Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2588463539', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-1416.2009.03.022', 'title': 'Role of cAMP-PKA signal transduction pathway in the ischemic preconditioning-induced attenuation of ischemia-reperfusion injury In isolated rat hearts', 'display_name': 'Role of cAMP-PKA signal transduction pathway in the ischemic preconditioning-induced attenuation of ischemia-reperfusion injury In isolated rat hearts', 'publication_year': 2009, 'publication_date': '2009-03-20', 'ids': {'openalex': 'https://openalex.org/W2588463539', 'doi': 'https://doi.org/10.3760/cma.j.issn.0254-1416.2009.03.022', 'mag': '2588463539'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN13107320092903/194404.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764665209', 'display_name': 'Zhonghua mazuixue zazhi', 'issn_l': '0254-1416', 'issn': ['0254-1416'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075174504', 'display_name': 'Xue Qing-hua', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I4210161896', 'display_name': 'Fu Wai Hospital', 'ror': 'https://ror.org/0590dnz19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210161896']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xue Qing-hua', 'raw_affiliation_strings': ['Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)', 'institution_ids': ['https://openalex.org/I200296433', 'https://openalex.org/I4210161896']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115596190', 'display_name': 'Yang Jing', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}, {'id': 'https://openalex.org/I4210161896', 'display_name': 'Fu Wai Hospital', 'ror': 'https://ror.org/0590dnz19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210161896']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Jing', 'raw_affiliation_strings': ['Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)', 'institution_ids': ['https://openalex.org/I200296433', 'https://openalex.org/I4210161896']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103200539', 'display_name': 'Weiping Cheng', 'orcid': 'https://orcid.org/0009-0006-9165-2240'}, 'institutions': [{'id': 'https://openalex.org/I4210161896', 'display_name': 'Fu Wai Hospital', 'ror': 'https://ror.org/0590dnz19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210161896']}, {'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cheng Wei-ping', 'raw_affiliation_strings': ['Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)', 'institution_ids': ['https://openalex.org/I4210161896', 'https://openalex.org/I200296433']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013214103', 'display_name': 'Lihuan Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210161896', 'display_name': 'Fu Wai Hospital', 'ror': 'https://ror.org/0590dnz19', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210161896']}, {'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'LI Li-huan', 'raw_affiliation_strings': ['Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology,Cardiovascular Institute and FuWai Hospital,CAMS and PUMC,Beijing 100037,China)', 'institution_ids': ['https://openalex.org/I4210161896', 'https://openalex.org/I200296433']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 64}, 'biblio': {'volume': '29', 'issue': '03', 'first_page': '268', 'last_page': '271'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10999', 'display_name': 'Organ Transplantation Techniques and Outcomes', 'score': 0.9934, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11189', 'display_name': 'Transplantation: Methods and Outcomes', 'score': 0.9767, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ischemic-preconditioning', 'display_name': 'Ischemic Preconditioning', 'score': 0.49435568}], 'concepts': [{'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.70820546}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.619723}, {'id': 'https://openalex.org/C2780114680', 'wikidata': 'https://www.wikidata.org/wiki/Q1413991', 'display_name': 'Reperfusion injury', 'level': 3, 'score': 0.58942556}, {'id': 'https://openalex.org/C2776755955', 'wikidata': 'https://www.wikidata.org/wiki/Q409632', 'display_name': 'Pentobarbital', 'level': 2, 'score': 0.5003586}, {'id': 'https://openalex.org/C2779311647', 'wikidata': 'https://www.wikidata.org/wiki/Q17148404', 'display_name': 'Ischemic preconditioning', 'level': 3, 'score': 0.49435568}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4576648}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.4403165}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.43443108}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4055152}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34055203}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.33402553}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14549676}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN13107320092903/194404.