Title: Expression of COX-2 and the relationship between COX-2 and PTEN in endometrial adenocarcinoma
Abstract: Objective To study the expression and clinical significance of COX-2 and the relation- ship between COX-2 and PTEN in endometrial adenocarcinoma(EAC).Methods The expression of COX-2, PTEN protein was detected by SP-immunohistochemical method in EAC,endometrial intraepithelial neoplasia, corresponding normal endometrium.Results The positive rates of COX-2 protein increased from normal en- dometrium(13.33%) to endometrial intraepithelial neoplasia(50.00%) and adenocarcinoma(64.58 %)(P0.05).COX-2 positive ratio was higher in poorer differentiation (81.82% vs 64.29% vs 4/9,P=0.007), deeper myometrial invasion(75.00% vs 57.14%,P=0.009),extrauterine invasion/metastasis and later stage (9/9vs 56.41%,P=0.001)(P0.05).In EAC with favorable prognosis,the expression pattern of COX-2 was correlated with PTEN(r_s=-0.400,P0.05).Conclusion COX-2 may be a parameter indicating tumor ag- gressiveness.In EAC with favorable prognosis,PTEN may regulate the expression of COX-2 protein.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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