Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2547311226', 'doi': 'https://doi.org/10.1016/j.jconrel.2016.10.026', 'title': 'Single ocular injection of a sustained-release anti -VEGF delivers 6 months pharmacokinetics and efficacy in a primate laser CNV model', 'display_name': 'Single ocular injection of a sustained-release anti -VEGF delivers 6 months pharmacokinetics and efficacy in a primate laser CNV model', 'publication_year': 2016, 'publication_date': '2016-11-01', 'ids': {'openalex': 'https://openalex.org/W2547311226', 'doi': 'https://doi.org/10.1016/j.jconrel.2016.10.026', 'mag': '2547311226', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27810558', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5494198'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jconrel.2016.10.026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161954266', 'display_name': 'Journal of Controlled Release', 'issn_l': '0168-3659', 'issn': ['0168-3659', '1873-4995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.jconrel.2016.10.026', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075831896', 'display_name': 'Peter Adamson', 'orcid': 'https://orcid.org/0000-0001-8234-1818'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Adamson', 'raw_affiliation_strings': ['GSK Ophthalmology', 'GSK, King of Prussia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, King of Prussia, PA, USA', 'institution_ids': []}, {'raw_affiliation_string': 'GSK Ophthalmology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022575975', 'display_name': 'Thomas Wilde', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas Wilde', 'raw_affiliation_strings': ['Drug Metabolism & Pharmacokinetics', 'GSK, King of Prussia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, King of Prussia, PA, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Drug Metabolism & Pharmacokinetics', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027493388', 'display_name': 'Eric Dobrzynski', 'orcid': 'https://orcid.org/0000-0001-5944-2178'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric Dobrzynski', 'raw_affiliation_strings': ['Drug Metabolism & Pharmacokinetics', 'GSK, King of Prussia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, King of Prussia, PA, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Drug Metabolism & Pharmacokinetics', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042815421', 'display_name': 'Caroline Sychterz', 'orcid': 'https://orcid.org/0000-0002-7255-8500'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Caroline Sychterz', 'raw_affiliation_strings': ['Drug Metabolism & Pharmacokinetics', 'GSK, King of Prussia, PA, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, King of Prussia, PA, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Drug Metabolism & Pharmacokinetics', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069635219', 'display_name': 'Rodd Polsky', 'orcid': 'https://orcid.org/0000-0001-6437-5002'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rodd Polsky', 'raw_affiliation_strings': ['GSK, King of Prussia, PA, USA', 'Safety Assessment'], 'affiliations': [{'raw_affiliation_string': 'GSK, King of Prussia, PA, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Safety Assessment', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019041353', 'display_name': 'Edit Kurali', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320354487', 'display_name': 'Target (United States)', 'ror': 'https://ror.org/05mkyac79', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1320354487']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edit Kurali', 'raw_affiliation_strings': ['GSK, King of Prussia, PA, USA', 'Target Science Statistics'], 'affiliations': [{'raw_affiliation_string': 'GSK, King of Prussia, PA, USA', 'institution_ids': []}, {'raw_affiliation_string': 'Target Science Statistics', 'institution_ids': ['https://openalex.org/I1320354487']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009625085', 'display_name': 'Richard Haworth', 'orcid': 'https://orcid.org/0000-0002-1668-9397'}, 'institutions': [], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Richard Haworth', 'raw_affiliation_strings': ['GSK Ware, UK', 'Safety Assessment'], 'affiliations': [{'raw_affiliation_string': 'GSK Ware, UK', 'institution_ids': []}, {'raw_affiliation_string': 'Safety Assessment', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055860359', 'display_name': 'Chi-Man Tang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Chi-Man Tang', 'raw_affiliation_strings': ['BioPharm Innovation', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Innovation', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064089380', 'display_name': 'Justyna Korczyńska', 'orcid': 'https://orcid.org/0000-0002-1886-6967'}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Justyna Korczynska', 'raw_affiliation_strings': ['BioPharm Discovery', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Discovery', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025061884', 