Publication Information

{'id': 'https://openalex.org/W2582393724', 'doi': 'https://doi.org/10.4049/jimmunol.1601515', 'title': 'Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization', 'display_name': 'Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization', 'publication_year': 2017, 'publication_date': '2017-01-23', 'ids': {'openalex': 'https://openalex.org/W2582393724', 'doi': 'https://doi.org/10.4049/jimmunol.1601515', 'mag': '2582393724', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28115590'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1601515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.4049/jimmunol.1601515', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5017540146', 'display_name': 'Eleni Vergadi', 'orcid': 'https://orcid.org/0000-0003-4026-0328'}, 'institutions': [{'id': 'https://openalex.org/I142617266', 'display_name': 'University of Crete', 'ror': 'https://ror.org/00dr28g20', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I142617266']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Eleni Vergadi', 'raw_affiliation_strings': ['*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and', '†Laboratory of Intensive Care Medicine, School of Medicine, University of Crete, Heraklion 71003, Greece'], 'affiliations': [{'raw_affiliation_string': '†Laboratory of Intensive Care Medicine, School of Medicine, University of Crete, Heraklion 71003, Greece', 'institution_ids': ['https://openalex.org/I142617266']}, {'raw_affiliation_string': '*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and', 'institution_ids': ['https://openalex.org/I142617266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004719496', 'display_name': 'Eleftheria Ieronymaki', 'orcid': 'https://orcid.org/0000-0002-8441-298X'}, 'institutions': [{'id': 'https://openalex.org/I142617266', 'display_name': 'University of Crete', 'ror': 'https://ror.org/00dr28g20', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I142617266']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Eleftheria Ieronymaki', 'raw_affiliation_strings': ['*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and'], 'affiliations': [{'raw_affiliation_string': '*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and', 'institution_ids': ['https://openalex.org/I142617266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008160511', 'display_name': 'Konstantina Lyroni', 'orcid': 'https://orcid.org/0000-0001-7446-0999'}, 'institutions': [{'id': 'https://openalex.org/I142617266', 'display_name': 'University of Crete', 'ror': 'https://ror.org/00dr28g20', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I142617266']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Konstantina Lyroni', 'raw_affiliation_strings': ['*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and'], 'affiliations': [{'raw_affiliation_string': '*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and', 'institution_ids': ['https://openalex.org/I142617266']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076804415', 'display_name': 'Katerina Vaporidi', 'orcid': 'https://orcid.org/0000-0002-7766-8688'}, 'institutions': [{'id': 'https://openalex.org/I142617266', 'display_name': 'University of Crete', 'ror': 'https://ror.org/00dr28g20', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I142617266']}], 'countries': ['GR'], 'is_corresponding': False, 'raw_author_name': 'Katerina Vaporidi', 'raw_affiliation_strings': ['†Laboratory of Intensive Care Medicine, School of Medicine, University of Crete, Heraklion 71003, Greece'], 'affiliations': [{'raw_affiliation_string': '†Laboratory of Intensive Care Medicine, School of Medicine, University of Crete, Heraklion 71003, Greece', 'institution_ids': ['https://openalex.org/I142617266']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059536565', 'display_name': 'Christos Tsatsanis', 'orcid': 'https://orcid.org/0000-0003-1214-4151'}, 'institutions': [{'id': 'https://openalex.org/I142617266', 'display_name': 'University of Crete', 'ror': 'https://ror.org/00dr28g20', 'country_code': 'GR', 'type': 'education', 'lineage': ['https://openalex.org/I142617266']}], 'countries': ['GR'], 'is_corresponding': True, 'raw_author_name': 'Christos Tsatsanis', 'raw_affiliation_strings': ['*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and'], 'affiliations': [{'raw_affiliation_string': '*Laboratory of Clinical Chemistry, School of Medicine, University of Crete, Heraklion 71003, Greece; and', 'institution_ids': ['https://openalex.org/I142617266']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5059536565'], 'corresponding_institution_ids': ['https://openalex.org/I142617266'], 'apc_list': None, 'apc_paid': None, 'fwci': 8.057, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 869, 'citation_normalized_percentile': {'value': 0.99895, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '198', 'issue': '3', 'first_page': '1006', 