208, 256], 'adapt': [14], 'hypoxia,': [16, 88], 'condition': [18], 'arises': [20], 'when': [21], 'O2': [22], 'demand': [23], 'exceeds': [24], 'supply.': [25], 'This': [26], 'is': [27, 71, 99, 151, 204], 'mediated': [28], 'through': [29], 'activation': [30], 'of': [31, 92, 175, 189, 198, 201, 213, 225, 252], 'hypoxia-inducible': [33], 'factor': [34], '(HIF)': [35], 'pathway.': [36], 'At': [37], 'physiological': [38], 'levels': [40], '(normoxia),': [41], 'HIF-prolyl': [42], 'hydroxylases': [43, 136, 203], '(PHDs)': [44], 'hydroxylate': [45], 'proline': [46], 'residues': [47], 'on': [48], 'HIF-α': [49, 69, 93, 103], 'subunits': [50, 94], 'leading': [51], 'their': [53], 'destabilization': [54], 'by': [55, 58, 82, 95, 171], 'promoting': [56], 'ubiquitination': [57], 'von-Hippel': [60], 'Lindau': [61], '(VHL)': [62], 'ubiquitin': [63], 'ligase': [64], 'and': [65, 97, 108, 127, 160, 223, 231, 246, 248], 'subsequent': [66], 'proteasomal': [67], 'degradation.': [68], 'transactivation': [70], 'also': [72, 138], 'repressed': [73], 'in': [74, 102, 147, 206], 'an': [75, 115, 250], 'O2-dependent': [76, 90], 'way': [77], 'due': [78], 'asparaginyl': [80], 'hydroxylation': [81, 91, 155], 'factor-inhibiting': [84], 'HIF': [85, 202], '(FIH).': [86], 'In': [87, 142, 235], 'PHDs': [96, 166, 230, 245], 'FIH': [98, 232, 247], 'reduced,': [100], 'resulting': [101], 'accumulation,': [104], 'dimerization': [105], 'with': [106, 192], 'HIF-β': [107], 'migration': [109], 'into': [110], 'nucleus': [112], 'induce': [114], 'adaptive': [116], 'transcriptional': [117], 'response.': [118], 'Although': [119], 'HIFs': [120], 'are': [121], 'canonical': [123], 'substrates': [124], 'PHD-': [126], 'FIH-mediated': [128], 'protein': [129, 148, 158], 'hydroxylation,': [130], 'increasing': [131], 'evidence': [132, 153], 'indicates': [133], 'these': [135], 'may': [137], 'alternative': [140, 164, 199, 226], 'targets.': [141], 'addition': [143], 'PHD-conferred': [145], 'alterations': [146], 'stability,': [149], 'there': [150], 'now': [152], 'can': [156, 167], 'affect': [157], 'activity': [159], 'protein/protein': [161], 'interactions': [162], 'substrates.': [165], 'be': [168], 'pharmacologically': [169], 'inhibited': [170], 'a': [172], 'new': [173], 'class': [174], 'drugs': [176], 'termed': [177], 'prolyl': [178], 'hydroxylase': [179, 214], 'inhibitors': [180, 215], 'which': [181], 'recently': [183, 240], 'been': [184], 'approved': [185], 'treatment': [188], 'anemia': [190], 'associated': [191], 'chronic': [193], 'kidney': [194], 'disease.': [195], 'The': [196], 'identification': [197], 'targets': [200, 228, 243], 'important': [205], 'order': [207], 'fully': [209], 'elucidate': [210], 'pharmacology': [212], '(PHI).': [216], 'Despite': [217], 'significant': [218], 'technical': [219], 'advances,': [220], 'screening,': [221], 'detection': [222], 'verification': [224], 'functional': [227], 'remain': [233], 'challenging.': [234], 'this': [236], 'review,': [237], 'we': [238], 'discuss': [239], 'proposed': [241], 'non-HIF': [242], 'provide': [249], 'overview': [251], 'techniques': [254], 'used': [255], 'identify': [257], 'these.': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2940577902', 'counts_by_year': [{'year': 2024, 'cited_by_count': 19}, {'year': 2023, 'cited_by_count': 49}, {'year': 2022, 'cited_by_count': 43}, {'year': 2021, 'cited_by_count': 27}, {'year': 2020, 'cited_by_count': 27}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-09-11T23:17:02.416787', 'created_date': '2019-05-03'}