Bone morphogenetic protein (BMP)-9 enhances high glucose-mediated microvascular damage

Name: Work Video:
Duration: 3 min 30 s
Description: Bone morphogenetic protein (BMP)-9, a member of the TGF-β superfamily of cytokines is produced in the liver. Culturing hepatic stellate cells (HSC) under conditions of high glucose was reported to enhance HSC activation in vitro.
H Gaitantzi; Peter M. Reuss; Karen Bieback; E Tüzen; Benito A. Yard; M Ebert; Han Moshage; Katja Breitkopf‐Heinlein
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Fac. Mannheim', 'Med. Fac. Mannheim; University of Heidelberg, Department of Medicine II, Mannheim, Germany'], 'affiliations': [{'raw_affiliation_string': 'Med. Fac. Mannheim; University of Heidelberg, Department of Medicine II, Mannheim, Germany', 'institution_ids': ['https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Med. Fac. Mannheim', 'institution_ids': ['https://openalex.org/I177802217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056052919', 'display_name': 'Peter M. Reuss', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I177802217', 'display_name': 'University of Mannheim', 'ror': 'https://ror.org/031bsb921', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I177802217']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'P Reuss', 'raw_affiliation_strings': ['Med. Fac. Mannheim', 'Med. Fac. Mannheim; University of Heidelberg, Department of Medicine II, Mannheim, Germany'], 'affiliations': [{'raw_affiliation_string': 'Med. Fac. Mannheim; University of Heidelberg, Department of Medicine II, Mannheim, Germany', 'institution_ids': ['https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Med. Fac. Mannheim', 'institution_ids': ['https://openalex.org/I177802217']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025667256', 'display_name': 'Karen Bieback', 'orcid': 'https://orcid.org/0000-0003-2621-0703'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I177802217', 'display_name': 'University of Mannheim', 'ror': 'https://ror.org/031bsb921', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I177802217']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'K Bieback', 'raw_affiliation_strings': ['Med. Fac. Mannheim', 'Med. Fac. Mannheim; University of Heidelberg, Institute of Transfusion Medicine and Immunology, Mannheim, Germany'], 'affiliations': [{'raw_affiliation_string': 'Med. Fac. 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'https://openalex.org/W193109527', 'https://openalex.org/W1574639750'], 'abstract_inverted_index': {'Bone': [0], 'morphogenetic': [1], 'protein': [2], '(BMP)-9,': [3], 'a': [4], 'member': [5], 'of': [6, 10, 24], 'the': [7, 15], 'TGF-β': [8], 'superfamily': [9], 'cytokines': [11], 'is': [12], 'produced': [13], 'in': [14, 33], 'liver.': [16], 'Culturing': [17], 'hepatic': [18], 'stellate': [19], 'cells': [20], '(HSC)': [21], 'under': [22], 'conditions': [23], 'high': [25], 'glucose': [26], 'was': [27], 'reported': [28], 'to': [29], 'enhance': [30], 'HSC': [31], 'activation': [32], 'vitro.': [34]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2562545969', 'counts_by_year': [], 'updated_date': '2024-12-07T09:23:54.795857', 'created_date': '2017-01-06'}
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