Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2567986926', 'doi': 'https://doi.org/10.1126/science.aah4307', 'title': '<i>SOX2</i> promotes lineage plasticity and antiandrogen resistance in <i>TP53</i> - and <i>RB1</i> -deficient prostate cancer', 'display_name': '<i>SOX2</i> promotes lineage plasticity and antiandrogen resistance in <i>TP53</i> - and <i>RB1</i> -deficient prostate cancer', 'publication_year': 2017, 'publication_date': '2017-01-05', 'ids': {'openalex': 'https://openalex.org/W2567986926', 'doi': 'https://doi.org/10.1126/science.aah4307', 'mag': '2567986926', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28059768', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5247742'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.aah4307', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5247742?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5067011080', 'display_name': 'Ping Mu', 'orcid': 'https://orcid.org/0000-0003-0955-0896'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ping Mu', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024562035', 'display_name': 'Zeda Zhang', 'orcid': 'https://orcid.org/0000-0002-7225-534X'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zeda Zhang', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025403673', 'display_name': 'Matteo Benelli', 'orcid': 'https://orcid.org/0000-0003-1227-356X'}, 'institutions': [{'id': 'https://openalex.org/I193223587', 'display_name': 'University of Trento', 'ror': 'https://ror.org/05trd4x28', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I193223587']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Matteo Benelli', 'raw_affiliation_strings': ['Centre for Integrative Biology, University of Trento, Trento, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Integrative Biology, University of Trento, Trento, Italy.', 'institution_ids': ['https://openalex.org/I193223587']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009209065', 'display_name': 'Wouter R. Karthaus', 'orcid': 'https://orcid.org/0000-0002-9234-9044'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wouter R. Karthaus', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040856140', 'display_name': 'Elizabeth Hoover', 'orcid': 'https://orcid.org/0000-0002-6215-2830'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth Hoover', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071797704', 'display_name': 'Chi-Chao Chen', 'orcid': 'https://orcid.org/0000-0003-1818-0196'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chi-Chao Chen', 'raw_affiliation_strings': ['Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050228096', 'display_name': 'John Wongvipat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John Wongvipat', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018656117', 'display_name': 'Sheng‐Yu Ku', 'orcid': 'https://orcid.org/0000-0003-4715-1888'}, 'institutions': [{'id': 'https://openalex.org/I1292894508', 'display_name': 'Roswell Park Comprehensive Cancer Center', 'ror': 'https://ror.org/0499dwk57', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1292894508']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sheng-Yu Ku', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, New York, NY 14263, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, New York, NY 14263, USA.', 'institution_ids': ['https://openalex.org/I1292894508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039539227', 'display_name': 'Dong Gao', 'orcid': 'https://orcid.org/0000-0003-1821-2741'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dong Gao', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011380715', 'display_name': 'Zhen Cao', 'orcid': 'https://orcid.org/0000-0002-8120-9951'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhen Cao', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109529034', 'display_name': 'Neel Shah', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Neel Shah', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105766519', 'display_name': 'Elizabeth Adams', 'orcid': 'https://orcid.org/0000-0003-4204-2690'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth J. Adams', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062426672', 'display_name': 'Wassim Abida', 'orcid': 'https://orcid.org/0000-0002-9006-7043'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wassim Abida', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103262395', 'display_name': 'Philip A. Watson', 'orcid': 'https://orcid.org/0000-0002-6096-8254'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philip A. Watson', 'raw_affiliation_strings': ['Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008401803', 'display_name': 'Davide Prandi', 'orcid': 'https://orcid.org/0000-0001-9885-6074'}, 'institutions': [{'id': 'https://openalex.org/I193223587', 'display_name': 'University of Trento', 'ror': 'https://ror.org/05trd4x28', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I193223587']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Davide Prandi', 'raw_affiliation_strings': ['Centre for Integrative Biology, University of Trento, Trento, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Centre