Preferential binding of a stable G3<scp>BP</scp> ribonucleoprotein complex to intron‐retaining transcripts in mouse brain and modulation of their expression in the cerebellum

Name: Work Video:
Duration: 3 min 30 s
Sophie Martin; Nicolás Bellora; Juan González‐Vallinas; Manuel Irimia; Karim Chebli; Marion de Toledo; Monika Raabe; Eduardo Eyras; Henning Urlaub; Ben J. Blencowe; Jamal Tazi
{'id': 'https://openalex.org/W2516365506', 'doi': 'https://doi.org/10.1111/jnc.13768', 'title': 'Preferential binding of a stable G3<scp>BP</scp> ribonucleoprotein complex to intron‐retaining transcripts in mouse brain and modulation of their expression in the cerebellum', 'display_name': 'Preferential binding of a stable G3<scp>BP</scp> ribonucleoprotein complex to intron‐retaining transcripts in mouse brain and modulation of their expression in the cerebellum', 'publication_year': 2016, 'publication_date': '2016-08-11', 'ids': {'openalex': 'https://openalex.org/W2516365506', 'doi': 'https://doi.org/10.1111/jnc.13768', 'mag': '2516365506', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27513819'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/jnc.13768', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13768', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13768', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5053557538', 'display_name': 'Sophie Martin', 'orcid': 'https://orcid.org/0000-0002-4458-7582'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210114166', 'display_name': 'Institut de Génétique Moléculaire de Montpellier', 'ror': 'https://ror.org/02785qs39', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210114166']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sophie Martin', 'raw_affiliation_strings': ['Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210114166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029345470', 'display_name': 'Nicolás Bellora', 'orcid': 'https://orcid.org/0000-0001-6637-3465'}, 'institutions': [{'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I70368782', 'display_name': 'National University of Comahue', 'ror': 'https://ror.org/02zvkba47', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I70368782']}, {'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['AR', 'ES'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Bellora', 'raw_affiliation_strings': ['Computational Genomics Group Universitat Pompeu Fabra PRBB, Barcelona, Spain', 'Laboratorio de Microbiología Aplicada y Biotecnología Instituto Andino‐Patagónico de Tecnologías Biológicas y Geoambientales (IPATEC) CONICET – UNComahue Bariloche Argentina'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Microbiología Aplicada y Biotecnología Instituto Andino‐Patagónico de Tecnologías Biológicas y Geoambientales (IPATEC) CONICET – UNComahue Bariloche Argentina', 'institution_ids': ['https://openalex.org/I151201029', 'https://openalex.org/I70368782']}, {'raw_affiliation_string': 'Computational Genomics Group Universitat Pompeu Fabra PRBB, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I170486558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002444980', 'display_name': 'Juan González‐Vallinas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Juan González‐Vallinas', 'raw_affiliation_strings': ['Computational Genomics Group Universitat Pompeu Fabra PRBB, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Computational Genomics Group Universitat Pompeu Fabra PRBB, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I170486558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018384674', 'display_name': 'Manuel Irimia', 'orcid': 'https://orcid.org/0000-0002-2179-2567'}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Manuel Irimia', 'raw_affiliation_strings': ['The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106083508', 'display_name': 'Karim Chebli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210114166', 'display_name': 'Institut de Génétique Moléculaire de Montpellier', 'ror': 'https://ror.org/02785qs39', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210114166']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Karim Chebli', 'raw_affiliation_strings': ['Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210114166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051740109', 'display_name': 'Marion de Toledo', 'orcid': 'https://orcid.org/0000-0002-7638-0041'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}, {'id': 'https://openalex.org/I4210114166', 'display_name': 'Institut de Génétique Moléculaire de Montpellier', 'ror': 'https://ror.org/02785qs39', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210114166']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Marion