'last_page': '1014'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11313', 'display_name': 'Immune cells in cancer', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13254', 'display_name': 'Macrophage Migration Inhibitory Factor', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/macrophage-polarization', 'display_name': 'Macrophage polarization', 'score': 0.738762}], 'concepts': [{'id': 'https://openalex.org/C2776682551', 'wikidata': 'https://www.wikidata.org/wiki/Q21072584', 'display_name': 'Macrophage polarization', 'level': 4, 'score': 0.738762}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.6622007}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5630061}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.5430796}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.5139086}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46029174}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.41552153}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4090221}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23544076}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14318335}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008262', 'descriptor_name': 'Macrophage Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016764', 'descriptor_name': 'Cell Polarity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004731', 'descriptor_name': 'Endotoxins', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D004731', 'descriptor_name': 'Endotoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051059', 'descriptor_name': 'PTEN Phosphohydrolase', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010587', 'descriptor_name': 'Phagocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000081382', 'descriptor_name': 'Pyruvate Dehydrogenase Acetyl-Transferring Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1601515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28115590', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.1601515', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 133, 'referenced_works': ['https://openalex.org/W1444407865', 'https://openalex.org/W1497000882', 'https://openalex.org/W1501750993', 'https://openalex.org/W1552576051', 'https://openalex.org/W1557103043', 'https://openalex.org/W1576981443', 'https://openalex.org/W1655528082', 'https://openalex.org/W1669895089', 'https://openalex.org/W1743492246', 'https://openalex.org/W1805013601', 'https://openalex.org/W1861384455', 'https://openalex.org/W1918903097', 'https://openalex.org/W1925160247', 'https://openalex.org/W1939939105', 'https://openalex.org/W1954571970', 'https://openalex.org/W1958426405', 'https://openalex.org/W1964361947', 'https://openalex.org/W1967934035', 'https://openalex.org/W1968670659', 'https://openalex.org/W1970763537', 'https://openalex.org/W1974550647', 'https://openalex.org/W1977255233', 'https://openalex.org/W1977435414', 'https://openalex.org/W1978476677', 'https://openalex.org/W1981056356', 'https://openalex.org/W1982219839', 'https://openalex.org/W1983995711', 'https://openalex.org/W1984110560', 'https://openalex.org/W1984803858', 'https://openalex.org/W1989837661', 'https://openalex.org/W1995618664', 'https://openalex.org/W1999447199', 'https://openalex.org/W2004078164', 'https://openalex.org/W2005646573', 'https://openalex.org/W2008232890', 'https://openalex.org/W2010817360', 'https://openalex.org/W2011928784', 'https://openalex.org/W2013316330', 'https://openalex.org/W2015472023', 'https://openalex.org/W2016089719', 'https://openalex.org/W2016291847', 'https://openalex.org/W2020004405', 'https://openalex.org/W2020744745', 'https://openalex.org/W2020920210', 'https://openalex.org/W2022739232', 'https://openalex.org/W2026758702', 'https://openalex.org/W2028536701', 'https://openalex.org/W2033802973', 'https://openalex.org/W2037338631', 'https://openalex.org/W2037432461', 'https://openalex.org/W2038286620', 'https://openalex.org/W2038781914', 'https://openalex.org/W2040850452', 'https://openalex.org/W2045386554', 'https://openalex.org/W2045628444', 'https://openalex.org/W2046905172', 'https://openalex.org/W2047159240', 'https://openalex.org/W2048708819', 'https://openalex.org/W2049542629', 'https://openalex.org/W2050344609', 'https://openalex.org/W2058094904', 'https://openalex.org/W2058645214', 'https://openalex.org/W2058845341', 'https://openalex.org/W2059763061', 'https://openalex.org/W2061716453', 'https://openalex.org/W2062943595', 'https://openalex.org/W2065165253', 'https://openalex.org/W2066529599', 'https://openalex.org/W2067647130', 'https://openalex.org/W2068331209', 'https://openalex.org/W2070065676', 'https://openalex.org/W2070968699', 'https://openalex.org/W2072564827', 'https://openalex.org/W2072657325', 'https://openalex.org/W2075860675', 'https://openalex.org/W2076174029', 'https://openalex.org/W2077124851', 'https://openalex.org/W2078513424', 'https://openalex.org/W2080503511', 