Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1986471561', 'doi': 'https://doi.org/10.1158/0008-5472.can-13-2541', 'title': 'Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity', 'display_name': 'Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity', 'publication_year': 2014, 'publication_date': '2014-01-01', 'ids': {'openalex': 'https://openalex.org/W1986471561', 'doi': 'https://doi.org/10.1158/0008-5472.can-13-2541', 'mag': '1986471561', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24240700', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4886090'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-13-2541', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/74/1/287.full.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://cancerres.aacrjournals.org/content/canres/74/1/287.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050305179', 'display_name': 'Ilirjana Bajrami', 'orcid': 'https://orcid.org/0000-0003-2617-2938'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ilirjana Bajrami', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029859470', 'display_name': 'Jessica Frankum', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jessica R. Frankum', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013141351', 'display_name': 'Asha Konde', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Asha Konde', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064459524', 'display_name': 'Rowan Miller', 'orcid': 'https://orcid.org/0000-0002-2400-1716'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rowan E. Miller', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004275667', 'display_name': 'Farah Rehman', 'orcid': 'https://orcid.org/0000-0003-3879-315X'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Farah L. Rehman', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018587370', 'display_name': 'Rachel Brough', 'orcid': 'https://orcid.org/0000-0002-1862-7130'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rachel Brough', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045885328', 'display_name': 'James Campbell', 'orcid': 'https://orcid.org/0000-0001-6756-8766'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'James Campbell', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616', 'https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061470053', 'display_name': 'David Sims', 'orcid': 'https://orcid.org/0000-0001-8960-8335'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'David Sims', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050276312', 'display_name': 'Rumana Rafiq', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rumana Rafiq', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037297745', 'display_name': 'Sean Hooper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sean Hooper', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052525388', 'display_name': 'Lina Chen', 'orcid': 'https://orcid.org/0000-0002-4576-6814'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lina Chen', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033008477', 'display_name': 'Iwanka Kozarewa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Iwanka Kozarewa', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084511882', 'display_name': 'Ioannis Assiotis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ioannis Assiotis', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091516461', 'display_name': 'Kerry Fenwick', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Kerry Fenwick', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057324933', 'display_name': 'Rachael Natrajan', 'orcid': 'https://orcid.org/0000-0002-9987-2946'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rachael Natrajan', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088018441', 'display_name': 'Christopher J. Lord', 'orcid': 'https://orcid.org/0000-0002-3226-0515'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Lord', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058973407', 'display_name': 'Alan Ashworth', 'orcid': 'https://orcid.org/0000-0003-1446-7878'}, 'institutions': [{'id': 'https://openalex.org/I142947616', 'display_name': 'Institute of Cancer Research', 'ror': 