Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2471583489', 'doi': 'https://doi.org/10.1038/srep29301', 'title': 'RNAi-mediated knockdown of the voltage gated sodium ion channel TcNav causes mortality in Tribolium castaneum', 'display_name': 'RNAi-mediated knockdown of the voltage gated sodium ion channel TcNav causes mortality in Tribolium castaneum', 'publication_year': 2016, 'publication_date': '2016-07-14', 'ids': {'openalex': 'https://openalex.org/W2471583489', 'doi': 'https://doi.org/10.1038/srep29301', 'mag': '2471583489', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27411529', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4944135'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep29301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1038/srep29301', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5035930391', 'display_name': 'Hesham M. Abd El Halim', 'orcid': 'https://orcid.org/0000-0003-4917-4733'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Hesham M. Abd El Halim', 'raw_affiliation_strings': ['Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK'], 'affiliations': [{'raw_affiliation_string': 'Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078201412', 'display_name': 'Baida Alshukri', 'orcid': 'https://orcid.org/0000-0003-1776-2784'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Baida M. H. Alshukri', 'raw_affiliation_strings': ['Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK'], 'affiliations': [{'raw_affiliation_string': 'Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036078729', 'display_name': 'Munawar Saleem Ahmad', 'orcid': 'https://orcid.org/0000-0003-0627-3969'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Munawar S. Ahmad', 'raw_affiliation_strings': ['Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK'], 'affiliations': [{'raw_affiliation_string': 'Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090115091', 'display_name': 'Erich Y. T. Nakasu', 'orcid': 'https://orcid.org/0000-0002-6275-8349'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Erich Y. T. Nakasu', 'raw_affiliation_strings': ['Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK'], 'affiliations': [{'raw_affiliation_string': 'Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063525265', 'display_name': 'Mohammed H. Awwad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207547235', 'display_name': 'Benha University', 'ror': 'https://ror.org/03tn5ee41', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I207547235']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Mohammed H. Awwad', 'raw_affiliation_strings': ['Zoology Department, Faculty of Science, Benha University, Benha, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Zoology Department, Faculty of Science, Benha University, Benha, Egypt', 'institution_ids': ['https://openalex.org/I207547235']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080932024', 'display_name': 'Elham M. Salama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I207547235', 'display_name': 'Benha University', 'ror': 'https://ror.org/03tn5ee41', 'country_code': 'EG', 'type': 'education', 'lineage': ['https://openalex.org/I207547235']}], 'countries': ['EG'], 'is_corresponding': False, 'raw_author_name': 'Elham M. Salama', 'raw_affiliation_strings': ['Entomology Department, Faculty of Science, Benha University, Benha, Egypt'], 'affiliations': [{'raw_affiliation_string': 'Entomology Department, Faculty of Science, Benha University, Benha, Egypt', 'institution_ids': ['https://openalex.org/I207547235']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059621693', 'display_name': 'Angharad M. R. Gatehouse', 'orcid': 'https://orcid.org/0000-0002-6406-2927'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Angharad M. R. Gatehouse', 'raw_affiliation_strings': ['Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK'], 'affiliations': [{'raw_affiliation_string': 'Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048722061', 'display_name': 'Martin G. Edwards', 'orcid': 'https://orcid.org/0000-0002-4863-653X'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin G. Edwards', 'raw_affiliation_strings': ['Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK'], 'affiliations': [{'raw_affiliation_string': 'Newcastle Institute for Research on Environment and Sustainability, School of Biology, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK', 'institution_ids': ['https://openalex.org/I84884186']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'fwci': 2.363, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '6', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11075', 'display_name': 'Molecular Mechanisms of Insect Resistance to Xenobiotics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11075', 'display_name': 'Molecular Mechanisms of Insect Resistance to Xenobiotics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-silencing', 'display_name': 'RNA silencing', 'score': 0.8315792}, {'id': 'https://openalex.org/keywords/rna-interference', 'display_name': 'RNA Interference', 'score': 0.591702}, {'id': 'https://openalex.org/keywords/therapeutic-rnai', 'display_name': 'Therapeutic RNAi', 'score': 0.545443}, {'id': 'https://openalex.org/keywords/red-flour-beetle', 'display_name': 'Red flour beetle', 'score': 0.53592396}, {'id': 