'display_name': 'Fiona Cook', 'orcid': 'https://orcid.org/0000-0001-5009-068X'}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Fiona Cook', 'raw_affiliation_strings': ['BioPharm Discovery', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Discovery', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069952736', 'display_name': 'Irene Papanicolaou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Irene Papanicolaou', 'raw_affiliation_strings': ['BioPharm Innovation', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Innovation', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060095959', 'display_name': 'Lemy Tsikna', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lemy Tsikna', 'raw_affiliation_strings': ['BioPharm Discovery', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Discovery', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102000932', 'display_name': 'Chris Roberts', 'orcid': 'https://orcid.org/0000-0002-6875-5552'}, 'institutions': [{'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}, {'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Chris Roberts', 'raw_affiliation_strings': ['BioPharm Discovery', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}, {'raw_affiliation_string': 'BioPharm Discovery', 'institution_ids': ['https://openalex.org/I4210158745']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087908846', 'display_name': 'Zoe Hughes-Thomas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Zoe Hughes-Thomas', 'raw_affiliation_strings': ['BioPharm Discovery', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Discovery', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051653410', 'display_name': 'James Walford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'James Walford', 'raw_affiliation_strings': ['BioPharm Process Research', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Process Research', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001506851', 'display_name': 'Daniel Gibson', 'orcid': 'https://orcid.org/0000-0003-0117-4988'}, 'institutions': [{'id': 'https://openalex.org/I4210158745', 'display_name': 'BioPharm (United Kingdom)', 'ror': 'https://ror.org/05ktp5w69', 'country_code': 'GB', 'type': 'company', 'lineage': ['https://openalex.org/I4210158745']}, {'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Daniel Gibson', 'raw_affiliation_strings': ['BioPharm Process Research', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'BioPharm Process Research', 'institution_ids': ['https://openalex.org/I4210158745']}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019132647', 'display_name': 'John Warrack', 'orcid': 'https://orcid.org/0000-0002-2842-6068'}, 'institutions': [{'id': 'https://openalex.org/I2800110054', 'display_name': 'Age UK', 'ror': 'https://ror.org/050x9d346', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2800110054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'John Warrack', 'raw_affiliation_strings': ['AnalyticalSciences', 'GSK Medicines Research Centre, Stevenage, UK'], 'affiliations': [{'raw_affiliation_string': 'AnalyticalSciences', 'institution_ids': []}, {'raw_affiliation_string': 'GSK Medicines Research Centre, Stevenage, UK', 'institution_ids': ['https://openalex.org/I2800110054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059196349', 'display_name': 'Jos Smal', 'orcid': None}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jos Smal', 'raw_affiliation_strings': ['OctoPlus NV, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'OctoPlus NV, Leiden, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052043958', 'display_name': 'R. Verrijk', 'orcid': None}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Ruud Verrijk', 'raw_affiliation_strings': ['OctoPlus NV, Leiden, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'OctoPlus NV, Leiden, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103005571', 'display_name': 'Paul E. Miller', 'orcid': 'https://orcid.org/0000-0002-6201-5035'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul E. Miller', 'raw_affiliation_strings': ['OSOD, Madison, WI, USA'], 'affiliations': [{'raw_affiliation_string': 'OSOD, Madison, WI, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072222944', 'display_name': 'T. Michael Nork', 'orcid': 'https://orcid.org/0000-0002-0687-373X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'T. Michael Nork', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027220659', 'display_name': 'Jeffery J. Prusakiewicz', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jeffery Prusakiewicz', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045360482', 'display_name': 'Timothy Streit', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Timothy Streit', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001483460', 'display_name': 'Steven D. Sorden', 'orcid': 'https://orcid.org/0000-0002-5093-8561'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Steven Sorden', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051953301', 