Title: Influence of elemene or heat shock treatment upon the expression of membrane HSP70 and HSPs gene in HepG_(2) cells
Abstract: The treatment of either elemene (50 #mu#g/ml, 1h) or heat shock (42deg C, 1h) could increase the membrane expression of HSP70, ActD had a synergistic action with both treatments. HSP70EP (Enhancer protein) gene was up-regulated and HSPA2 gene was down-regulated in both treatments. HSF1 gene was up-regulated in heat shock treatment but down-regulated in elemene treatment. The genes closely correlated with tumor immune, such as HSP70, HSP72, HSP75, HSP90 and gp96 were not changed. Comparing with heat shock treatment, elemene can cause a higher percentn of HSP70 membrane expression in HepG2 cells and that may be caused by its altering the distribution of the already existing HSP70 and/or accelerating the HSP70 mRNA translation. Both treatments can change the expression of genes associated with the transcription control factors of HSPs and decrease HSPA2 gene expression.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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