Publication Information

{'id': 'https://openalex.org/W2551453019', 'doi': 'https://doi.org/10.1038/srep37759', 'title': 'LukMF′ is the major secreted leukocidin of bovine Staphylococcus aureus and is produced in vivo during bovine mastitis', 'display_name': 'LukMF′ is the major secreted leukocidin of bovine Staphylococcus aureus and is produced in vivo during bovine mastitis', 'publication_year': 2016, 'publication_date': '2016-11-25', 'ids': {'openalex': 'https://openalex.org/W2551453019', 'doi': 'https://doi.org/10.1038/srep37759', 'mag': '2551453019', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27886237', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5123576'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep37759', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1038/srep37759', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050559485', 'display_name': 'Manouk Vrieling', 'orcid': 'https://orcid.org/0000-0002-5465-4515'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Manouk Vrieling', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002527329', 'display_name': 'Eveline Boerhout', 'orcid': 'https://orcid.org/0000-0002-0382-5046'}, 'institutions': [{'id': 'https://openalex.org/I4210162999', 'display_name': 'MSD (Netherlands)', 'ror': 'https://ror.org/05y28vr04', 'country_code': 'NL', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155', 'https://openalex.org/I4210162999']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Eveline M. Boerhout', 'raw_affiliation_strings': ['Ruminant Research and Development, MSD Animal Health, Wim de Körverstraat 35, AA Boxmeer, 5830, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Ruminant Research and Development, MSD Animal Health, Wim de Körverstraat 35, AA Boxmeer, 5830, The Netherlands', 'institution_ids': ['https://openalex.org/I4210162999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084868705', 'display_name': 'Glenn F. van Wigcheren', 'orcid': 'https://orcid.org/0000-0001-7787-0002'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Glenn F. van Wigcheren', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006179165', 'display_name': 'Kirsten J. Koymans', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Kirsten J. Koymans', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021820049', 'display_name': 'Tanja G. T. Mols-Vorstermans', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162999', 'display_name': 'MSD (Netherlands)', 'ror': 'https://ror.org/05y28vr04', 'country_code': 'NL', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155', 'https://openalex.org/I4210162999']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Tanja G. Mols-Vorstermans', 'raw_affiliation_strings': ['Ruminant Research and Development, MSD Animal Health, Wim de Körverstraat 35, AA Boxmeer, 5830, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Ruminant Research and Development, MSD Animal Health, Wim de Körverstraat 35, AA Boxmeer, 5830, The Netherlands', 'institution_ids': ['https://openalex.org/I4210162999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102737957', 'display_name': 'Carla J. C. de Haas', 'orcid': 'https://orcid.org/0000-0002-2059-4526'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Carla J. C. de Haas', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104034050', 'display_name': 'Piet C. Aerts', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Piet C. Aerts', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023465997', 'display_name': 'Ineke Daemen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ineke J. J. M. Daemen', 'raw_affiliation_strings': ['Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058123402', 'display_name': 'Kok P. M. van Kessel', 'orcid': 'https://orcid.org/0000-0003-1268-5484'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Kok P. M. van Kessel', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085949822', 'display_name': 'Ad P. Koets', 'orcid': 'https://orcid.org/0000-0001-9809-3679'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ad P. Koets', 'raw_affiliation_strings': ['Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047483416', 'display_name': 'Victor P. M. G. Rutten', 'orcid': 'https://orcid.org/0000-0002-6171-1805'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Victor P. M. G. Rutten', 'raw_affiliation_strings': ['Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065603676', 'display_name': 'Piet J. M. Nuijten', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162999', 'display_name': 'MSD (Netherlands)', 'ror': 'https://ror.org/05y28vr04', 'country_code': 'NL', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155', 'https://openalex.org/I4210162999']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Piet J.M. Nuijten', 'raw_affiliation_strings': ['Ruminant Research and Development, MSD Animal Health, Wim de Körverstraat 35, AA Boxmeer, 5830, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Ruminant Research and Development, MSD Animal Health, Wim de Körverstraat 35, AA Boxmeer, 5830, The Netherlands', 'institution_ids': ['https://openalex.org/I4210162999']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085753329', 'display_name': 'Jos A. G. van Strijp', 'orcid': 'https://orcid.org/0000-0001-6253-0830'}, 'institutions': [{'id': 