Title: [Secondary structure of the M2 protein of influenza type A virus and its role in forming resistance to rimantadine and deitiforin].
Abstract:Studies of the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow a purposeful design of new compounds with a broad spectrum of antiviral activi...Studies of the molecular aspects of resistance of influenza virus A to drugs (rimantadine, deytiforine, amantadine) allow a purposeful design of new compounds with a broad spectrum of antiviral activity and evoking no resistance. In this work the nucleotide sequence of rimantadine- and deytiforine-resistant influenza A strain Leningrad/156/83 (H3N2) was compared with that of A/Victoria/35/72. The influence of aminoacid substitutions in the M2 protein on its secondary structure in the membrane and its role in resistance development was shown.Read More
Publication Year: 1994
Publication Date: 1994-09-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 3
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