Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2553162721', 'doi': 'https://doi.org/10.4155/fmc-2016-0192', 'title': 'HSP70: therapeutic potential in acute and chronic cardiac disease settings', 'display_name': 'HSP70: therapeutic potential in acute and chronic cardiac disease settings', 'publication_year': 2016, 'publication_date': '2016-11-15', 'ids': {'openalex': 'https://openalex.org/W2553162721', 'doi': 'https://doi.org/10.4155/fmc-2016-0192', 'mag': '2553162721', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27845575'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4155/fmc-2016-0192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122867665', 'display_name': 'Future Medicinal Chemistry', 'issn_l': '1756-8919', 'issn': ['1756-8919', '1756-8927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320316', 'host_organization_name': 'Future Science Ltd', 'host_organization_lineage': ['https://openalex.org/P4310320316'], 'host_organization_lineage_names': ['Future Science Ltd'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011259664', 'display_name': 'Bianca C. Bernardo', 'orcid': 'https://orcid.org/0000-0002-4534-0549'}, 'institutions': [{'id': 'https://openalex.org/I142471025', 'display_name': 'Baker Heart and Diabetes Institute', 'ror': 'https://ror.org/03rke0285', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I142471025']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Bianca C Bernardo', 'raw_affiliation_strings': ['Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia'], 'affiliations': [{'raw_affiliation_string': 'Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia', 'institution_ids': ['https://openalex.org/I142471025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031087686', 'display_name': 'Kate L. Weeks', 'orcid': 'https://orcid.org/0000-0002-4844-6437'}, 'institutions': [{'id': 'https://openalex.org/I142471025', 'display_name': 'Baker Heart and Diabetes Institute', 'ror': 'https://ror.org/03rke0285', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I142471025']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Kate L Weeks', 'raw_affiliation_strings': ['Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia'], 'affiliations': [{'raw_affiliation_string': 'Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia', 'institution_ids': ['https://openalex.org/I142471025']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050661906', 'display_name': 'Natalie L. Patterson', 'orcid': 'https://orcid.org/0009-0004-5586-6992'}, 'institutions': [{'id': 'https://openalex.org/I142471025', 'display_name': 'Baker Heart and Diabetes Institute', 'ror': 'https://ror.org/03rke0285', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I142471025']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Natalie L Patterson', 'raw_affiliation_strings': ['Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia'], 'affiliations': [{'raw_affiliation_string': 'Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia', 'institution_ids': ['https://openalex.org/I142471025']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049355201', 'display_name': 'Julie R. McMullen', 'orcid': 'https://orcid.org/0000-0002-8316-1066'}, 'institutions': [{'id': 'https://openalex.org/I142471025', 'display_name': 'Baker Heart and Diabetes Institute', 'ror': 'https://ror.org/03rke0285', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I142471025']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Julie R McMullen', 'raw_affiliation_strings': ['Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia', 'Department of Physiology and Department of Medicine, Monash University, Clayton, Victoria3800, Australia'], 'affiliations': [{'raw_affiliation_string': 'Baker IDI Heart & Diabetes Institute, Melbourne, 3004, Australia', 'institution_ids': ['https://openalex.org/I142471025']}, {'raw_affiliation_string': 'Department of Physiology and Department of Medicine, Monash University, Clayton, Victoria3800, Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.95, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.742704, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '8', 'issue': '18', 'first_page': '2177', 'last_page': '2183'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chaperone', 'display_name': 'Chaperone (clinical)', 'score': 0.534688}, {'id': 'https://openalex.org/keywords/homeostasis', 'display_name': 'Homeostasis', 'score': 0.51521116}], 'concepts': [{'id': 'https://openalex.org/C68991219', 'wikidata': 'https://www.wikidata.org/wiki/Q419102', 'display_name': 'Hsp70', 'level': 4, 'score': 0.81570965}, {'id': 'https://openalex.org/C205260736', 'wikidata': 'https://www.wikidata.org/wiki/Q418939', 'display_name': 'Heat shock protein', 'level': 3, 'score': 0.75237167}, {'id': 'https://openalex.org/C2775962898', 'wikidata': 'https://www.wikidata.org/wiki/Q5073152', 'display_name': 'Chaperone (clinical)', 'level': 2, 'score': 0.534688}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.5261673}, {'id': 'https://openalex.org/C63645605', 'wikidata': 'https://www.wikidata.org/wiki/Q103191', 'display_name': 'Homeostasis', 'level': 2, 'score': 0.51521116}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.50043964}, {'id': 'https://openalex.org/C136238340', 