de Toledo', 'raw_affiliation_strings': ['Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France', 'institution_ids': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210114166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102692030', 'display_name': 'Monika Raabe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Monika Raabe', 'raw_affiliation_strings': ['Max Planck Institute for Biophysical Chemistry Göttingen Germany'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute for Biophysical Chemistry Göttingen Germany', 'institution_ids': ['https://openalex.org/I4210131661']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061877048', 'display_name': 'Eduardo Eyras', 'orcid': 'https://orcid.org/0000-0003-0793-6218'}, 'institutions': [{'id': 'https://openalex.org/I11932220', 'display_name': 'Institució Catalana de Recerca i Estudis Avançats', 'ror': 'https://ror.org/0371hy230', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I11932220']}, {'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Eduardo Eyras', 'raw_affiliation_strings': ['Catalan Institution for Research and Advanced Studies (ICREA) Passeig Lluís Companys 23 Barcelona Spain', 'Computational Genomics Group Universitat Pompeu Fabra PRBB, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Catalan Institution for Research and Advanced Studies (ICREA) Passeig Lluís Companys 23 Barcelona Spain', 'institution_ids': ['https://openalex.org/I11932220']}, {'raw_affiliation_string': 'Computational Genomics Group Universitat Pompeu Fabra PRBB, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I170486558']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089006758', 'display_name': 'Henning Urlaub', 'orcid': 'https://orcid.org/0000-0003-1837-5233'}, 'institutions': [{'id': 'https://openalex.org/I4210131661', 'display_name': 'Max Planck Institute for Biophysical Chemistry', 'ror': 'https://ror.org/03e76ya46', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210131661']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Henning Urlaub', 'raw_affiliation_strings': ['Max Planck Institute for Biophysical Chemistry Göttingen Germany'], 'affiliations': [{'raw_affiliation_string': 'Max Planck Institute for Biophysical Chemistry Göttingen Germany', 'institution_ids': ['https://openalex.org/I4210131661']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112211822', 'display_name': 'Ben J. Blencowe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ben J. Blencowe', 'raw_affiliation_strings': ['The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada', 'institution_ids': ['https://openalex.org/I185261750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013576274', 'display_name': 'Jamal Tazi', 'orcid': 'https://orcid.org/0000-0002-1949-8748'}, 'institutions': [{'id': 'https://openalex.org/I4210114166', 'display_name': 'Institut de Génétique Moléculaire de Montpellier', 'ror': 'https://ror.org/02785qs39', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I19894307', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210114166']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Jamal Tazi', 'raw_affiliation_strings': ['Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France'], 'affiliations': [{'raw_affiliation_string': 'Institut de Génétique Moléculaire de Montpellier CNRS UMR5535 Montpellier France', 'institution_ids': ['https://openalex.org/I4210114166', 'https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 8, 'corresponding_author_ids': ['https://openalex.org/A5013576274'], 'corresponding_institution_ids': ['https://openalex.org/I4210114166', 'https://openalex.org/I1294671590'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.713, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '139', 'issue': '3', 'first_page': '349', 'last_page': '368'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'RNA regulation and disease', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stress-granule', 'display_name': 'Stress granule', 'score': 0.423577}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7858949}, {'id': 'https://openalex.org/C94671646', 'wikidata': 'https://www.wikidata.org/wiki/Q207551', 'display_name': 'Intron', 'level': 3, 'score': 0.6920389}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.55961937}, {'id': 'https://openalex.org/C41282012', 'wikidata': 'https://www.wikidata.org/wiki/Q3928341', 'display_name': 'RNA-binding protein', 'level': 4, 'score': 0.52149475}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46141088}, {'id': 'https://openalex.org/C75934600', 'wikidata': 'https://www.wikidata.org/wiki/Q419245', 'display_name': 'Ribonucleoprotein', 'level': 4, 'score': 0.45302364}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.43659672}, {'id': 