Publication Information

{'id': 'https://openalex.org/W2561521455', 'doi': 'https://doi.org/10.1152/ajpheart.00596.2016', 'title': 'Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model', 'display_name': 'Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model', 'publication_year': 2016, 'publication_date': '2016-12-30', 'ids': {'openalex': 'https://openalex.org/W2561521455', 'doi': 'https://doi.org/10.1152/ajpheart.00596.2016', 'mag': '2561521455', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/28039201'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.00596.2016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000627508', 'display_name': 'Georgina Palau-Caballero', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Georgina Palau-Caballero', 'raw_affiliation_strings': ['Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027992807', 'display_name': 'John Walmsley', 'orcid': 'https://orcid.org/0000-0001-9171-7530'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'John Walmsley', 'raw_affiliation_strings': ['Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078850892', 'display_name': 'Vanessa van Empel', 'orcid': 'https://orcid.org/0000-0002-6864-0296'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Vanessa Van Empel', 'raw_affiliation_strings': ['Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034213745', 'display_name': 'Joost Lumens', 'orcid': 'https://orcid.org/0000-0001-8129-7384'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Joost Lumens', 'raw_affiliation_strings': ['Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and', 'institution_ids': ['https://openalex.org/I34352273']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080175953', 'display_name': 'Tammo Delhaas', 'orcid': 'https://orcid.org/0000-0001-6897-9700'}, 'institutions': [{'id': 'https://openalex.org/I34352273', 'display_name': 'Maastricht University', 'ror': 'https://ror.org/02jz4aj89', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I34352273']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tammo Delhaas', 'raw_affiliation_strings': ['Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; and', 'institution_ids': ['https://openalex.org/I34352273']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5000627508'], 'corresponding_institution_ids': ['https://openalex.org/I34352273'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.059, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.917078, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '312', 'issue': '4', 'first_page': 'H691', 'last_page': 'H700'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10728', 'display_name': 'Pulmonary Hypertension Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10821', 'display_name': 'Cardiovascular Function and Risk Factors', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12230', 'display_name': 'Cardiovascular Issues in Pregnancy', 'score': 0.964, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/right-ventricular-failure', 'display_name': 'Right ventricular failure', 'score': 0.4389132}], 'concepts': [{'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.76753926}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6844807}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6061882}, {'id': 'https://openalex.org/C2780930700', 'wikidata': 'https://www.wikidata.org/wiki/Q1128595', 'display_name': 'Pulmonary hypertension', 'level': 2, 'score': 0.5170632}, {'id': 'https://openalex.org/C2910414618', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Right ventricular failure', 'level': 3, 'score': 0.4389132}], 'mesh': [{'descriptor_ui': 'D006346', 'descriptor_name': 'Heart Septum', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D018497', 'descriptor_name': 'Ventricular Dysfunction, Right', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006333', 'descriptor_name': 'Heart Failure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006333', 'descriptor_name': 'Heart Failure', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D006346', 'descriptor_name': 'Heart Septum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006976', 'descriptor_name': 'Hypertension, Pulmonary', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D009200', 'descriptor_name': 'Myocardial Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D011651', 'descriptor_name': 'Pulmonary Artery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011652', 'descriptor_name': 'Pulmonary Circulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018497', 'descriptor_name': 'Ventricular Dysfunction, Right', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D018497', 'descriptor_name': 'Ventricular Dysfunction, Right', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016276', 'descriptor_name': 'Ventricular Function', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpheart.00596.2016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S87338489', 'display_name': 'AJP Heart and Circulatory Physiology', 'issn_l': '0363-6135', 'issn': ['0363-6135', '1522-1539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/28039201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321642', 'funder_display_name': 'Hartstichting', 'award_id': 'NHS-2012T010'}], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1000878858', 