'https://ror.org/043jzw605', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I142947616']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alan Ashworth', 'raw_affiliation_strings': ["Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Authors' Affiliations:\u20081The CRUK Gene Function Laboratory, 2Functional Genomics Laboratory, Breakthrough Breast Cancer Research Centre, and 3Tumour Profiling Unit, The Institute of Cancer Research, London, United Kingdom", 'institution_ids': ['https://openalex.org/I142947616']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 13.539, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 313, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '74', 'issue': '1', 'first_page': '287', 'last_page': '297'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11914', 'display_name': 'Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11914', 'display_name': 'Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10769', 'display_name': 'Genetic Research on BRCA Mutations and Cancer Risk', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9924, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/olaparib', 'display_name': 'Olaparib', 'score': 0.95599663}, {'id': 'https://openalex.org/keywords/parp1', 'display_name': 'PARP1', 'score': 0.9333248}, {'id': 'https://openalex.org/keywords/parp-inhibitor', 'display_name': 'PARP inhibitor', 'score': 0.59633446}, {'id': 'https://openalex.org/keywords/parp-inhibitors', 'display_name': 'PARP Inhibitors', 'score': 0.537507}, {'id': 'https://openalex.org/keywords/brca1/2-deficiency', 'display_name': 'BRCA1/2 Deficiency', 'score': 0.525224}, {'id': 'https://openalex.org/keywords/cancer-susceptibility', 'display_name': 'cancer susceptibility', 'score': 0.521258}, {'id': 'https://openalex.org/keywords/synthetic-lethality', 'display_name': 'Synthetic Lethality', 'score': 0.510509}, {'id': 'https://openalex.org/keywords/genetic-testing', 'display_name': 'Genetic Testing', 'score': 0.508529}], 'concepts': [{'id': 'https://openalex.org/C2779962180', 'wikidata': 'https://www.wikidata.org/wiki/Q7083106', 'display_name': 'Olaparib', 'level': 5, 'score': 0.95599663}, {'id': 'https://openalex.org/C2778480876', 'wikidata': 'https://www.wikidata.org/wiki/Q21112674', 'display_name': 'PARP1', 'level': 5, 'score': 0.9333248}, {'id': 'https://openalex.org/C2778502085', 'wikidata': 'https://www.wikidata.org/wiki/Q7662767', 'display_name': 'Synthetic lethality', 'level': 4, 'score': 0.80753636}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.64831567}, {'id': 'https://openalex.org/C2779138821', 'wikidata': 'https://www.wikidata.org/wiki/Q7118227', 'display_name': 'PARP inhibitor', 'level': 5, 'score': 0.59633446}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.56350064}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.5179516}, {'id': 'https://openalex.org/C2779012473', 'wikidata': 'https://www.wikidata.org/wiki/Q3235015', 'display_name': 'RAD51', 'level': 4, 'score': 0.46513006}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.4435762}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.44004577}, {'id': 'https://openalex.org/C102744134', 'wikidata': 'https://www.wikidata.org/wiki/Q22280388', 'display_name': 'Homologous recombination', 'level': 3, 'score': 0.41389006}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.38719422}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.1816696}, {'id': 'https://openalex.org/C182979987', 'wikidata': 'https://www.wikidata.org/wiki/Q3907241', 'display_name': 'Poly ADP ribose polymerase', 'level': 4, 'score': 0.15046349}, {'id': 'https://openalex.org/C82381507', 'wikidata': 'https://www.wikidata.org/wiki/Q416878', 'display_name': 'Polymerase', 'level': 3, 'score': 0.13821137}], 'mesh': [{'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000067856', 'descriptor_name': 'Poly(ADP-ribose) Polymerase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018284', 'descriptor_name': 'Cystadenocarcinoma, Serous', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D018284', 'descriptor_name': 'Cystadenocarcinoma, Serous', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D018284', 'descriptor_name': 'Cystadenocarcinoma, Serous', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018284', 'descriptor_name': 