Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3012090543', 'doi': 'https://doi.org/10.36233/0507-4088-2020-65-1-16-20', 'title': 'Adamantan derivatives capable of inhibiting the reproduction of a Rimantadine resistant strain of influenza A(H1N1)pdm09 virus <i>(Influenza A virus, Alphainfluenzavirus, Orthomyxoviridae)</i>', 'display_name': 'Adamantan derivatives capable of inhibiting the reproduction of a Rimantadine resistant strain of influenza A(H1N1)pdm09 virus <i>(Influenza A virus, Alphainfluenzavirus, Orthomyxoviridae)</i>', 'publication_year': 2020, 'publication_date': '2020-02-20', 'ids': {'openalex': 'https://openalex.org/W3012090543', 'doi': 'https://doi.org/10.36233/0507-4088-2020-65-1-16-20', 'mag': '3012090543', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/32496716'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.36233/0507-4088-2020-65-1-16-20', 'pdf_url': 'https://virusjour.elpub.ru/jour/article/download/262/158', 'source': {'id': 'https://openalex.org/S2751906956', 'display_name': 'Problems of Virology', 'issn_l': '0507-4088', 'issn': ['0507-4088', '2411-2097'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': 'https://openalex.org/P4322614451', 'host_organization_name': 'Central Research Institute for Epidemiology', 'host_organization_lineage': ['https://openalex.org/P4322614451'], 'host_organization_lineage_names': ['Central Research Institute for Epidemiology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'diamond', 'oa_url': 'https://virusjour.elpub.ru/jour/article/download/262/158', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064603403', 'display_name': 'Т. М. Garaev', 'orcid': 'https://orcid.org/0000-0002-3651-5730'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'T. M. Garaev', 'raw_affiliation_strings': ['National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya'], 'affiliations': [{'raw_affiliation_string': 'National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025287649', 'display_name': 'A. I. Odnovorov', 'orcid': 'https://orcid.org/0000-0001-9355-2522'}, 'institutions': [{'id': 'https://openalex.org/I126527374', 'display_name': "Peoples' Friendship University of Russia", 'ror': 'https://ror.org/02dn9h927', 'country_code': 'RU', 'type': 'education', 'lineage': ['https://openalex.org/I126527374']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'A. I. Odnovorov', 'raw_affiliation_strings': ["Russian Peoples' Friendship University of Russia"], 'affiliations': [{'raw_affiliation_string': "Russian Peoples' Friendship University of Russia", 'institution_ids': ['https://openalex.org/I126527374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076122543', 'display_name': 'Elena S. Kirillova', 'orcid': 'https://orcid.org/0000-0001-7977-7530'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E. S. Kirillova', 'raw_affiliation_strings': ['National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya'], 'affiliations': [{'raw_affiliation_string': 'National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000337140', 'display_name': 'Burtseva Ei', 'orcid': 'https://orcid.org/0000-0003-2518-6801'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E. I. Burtseva', 'raw_affiliation_strings': ['National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya'], 'affiliations': [{'raw_affiliation_string': 'National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086369422', 'display_name': 'М. П. Финогенова', 'orcid': 'https://orcid.org/0000-0002-3611-3897'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M. P. Finogenova', 'raw_affiliation_strings': ['National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya'], 'affiliations': [{'raw_affiliation_string': 'National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081940234', 'display_name': 'Е. А. Мукашева', 'orcid': 'https://orcid.org/0000-0002-5688-5309'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E. A. Mukasheva', 'raw_affiliation_strings': ['National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya'], 'affiliations': [{'raw_affiliation_string': 'National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012725682', 'display_name': 'Т. В. Гребенникова', 'orcid': 'https://orcid.org/0000-0002-6141-9361'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'T. V. Grebennikova', 'raw_affiliation_strings': ['National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya'], 'affiliations': [{'raw_affiliation_string': 