Publication Information

{'id': 'https://openalex.org/W2494097070', 'doi': 'https://doi.org/10.1158/1538-7445.am2016-3342', 'title': 'Abstract 3342: Galiellalactone derivative targets stem cell population in ENZ-resistant prostate cancer through inhibition of STAT3', 'display_name': 'Abstract 3342: Galiellalactone derivative targets stem cell population in ENZ-resistant prostate cancer through inhibition of STAT3', 'publication_year': 2016, 'publication_date': '2016-07-15', 'ids': {'openalex': 'https://openalex.org/W2494097070', 'doi': 'https://doi.org/10.1158/1538-7445.am2016-3342', 'mag': '2494097070'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2016-3342', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055642554', 'display_name': 'Sepideh Vahid', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sepideh Vahid', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056176506', 'display_name': 'Daksh Thaper', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Daksh Thaper', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111631918', 'display_name': 'Alistair Davies', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Alistair Davies', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022425928', 'display_name': 'Micaela Janse Van Rensburg', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Micaela Janse Van Rensburg', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103277474', 'display_name': 'Kate Gibson', 'orcid': 'https://orcid.org/0000-0003-1417-1831'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kate Gibson', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013163254', 'display_name': 'Kirsi Ketola', 'orcid': 'https://orcid.org/0000-0001-6484-9861'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Krisi Ketola', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077167332', 'display_name': 'Martin Johansson', 'orcid': 'https://orcid.org/0000-0001-8510-3102'}, 'institutions': [{'id': 'https://openalex.org/I4210104173', 'display_name': 'Glactone Pharma (Sweden)', 'ror': 'https://ror.org/01azp7v94', 'country_code': 'SE', 'type': 'company', 'lineage': ['https://openalex.org/I4210104173']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Martin Johansson', 'raw_affiliation_strings': ['2Glactone Pharma Development, Helsingborg, Sweden.'], 'affiliations': [{'raw_affiliation_string': '2Glactone Pharma Development, Helsingborg, Sweden.', 'institution_ids': ['https://openalex.org/I4210104173']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102968181', 'display_name': 'Jennifer L. Bishop', 'orcid': 'https://orcid.org/0000-0003-3676-8743'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Jennifer L. Bishop', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081653545', 'display_name': 'Amina Zoubeidi', 'orcid': 'https://orcid.org/0000-0002-0498-142X'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Amina Zoubeidi', 'raw_affiliation_strings': ['1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;'], 'affiliations': [{'raw_affiliation_string': '1Vancouver Prostate Centre, Vancouver, British Columbia, Canada;', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '76', 'issue': '14_Supplement', 'first_page': '3342', 'last_page': '3342'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 0.9942, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9681, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9164, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.6911748}, {'id': 'https://openalex.org/keywords/side-population', 'display_name': 'Side population', 'score': 0.43880188}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.6911748}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.66763395}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.6630703}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.65129465}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.5977778}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.53467894}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.5078171}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45027322}, {'id': 'https://openalex.org/C2780546549', 'wikidata': 'https://www.wikidata.org/wiki/Q7508338', 'display_name': 'Side population', 'level': 4, 'score': 0.43880188}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.40021655}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39455104}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35998398}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26458618}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.17594475}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.16459867}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2016-3342', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.47, 'id': 'https://metadata.un.org/sdg/1', 'display_name': 'No poverty'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362621709', 'https://openalex.org/W4362609326', 'https://openalex.org/W4362609250', 'https://openalex.org/W4362495275', 'https://openalex.org/W4362495086', 'https://openalex.org/W2991319487', 'https://openalex.org/W2890810587', 'https://openalex.org/W2767048879', 'https://openalex.org/W2737056430', 'https://openalex.org/W2561061456'], 'abstract_inverted_index': {'Abstract': [0], 'Background:': [1], 'Androgen': [2], 'ablation': [3], 'remains': [4], 'the': [5, 28, 85, 151, 189, 232, 241, 287, 302, 340, 354, 370, 379, 425, 430], 'most': [6, 15], 'effective': [7, 362], 'therapy': [8], 'for': [9, 433], 