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764665209', 'display_name': 'Zhonghua mazuixue zazhi', 'issn_l': '0254-1416', 'issn': ['0254-1416'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032856417', 'https://openalex.org/W3031769436', 'https://openalex.org/W3031642309', 'https://openalex.org/W3031494137', 'https://openalex.org/W3030574834', 'https://openalex.org/W3030517493', 'https://openalex.org/W3030475054', 'https://openalex.org/W3030413861', 'https://openalex.org/W3030369343', 'https://openalex.org/W3029635137', 'https://openalex.org/W3029448007', 'https://openalex.org/W3029321344', 'https://openalex.org/W3028888158', 'https://openalex.org/W3028851989', 'https://openalex.org/W3028778539', 'https://openalex.org/W2752275381', 'https://openalex.org/W2374316218', 'https://openalex.org/W2366853764', 'https://openalex.org/W2354847270', 'https://openalex.org/W2350394824'], 'abstract_inverted_index': {'Objective': [0], 'To': [1], 'investigate': [2], 'the': [3, 11, 189, 253], 'role': [4], 'of': [5, 15, 53, 105, 165, 178, 182, 202, 206, 214, 349, 362], 'cAMP-PKA': [6, 354], 'signal': [7, 355], 'transduction': [8, 356], 'pathway': [9, 357], 'in': [10, 17, 40, 97, 188, 252, 259, 276, 316, 332, 344], 'ischemie': [12], 'pleeonditioning-induced': [13], 'attenuation': [14], 'ischemia.1eperfusion(ITR)injury': [16], 'isohted': [18], 'rat': [19], 'hearts.Methods': [20], 'Fifty': [21], 'healthy': [22], 'adult': [23], 'SD': [24], 'rats': [25], 'weighing': [26], '300-350': [27], 'g': [28], 'were': [29, 36, 83, 155, 192, 197, 238, 245, 256, 298, 306, 313], 'anesthetized': [30], 'with': [31, 44, 141, 228, 288], 'intraperitoneal(IP)pentobarbital': [32], '50': [33], 'meg/kg.Their': [34], 'he.arts': [35], 'excised': [37], 'and': [38, 93, 116, 125, 160, 175, 180, 184, 212, 220, 234, 243, 249, 262, 269, 280, 294, 304, 310, 319, 325], 'perfused': [39], 'a': [41, 50], 'Langendorff': [42], 'apparatus': [43], '37℃': [45], 'oxygenated(95%O2-5%CO2)modified': [46], 'K-H': [47], 'solution': [48], 'at': [49, 109, 131, 157, 172, 199], 'constant': [51], 'pressure': [52], '70': [54], 'cm': [55], 'H2O,and': [56], 'randomly': [57], 'divided': [58], 'into': [59], '5': [60, 106, 110, 119, 132], 'groups(n=10': [61], 'each):group': [62], 'Ⅰ': [63], 'I/R;group': [64], 'Ⅱ': [65, 265, 283], 'ischemic': [66], 'preconditioning(IPC);groupⅢH89(PKA': [67], 'inhibitor);group': [68], 'Ⅳ': [69, 117, 323], 'PDTC(NF-κB': [70], 'inhibitor)and': [71], 'group': [72, 98, 260, 277, 317, 333], 'Ⅴ': [73, 138, 267], 'db-cAMP.The': [74], 'experiment': [75], 'started': [76], 'after': [77], '10': [78, 123], 'min': [79, 91, 95, 107, 111, 120, 133, 147, 177], 'stabilization.The': [80], 'isolated': [81, 345], 'hearts': [82, 346], 'tinct': [84], 'perfuzed': [85], 'for': [86, 145, 204], '30': [87, 94, 146, 163, 176, 200], 'min.followed': [88], 'by': [89, 347], '60': [90], 'ischemia': [92, 108], 'leperfusion': [96], 'I/R(Ⅰ).Group': [99], 'IPC(Ⅱ)w88': [100], 'subjected': [101], 'to': [102], '3': [103, 129], 'episodes': [104], 'intervals': [112, 134], 'before': [113, 136, 148], 'I/R.Group': [114, 137], 'Ⅲ': [115, 335], 'received': [118], 'perfnsion': [121], 'withH89': [122], 'μmol/L': [124, 128, 144], 'PDTC': [126, 279, 320], '100': [127], 'times': [130], 'respectively': [135], 'was': [139, 170, 273, 329], 'peffnsed': [140], 'db-cAMP': [142, 263, 281], '200': [143], 'I/R.Left': [149], 'ventricular': [150], 'developed': [151], 'pressure(LVDP)and': [152], '±': [153, 241, 301], 'dp/dtu': [154], 'measured': [156, 171], 'stabilization': [158, 173], 'period': [159, 174], '10,': [161], '20,': [162], 'rain': [164, 201], 'reperfusion.': [166], 'Coronary': [167], 'flow': [168], '(CF)': [169], 'reperfusion': [179, 203, 372], 'activities': [181, 251, 312], 'LDH': [183, 311], 'creafinc': [185], 'kinase': [186], '(CK)': [187], 'coronary': [190, 254], 'effluent': [191, 255], 'determined.': [193], 'The': [194], 'myocardial': [195], 'specimens': [196], 'obtained': [198], 'determination': [205], 'NF-κB-DNA': [207, 231, 291, 350], 'binding': [208, 232, 292, 351], 'activity': [209, 233, 293, 352], '(by': [210, 217, 223], 'EMSA)': [211], 'expression': [213, 237, 272, 297, 328], 'TNF-κ': [215], 'mBNA': [216, 296], 'RT-PCR': [218], ')': [219, 268, 324], 'p-CBEB': [221], '(Ser133)': [222, 271, 327], 'Western': [224], 'blot).': [225], 'Results': [226], 'Compared': [227, 287], '1/R': [229], 'group,': [230, 290], 'TNF-α': [235, 295], 'mRNA': [236], 'significandy': [239, 246], 'decreased,': [240, 308], 'dp/dt': [242], 'CF': [244, 305], 'increased,': [247, 300], 'CK': [248, 309], 'LHD': [250], 'significantly': [257, 274, 299, 307, 314, 330], 'decreased': [258, 331], 'IPC': [261, 289], '(group': [264, 282, 321], ',': [266, 284], 'p-CREB': [270, 326], 'increased': [275, 315], 'IPC,': [278], 'Ⅳ,Ⅴ': [285], ').': [286, 336], 'dp/dtmax,': [302], 'LVDP': [303], 'H89': [318], 'Ⅲ,': [322], 'H89(group': [334], 'Conclusion': [337], 'lschemic': [338], 'preconditioning': [339], 'can': [340], 'attenuate': [341], 'I/R': [342], 'injury': [343, 373], 'inhibition': [348], 'via': [353], 'which': [358], 'reduces': [359], 'gene': [360], 'transcription': [361], 'inflammatory': [363], 'cytokine.\r\n\r\nKey': [364], 'words:': [365], '\r\nCyclic': [366], 'AMP;\xa0Cyclic': [367], 'AMP-dependent': [368], 'protein': [369], 'kinases;\xa0Ischemic': [370], 'preconditioning;\xa0Myocardial': [371]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2588463539', 'counts_by_year': [], 'updated_date': '2024-12-24T11:43:50.321715', 'created_date': '2017-02-24'}