'https://openalex.org/W1553632669', 'https://openalex.org/W195128739', 'https://openalex.org/W1967892540', 'https://openalex.org/W1969190078', 'https://openalex.org/W1976010247', 'https://openalex.org/W2017138224', 'https://openalex.org/W2022301964', 'https://openalex.org/W2031359510', 'https://openalex.org/W2044505998', 'https://openalex.org/W2046413681', 'https://openalex.org/W2049181319', 'https://openalex.org/W2051110852', 'https://openalex.org/W2065445785', 'https://openalex.org/W2072269927', 'https://openalex.org/W2072659094', 'https://openalex.org/W2075537770', 'https://openalex.org/W2092195299', 'https://openalex.org/W2102607047', 'https://openalex.org/W2107254439', 'https://openalex.org/W2127994875', 'https://openalex.org/W2128070479', 'https://openalex.org/W2130361326', 'https://openalex.org/W2134006584', 'https://openalex.org/W2141658487', 'https://openalex.org/W2147165810', 'https://openalex.org/W2153682204', 'https://openalex.org/W2155732203', 'https://openalex.org/W2161370807', 'https://openalex.org/W2162152294', 'https://openalex.org/W2167172008', 'https://openalex.org/W2177767425', 'https://openalex.org/W2185549840', 'https://openalex.org/W2216997493', 'https://openalex.org/W2217190791', 'https://openalex.org/W2264324122', 'https://openalex.org/W765837929'], 'related_works': ['https://openalex.org/W3183948672', 'https://openalex.org/W3173606202', 'https://openalex.org/W3110381201', 'https://openalex.org/W2956160923', 'https://openalex.org/W2948807893', 'https://openalex.org/W2778153218', 'https://openalex.org/W2748952813', 'https://openalex.org/W2603866746', 'https://openalex.org/W2402655459', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': {'Rapid': [0], 'leftward': [1], 'septal': [2, 144, 256], 'motion': [3, 145, 264, 285], '(RLSM)': [4], 'during': [5], 'early': [6], 'left': [7, 294], 'ventricular': [8, 23, 174, 272, 278, 295], '(LV)': [9], 'diastole': [10], 'is': [11, 265, 286], 'observed': [12, 118], 'in': [13, 50, 108, 119, 132, 173, 178, 183, 192, 258, 263, 284], 'patients': [14, 184], 'with': [15, 96, 149, 185], 'pulmonary': [16, 259], 'arterial': [17, 260], 'hypertension': [18], '(PAH).': [19], 'RLSM': [20, 49, 65, 92, 116, 177, 182, 208, 232], 'exacerbates': [21], 'right': [22, 271, 292], '(RV)': [24], 'systolic': [25], 'dysfunction': [26, 152, 162], 'and': [27, 48, 71, 78, 81, 114, 122, 158, 168, 195, 226, 293], 'impairs': [28], 'LV': [29, 99, 160, 227, 244], 'filling.': [30], 'Increased': [31], 'RV': [32, 38, 97, 106, 150, 193, 204, 215, 225, 238], 'wall': [33], 'tension': [34], 'caused': [35], 'by': [36, 66, 269, 276], 'increased': [37], 'afterload': [39], 'has': [40], 'been': [41], 'suggested': [42], 'to': [43, 60, 188], 'cause': [44], 'interventricular': [45, 111, 155, 165], 'relaxation': [46, 112, 156, 166, 175, 279], 'dyssynchrony': [47, 113, 157, 167, 172], 'PAH.': [51, 124, 179], 'Simulations': [52, 74], 'using': [53], 'the': [54, 62, 89, 252], 'CircAdapt': [55], 'computational': [56], 'model': [57], 'were': [58, 84], 'used': [59, 199], 'unravel': [61], 'mechanism': [63, 253], 'underlying': [64, 254], 'mechanistically': [67], 'linking': [68], 'myocardial': [69], 'tissue': [70], 'pump': [72], 'function.': [73, 229], 'of': [75, 181, 203, 224, 231, 243], 'healthy': [76], 'circulation': [77], 'mild,': [79], 'moderate,': [80], 'severe': [82, 123, 133], 'PAH': [83, 94, 109, 147, 186], 'performed.': [85], 'We': [86], 'also': [87, 220, 275], 'assessed': [88], 'effects': [90], 'on': [91], 'when': [93], 'coexists': [95], 'or': [98, 240, 282], 'contractile': [100, 151, 161, 228], 'dysfunction.': [101], 'Our': [102], 'results': [103], 'showed': [104], 'prolonged': [105], 'shortening': [107], 'causing': [110], 'RLSM.': [115, 159, 169], 'was': [117], 'both': [120, 154, 164], 'moderate': [121], 'A': [125, 248], 'negative': [126, 137], 'transseptal': [127], 'pressure': [128, 138], 'gradient': [129, 139], 'only': [130], 'occurred': [131], 'PAH,': [134], 'demonstrating': [135], 'that': [136], 'does': [140, 209], 'not': [141, 210, 266], 'entirely': [142], 'explain': [143], 'abnormalities.': [146], 'coexisting': [148], 'exacerbated': [153], 'reduced': [163], 'In': [170], 'conclusion,': [171], 'causes': [176], 'Onset': [180], 'appears': [187], 'indicate': [189, 221], 'a': [190, 201, 241, 287], 'worsening': [191], 'function': [194, 239], 'hence': [196], 'can': [197, 219, 233], 'be': [198], 'as': [200], 'sign': [202], 'failure.': [205], 'However,': [206], 'altered': [207, 214, 222, 270, 277], 'necessarily': [211], 'imply': [212], 'an': [213], 'afterload,': [216, 273], 'but': [217, 274], 'it': [218], 'interplay': [223, 290], 'Reduction': [230], 'result': [234], 'from': [235], 'either': [236], 'improved': [237], 'deterioration': [242], 'function.NEW': [245], '&': [246], 'NOTEWORTHY': [247], 'novel': [249], 'approach': [250], 'describes': [251], 'abnormal': [255], 'dynamics': [257], 'hypertension.': [261], 'Change': [262], 'uniquely': [267], 'induced': [268], 'dyssynchrony.': [280], 'Extension': [281], 'change': [283], 'marker': [288], 'reflecting': [289], 'between': [291], 'contractility.': [296]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2561521455', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}], 'updated_date': '2024-12-13T17:58:49.689061', 'created_date': '2017-01-06'}