Publication Information

{'id': 'https://openalex.org/W2492664971', 'doi': 'https://doi.org/10.1158/1538-7445.am2016-2743', 'title': 'Abstract 2743: Finding determinants of PARP inhibitor sensitivity using genome-wide and focused CRISPR screens', 'display_name': 'Abstract 2743: Finding determinants of PARP inhibitor sensitivity using genome-wide and focused CRISPR screens', 'publication_year': 2016, 'publication_date': '2016-07-15', 'ids': {'openalex': 'https://openalex.org/W2492664971', 'doi': 'https://doi.org/10.1158/1538-7445.am2016-2743', 'mag': '2492664971'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2016-2743', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085843094', 'display_name': 'Stephen J. Pettitt', 'orcid': 'https://orcid.org/0000-0003-3313-3857'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen Pettitt', 'raw_affiliation_strings': ['1Institute of Cancer Research, London, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Research, London, United Kingdom;', 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064025035', 'display_name': 'Dragomir B. Krastev', 'orcid': 'https://orcid.org/0000-0003-4298-7272'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Dragomir B. Krastev', 'raw_affiliation_strings': ['1Institute of Cancer Research, London, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Research, London, United Kingdom;', 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070334795', 'display_name': 'Feifei Song', 'orcid': 'https://orcid.org/0000-0001-8571-3111'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Feifei Song', 'raw_affiliation_strings': ['1Institute of Cancer Research, London, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Research, London, United Kingdom;', 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058973407', 'display_name': 'Alan Ashworth', 'orcid': 'https://orcid.org/0000-0003-1446-7878'}, 'institutions': [{'id': 'https://openalex.org/I4210167126', 'display_name': 'UCSF Helen Diller Family Comprehensive Cancer Center', 'ror': 'https://ror.org/05yndxy10', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I180670191', 'https://openalex.org/I4210110664', 'https://openalex.org/I4210167126']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan Ashworth', 'raw_affiliation_strings': ['2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.'], 'affiliations': [{'raw_affiliation_string': '2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA.', 'institution_ids': ['https://openalex.org/I4210167126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5088018441', 'display_name': 'Christopher J. Lord', 'orcid': 'https://orcid.org/0000-0002-3226-0515'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Lord', 'raw_affiliation_strings': ['1Institute of Cancer Research, London, United Kingdom;'], 'affiliations': [{'raw_affiliation_string': '1Institute of Cancer Research, London, United Kingdom;', 'institution_ids': ['https://openalex.org/I142947616']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.147, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.465415, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '76', 'issue': '14_Supplement', 'first_page': '2743', 'last_page': '2743'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9848, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9848, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/olaparib', 'display_name': 'Olaparib', 'score': 0.93102384}, {'id': 'https://openalex.org/keywords/parp-inhibitor', 'display_name': 'PARP inhibitor', 'score': 0.8777294}, {'id': 'https://openalex.org/keywords/parp1', 'display_name': 'PARP1', 'score': 0.8076975}, {'id': 'https://openalex.org/keywords/veliparib', 'display_name': 'Veliparib', 'score': 0.5286874}, {'id': 'https://openalex.org/keywords/synthetic-lethality', 