'https://openalex.org/C117838200', 'wikidata': 'https://www.wikidata.org/wiki/Q14592582', 'display_name': 'Stress granule', 'level': 5, 'score': 0.423577}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.38128504}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.30849677}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.29975277}, {'id': 'https://openalex.org/C149364088', 'wikidata': 'https://www.wikidata.org/wiki/Q185917', 'display_name': 'Translation (biology)', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002531', 'descriptor_name': 'Cerebellum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000429', 'descriptor_name': 'Alcohol Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000429', 'descriptor_name': 'Alcohol Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002531', 'descriptor_name': 'Cerebellum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003432', 'descriptor_name': 'Cross-Linking Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003594', 'descriptor_name': 'Cytoplasmic Granules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003594', 'descriptor_name': 'Cytoplasmic Granules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059014', 'descriptor_name': 'High-Throughput Nucleotide Sequencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007438', 'descriptor_name': 'Introns', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000075223', 'descriptor_name': 'Poly-ADP-Ribose Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020365', 'descriptor_name': 'RNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000067776', 'descriptor_name': 'RNA Recognition Motif Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062085', 'descriptor_name': 'RNA, Long Noncoding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062085', 'descriptor_name': 'RNA, Long Noncoding', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043222', 'descriptor_name': 'Ubiquitin Thiolesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/jnc.13768', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13768', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-03034311', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-03034311', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11336/62969', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/62969/2/CONICET_Digital_Nro.6e45729d-02d3-48bc-a583-b9e25cebd5ee_A.pdf', 'source': {'id': 'https://openalex.org/S4306402455', 'display_name': 'CONICET Digital (CONICET)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210148385', 'host_organization_name': 'Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society', 'host_organization_lineage': ['https://openalex.org/I4210148385'], 'host_organization_lineage_names': ['Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.openaccessrepository.it/record/171832', 'pdf_url': 'https://www.openaccessrepository.it/record/171832/files/fulltext.pdf', 'source': {'id': 'https://openalex.org/S4306402478', 'display_name': 'INFM-OAR (INFN Catania)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210116497', 'host_organization_name': 'Istituto Nazionale di Fisica Nucleare, Sezione di Catania', 'host_organization_lineage': ['https://openalex.org/I4210116497'], 'host_organization_lineage_names': ['Istituto Nazionale di Fisica Nucleare, Sezione di Catania'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27513819', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/jnc.13768', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jnc.13768', 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321589', 'funder_display_name': 'Fondation pour la Recherche Médicale', 'award_id': 'Equipe FRM 2011 – no. DEQ20111223745'}], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1561508140', 'https://openalex.org/W1570386882', 'https://openalex.org/W1823558083', 'https://openalex.org/W1966396944', 'https://openalex.org/W1966735041', 'https://openalex.org/W1971105753', 'https://openalex.org/W1972092604', 'https://openalex.org/W1974272975', 'https://openalex.org/W1978547782', 'https://openalex.org/W1981640964', 'https://openalex.org/W1982551574', 'https://openalex.org/W1983869713', 'https://openalex.org/W1985581648', 'https://openalex.org/W1987169168', 'https://openalex.org/W1988329333', 'https://openalex.org/W1988643590', 'https://openalex.org/W1989177998', 'https://openalex.org/W1990892368', 'https://openalex.org/W1998535063', 'https://openalex.org/W2004746002', 'https://openalex.org/W2007239552', 'https://openalex.org/W2019304093', 'https://openalex.org/W2020158437', 'https://openalex.org/W2024301699', 'https://openalex.org/W2024795561', 'https://openalex.org/W2025648894', 'https://openalex.org/W2025873925', 