'display_name': 'Craig B Struble', 'orcid': 'https://orcid.org/0000-0003-2744-9732'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Craig Struble', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029728147', 'display_name': 'Brian J. Christian', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Brian Christian', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019152250', 'display_name': 'I. Catchpole', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Ian R. Catchpole', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4540, 'currency': 'USD', 'value_usd': 4540, 'provenance': 'doaj'}, 'apc_paid': {'value': 4540, 'currency': 'USD', 'value_usd': 4540, 'provenance': 'doaj'}, 'fwci': 6.321, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.916381, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '244', 'issue': None, 'first_page': '1', 'last_page': '13'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10170', 'display_name': 'Age-Related Macular Degeneration Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2731', 'display_name': 'Ophthalmology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11377', 'display_name': 'Vitreoretinal Surgery Techniques', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12484', 'display_name': 'Diagnosis and Treatment of Retinopathy of Prematurity', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aflibercept', 'display_name': 'Aflibercept', 'score': 0.6289791}, {'id': 'https://openalex.org/keywords/vascular-endothelial-growth-factor', 'display_name': 'Vascular Endothelial Growth Factor', 'score': 0.582672}, {'id': 'https://openalex.org/keywords/intravitreal-injection', 'display_name': 'Intravitreal Injection', 'score': 0.562308}, {'id': 'https://openalex.org/keywords/intravitreal-bevacizumab', 'display_name': 'Intravitreal Bevacizumab', 'score': 0.508627}, {'id': 'https://openalex.org/keywords/microparticle', 'display_name': 'Microparticle', 'score': 0.4151181}], 'concepts': [{'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.68210906}, {'id': 'https://openalex.org/C2778749236', 'wikidata': 'https://www.wikidata.org/wiki/Q4689286', 'display_name': 'Aflibercept', 'level': 4, 'score': 0.6289791}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.57161057}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.5632567}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.50674325}, {'id': 'https://openalex.org/C2776403814', 'wikidata': 'https://www.wikidata.org/wiki/Q27429789', 'display_name': 'Macular degeneration', 'level': 2, 'score': 0.49511233}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.439219}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.4245956}, {'id': 'https://openalex.org/C2777521759', 'wikidata': 'https://www.wikidata.org/wiki/Q61186', 'display_name': 'Microparticle', 'level': 2, 'score': 0.4151181}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4128512}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.29773867}, {'id': 'https://openalex.org/C118487528', 'wikidata': 'https://www.wikidata.org/wiki/Q161437', 'display_name': 'Ophthalmology', 'level': 1, 'score': 0.2873415}, {'id': 'https://openalex.org/C2777802072', 'wikidata': 'https://www.wikidata.org/wiki/Q413299', 'display_name': 'Bevacizumab', 'level': 3, 'score': 0.22044602}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19096291}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17403352}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1597369}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.13058025}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D020256', 'descriptor_name': 'Choroidal Neovascularization', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D003692', 'descriptor_name': 'Delayed-Action Preparations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004337', 'descriptor_name': 'Drug Carriers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065546', 'descriptor_name': 'Drug Liberation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007141', 'descriptor_name': 'Immunoglobulin Fc Fragments', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007074', 'descriptor_name': 'Immunoglobulin G', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D058449', 'descriptor_name': 'Intravitreal Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007834', 'descriptor_name': 'Lasers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008252', 'descriptor_name': 'Macaca fascicularis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008863', 'descriptor_name': 'Microspheres', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010316', 'descriptor_name': 'Particle Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011091', 'descriptor_name': 'Polyesters', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057135', 'descriptor_name': 'Wet Macular Degeneration', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jconrel.2016.10.026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161954266', 'display_name': 'Journal of Controlled Release', 'issn_l': '0168-3659', 'issn': ['0168-3659', '1873-4995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5494198', 'pdf_url': 'https://europepmc.org/articles/pmc5494198?