'display_name': 'Synthetic Lethality', 'score': 0.50522643}, {'id': 'https://openalex.org/keywords/genetic-screen', 'display_name': 'Genetic screen', 'score': 0.4463651}], 'concepts': [{'id': 'https://openalex.org/C2779962180', 'wikidata': 'https://www.wikidata.org/wiki/Q7083106', 'display_name': 'Olaparib', 'level': 5, 'score': 0.93102384}, {'id': 'https://openalex.org/C2779138821', 'wikidata': 'https://www.wikidata.org/wiki/Q7118227', 'display_name': 'PARP inhibitor', 'level': 5, 'score': 0.8777294}, {'id': 'https://openalex.org/C2778480876', 'wikidata': 'https://www.wikidata.org/wiki/Q21112674', 'display_name': 'PARP1', 'level': 5, 'score': 0.8076975}, {'id': 'https://openalex.org/C98108389', 'wikidata': 'https://www.wikidata.org/wiki/Q412563', 'display_name': 'CRISPR', 'level': 3, 'score': 0.7209436}, {'id': 'https://openalex.org/C16318435', 'wikidata': 'https://www.wikidata.org/wiki/Q149299', 'display_name': 'Mutagenesis', 'level': 4, 'score': 0.6813735}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.59371805}, {'id': 'https://openalex.org/C2781312401', 'wikidata': 'https://www.wikidata.org/wiki/Q7919041', 'display_name': 'Veliparib', 'level': 5, 'score': 0.5286874}, {'id': 'https://openalex.org/C2778502085', 'wikidata': 'https://www.wikidata.org/wiki/Q7662767', 'display_name': 'Synthetic lethality', 'level': 4, 'score': 0.50522643}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.48477978}, {'id': 'https://openalex.org/C182979987', 'wikidata': 'https://www.wikidata.org/wiki/Q3907241', 'display_name': 'Poly ADP ribose polymerase', 'level': 4, 'score': 0.46529424}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.4650724}, {'id': 'https://openalex.org/C207177822', 'wikidata': 'https://www.wikidata.org/wiki/Q5050812', 'display_name': 'Genetic screen', 'level': 4, 'score': 0.4463651}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.43925917}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.43288428}, {'id': 'https://openalex.org/C176944494', 'wikidata': 'https://www.wikidata.org/wiki/Q1415380', 'display_name': 'Point mutation', 'level': 4, 'score': 0.42276317}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.39404315}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.30019212}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.2892717}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.10761267}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2016-2743', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4362541711', 'https://openalex.org/W4361821986', 'https://openalex.org/W4296617455', 'https://openalex.org/W4229451438', 'https://openalex.org/W3009707110', 'https://openalex.org/W2604531394', 'https://openalex.org/W2515153059', 'https://openalex.org/W2283134145', 'https://openalex.org/W2142508143', 'https://openalex.org/W1986471561'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1, 66, 215, 229], 'are': [2, 49], 'using': [3, 126, 320], 'genomic': [4], 'approaches': [5], 'to': [6, 113, 211, 238, 285], 'study': [7, 52], 'the': [8, 59, 96, 160, 182, 187, 206, 330, 335], 'mechanism': [9, 106, 207], 'of': [10, 12, 22, 53, 63, 72, 88, 141, 184, 197, 208, 260, 316, 329, 334], 'action': [11, 209, 295], 'targeted': [13], 'cancer': [14], 'drugs,': [15, 24], 'particularly': [16], 'poly(ADP-ribose)': [17], 'polymerase': [18], '(PARP)': [19], 'inhibitors.': [20, 93, 185], 'One': [21], 'these': [23, 64], 'olaparib': [25, 89], 'was': [26, 83, 202], 'recently': [27], 'approved': [28], 'for': [29, 85, 292, 338], 'use': [30], 'in': [31, 76, 131, 159, 181, 195, 263, 267, 279], 'ovarian': [32], 'cancers': [33], 'with': [34, 43], 'germline': [35], 'BRCA1/2': [36], 'mutations': [37, 144, 242, 262], 'and': [38, 45, 90, 176, 201, 252, 296, 322], 'many': [39], 'other': [40, 46, 91, 286], 'clinical': [41, 61, 298], 'trials': [42], 