'https://openalex.org/I3018483916', 'display_name': 'University Medical Center Utrecht', 'ror': 'https://ror.org/0575yy874', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3018483916']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I2802164966', 'display_name': 'University Hospital Heidelberg', 'ror': 'https://ror.org/013czdx64', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802164966']}], 'countries': ['DE', 'NL'], 'is_corresponding': False, 'raw_author_name': 'Jos A. G. van Strijp', 'raw_affiliation_strings': ['Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, University Medical Center Utrecht, Heidelberglaan, PO G04.614, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I3018483916', 'https://openalex.org/I223822909', 'https://openalex.org/I2802164966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041724416', 'display_name': 'Lindert Benedictus', 'orcid': 'https://orcid.org/0000-0001-7605-2710'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Lindert Benedictus', 'raw_affiliation_strings': ['Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan, 3584, CL Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 4.34, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 63, 'citation_normalized_percentile': {'value': 0.890682, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10195', 'display_name': 'Methicillin-Resistant Staphylococcus aureus Infections', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10195', 'display_name': 'Methicillin-Resistant Staphylococcus aureus Infections', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10593', 'display_name': 'Bacterial Biofilms and Quorum Sensing Mechanisms', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11226', 'display_name': 'Bovine Mastitis and Milk Quality', 'score': 0.9689, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/leukocidin', 'display_name': 'Leukocidin', 'score': 0.8934208}, {'id': 'https://openalex.org/keywords/hemolysin', 'display_name': 'Hemolysin', 'score': 0.5380338}, {'id': 'https://openalex.org/keywords/panton–valentine-leukocidin', 'display_name': 'Panton–Valentine leukocidin', 'score': 0.5346498}, {'id': 'https://openalex.org/keywords/virulence-factor', 'display_name': 'Virulence factor', 'score': 0.5124517}, {'id': 'https://openalex.org/keywords/staphylococcus-aureus', 'display_name': 'Staphylococcus aureus', 'score': 0.467985}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.4356628}], 'concepts': [{'id': 'https://openalex.org/C2776344049', 'wikidata': 'https://www.wikidata.org/wiki/Q835061', 'display_name': 'Mastitis', 'level': 2, 'score': 0.90855217}, {'id': 'https://openalex.org/C2777805791', 'wikidata': 'https://www.wikidata.org/wiki/Q16889545', 'display_name': 'Leukocidin', 'level': 5, 'score': 0.8934208}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.838709}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.81744444}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6218787}, {'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.61408985}, {'id': 'https://openalex.org/C2776460866', 'wikidata': 'https://www.wikidata.org/wiki/Q170065', 'display_name': 'Pathogen', 'level': 2, 'score': 0.58891684}, {'id': 'https://openalex.org/C2777334864', 'wikidata': 'https://www.wikidata.org/wiki/Q34879', 'display_name': 'Staphylococcal infections', 'level': 4, 'score': 0.58189464}, {'id': 'https://openalex.org/C136139683', 'wikidata': 'https://www.wikidata.org/wiki/Q2746278', 'display_name': 'Hemolysin', 'level': 4, 'score': 0.5380338}, {'id': 'https://openalex.org/C2777859817', 'wikidata': 'https://www.wikidata.org/wiki/Q905828', 'display_name': 'Panton–Valentine leukocidin', 'level': 5, 'score': 0.5346498}, {'id': 'https://openalex.org/C2781090273', 'wikidata': 'https://www.wikidata.org/wiki/Q1623405', 'display_name': 'Virulence factor', 'level': 4, 'score': 0.5124517}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.44034353}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.4356628}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.41910502}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.29874146}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.26287383}, {'id': 'https://openalex.org/C2777052132', 'wikidata': 'https://www.wikidata.org/wiki/Q595158', 'display_name': 'Methicillin-resistant Staphylococcus aureus', 'level': 4, 'score': 0.1495339}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.079138786}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007956', 'descriptor_name': 'Leukocidins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008414', 'descriptor_name': 'Mastitis, Bovine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007956', 'descriptor_name': 'Leukocidins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007956', 'descriptor_name': 'Leukocidins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008414', 'descriptor_name': 'Mastitis, Bovine', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D008414', 'descriptor_name': 'Mastitis, Bovine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013203', 'descriptor_name': 'Staphylococcal Infections', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D013203', 'descriptor_name': 'Staphylococcal Infections', 'qualifier_ui': 'Q000662', 'qualifier_name': 'veterinary', 