for Integrative Biology, University of Trento, Trento, Italy.', 'institution_ids': ['https://openalex.org/I193223587']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032585553', 'display_name': 'Chun‐Hao Huang', 'orcid': 'https://orcid.org/0000-0002-3233-5943'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chun-Hao Huang', 'raw_affiliation_strings': ['Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004111432', 'display_name': 'Elisa de Stanchina', 'orcid': 'https://orcid.org/0000-0002-3873-315X'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elisa de Stanchina', 'raw_affiliation_strings': ['Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025451142', 'display_name': 'Scott W. Lowe', 'orcid': 'https://orcid.org/0000-0002-5284-9650'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott W. Lowe', 'raw_affiliation_strings': ['Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.', 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Weill Cornell Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.', 'institution_ids': ['https://openalex.org/I1344073410']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081026905', 'display_name': 'Leigh Ellis', 'orcid': 'https://orcid.org/0000-0003-4739-5049'}, 'institutions': [{'id': 'https://openalex.org/I1292894508', 'display_name': 'Roswell Park Comprehensive Cancer Center', 'ror': 'https://ror.org/0499dwk57', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1292894508']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Leigh Ellis', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, New York, NY 14263, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, New York, NY 14263, USA.', 'institution_ids': ['https://openalex.org/I1292894508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047882814', 'display_name': 'Himisha Beltran', 'orcid': 'https://orcid.org/0000-0003-3259-2226'}, 'institutions': [{'id': 'https://openalex.org/I2801107848', 'display_name': 'New York Hospital Queens', 'ror': 'https://ror.org/01j17xg39', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801107848']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I4387153466', 'display_name': 'Weill Cornell Medicine', 'ror': 'https://ror.org/02r109517', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295', 'https://openalex.org/I4387153466']}, {'id': 'https://openalex.org/I4210096498', 'display_name': 'Presbyterian Hospital', 'ror': 'https://ror.org/00n2w1t65', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321404777', 'https://openalex.org/I4210096498']}, {'id': 'https://openalex.org/I1340179700', 'display_name': 'NewYork–Presbyterian Hospital', 'ror': 'https://ror.org/03gzbrs57', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340179700']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Himisha Beltran', 'raw_affiliation_strings': ['Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY 10065, USA.', 'Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I2801107848', 'https://openalex.org/I4210096498', 'https://openalex.org/I4387153466', 'https://openalex.org/I1340179700', 'https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I205783295', 'https://openalex.org/I4387153466']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035068594', 'display_name': 'Mark A. Rubin', 'orcid': 'https://orcid.org/0000-0002-8321-9950'}, 'institutions': [{'id': 'https://openalex.org/I4387153466', 'display_name': 'Weill Cornell Medicine', 'ror': 'https://ror.org/02r109517', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295', 'https://openalex.org/I4387153466']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I4210096498', 'display_name': 'Presbyterian Hospital', 'ror': 'https://ror.org/00n2w1t65', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321404777', 'https://openalex.org/I4210096498']}, {'id': 'https://openalex.org/I2801107848', 'display_name': 'New York Hospital Queens', 'ror': 'https://ror.org/01j17xg39', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801107848']}, {'id': 'https://openalex.org/I1340179700', 'display_name': 'NewYork–Presbyterian Hospital', 'ror': 'https://ror.org/03gzbrs57', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340179700']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark A. Rubin', 'raw_affiliation_strings': ['Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY 10065, USA.', 'Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY 10021, USA.'], 'affiliations': [{'raw_affiliation_string': 'Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I4387153466', 'https://openalex.org/I4210096498', 'https://openalex.org/I2801107848', 'https://openalex.org/I1340179700', 'https://openalex.org/I205783295']}, {'raw_affiliation_string': 'Sandra and Edward Meyer Cancer Center at Weill Cornell Medicine, New York, NY 10021, USA.', 'institution_ids': ['https://openalex.org/I205783295', 'https://openalex.org/I4387153466']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006539902', 'display_name': 'David W. Goodrich', 'orcid': 'https://orcid.org/0000-0002-1021-1827'}, 'institutions': [{'id': 'https://openalex.org/I1292894508', 'display_name': 'Roswell Park Comprehensive Cancer Center', 'ror': 