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494198', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27810558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jconrel.2016.10.026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S161954266', 'display_name': 'Journal of Controlled Release', 'issn_l': '0168-3659', 'issn': ['0168-3659', '1873-4995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.53}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W176266815', 'https://openalex.org/W1973628995', 'https://openalex.org/W1975107877', 'https://openalex.org/W1978749554', 'https://openalex.org/W1982078960', 'https://openalex.org/W1982855531', 'https://openalex.org/W1984548348', 'https://openalex.org/W1996185087', 'https://openalex.org/W2001381288', 'https://openalex.org/W2004282377', 'https://openalex.org/W2012757283', 'https://openalex.org/W2015172823', 'https://openalex.org/W2015707047', 'https://openalex.org/W2016418766', 'https://openalex.org/W2031982361', 'https://openalex.org/W2033693708', 'https://openalex.org/W2043234704', 'https://openalex.org/W2054072746', 'https://openalex.org/W2055348294', 'https://openalex.org/W2066202831', 'https://openalex.org/W2077932437', 'https://openalex.org/W2090913210', 'https://openalex.org/W2098155102', 'https://openalex.org/W2105661731', 'https://openalex.org/W2116430091', 'https://openalex.org/W2125587232', 'https://openalex.org/W2144965887', 'https://openalex.org/W2154869591', 'https://openalex.org/W2155391696', 'https://openalex.org/W2168009513', 'https://openalex.org/W2169250157', 'https://openalex.org/W2233530828', 'https://openalex.org/W2290195878', 'https://openalex.org/W2317376713', 'https://openalex.org/W3016236341', 'https://openalex.org/W3141897683'], 'related_works': ['https://openalex.org/W4230511471', 'https://openalex.org/W3203955741', 'https://openalex.org/W3151044076', 'https://openalex.org/W3134454981', 'https://openalex.org/W2576401260', 'https://openalex.org/W2325726284', 'https://openalex.org/W2191662309', 'https://openalex.org/W2165526979', 'https://openalex.org/W2085743381', 'https://openalex.org/W1663750035'], 'abstract_inverted_index': {'A': [0], 'potent': [1], 'anti-vascular': [2], 'endothelial': [3], 'growth': [4], 'factor': [5], '(VEGF)': [6], 'biologic': [7], 'and': [8, 78, 104, 123, 172], 'a': [9, 24, 29, 48, 53, 93, 154, 160], 'compatible': [10], 'delivery': [11, 57, 148], 'system': [12, 58], 'were': [13], 'co-evaluated': [14], 'for': [15, 74, 147, 185], 'protection': [16, 158], 'against': [17, 76, 135], 'wet': [18, 165], 'age-related': [19], 'macular': [20], 'degeneration': [21], '(AMD)': [22], 'over': [23, 111, 126, 167], '6': [25, 127, 168], 'month': [26], 'period': [27], 'following': [28], 'single': [30], 'intravitreal': [31], '(IVT)': [32], 'injection.': [33, 190], 'The': [34, 56, 67, 86], 'anti-VEGF': [35, 42, 151], 'molecule': [36, 68, 152], 'is': [37, 59, 89], 'dimeric,': [38], 'containing': [39], 'two': [40], 'different': [41], 'domain': [43], 'antibodies': [44], '(dAb)': [45], 'attached': [46], 'to': [47, 132], 'human': [49], 'IgG1': [50], 'Fc': [51], 'region:': [52], 'dual': [54, 87, 119], 'dAb.': [55], 'based': [60], 'on': [61], 'microparticles': [62, 110, 175], 'of': [63, 145, 149, 164, 174, 182], 'PolyActive™': [64], 'hydrogel': [65], 'co-polymer.': [66], 'was': [69], 'evaluated': [70], 'both': [71], 'in': [72, 79, 84, 98, 114, 121, 159, 176], 'vitro': [73], 'potency': [75], 'VEGF': [77, 99], 'ocular': [80], 'VEGF-driven': [81], 'efficacy': [82], 'models': [83], 'vivo.': [85], 'dAb': [88, 120], 'highly': [90], 'potent,': [91], 'showing': [92, 157], 'lower': [94], 'IC50': [95], 'than': [96], 'aflibercept': [97], 'receptor': [100], 'binding': [101], 'assays': [102], '(RBAs)': [103], 'retaining': [105], 'activity': [106], 'upon': [107], 'release': [108, 187], 'from': [109], '12': [112], 'months': [113, 128], 'vitro.': [115], 'Microparticles': [116], 'released': [117], 'functional': [118], 'rabbit': [122], 'primate': [124, 162], 'eyes': [125], 'at': [129], 'sufficient': [130], 'levels': [131], 'protect': [133], 'Cynomolgus': [134], 'laser-induced': [136], 'grade': [137], 'IV': [138], 'choroidal': [139], 'neovascularisation': [140], '(CNV).': [141], 'This': [142], 'demonstrates': [143], 'proof': [144], 'concept': [146], 'an': [150], 'within': [153], 'sustained-release': [155], 'system,': [156], 'pre-clinical': [161], 'model': [163], 'AMD': [166], 'months.': [169], 'Polymer': [170], 'breakdown': [171], 'movement': [173], 'the': [177], 'eye': [178], 'may': [179], 'limit': [180], 'development': [181], 'particle-based': [183], 'approaches': [184], 'sustained': [186], 'after': [188], 'IVT': [189]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2547311226', 'counts_by_year': [{'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-19T00:38:36.206402', 'created_date': '2016-11-11'}