'wikidata': 'https://www.wikidata.org/wiki/Q7251455', 'display_name': 'Protein aggregation', 'level': 2, 'score': 0.48107505}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.43485665}, {'id': 'https://openalex.org/C2781300812', 'wikidata': 'https://www.wikidata.org/wiki/Q178061', 'display_name': 'Shock (circulatory)', 'level': 2, 'score': 0.42515346}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.42222452}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4098633}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.38572803}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37466446}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.31473714}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2460315}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20123285}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.14986572}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.123711646}], 'mesh': [{'descriptor_ui': 'D018840', 'descriptor_name': 'HSP70 Heat-Shock Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D006331', 'descriptor_name': 'Heart Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006331', 'descriptor_name': 'Heart Diseases', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000208', 'descriptor_name': 'Acute Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002908', 'descriptor_name': 'Chronic Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018840', 'descriptor_name': 'HSP70 Heat-Shock Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018840', 'descriptor_name': 'HSP70 Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006331', 'descriptor_name': 'Heart Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4155/fmc-2016-0192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122867665', 'display_name': 'Future Medicinal Chemistry', 'issn_l': '1756-8919', 'issn': ['1756-8919', '1756-8927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320316', 'host_organization_name': 'Future Science Ltd', 'host_organization_lineage': ['https://openalex.org/P4310320316'], 'host_organization_lineage_names': ['Future Science Ltd'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27845575', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1965754110', 'https://openalex.org/W1966502113', 'https://openalex.org/W1973328141', 'https://openalex.org/W1978489370', 'https://openalex.org/W1982260690', 'https://openalex.org/W1986289438', 'https://openalex.org/W1988290681', 'https://openalex.org/W1990957620', 'https://openalex.org/W1996217706', 'https://openalex.org/W2007086982', 'https://openalex.org/W2009819018', 'https://openalex.org/W2014044948', 'https://openalex.org/W2029013337', 'https://openalex.org/W2039175679', 'https://openalex.org/W2045153334', 'https://openalex.org/W2080465043', 'https://openalex.org/W2088335071', 'https://openalex.org/W2100810063', 'https://openalex.org/W2104606170', 'https://openalex.org/W2140735579', 'https://openalex.org/W2141123335', 'https://openalex.org/W2143797732', 'https://openalex.org/W2148823498', 'https://openalex.org/W2151884159', 'https://openalex.org/W2214382398', 'https://openalex.org/W2235806863', 'https://openalex.org/W2783469117', 'https://openalex.org/W4295356918'], 'related_works': ['https://openalex.org/W3150918846', 'https://openalex.org/W2411775713', 'https://openalex.org/W2379220137', 'https://openalex.org/W2353187387', 'https://openalex.org/W2081402053', 'https://openalex.org/W2061936937', 'https://openalex.org/W2021879337', 'https://openalex.org/W2014434155', 'https://openalex.org/W2001704527', 'https://openalex.org/W157115903'], 'abstract_inverted_index': {'Heat': [0], 'shock': [1, 24], 'proteins': [2, 7], 'are': [3, 9], 'a': [4, 34, 61, 96], 'family': [5], 'of': [6, 81, 87, 111], 'that': [8, 54], 'produced': [10], 'by': [11], 'cells': [12], 'in': [13, 45, 57, 84, 108], 'response': [14, 46], 'to': [15, 17, 31, 37, 47, 103], 'exposure': [16], 'stressful': [18], 'conditions.': [19], 'The': [20], 'best': [21], 'studied': [22], 'heat': [23], 'protein': [25, 43], 'is': [26, 29, 101], 'HSP70,': [27], 'which': [28], 'known': [30], 'act': [32], 'as': [33], 'molecular': [35], 'chaperone': [36], 'maintain': [38], 'cellular': [39], 'homeostasis': [40], 'and': [41, 113], 'inhibit': [42], 'aggregation': [44], 'stress.': [48, 90], 'While': [49], 'early': [50], 'animal': [51], 'studies': [52, 76], 'suggested': [53], 'increasing': [55, 82], 'HSP70': [56, 83, 92, 106], 'the': [58], 'heart': [59], '(using': [60], 'transgenic,': [62], 'gene': [63], 'transfer': [64], 'or': [65], 'pharmacological': [66], 'approach)': [67], 'provided': [68], 'cardiac': [69, 73, 89, 115], 'protection': [70], 'against': [71], 'acute': [72, 112], 'stress,': [74], 'recent': [75], 'have': [77], 'found': [78], 'no': [79], 'benefit': [80], 'mouse': [85], 'models': [86, 110], 'chronic': [88, 114], 'As': [91], 'has': [93], 'been': [94], 'considered': [95], 'potential': [97], 'therapeutic': [98], 'target,': [99], 'it': [100], 'important': [102], 'comprehensively': [104], 'assess': [105], 'therapies': [107], 'preclinical': [109], 'disease.': [116]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2553162721', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}], 'updated_date': '2025-01-10T04:59:50.296364', 'created_date': '2016-11-30'}