'National Research Centre for Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.525, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.999622, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 82, 'max': 84}, 'biblio': {'volume': '65', 'issue': '1', 'first_page': '16', 'last_page': '20'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10947', 'display_name': 'Fluorine in Organic Chemistry', 'score': 0.9728, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10947', 'display_name': 'Fluorine in Organic Chemistry', 'score': 0.9728, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12910', 'display_name': 'Eicosanoids and Hypertension Pharmacology', 'score': 0.9596, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 0.9161, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rimantadine', 'display_name': 'Rimantadine', 'score': 0.98378754}, {'id': 'https://openalex.org/keywords/amantadine', 'display_name': 'Amantadine', 'score': 0.7493315}, {'id': 'https://openalex.org/keywords/strain', 'display_name': 'Strain (injury)', 'score': 0.55444336}], 'concepts': [{'id': 'https://openalex.org/C2780391423', 'wikidata': 'https://www.wikidata.org/wiki/Q42171', 'display_name': 'Rimantadine', 'level': 4, 'score': 0.98378754}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.77608955}, {'id': 'https://openalex.org/C2777374534', 'wikidata': 'https://www.wikidata.org/wiki/Q409761', 'display_name': 'Amantadine', 'level': 2, 'score': 0.7493315}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.7436528}, {'id': 'https://openalex.org/C2777546802', 'wikidata': 'https://www.wikidata.org/wiki/Q834390', 'display_name': 'Influenza A virus', 'level': 3, 'score': 0.65374285}, {'id': 'https://openalex.org/C68434959', 'wikidata': 'https://www.wikidata.org/wiki/Q1908996', 'display_name': 'Viral matrix protein', 'level': 3, 'score': 0.5764705}, {'id': 'https://openalex.org/C2778022156', 'wikidata': 'https://www.wikidata.org/wiki/Q576145', 'display_name': 'Strain (injury)', 'level': 2, 'score': 0.55444336}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.5040323}, {'id': 'https://openalex.org/C2781416681', 'wikidata': 'https://www.wikidata.org/wiki/Q287246', 'display_name': 'Orthomyxoviridae', 'level': 4, 'score': 0.4746949}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47107568}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43405432}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.32976174}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14492792}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.36233/0507-4088-2020-65-1-16-20', 'pdf_url': 'https://virusjour.elpub.ru/jour/article/download/262/158', 'source': {'id': 'https://openalex.org/S2751906956', 'display_name': 'Problems of Virology', 'issn_l': '0507-4088', 'issn': ['0507-4088', '2411-2097'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': 'https://openalex.org/P4322614451', 'host_organization_name': 'Central Research Institute for Epidemiology', 'host_organization_lineage': ['https://openalex.org/P4322614451'], 'host_organization_lineage_names': ['Central Research Institute for Epidemiology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.36233/0507-4088-2020-65-1-16-20', 'pdf_url': 'https://virusjour.elpub.ru/jour/article/download/262/158', 'source': {'id': 'https://openalex.org/S2751906956', 'display_name': 'Problems of Virology', 'issn_l': '0507-4088', 'issn': ['0507-4088', '2411-2097'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': 'https://openalex.org/P4322614451', 'host_organization_name': 'Central Research Institute for Epidemiology', 'host_organization_lineage': ['https://openalex.org/P4322614451'], 'host_organization_lineage_names': ['Central Research Institute for Epidemiology'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 14, 'referenced_works': ['https://openalex.org/W177909858', 'https://openalex.org/W1974452612', 'https://openalex.org/W1982909744', 'https://openalex.org/W2008601231', 'https://openalex.org/W2037087307', 'https://openalex.org/W2061027258', 'https://openalex.org/W2082643644', 'https://openalex.org/W2099344204', 'https://openalex.org/W2138198678', 'https://openalex.org/W2267304405', 'https://openalex.org/W2327175121', 'https://openalex.org/W2408113050', 'https://openalex.org/W2754415252', 'https://openalex.org/W4256116681'], 'related_works': ['https://openalex.org/W4295408859', 'https://openalex.org/W4290117673', 'https://openalex.org/W4200370768', 