Publication Information

{'id': 'https://openalex.org/W2507848905', 'doi': 'https://doi.org/10.3390/molecules21081071', 'title': 'Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate against TBHP-Induced Oxidative Damage in SH-SY5Y Cells', 'display_name': 'Neuroprotective Effects of Methyl 3,4-Dihydroxybenzoate against TBHP-Induced Oxidative Damage in SH-SY5Y Cells', 'publication_year': 2016, 'publication_date': '2016-08-22', 'ids': {'openalex': 'https://openalex.org/W2507848905', 'doi': 'https://doi.org/10.3390/molecules21081071', 'mag': '2507848905', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27556437', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6274188'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules21081071', 'pdf_url': 'https://www.mdpi.com/1420-3049/21/8/1071/pdf?version=1471851201', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/1420-3049/21/8/1071/pdf?version=1471851201', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101775556', 'display_name': 'Liang Cai', 'orcid': 'https://orcid.org/0000-0002-9293-2432'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}, {'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liang Cai', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'School of International Education, Anhui Medical University, Hefei 230000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}, {'raw_affiliation_string': 'School of International Education, Anhui Medical University, Hefei 230000, China', 'institution_ids': ['https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005636590', 'display_name': 'Lifang Wang', 'orcid': 'https://orcid.org/0000-0002-1709-9401'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}, {'id': 'https://openalex.org/I190242452', 'display_name': 'Guangdong Pharmaceutical University', 'ror': 'https://ror.org/02vg7mz57', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I190242452']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li-Fang Wang', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'School of Nursing, Guangdong Pharmaceutical University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}, {'raw_affiliation_string': 'School of Nursing, Guangdong Pharmaceutical University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I190242452']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101114591', 'display_name': 'Junping Pan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun-Ping Pan', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084597763', 'display_name': 'Xiang-Nan Mi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiang-Nan Mi', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100459176', 'display_name': 'Zheng Zhang', 'orcid': 'https://orcid.org/0000-0003-2497-0362'}, 'institutions': [{'id': 'https://openalex.org/I4210162753', 'display_name': 'First Affiliated Hospital of Jinan University', 'ror': 'https://ror.org/05d5vvz89', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162753']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zheng Zhang', 'raw_affiliation_strings': ['The First Affiliated Hospital of Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'The First Affiliated Hospital of Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I4210162753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029584265', 'display_name': 'Hai-Ju Geng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hai-Ju Geng', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100446908', 'display_name': 'Jiahui Wang', 'orcid': 'https://orcid.org/0000-0002-0867-8612'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jia-Hui Wang', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040844521', 'display_name': 'Songhui Hu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Song-Hui Hu', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100441631', 'display_name': 'Wei Zhang', 'orcid': 'https://orcid.org/0000-0002-4375-0368'}, 'institutions': [{'id': 'https://openalex.org/I4210127460', 'display_name': 'Ningxia Medical University', 'ror': 'https://ror.org/02h8a1848', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I4210127460']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Zhang', 'raw_affiliation_strings': ['Department of Pathogen Biology and Medical Immunology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750021, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathogen Biology and Medical Immunology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750021, China', 'institution_ids': ['https://openalex.org/I4210127460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060439422', 'display_name': 'Qin Gao', 'orcid': 'https://orcid.org/0000-0002-7599-4295'}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qin