'is_major_topic': False}, {'descriptor_ui': 'D013203', 'descriptor_name': 'Staphylococcal Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013211', 'descriptor_name': 'Staphylococcus aureus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep37759', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123576', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27886237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep37759', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.5, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1484104077', 'https://openalex.org/W1581696537', 'https://openalex.org/W1955876850', 'https://openalex.org/W1979289744', 'https://openalex.org/W1990621187', 'https://openalex.org/W1991084748', 'https://openalex.org/W1992325716', 'https://openalex.org/W1992650918', 'https://openalex.org/W1996486159', 'https://openalex.org/W2003484929', 'https://openalex.org/W2005875337', 'https://openalex.org/W2008504003', 'https://openalex.org/W2018545789', 'https://openalex.org/W2036177806', 'https://openalex.org/W2037679972', 'https://openalex.org/W2045155970', 'https://openalex.org/W2051044531', 'https://openalex.org/W2052831663', 'https://openalex.org/W2057013257', 'https://openalex.org/W2068396700', 'https://openalex.org/W2080732258', 'https://openalex.org/W2083532154', 'https://openalex.org/W2084502463', 'https://openalex.org/W2090544282', 'https://openalex.org/W2093770376', 'https://openalex.org/W2113691490', 'https://openalex.org/W2115442028', 'https://openalex.org/W2119768770', 'https://openalex.org/W2120432544', 'https://openalex.org/W2121452572', 'https://openalex.org/W2127453904', 'https://openalex.org/W2132115510', 'https://openalex.org/W2133530652', 'https://openalex.org/W2146759278', 'https://openalex.org/W2148639799', 'https://openalex.org/W2152423566', 'https://openalex.org/W2156586940', 'https://openalex.org/W2161921408', 'https://openalex.org/W2163609676', 'https://openalex.org/W2164778664', 'https://openalex.org/W2164857402', 'https://openalex.org/W2167763271', 'https://openalex.org/W2218183054', 'https://openalex.org/W2283824474', 'https://openalex.org/W2314649741', 'https://openalex.org/W2466306576', 'https://openalex.org/W2481266673', 'https://openalex.org/W3147194314'], 'related_works': ['https://openalex.org/W4205979088', 'https://openalex.org/W3025843160', 'https://openalex.org/W2560009137', 'https://openalex.org/W2411102613', 'https://openalex.org/W2380125479', 'https://openalex.org/W2161530970', 'https://openalex.org/W2062457984', 'https://openalex.org/W2010180224', 'https://openalex.org/W2008516462', 'https://openalex.org/W1966638080'], 'abstract_inverted_index': {'Staphylococcus': [0], 'aureus': [1, 18, 51, 189], 'is': [2], 'a': [3, 10, 75, 174], 'major': [4, 108], 'human': [5], 'and': [6, 9, 63, 71, 80, 92, 106, 154, 177], 'animal': [7], 'pathogen': [8], 'common': [11], 'cause': [12], 'of': [13, 42, 48, 117, 152, 163, 171, 181], 'mastitis': [14, 90, 190], 'in': [15, 29, 45, 57, 119, 147, 156, 191], 'cattle.': [16, 192], 'S.': [17, 50, 188], 'secretes': [19], 'several': [20], 'leukocidins': [21, 44], 'that': [22, 55], 'target': [23], 'bovine': [24, 49, 69, 76, 89, 111, 120], 'neutrophils,': [25, 70], 'crucial': [26], 'effector': [27], 'cells': [28], 'the': [30, 40, 46, 60, 107, 115, 150, 161, 169, 179], 'defence': [31], 'against': [32], 'bacterial': [33], 'pathogens.': [34], 'In': [35], 'this': [36], 'study,': [37], 'we': [38, 83], 'investigated': [39], 'role': [41, 116], 'staphylococcal': [43], 'pathogenesis': [47], 'disease.': [52], 'We': [53], 'show': [54], 'LukAB,': [56], 'contrast': [58], 'to': [59, 67, 186], 'γ-hemolysins,': [61], 'LukED,': [62], "LukMF',": [64], 'was': [65, 98, 102, 145], 'unable': [66], 'kill': [68], 'identified': [72], 'CXCR2': [73], 'as': [74, 173], 'receptor': [77], 'for': [78], 'HlgAB': [79], 'LukED.': [81], 'Furthermore,': [82], 'assessed': [84], 'functional': [85], 'leukocidin': [86, 96], 'secretion': [87], 'by': [88], 'isolates': [91], 'observed': [93], 'that,': [94], 'although': [95], 'production': [97], 'strain': [99], 'dependent,': [100], "LukMF'": [101, 118, 172, 185], 'most': [103], 'abundantly': [104], 'secreted': [105], 'toxin': [109], 'killing': [110], 'neutrophils.': [112], 'To': [113], 'determine': [114], 'mastitis,': [121], 'cattle': [122], 'were': [123, 158], 'challenged': [124], 'with': [125, 137, 160], 'high': [126], '(S1444)': [127], 'or': [128], 'intermediate': [129], '(S1449,': [130], 'S1463)': [131], "LukMF'-producing": [132], 'isolates.': [133], 'Only': [134], 'animals': [135], 'infected': [136], 'S1444': [138], 'developed': [139], 'severe': [140], 'clinical': [141], 'symptoms.': [142], 'Importantly,': [143], 'LukM': [144], 'produced': [146], 'vivo': [148], 'during': [149], 'course': [151], 'infection': [153], 'levels': [155], 'milk': [157], 'associated': [159], 'severity': [162], 'mastitis.': [164], 'Altogether,': [165], 'these': [166], 'findings': [167], 'underline': [168], 'importance': [170], 'virulence': [175], 'factor': [176], 'support': [178], 'development': [180], 'therapeutic': [182], 'approaches': [183], 'targeting': [184], 'control': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2551453019', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-09-27T03:51:25.314029', 'created_date': '2016-11-30'}