'https://openalex.org/W2028036660', 'https://openalex.org/W2028622736', 'https://openalex.org/W2040356728', 'https://openalex.org/W2044117548', 'https://openalex.org/W2048446503', 'https://openalex.org/W2049369269', 'https://openalex.org/W2070136298', 'https://openalex.org/W2078779212', 'https://openalex.org/W2086312703', 'https://openalex.org/W2094571195', 'https://openalex.org/W2098150710', 'https://openalex.org/W2101042581', 'https://openalex.org/W2103478682', 'https://openalex.org/W2105694586', 'https://openalex.org/W2106488393', 'https://openalex.org/W2110739636', 'https://openalex.org/W2112538318', 'https://openalex.org/W2123977077', 'https://openalex.org/W2124985265', 'https://openalex.org/W2127938920', 'https://openalex.org/W2131004718', 'https://openalex.org/W2131779930', 'https://openalex.org/W2132546148', 'https://openalex.org/W2133318565', 'https://openalex.org/W2133678000', 'https://openalex.org/W2139440265', 'https://openalex.org/W2160598189', 'https://openalex.org/W2174346028', 'https://openalex.org/W2184760435', 'https://openalex.org/W2311204218', 'https://openalex.org/W2421877751', 'https://openalex.org/W4243584933'], 'related_works': ['https://openalex.org/W4240704896', 'https://openalex.org/W3090446747', 'https://openalex.org/W2171581216', 'https://openalex.org/W2162713462', 'https://openalex.org/W2093797995', 'https://openalex.org/W2087463521', 'https://openalex.org/W2083872838', 'https://openalex.org/W2056412942', 'https://openalex.org/W2036321075', 'https://openalex.org/W1968177409'], 'abstract_inverted_index': {'Neuronal': [0], 'granules': [1], 'play': [2], 'an': [3, 147, 180], 'important': [4], 'role': [5], 'in': [6, 16, 34, 40, 117, 134, 152, 182, 186, 196], 'the': [7, 19, 25, 62, 68, 74, 118, 122, 125, 135, 142, 164, 167, 177, 183, 187], 'localization': [8], 'and': [9, 37, 53, 57, 73, 79, 83, 97, 104, 127, 208], 'transport': [10], 'of': [11, 124, 137, 149, 166, 179], 'translationally': [12], 'silenced': [13], 'messenger': [14], 'ribonucleoproteins': [15], 'neurons.': [17], 'Among': [18, 141], 'factors': [20], 'associated': [21, 63], 'with': [22, 110], 'these': [23], 'granules,': [24], 'RNA-binding': [26, 75], 'protein': [27], 'G3BP1': [28, 49, 128, 138, 160], '(stress-granules': [29], 'assembly': [30], 'factor)': [31], 'is': [32, 38, 194, 220], 'involved': [33, 151, 195], 'neuronal': [35, 157, 214], 'plasticity': [36], 'induced': [39], "Alzheimer's": [41], 'disease.': [42], 'We': [43], 'immunopurified': [44], 'a': [45, 197], 'stable': [46], 'complex': [47], 'containing': [48], 'from': [50], 'mouse': [51], 'brain': [52, 126], 'performed': [54], 'high-throughput': [55], 'sequencing': [56], 'cross-linking': [58], 'immunoprecipitation': [59], 'to': [60, 92, 98, 114, 121, 162, 201], 'identify': [61], 'RNAs.': [64, 107], 'The': [65, 88], 'G3BP-complex': [66, 89], 'contained': [67], 'deubiquitinating': [69], 'protease': [70], 'USP10,': [71], 'CtBP1': [72], 'proteins': [76], 'Caprin-1,': [77], 'G3BP2a': [78], 'splicing': [80], 'factor': [81], 'proline': [82], 'glutamine': [84], 'rich,': [85], 'or': [86], 'PSF.': [87], 'binds': [90], 'preferentially': [91], 'transcripts': [93, 109], 'that': [94, 192], 'retain': [95], 'introns,': [96], 'non-coding': [99, 106, 203], 'sequences': [100], 'like': [101], "3'-untranslated": [102], 'region': [103], 'long': [105], 'Specific': [108], 'retained': [111], 'introns': [112], 'appear': [113], 'be': [115], 'enriched': [116, 143], 'cerebellum': [119, 136], 'compared': [120], 'rest': [123], 'depletion': [129], 'decreased': [130], 'this': [131], 'intron': [132, 181, 218], 'retention': [133, 178, 219], 'knockout': [139], 'mice.': [140], 'transcripts,': [144, 207], 'we': [145], 'found': [146], 'overrepresentation': [148], 'genes': [150], 'synaptic': [153], 'transmission,': [154], 'especially': [155], 'glutamate-related': [156], 'transmission.': [158], 'Notably,': [159], 'seems': [161], 'repress': [163], 'expression': [165], 'mature': [168], 'Grm5': [169], '(metabotropic': [170], 'glutamate': [171], 'receptor': [172], '5)': [173], 'transcript,': [174], 'by': [175], 'promoting': [176], 'immature': [184], 'transcript': [185], 'cerebellum.': [188], 'Our': [189], 'results': [190], 'suggest': [191], 'G3BP': [193], 'new': [198], 'functional': [199], 'mechanism': [200], 'regulate': [202], 'RNAs': [204], 'including': [205], 'intron-retaining': [206], 'thus': [209], 'have': [210], 'broad': [211], 'implications': [212], 'for': [213], 'gene': [215], 'regulation,': [216], 'where': [217], 'widespread.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2516365506', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2025-01-09T23:45:46.249331', 'created_date': '2016-09-16'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