'https://openalex.org/W2087812126', 'https://openalex.org/W2089695345', 'https://openalex.org/W2090338505', 'https://openalex.org/W2093604148', 'https://openalex.org/W2094166501', 'https://openalex.org/W2094941596', 'https://openalex.org/W2098023359', 'https://openalex.org/W2100458159', 'https://openalex.org/W2101372645', 'https://openalex.org/W2101619948', 'https://openalex.org/W2103002807', 'https://openalex.org/W2103711575', 'https://openalex.org/W2111946566', 'https://openalex.org/W2111967854', 'https://openalex.org/W2116152492', 'https://openalex.org/W2117695552', 'https://openalex.org/W2122871827', 'https://openalex.org/W2127135127', 'https://openalex.org/W2127543830', 'https://openalex.org/W2127642399', 'https://openalex.org/W2132312856', 'https://openalex.org/W2139459968', 'https://openalex.org/W2141123924', 'https://openalex.org/W2143019317', 'https://openalex.org/W2143041135', 'https://openalex.org/W2143781587', 'https://openalex.org/W2145558487', 'https://openalex.org/W2146186986', 'https://openalex.org/W2149159072', 'https://openalex.org/W2152701478', 'https://openalex.org/W2158855891', 'https://openalex.org/W2159560463', 'https://openalex.org/W2160167304', 'https://openalex.org/W2160315579', 'https://openalex.org/W2162444234', 'https://openalex.org/W2162606414', 'https://openalex.org/W2164097355', 'https://openalex.org/W2169417150', 'https://openalex.org/W2210729715', 'https://openalex.org/W2215729635', 'https://openalex.org/W2285631336', 'https://openalex.org/W2287265171', 'https://openalex.org/W2301014480', 'https://openalex.org/W2301614070', 'https://openalex.org/W2409612186', 'https://openalex.org/W2416233116', 'https://openalex.org/W2466619418', 'https://openalex.org/W2498735128', 'https://openalex.org/W3149733752', 'https://openalex.org/W4242061227', 'https://openalex.org/W4248219898', 'https://openalex.org/W4313379129', 'https://openalex.org/W785362024', 'https://openalex.org/W945377105'], 'related_works': ['https://openalex.org/W4206939639', 'https://openalex.org/W4205189596', 'https://openalex.org/W3183179750', 'https://openalex.org/W3116479654', 'https://openalex.org/W2982360817', 'https://openalex.org/W2916964185', 'https://openalex.org/W2422815049', 'https://openalex.org/W2098584395', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597'], 'abstract_inverted_index': {'Macrophages': [0], 'become': [1], 'activated': [2], 'initiating': [3], 'innate': [4], 'immune': [5], 'responses.': [6], 'Depending': [7], 'on': [8, 134, 145], 'the': [9, 20, 52, 131, 135, 138], 'signals,': [10], 'macrophages': [11], 'obtain': [12], 'an': [13], 'array': [14], 'of': [15, 23, 72, 81, 92, 137], 'activation': [16, 66], 'phenotypes,': [17], 'described': [18], 'by': [19, 115], 'broad': [21], 'terms': [22], 'M1': [24], 'or': [25, 87], 'M2': [26], 'phenotype.': [27, 67], 'The': [28], 'PI3K/Akt/mTOR': [29], 'pathway': [30, 54, 101, 141], 'mediates': [31], 'signals': [32, 59], 'from': [33], 'multiple': [34], 'receptors': [35], 'including': [36, 122], 'insulin': [37], 'receptors,': [38, 42, 44, 46], 'pathogen-associated': [39], 'molecular': [40], 'pattern': [41], 'cytokine': [43], 'adipokine': [45], 'and': [47, 57, 78, 90, 105, 111, 120, 125, 148], 'hormones.': [48], 'As': [49], 'a': [50, 70], 'result,': [51], 'Akt': [53, 68, 99, 139, 150], 'converges': [55], 'inflammatory': [56, 112, 117], 'metabolic': [58], 'to': [60], 'regulate': [61], 'macrophage': [62, 109], 'responses': [63], 'modulating': [64], 'their': [65], 'is': [69], 'family': [71], 'three': [73], 'serine-threonine': [74], 'kinases,': [75], 'Akt1,': [76], 'Akt2,': [77], 'Akt3.': [79], 'Generation': [80], 'mice': [82], 'lacking': [83], 'individual': [84], 'Akt,': [85], 'PI3K,': [86], 'mTOR': [88], 'isoforms': [89], 'utilization': [91], 'RNA': [93], 'interference': [94], 'technology': [95], 'have': [96, 103], 'revealed': [97], 'that': [98], 'signaling': [100, 140], 'components': [102], 'distinct': [104], 'isoform-specific': [106, 151], 'roles': [107], 'in': [108, 142], 'biology': [110], 'disease': [113], 'regulation,': [114], 'controlling': [116], 'cytokines,': [118], 'miRNAs,': [119], 'functions': [121], 'phagocytosis,': [123], 'autophagy,': [124], 'cell': [126], 'metabolism.': [127], 'Herein,': [128], 'we': [129], 'review': [130], 'current': [132], 'knowledge': [133], 'role': [136], 'macrophages,': [143], 'focusing': [144], 'M1/M2': [146], 'polarization': [147], 'highlighting': [149], 'functions.': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2582393724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 178}, {'year': 2023, 'cited_by_count': 178}, {'year': 2022, 'cited_by_count': 140}, {'year': 2021, 'cited_by_count': 126}, {'year': 2020, 'cited_by_count': 120}, {'year': 2019, 'cited_by_count': 67}, {'year': 2018, 'cited_by_count': 39}, {'year': 2017, 'cited_by_count': 18}], 'updated_date': '2025-01-09T14:12:47.556935', 'created_date': '2017-02-03'}