Title: Signal transduction of bone morphogenetic protein-7 (BMP-7) and BMP-7 receptor
Abstract:Bone morphogenetic protein-7 is a member of the bone morphogenetic protein family and can induce bone formation. It is also a member of the transforming growth factor-#beta# (TGF-#beta# superfamily. B...Bone morphogenetic protein-7 is a member of the bone morphogenetic protein family and can induce bone formation. It is also a member of the transforming growth factor-#beta# (TGF-#beta# superfamily. BMP-7 receptor, a membrane protein receptor, belongs to the superfamily of the transforming growth factor-#beta# receptors. One BMP-7 binds to type II serine/threonine kinase receptors (ActR II, IIB), the receptor protein kinase is activated and forms a heterodimer by binding to type I (mainly ALK2) receptors, which phosphorylate serine/threonine residue. Activation of type I receptor can phosphorylate C terminal SSXS motif of Smad1, Smad5 or Smad 8, and then forms complex with Smad4 to enter nuclei thereby regulating genes.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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