'Cystadenocarcinoma, Serous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015894', 'descriptor_name': 'Genome, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055106', 'descriptor_name': 'Genome-Wide Association Study', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018095', 'descriptor_name': 'Germ-Line Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D010051', 'descriptor_name': 'Ovarian Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010793', 'descriptor_name': 'Phthalazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010793', 'descriptor_name': 'Phthalazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010879', 'descriptor_name': 'Piperazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071137', 'descriptor_name': 'Poly (ADP-Ribose) Polymerase-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011065', 'descriptor_name': 'Poly(ADP-ribose) Polymerases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 12, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-13-2541', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/74/1/287.full.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4886090', 'pdf_url': 'https://europepmc.org/articles/pmc4886090?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886090', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400918', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_1_from_Genome-wide_Profiling_of_Genetic_Synthetic_Lethality_Identifies_CDK12_as_a_Novel_Determinant_of_PARP1_2_Inhibitor_Sensitivity/22400918/1/files/39846695.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400915', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_2_from_Genome-wide_Profiling_of_Genetic_Synthetic_Lethality_Identifies_CDK12_as_a_Novel_Determinant_of_PARP1_2_Inhibitor_Sensitivity/22400915/1/files/39846692.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400909', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_4_from_Genome-wide_Profiling_of_Genetic_Synthetic_Lethality_Identifies_CDK12_as_a_Novel_Determinant_of_PARP1_2_Inhibitor_Sensitivity/22400909/1/files/39846686.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400906', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_5_from_Genome-wide_Profiling_of_Genetic_Synthetic_Lethality_Identifies_CDK12_as_a_Novel_Determinant_of_PARP1_2_Inhibitor_Sensitivity/22400906/1/files/39846683.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400921', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Information_from_Genome-wide_Profiling_of_Genetic_Synthetic_Lethality_Identifies_CDK12_as_a_Novel_Determinant_of_PARP1_2_Inhibitor_Sensitivity/22400921/1/files/39846698.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400912', 'pdf_url': 'https://aacr.figshare.com/articles/journal_contribution/Supplementary_Table_3_from_Genome-wide_Profiling_of_Genetic_Synthetic_Lethality_Identifies_CDK12_as_a_Novel_Determinant_of_PARP1_2_Inhibitor_Sensitivity/22400912/1/files/39846689.pdf', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22400924', 'pdf_url': 'https://aacr.figshare.com/ndownloader/files/39846701', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/7vp4783k', 'pdf_url': 'https://escholarship.org/content/qt7vp4783k/qt7vp4783k.pdf?t=rtsjlp', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24240700', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-13-2541', 'pdf_url': 'https://cancerres.aacrjournals.org/content/canres/74/1/287.full.pdf', 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1936760158', 'https://openalex.org/W1967099832', 'https://openalex.org/W1973268287', 'https://openalex.org/W1979736396', 'https://openalex.org/W1985638918', 'https://openalex.org/W2015360671', 'https://openalex.org/W2016758355', 'https://openalex.org/W2019845283', 'https://openalex.org/W2061019285', 'https://openalex.org/W2062511407', 'https://openalex.org/W2065849886', 'https://openalex.org/W2074730941', 'https://openalex.org/W2089355082', 'https://openalex.org/W2098737737', 'https://openalex.org/W2100525241', 'https://openalex.org/W2103770333', 'https://openalex.org/W2105924489', 'https://openalex.org/W2106340365', 'https://openalex.org/W2113432847', 'https://openalex.org/W2114843025', 'https://openalex.org/W2114860131', 'https://openalex.org/W2116005493', 'https://openalex.org/W2117964602', 