'https://ror.org/0499dwk57', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1292894508']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David W. Goodrich', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, New York, NY 14263, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, New York, NY 14263, USA.', 'institution_ids': ['https://openalex.org/I1292894508']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070658179', 'display_name': 'Francesca Demichelis', 'orcid': 'https://orcid.org/0000-0002-8266-8631'}, 'institutions': [{'id': 'https://openalex.org/I2801107848', 'display_name': 'New York Hospital Queens', 'ror': 'https://ror.org/01j17xg39', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801107848']}, {'id': 'https://openalex.org/I1340179700', 'display_name': 'NewYork–Presbyterian Hospital', 'ror': 'https://ror.org/03gzbrs57', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1340179700']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I4387153466', 'display_name': 'Weill Cornell Medicine', 'ror': 'https://ror.org/02r109517', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295', 'https://openalex.org/I4387153466']}, {'id': 'https://openalex.org/I193223587', 'display_name': 'University of Trento', 'ror': 'https://ror.org/05trd4x28', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I193223587']}, {'id': 'https://openalex.org/I4210096498', 'display_name': 'Presbyterian Hospital', 'ror': 'https://ror.org/00n2w1t65', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1321404777', 'https://openalex.org/I4210096498']}], 'countries': ['IT', 'US'], 'is_corresponding': False, 'raw_author_name': 'Francesca Demichelis', 'raw_affiliation_strings': ['Centre for Integrative Biology, University of Trento, Trento, Italy.', 'Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Englander Institute for Precision Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I2801107848', 'https://openalex.org/I1340179700', 'https://openalex.org/I205783295', 'https://openalex.org/I4387153466', 'https://openalex.org/I4210096498']}, {'raw_affiliation_string': 'Centre for Integrative Biology, University of Trento, Trento, Italy.', 'institution_ids': ['https://openalex.org/I193223587']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034963668', 'display_name': 'Charles L. Sawyers', 'orcid': 'https://orcid.org/0000-0003-4955-6475'}, 'institutions': [{'id': 'https://openalex.org/I1334819555', 'display_name': 'Memorial Sloan Kettering Cancer Center', 'ror': 'https://ror.org/02yrq0923', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334819555']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Charles L. Sawyers', 'raw_affiliation_strings': ['Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.', 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.'], 'affiliations': [{'raw_affiliation_string': 'Human Oncology and Pathology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.', 'institution_ids': ['https://openalex.org/I1334819555']}, {'raw_affiliation_string': 'Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.', 'institution_ids': ['https://openalex.org/I1344073410']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 9, 'corresponding_author_ids': ['https://openalex.org/A5034963668'], 'corresponding_institution_ids': ['https://openalex.org/I1334819555', 'https://openalex.org/I1344073410'], 'apc_list': None, 'apc_paid': None, 'fwci': 82.558, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 857, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '355', 'issue': '6320', 'first_page': '84', 'last_page': '88'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9857, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lineage', 'display_name': 'Lineage (genetic)', 'score': 0.59198564}, {'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.44347802}], 'concepts': [{'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8080225}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6449533}, {'id': 'https://openalex.org/C2776817793', 'wikidata': 'https://www.wikidata.org/wiki/Q6553369', 'display_name': 'Lineage (genetic)', 'level': 3, 'score': 0.59198564}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.58162844}, {'id': 'https://openalex.org/C2777933648', 'wikidata': 'https://www.wikidata.org/wiki/Q21114866', 'display_name': 'SOX2', 'level': 4, 'score': 0.56779784}, {'id': 'https://openalex.org/C50171091', 'wikidata': 'https://www.wikidata.org/wiki/Q17917770', 'display_name': 'EZH2', 'level': 4, 'score': 0.5542601}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5146326}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4913527}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.47989357}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4593537}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.45840883}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.4560809}, {'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.44347802}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43534186}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.39679155}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3625098}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3281532}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.240574}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13816568}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.09009588}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06216991}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D056286', 