Gao', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080932213', 'display_name': 'Wutian Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177725633', 'display_name': 'Chinese University of Hong Kong', 'ror': 'https://ror.org/00t33hh48', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177725633']}, {'id': 'https://openalex.org/I889458895', 'display_name': 'University of Hong Kong', 'ror': 'https://ror.org/02zhqgq86', 'country_code': 'HK', 'type': 'education', 'lineage': ['https://openalex.org/I889458895']}], 'countries': ['CN', 'HK'], 'is_corresponding': False, 'raw_author_name': 'Wu-Tian Wu', 'raw_affiliation_strings': ['Department of Anatomy, Li Ka Shing Faculty of Medicine of The University of Hong Kong, Hong Kong 999077, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, Li Ka Shing Faculty of Medicine of The University of Hong Kong, Hong Kong 999077, China', 'institution_ids': ['https://openalex.org/I177725633', 'https://openalex.org/I889458895']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100531212', 'display_name': 'Huanmin Luo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I159948400', 'display_name': 'Jinan University', 'ror': 'https://ror.org/02xe5ns62', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I159948400']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Huan-Min Luo', 'raw_affiliation_strings': ['Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'Institute of Brain Sciences, Jinan University, Guangzhou 510632, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Brain Sciences, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}, {'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, China', 'institution_ids': ['https://openalex.org/I159948400']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5100531212'], 'corresponding_institution_ids': ['https://openalex.org/I159948400'], 'apc_list': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'apc_paid': {'value': 2300, 'currency': 'CHF', 'value_usd': 2490, 'provenance': 'doaj'}, 'fwci': 1.188, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '21', 'issue': '8', 'first_page': '1071', 'last_page': '1071'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13012', 'display_name': 'Coenzyme Q10 studies and effects', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13013', 'display_name': 'Free Radicals and Antioxidants', 'score': 0.9893, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sh-sy5y', 'display_name': 'SH-SY5Y', 'score': 0.919018}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.69837904}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.5256808}], 'concepts': [{'id': 'https://openalex.org/C2779083432', 'wikidata': 'https://www.wikidata.org/wiki/Q7390126', 'display_name': 'SH-SY5Y', 'level': 4, 'score': 0.919018}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.7362466}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.69837904}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.6141913}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.6131743}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.612653}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5916161}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5270574}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.5256808}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.50274825}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.49430466}, {'id': 'https://openalex.org/C88634738', 'wikidata': 'https://www.wikidata.org/wiki/Q24769543', 'display_name': 'Annexin', 'level': 3, 'score': 0.49309513}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.45522013}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43242663}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.34981185}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.28537375}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24003902}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.22023073}, {'id': 'https://openalex.org/C2776715637', 'wikidata': 'https://www.wikidata.org/wiki/Q938205', 'display_name': 'Neuroblastoma', 'level': 3, 'score': 0.2090491}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D062385', 'descriptor_name': 'Hydroxybenzoates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020122', 'descriptor_name': 'tert-Butylhydroperoxide', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000111', 'descriptor_name': 'Acetylcysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062385', 'descriptor_name': 'Hydroxybenzoates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020122', 'descriptor_name': 'tert-Butylhydroperoxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules21081071', 'pdf_url': 'https://www.mdpi.com/1420-3049/21/8/1071/pdf?version=1471851201', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/7be5f5d5233043ccb711af0ee6748cb9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6274188', 'pdf_url': 'https://europepmc.org/articles/pmc6274188?