'this': [44, 217], 'PARP': [47, 92, 99, 109, 135, 198, 268, 317], 'inhibitors': [48], 'underway.': [50], 'Experimental': [51], 'potential': [54], 'resistance': [55], 'mechanisms': [56], 'can': [57], 'inform': [58], 'ongoing': [60], 'development': [62], 'drugs.': [65], 'previously': [67], 'carried': [68, 121], 'out': [69, 122], 'a': [70, 104, 116, 123, 151, 155, 168, 221, 231, 258, 273, 290], 'loss': [71, 140], 'function': [73, 142], 'mutagenesis': [74, 130], 'screen': [75, 125, 189], 'haploid': [77], 'cells,': [78], 'which': [79], 'showed': [80], 'that': [81, 98, 172, 235, 243, 265], 'PARP1': [82, 191, 245, 264], 'required': [84], 'cellular': [86], 'toxicity': [87, 101, 200], 'This': [94, 165], 'supported': [95], 'hypothesis': [97], 'inhibitor': [100, 136, 199, 269, 318], 'occurs': [102], 'via': [103], 'poisoning': [105], 'where': [107], 'inhibited': [108], 'is': [110, 283], 'tightly': [111], 'bound': [112], 'DNA,': [114], 'forming': [115], 'toxic': [117], 'lesion.': [118], 'Recently': [119], 'we': [120, 148, 256], 'similar': [124], 'genome-wide': [127, 321], 'lentiviral': [128], 'CRISPR-Cas9': [129], 'diploid': [132], 'cells.': [133], 'Many': [134], 'resistant': [137], 'clones': [138], 'had': [139], 'Parp1': [143, 161, 170], 'as': [145], 'expected.': [146], 'However,': [147], 'also': [149], 'isolated': [150], 'point': [152], 'mutation': [153], 'affecting': [154], 'single': [156], 'amino': [157], 'acid': [158], 'DNA': [162, 175, 192], 'binding': [163, 193], 'domain.': [164], 'mutant': [166], 'encodes': [167], 'stable': [169], 'protein': [171, 246], 'cannot': [173], 'bind': [174], 'does': [177], 'not': [178], 'become': [179], 'trapped': [180], 'presence': [183], 'Thus': [186], 'CRISPR': [188, 324], 'implicated': [190], 'directly': [194], 'determination': [196], 'extremely': [203], 'informative': [204], 'about': [205], 'compared': [210], 'conventional': [212], 'loss-of-function': [213], 'mutagenesis.': [214], 'extended': [216], 'approach': [218, 282], 'by': [219], 'synthesising': [220], 'high-density': [222], 'focused': [223, 323], 'sgRNA': [224], 'library': [225], 'targeting': [226], 'only': [227], 'PARP1.': [228, 280], 'developed': [230], 'reporter': [232], 'cell': [233], 'line': [234], 'allows': [236], 'us': [237, 272], 'selectively': [239], 'isolate': [240], 'in-frame': [241], 'preserve': [244], 'expression.': [247], 'By': [248], 'deep': [249], 'sequencing': [250], 'mutagenised': [251], 'appropriately': [253], 'selected': [254], 'cells': [255], 'identified': [257], 'series': [259], 'subtle': [261], 'result': [266], 'resistance,': [270], 'giving': [271], 'detailed': [274], 'insight': [275], 'into': [276], 'structure-function': [277], 'relationships': [278], 'The': [281], 'applicable': [284], 'drug': [287, 294], 'targets,': [288], 'providing': [289], 'framework': [291], 'understanding': [293], 'predicting': [297], 'resistance.': [299], 'Citation': [300], 'Format:': [301], 'Stephen': [302], 'Pettitt,': [303], 'Dragomir': [304], 'B.': [305], 'Krastev,': [306], 'Feifei': [307], 'Song,': [308], 'Alan': [309], 'Ashworth,': [310], 'Christopher': [311], 'J.': [312], 'Lord.': [313], 'Finding': [314], 'determinants': [315], 'sensitivity': [319], 'screens.': [325], '[abstract].': [326], 'In:': [327], 'Proceedings': [328], '107th': [331], 'Annual': [332], 'Meeting': [333], 'American': [336], 'Association': [337], 'Cancer': [339, 350], 'Research;': [340], '2016': [341], 'Apr': [342], '16-20;': [343], 'New': [344], 'Orleans,': [345], 'LA.': [346], 'Philadelphia': [347], '(PA):': [348], 'AACR;': [349], 'Res': [351], '2016;76(14': [352], 'Suppl):Abstract': [353], 'nr': [354], '2743.': [355]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2492664971', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-12T01:16:48.858169', 'created_date': '2016-08-23'}