'descriptor_name': 'Retinoblastoma Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001549', 'descriptor_name': 'Benzamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019070', 'descriptor_name': 'Cell Lineage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000066670', 'descriptor_name': 'Cell Plasticity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055748', 'descriptor_name': 'SOXB1 Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.aah4307', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5247742', 'pdf_url': 'https://europepmc.org/articles/pmc5247742?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247742', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28059768', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5247742', 'pdf_url': 'https://europepmc.org/articles/pmc5247742?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1578291413', 'https://openalex.org/W1979001955', 'https://openalex.org/W1980168406', 'https://openalex.org/W1980497534', 'https://openalex.org/W1999614615', 'https://openalex.org/W2002937040', 'https://openalex.org/W2003955264', 'https://openalex.org/W2005274657', 'https://openalex.org/W2023171799', 'https://openalex.org/W2023400202', 'https://openalex.org/W2065388551', 'https://openalex.org/W2076047032', 'https://openalex.org/W2080534618', 'https://openalex.org/W2080748037', 'https://openalex.org/W2081620485', 'https://openalex.org/W2085252210', 'https://openalex.org/W2091540336', 'https://openalex.org/W2094252220', 'https://openalex.org/W2095885501', 'https://openalex.org/W2095932050', 'https://openalex.org/W2119504728', 'https://openalex.org/W2119758846', 'https://openalex.org/W2130955565', 'https://openalex.org/W2133339454', 'https://openalex.org/W2134988422', 'https://openalex.org/W2136792748', 'https://openalex.org/W2137974207', 'https://openalex.org/W2140290142', 'https://openalex.org/W2145927337', 'https://openalex.org/W2150170782', 'https://openalex.org/W2150575159', 'https://openalex.org/W2161112598', 'https://openalex.org/W2169456326', 'https://openalex.org/W2171171429', 'https://openalex.org/W2181283187', 'https://openalex.org/W2262087934', 'https://openalex.org/W2273958019', 'https://openalex.org/W2290217854', 'https://openalex.org/W4252232449'], 'related_works': ['https://openalex.org/W4394724610', 'https://openalex.org/W4362621709', 'https://openalex.org/W4362609326', 'https://openalex.org/W4362609250', 'https://openalex.org/W4362495275', 'https://openalex.org/W4361940014', 'https://openalex.org/W4361890616', 'https://openalex.org/W2890810587', 'https://openalex.org/W1993338898', 'https://openalex.org/W1848444843'], 'abstract_inverted_index': {'Some': [0], 'cancers': [1], 'evade': [2], 'targeted': [3], 'therapies': [4], 'through': [5, 131], 'a': [6, 19, 56, 117], 'mechanism': [7], 'known': [8], 'as': [9], 'lineage': [10, 21, 71, 132], 'plasticity,': [11], 'whereby': [12], 'tumor': [13, 112], 'cells': [14, 65], 'acquire': [15], 'phenotypic': [16, 57], 'characteristics': [17], 'of': [18, 78, 88, 119], 'cell': [20], 'whose': [22], 'survival': [23], 'no': [24], 'longer': [25], 'depends': [26], 'on': [27], 'the': [28, 51, 76, 89], 'drug': [29, 53], 'target.': [30], 'We': [31], 'use': [32], 'in': [33, 36, 111], 'vitro': [34], 'and': [35, 80, 94, 101], 'vivo': [37], 'human': [38], 'prostate': [39], 'cancer': [40], 'models': [41], 'to': [42, 50, 66], 'show': [43], 'that': [44], 'these': [45], 'tumors': [46], 'can': [47, 95, 115], 'develop': [48], 'resistance': [49, 130], 'antiandrogen': [52, 127], 'enzalutamide': [54], 'by': [55, 75, 85, 98, 105], 'shift': [58], 'from': [59], 'androgen': [60], 'receptor': [61], '(AR)-dependent': [62], 'luminal': [63], 'epithelial': [64], 'AR-independent': [67], 'basal-like': [68], 'cells.': [69], 'This': [70], 'plasticity': [72, 122], 'is': [73, 83], 'enabled': [74], 'loss': [77], 'TP53': [79, 100], 'RB1': [81, 102], 'function,': [82], 'mediated': [84], 'increased': [86, 120], 'expression': [87], 'reprogramming': [90], 'transcription': [91], 'factor': [92], 'SOX2,': [93], 'be': [96], 'reversed': [97], 'restoring': [99], 'function': [103], 'or': [104], 'inhibiting': [106], 'SOX2': [107], 'expression.': [108], 'Thus,': [109], 'mutations': [110], 'suppressor': [113], 'genes': [114], 'create': [116], 'state': [118], 'cellular': [121], 'that,': [123], 'when': [124], 'challenged': [125], 'with': [126], 'therapy,': [128], 'promotes': [129], 'switching.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2567986926', 'counts_by_year': [{'year': 2024, 'cited_by_count': 108}, {'year': 2023, 'cited_by_count': 109}, {'year': 2022, 'cited_by_count': 127}, {'year': 2021, 'cited_by_count': 123}, {'year': 2020, 'cited_by_count': 114}, {'year': 2019, 'cited_by_count': 103}, {'year': 2018, 'cited_by_count': 115}, {'year': 2017, 'cited_by_count': 53}], 'updated_date': '2024-12-15T00:26:05.653700', 'created_date': '2017-01-13'}