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274188', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27556437', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/molecules21081071', 'pdf_url': 'https://www.mdpi.com/1420-3049/21/8/1071/pdf?version=1471851201', 'source': {'id': 'https://openalex.org/S108911230', 'display_name': 'Molecules', 'issn_l': '1420-3049', 'issn': ['1420-3049', '1433-1373'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1542447625', 'https://openalex.org/W1825629489', 'https://openalex.org/W1882550848', 'https://openalex.org/W1947629381', 'https://openalex.org/W2007057690', 'https://openalex.org/W2018931324', 'https://openalex.org/W2030281502', 'https://openalex.org/W2034574233', 'https://openalex.org/W2042996709', 'https://openalex.org/W2043675475', 'https://openalex.org/W2044601719', 'https://openalex.org/W2049073341', 'https://openalex.org/W2056880208', 'https://openalex.org/W2060583129', 'https://openalex.org/W2061213886', 'https://openalex.org/W2062171726', 'https://openalex.org/W2065913122', 'https://openalex.org/W2071869875', 'https://openalex.org/W2074310251', 'https://openalex.org/W2075194339', 'https://openalex.org/W2077152493', 'https://openalex.org/W2078352293', 'https://openalex.org/W2080777048', 'https://openalex.org/W2081412929', 'https://openalex.org/W2108079568', 'https://openalex.org/W2116562304', 'https://openalex.org/W2129256971', 'https://openalex.org/W2151501496', 'https://openalex.org/W2157434148', 'https://openalex.org/W2165201727', 'https://openalex.org/W2167557753', 'https://openalex.org/W2170335800', 'https://openalex.org/W2171946288', 'https://openalex.org/W2172249877', 'https://openalex.org/W2254142936', 'https://openalex.org/W2372593253', 'https://openalex.org/W2419098006', 'https://openalex.org/W4210273716', 'https://openalex.org/W4234623156'], 'related_works': ['https://openalex.org/W3030667680', 'https://openalex.org/W2990301750', 'https://openalex.org/W2377430322', 'https://openalex.org/W2374560192', 'https://openalex.org/W2365474659', 'https://openalex.org/W2341333145', 'https://openalex.org/W2266631222', 'https://openalex.org/W2243000210', 'https://openalex.org/W2030968933', 'https://openalex.org/W1191950147'], 'abstract_inverted_index': {'This': [0], 'study': [1], 'investigated': [2], 'the': [3, 23, 52, 66, 127], 'neuroprotective': [4, 150], 'effects': [5], 'of': [6, 42, 54, 99, 129], 'methyl': [7], '3,4-dihydroxybenzoate': [8], '(MDHB)': [9], 'against': [10], 't-butyl': [11], 'hydroperoxide': [12], '(TBHP)': [13], 'induced': [14], 'oxidative': [15, 112, 155], 'damage': [16, 114], 'in': [17, 29, 138, 160], 'SH-SY5Y': [18, 26, 140, 161], '(human': [19], 'neuroblastoma': [20], 'cells)': [21], 'and': [22, 37, 69, 103, 135, 157], 'underlying': [24], 'mechanisms.': [25], 'were': [27, 105], 'cultured': [28], 'DMEM': [30], '+': [31], '10%': [32], 'FBS': [33], 'for': [34, 47, 58], '24': [35, 59], 'h': [36, 49], 'pretreated': [38], 'with': [39], 'different': [40], 'concentrations': [41], 'MDHB': [43, 146], 'or': [44], 'N-acetyl-l-cysteine': [45], '(NAC)': [46], '4': [48], 'prior': [50], 'to': [51, 80, 92, 125], 'addition': [53], '40': [55], 'μM': [56], 'TBHP': [57], 'h.': [60], 'Cell': [61], 'viability': [62], 'was': [63, 78, 90, 117, 123], 'analyzed': [64], 'using': [65, 107, 119], 'methylthiazolyltetrazolium': [67], '(MTT)': [68], 'lactate': [70], 'dehydrogenase': [71], '(LDH)': [72], 'assays.': [73], 'An': [74], 'annexin': [75], 'V-FITC': [76], 'assay': [77, 89], 'used': [79, 91, 124], 'detect': [81], 'cell': [82], 'apoptosis': [83, 159], 'rates.': [84], 'The': [85, 97, 111], "2',7'-dichlorofluorescin": [86], 'diacetate': [87], '(DCFH-DA)': [88], 'determine': [93, 126], 'intracellular': [94], 'ROS': [95], 'levels.': [96], 'activities': [98], 'antioxidative': [100], 'enzymes': [101], '(GSH-Px': [102], 'SOD)': [104], 'measured': [106], 'commercially': [108], 'available': [109], 'kits.': [110], 'DNA': [113], 'marker': [115], '8-OHdG': [116], 'detected': [118], 'ELISA.': [120], 'Western': [121], 'blotting': [122], 'expression': [128], 'Bcl-2,': [130], 'Bax,': [131], 'caspase': [132], '3,': [133], 'p-Akt': [134], 'Akt': [136], 'proteins': [137], 'treated': [139], 'cells.': [141, 162], 'Our': [142], 'results': [143], 'showed': [144], 'that': [145, 152], 'is': [147], 'an': [148], 'effective': [149], 'compound': [151], 'can': [153], 'mitigate': [154], 'stress': [156], 'inhibit': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2507848905', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-24T12:06:12.457413', 'created_date': '2016-09-16'}