Title: Clinical application of aflibercept for the treatment of wet age-related macular degeneration
Abstract: Age-related macular degeneration(AMD) is a major cause of blindness in elderly populations.Wet AMD,which is characterized by choroidal neovascularization (CNV),is the leading cause of vision loss.Anti-VEGF therapy is the current first-line treatment for wet AMD.Aflibercept (Eylea) is the latest member in the anti-VEGF drugs for ophthalmic application.The dose interval of Aflibercept can be extended but yield stable therapeutic effect due to its wider binding range (VEGF-A,VEGF-B,placental growth factor),better affinity,as well as longer half-life.At present,quite a few clinical trials about Aflibercept application have completed or are undergoing.As further confirmation of its efficacy and safety goes on,Aflibercept,alone or in combination with other anti-VEGF agents,could become a new therapeutic option for wet AMD.
Key words:
age-related macular degeneration; choroidal neovascularization; aflibercept; vascular endothelial growth factor
Publication Year: 2014
Publication Date: 2014-10-22
Language: en
Type: article
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