'patients': [10, 16, 52, 367], 'with': [11, 25, 64, 98, 125, 156, 244, 277, 344, 353], 'advanced': [12], 'disease.': [13], 'Unfortunately,': [14], 'progress': [17], 'to': [18, 113, 137, 154, 207, 231, 237, 349, 364], 'castrate': [19], 'resistant': [20, 62, 346], 'prostate': [21, 88, 415], 'cancer': [22, 89, 118, 416], '(CRPC)': [23], 'characterized': [24], 'hyper-activation': [26, 205], 'of': [27, 75, 80, 87, 100, 117, 135, 145, 150, 167, 249, 258, 321, 328, 342, 372, 381, 419, 424, 429], 'androgen': [29], 'receptor': [30], '(AR).': [31], 'Enzalutamide,': [32], 'a': [33, 65, 101, 122, 133, 164, 332], 'potent': [34], 'AR': [35, 59, 68, 152, 186], 'inhibitor': [36, 69, 144, 234, 357], 'showed': [37, 221], 'efficacy': [38], 'by': [39, 211, 264, 269, 377], 'prolonging': [40], 'survival': [41, 127], 'in': [42, 51, 54, 60, 84, 128, 286, 307, 336, 375, 413], 'CRPC': [43, 208, 238, 313, 347, 376], 'patients.': [44, 129], 'However,': [45], 'ENZ': [46, 61, 157, 308, 345, 373], 'resistance': [47, 109, 309, 330, 374], '(ENZR)': [48], 'rapidly': [49], 'occurs': [50], 'and': [53, 78, 93, 160, 169, 184, 193, 202, 217, 224, 254, 282, 289], 'our': [55], 'pre-clinical': [56, 298], 'model': [57, 166], 'targeting': [58, 301], 'tumors': [63, 179], '3rd': [66], 'generation': [67], 'is': [70, 90], 'short': [71], 'lived.': [72], 'The': [73, 256], 'role': [74], 'signal': [76], 'transducer': [77], 'activator': [79], 'transcription': [81], '(STAT)': [82], '3': [83], 'progression': [86], 'well': [91, 311, 318], 'established': [92], 'has': [94, 110], 'been': [95, 111], 'repeatedly': [96], 'linked': [97], 'maintenance': [99], 'stem': [102, 322, 382, 410], 'cell': [103, 172, 190, 226, 315, 323, 411], 'phenotype': [104, 123, 140], 'across': [105], 'cancers.': [106], 'Additionally,': [107], 'drug': [108], 'hypothesized': [112], 'occur': [114], 'via': [115], 'enrichment': [116], 'stem-like': [119], 'cells': [120, 243], '(CSC),': [121], 'associated': [124], 'poor': [126], 'Therefore,': [130], 'we': [131, 296], 'propose': [132], 'shift': [134], 'focus': [136], 'target': [138], 'CSC': [139, 200, 260], 'using': [141, 305], 'small': [142, 355], 'molecule': [143, 356], 'STAT3': [146, 204, 233, 303, 352], 'called': [147], 'GPA500,': [148], 'instead': [149], 'axis': [153], 'deal': [155], 'resistance.': [158], 'Methods': [159], 'Results:': [161], 'We': [162], 'developed': [163], 'unique': [165], 'ENZ-resistance': [168], 'found': [170], 'that': [171, 222, 275, 300], 'lines': [173, 191, 227], 'derived': [174], 'from': [175], 'serially': [176], 'passaged': [177], 'ENZR': [178, 329, 366], 'displayed': [180], 'broad': [181], 'genetic': [182], 'diversity': [183], 'differential': [185], 'activity.': [187], 'Notably,': [188], '42DENZR': [192, 223], '42FENZR': [194, 225], 'are': [195], 'PSAlow,': [196], 'harbor': [197], 'an': [198, 361], 'expanded': [199], 'population': [201, 285, 412], 'have': [203], 'compared': [206, 236], 'controls': [209], 'measured': [210, 268], 'STAT3-luc': [212], 'reporter.': [213], 'Accordingly,': [214], 'Crystal': [215], 'Violet': [216], 'MTT': [218], 'proliferation': [219, 316], 'assays': [220], 'were': [228], 'more': [229], 'sensitive': [230], 'GPA500': [235, 245, 278, 306, 358], 'control.': [239], 'Targeting': [240, 351], 'ENZ-R': [242], 'reduced': [246, 265, 279], 'mRNA': [247], 'levels': [248], 'CD133,': [250], 'CD44,': [251], 'SOX2,': [252], 'OCT4': [253], 'Nanog.': [255], 'reduction': [257], 'these': [259], 'markers': [261], 'was': [262], 'accompanied': [263], 'self-renewal': [266], 'capacity': [267], 'spheroid': [270], 'assay.': [271], 'Cytometry': [272], 'analysis': [273], 'revealed': [274], 'treatment': [276], 'α2β1+,': [280], 'CD44+': [281], 'CD133+': [283], '(CSC)': [284], '42D': [288], '42F': [290], 'cells.': [291, 383], 'Conclusion:': [292], 'In': [293], 'this': [294], 'study,': [295], 'provide': [297, 360], 'proof': [299], 'pathway': [304], 'as': [310, 312, 317, 319, 339], 'reduces': [314], 'expression': [320], 'markers.': [324], 'Impact:': [325], 'Exploring': [326], 'mechanisms': [327], 'serves': [331], 'critical': [333], 'unmet': [334], 'need': [335], 'PCa': [337], 'oncology,': [338], 'number': [341], 'men': [343], 'continues': [348], 'rise.': [350], 'may': [359], 'method': [363], 'treat': [365], 'or': [368], 'delay': [369], 'emergence': [371, 380], 'reducing': [378], 'Citation': [384], 'Format:': [385], 'Sepideh': [386], 'Vahid,': [387], 'Daksh': [388], 'Thaper,': [389], 'Alistair': [390], 'Davies,': [391], 'Micaela': [392], 'Janse': [393], 'Van': [394], 'Rensburg,': [395], 'Kate': [396], 'Gibson,': [397], 'Krisi': [398], 'Ketola,': [399], 'Martin': [400], 'Johansson,': [401], 'Jennifer': [402], 'L.': [403], 'Bishop,': [404], 'Amina': [405], 'Zoubeidi.': [406], 'Galiellalactone': [407], 'derivative': [408], 'targets': [409], 'ENZ-resistant': [414], 'through': [417], 'inhibition': [418], 'STAT3.': [420], '[abstract].': [421], 'In:': [422], 'Proceedings': [423], '107th': [426], 'Annual': [427], 'Meeting': [428], 'American': [431], 'Association': [432], 'Cancer': [434, 445], 'Research;': [435], '2016': [436], 'Apr': [437], '16-20;': [438], 'New': [439], 'Orleans,': [440], 'LA.': [441], 'Philadelphia': [442], '(PA):': [443], 'AACR;': [444], 'Res': [446], '2016;76(14': [447], 'Suppl):Abstract': [448], 'nr': [449], '3342.': [450]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2494097070', 'counts_by_year': [], 'updated_date': '2024-12-12T23:16:50.133001', 'created_date': '2016-08-23'}