'https://openalex.org/W2418398342', 'https://openalex.org/W233802631', 'https://openalex.org/W2170312298', 'https://openalex.org/W2170001694', 'https://openalex.org/W2050331822', 'https://openalex.org/W2004189247', 'https://openalex.org/W1956785516'], 'abstract_inverted_index': {'Introduction.': [0], 'Adamantanthane-type': [1], 'drugs': [2, 38, 81], 'such': [3], 'as': [4, 21, 316], 'rimantadine': [5], 'and': [6, 129, 137, 159, 191, 268, 307], 'amantadine': [7], 'have': [8, 29], 'long': [9], 'been': [10], 'used': [11, 315], 'to': [12, 32, 94, 100, 110, 119, 203, 228, 305], 'treat': [13], 'diseases': [14], 'caused': [15], 'by': [16, 91, 143, 155], 'influenza': [17, 27, 124, 180, 198, 301, 332], 'A': [18, 45, 125, 302, 333], 'virus.': [19, 269, 334], 'However,': [20], 'a': [22, 59, 220, 234, 322], 'result': [23], 'of': [24, 61, 75, 79, 86, 98, 106, 115, 123, 132, 150, 157, 164, 179, 186, 188, 196, 214, 244, 265, 272, 281, 288, 300, 321, 325, 331], 'the': [25, 40, 50, 70, 76, 84, 92, 101, 107, 112, 120, 151, 197, 204, 215, 238, 245, 255, 266, 274, 278, 289, 298], 'mutations,': [26], 'viruses': [28], 'become': [30], 'resistant': [31, 240, 304], 'aminoadamantans.': [33], 'The': [34, 148, 193, 211, 242, 270, 291, 310], 'target': [35, 103], 'for': [36, 237, 247, 262, 285, 319], 'these': [37], 'was': [39, 153, 201, 217, 283], 'protein': [41, 51, 102], 'channel': [42], 'M2.': [43], 'Influenza': [44], 'virus': [46, 126, 182, 199, 256, 303], 'M2': [47], 'viroporin': [48], 'in': [49, 66, 83, 127, 169, 183, 208, 219, 277], 'shell': [52], 'forms': [53], 'fairly': [54], 'specific': [55], 'ion': [56], 'channels': [57], 'with': [58, 134, 176, 254], 'diameter': [60], 'about': [62], '11': [63], 'Å,': [64], 'specializing': [65], 'transporting': [67], 'protons': [68], 'inside': [69], 'viral': [71], 'particle': [72], '(virion).': [73], 'Restoration': [74], 'antiviral': [77, 113, 212], 'properties': [78, 114, 163], 'adamantanthane-type': [80], 'consists': [82], 'selection': [85], 'advanced': [87, 329], 'functional': [88], 'groups': [89], 'bound': [90], 'carbocycle': [93], 'find': [95], 'new': [96, 116, 323], 'sites': [97], 'binding': [99], 'M2.The': [104], 'рurpose': [105], 'study': [108], 'is': [109, 232], 'identify': [111], 'adamantanum': [117], 'derivatives': [118], 'pandemic': [121, 177], 'strain': [122, 178, 195], 'vitro.Material': [128], 'methods.': [130, 147, 161], 'Compounds': [131], 'aminoadamantans': [133], 'amino': [135], 'acids': [136], 'other': [138], 'organic': [139], 'molecules': [140], 'were': [141, 167, 257], 'obtained': [142, 311], 'classical': [144], 'peptide': [145], 'synthesis': [146], 'structure': [149], 'compound': [152], 'tested': [154], 'means': [156], 'physical': [158], 'chemical': [160], 'Antiviral': [162], 'synthetic': [165, 293], 'compounds': [166, 190, 205, 216, 248, 282, 287, 294, 312], 'studied': [168], 'vitro': [170], 'on': [171], 'monolayer': [172], 'MDCK': [173], 'cells': [174], 'infected': [175], 'A/California/07/2009': [181], 'two': [184, 250], 'schemes': [185], 'administration': [187], 'investigated': [189], 'virus.Results.': [192], 'reference': [194], 'A/California/07/2009(H1N1)': [200], 'sensitive': [202], 'under': [206], 'test': [207], 'varying': [209], 'degrees.': [210], 'activity': [213], 'expressed': [218], '50%': [221], 'inhibitory': [222, 275], 'concentration': [223, 276], '(IС50)': [224], 'ranging': [225], 'from': [226], '0.5': [227], '2.5': [229], 'мкM,': [230], 'which': [231], 'generally': [233], 'good': [235], 'indicator': [236], 'Rimantadine/Amantadine': [239], 'strain.Discussion.': [241], 'values': [243], 'IС50': [246], 'introduced': [249], 'hours': [251], 'before': [252], 'contact': [253], 'slightly': [258], 'higher': [259], 'than': [260], 'those': [261], 'single-moment': [263], 'introduction': [264], 'substance': [267], 'effect': [271], 'increasing': [273], 'prophylactic': [279], 'scheme': [280], 'valid': [284], 'all': [286], 'experiment.Conclusion.': [290], 'presented': [292], 'are': [295], 'active': [296], 'against': [297, 328], 'variant': [299], 'Rimantadine': [306], 'Amantadine': [308], 'preparations.': [309], 'can': [313], 'be': [314], 'model': [317], 'structures': [318], 'creation': [320], 'drug': [324], 'direct': [326], 'action': [327], 'strains': [330]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3012090543', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-12T12:20:20.654747', 'created_date': '2020-03-23'}