'https://openalex.org/W2123696077', 'https://openalex.org/W2123814549', 'https://openalex.org/W2124507445', 'https://openalex.org/W2129063117', 'https://openalex.org/W2132717160', 'https://openalex.org/W2135195813', 'https://openalex.org/W2142658272', 'https://openalex.org/W2143392091', 'https://openalex.org/W2149441684', 'https://openalex.org/W2151876400', 'https://openalex.org/W2157899948', 'https://openalex.org/W2160466424', 'https://openalex.org/W2170490448', 'https://openalex.org/W2257499491'], 'related_works': ['https://openalex.org/W4362541711', 'https://openalex.org/W4361821986', 'https://openalex.org/W4296617455', 'https://openalex.org/W4229451438', 'https://openalex.org/W3216411852', 'https://openalex.org/W3135348276', 'https://openalex.org/W2807317098', 'https://openalex.org/W2740076773', 'https://openalex.org/W2515153059', 'https://openalex.org/W2283134145'], 'abstract_inverted_index': {'Small-molecule': [0], 'inhibitors': [1, 30, 212], 'of': [2, 51, 68, 73, 79, 101, 110, 123, 126, 145, 151, 168, 177, 181, 210], 'PARP1/2,': [3], 'such': [4, 82], 'as': [5, 12, 83, 140, 202], 'olaparib,': [6], 'have': [7], 'been': [8], 'proposed': [9], 'to': [10, 115, 118, 161, 164, 186], 'serve': [11], 'a': [13, 56, 141, 203], 'synthetic': [14, 58], 'lethal': [15, 59], 'therapy': [16], 'for': [17, 61], 'cancers': [18], 'that': [19, 44, 195, 216], 'harbor': [20], 'BRCA1': [21], 'or': [22], 'BRCA2': [23], 'mutations.': [24, 41], 'Indeed,': [25], 'in': [26, 35, 98, 190, 199, 206], 'clinical': [27, 208], 'trials,': [28], 'PARP1/2': [29, 119, 146, 165, 211], 'elicit': [31], 'sustained': [32], 'antitumor': [33], 'responses': [34], 'patients': [36], 'with': [37, 130], 'germline': [38], 'BRCA': [39], 'gene': [40], 'In': [42, 66, 91, 149], 'hypothesizing': [43], 'additional': [45], 'genetic': [46], 'determinants': [47, 78], 'might': [48], 'direct': [49], 'use': [50, 201], 'these': [52], 'drugs,': [53], 'we': [54], 'conducted': [55], 'genome-wide': [57], 'screen': [60], 'candidate': [62, 127], 'olaparib': [63, 80], 'sensitivity': [64, 117, 128, 163], 'genes.': [65, 90], 'support': [67], 'this': [69], 'hypothesis,': [70], 'the': [71, 93, 124], 'set': [72, 94], 'identified': [74, 137], 'genes': [75, 96, 129, 184], 'included': [76, 95], 'known': [77, 113, 185], 'sensitivity,': [81], 'BRCA1,': [84], 'RAD51,': [85], 'and': [86, 106, 174, 213], "Fanconi's": [87], 'anemia': [88], 'susceptibility': [89], 'addition,': [92], 'implicated': [97], 'established': [99], 'networks': [100], 'DNA': [102, 104, 134, 169], 'repair,': [103], 'cohesion,': [105], 'chromatin': [107], 'remodeling,': [108], 'none': [109], 'which': [111], 'were': [112], 'previously': [114], 'confer': [116, 162], 'inhibition.': [120], 'Notably,': [121], 'integration': [122], 'list': [125], 'data': [131], 'from': [132], 'tumor': [133], 'sequencing': [135], 'studies': [136], 'CDK12': [138, 157, 192], 'deficiency': [139], 'clinically': [142], 'relevant': [143], 'biomarker': [144], 'inhibitor': [147], 'sensitivity.': [148], 'models': [150], 'high-grade': [152], 'serous': [153], 'ovarian': [154], 'cancer': [155], '(HGS-OVCa),': [156], 'attenuation': [158], 'was': [159], 'sufficient': [160], 'inhibition,': [166], 'suppression': [167], 'repair': [170], 'via': [171], 'homologous': [172], 'recombination,': [173], 'reduced': [175], 'expression': [176], 'BRCA1.': [178], 'As': [179], 'one': [180], 'only': [182], 'nine': [183], 'be': [187], 'significantly': [188], 'mutated': [189], 'HGS-OVCa,': [191], 'has': [193], 'properties': [194], 'should': [196], 'confirm': [197], 'interest': [198], 'its': [200], 'biomarker,': [204], 'particularly': [205], 'ongoing': [207], 'trials': [209], 'other': [214], 'agents': [215], 'trigger': [217], 'replication': [218], 'fork': [219], 'arrest.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1986471561', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 29}, {'year': 2022, 'cited_by_count': 40}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 48}, {'year': 2019, 'cited_by_count': 29}, {'year': 2018, 'cited_by_count': 33}, {'year': 2017, 'cited_by_count': 28}, {'year': 2016, 'cited_by_count': 26}, {'year': 2015, 'cited_by_count': 17}, {'year': 2014, 'cited_by_count': 11}], 'updated_date': '2024-09-09T00:57:26.991149', 'created_date': '2016-06-24'}