'https://openalex.org/keywords/rna-guided', 'display_name': 'RNA-Guided', 'score': 0.507982}], 'concepts': [{'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.9671923}, {'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.9272616}, {'id': 'https://openalex.org/C2191507', 'wikidata': 'https://www.wikidata.org/wiki/Q7277185', 'display_name': 'RNA silencing', 'level': 5, 'score': 0.8315792}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6351683}, {'id': 'https://openalex.org/C2780554804', 'wikidata': 'https://www.wikidata.org/wiki/Q837947', 'display_name': 'Red flour beetle', 'level': 3, 'score': 0.53592396}, {'id': 'https://openalex.org/C50952357', 'wikidata': 'https://www.wikidata.org/wiki/Q424960', 'display_name': 'Sodium channel', 'level': 3, 'score': 0.5054641}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.5053697}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.5048266}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.4979732}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43901652}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.432069}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.42883247}, {'id': 'https://openalex.org/C33070731', 'wikidata': 'https://www.wikidata.org/wiki/Q7218', 'display_name': 'Toxicology', 'level': 1, 'score': 0.34684134}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.28226942}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.26375586}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.20796001}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20760998}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.1595762}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019476', 'descriptor_name': 'Insect Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D061566', 'descriptor_name': 'Voltage-Gated Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001681', 'descriptor_name': 'Biological Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012330', 'descriptor_name': 'RNA, Double-Stranded', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014231', 'descriptor_name': 'Tribolium', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep29301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4944135', 'pdf_url': 'https://europepmc.org/articles/pmc4944135?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://eprint.ncl.ac.uk/fulltext.aspx?url=226971/04B0B893-8BE2-4EBE-A0BF-2D1C97AABE54.pdf&pub_id=226971', 'pdf_url': 'https://eprint.ncl.ac.uk/fulltext.aspx?url=226971/04B0B893-8BE2-4EBE-A0BF-2D1C97AABE54.pdf&pub_id=226971', 'source': {'id': 'https://openalex.org/S4306402485', 'display_name': 'Newcastle University ePrints (Newcastle Univesity)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I84884186', 'host_organization_name': 'Newcastle University', 'host_organization_lineage': ['https://openalex.org/I84884186'], 'host_organization_lineage_names': ['Newcastle University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27411529', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/srep29301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W124278207', 'https://openalex.org/W1534256444', 'https://openalex.org/W1556956901', 'https://openalex.org/W1569317193', 'https://openalex.org/W1647075334', 'https://openalex.org/W1741214660', 'https://openalex.org/W182621526', 'https://openalex.org/W1833905419', 'https://openalex.org/W1951750867', 'https://openalex.org/W1964184380', 'https://openalex.org/W1972937465', 'https://openalex.org/W1973498157', 'https://openalex.org/W1976879480', 'https://openalex.org/W1984518161', 'https://openalex.org/W1985088360', 'https://openalex.org/W1989313716', 'https://openalex.org/W1990695417', 'https://openalex.org/W1994017019', 'https://openalex.org/W1994113364', 'https://openalex.org/W2007233596', 'https://openalex.org/W2008096621', 'https://openalex.org/W2008747961', 'https://openalex.org/W2010404725', 'https://openalex.org/W2010419186', 'https://openalex.org/W2010747656', 'https://openalex.org/W2013765116', 'https://openalex.org/W2023270829', 'https://openalex.org/W2029679095', 'https://openalex.org/W2041395543', 'https://openalex.org/W2046737371', 'https://openalex.org/W2054363760', 'https://openalex.org/W2058860498', 'https://openalex.org/W2061695857', 'https://openalex.org/W2069853767', 'https://openalex.org/W2070342682', 'https://openalex.org/W2073840770', 'https://openalex.org/W2074911766', 'https://openalex.org/W2074923733', 'https://openalex.org/W2077131627', 'https://openalex.org/W2077808289', 'https://openalex.org/W2078285379', 'https://openalex.org/W2079353889', 'https://openalex.org/W2080014437', 'https://openalex.org/W2081514938', 'https://openalex.org/W2091052084', 'https://openalex.org/W2092704486', 'https://openalex.org/W2106523433', 'https://openalex.org/W2107277218', 'https://openalex.org/W2114406978', 'https://openalex.org/W2124791602', 'https://openalex.org/W2129469428', 'https://openalex.org/W2132493501', 'https://openalex.org/W2141850876', 'https://openalex.org/W2145376808', 'https://openalex.org/W2149724015', 'https://openalex.org/W2150809319', 'https://openalex.org/W2152730479', 'https://openalex.org/W2152845515', 'https://openalex.org/W2157336073', 'https://openalex.org/W2158809385', 'https://openalex.org/W2159037631', 'https://openalex.org/W2164437435', 'https://openalex.org/W2175398165', 'https://openalex.org/W2267894164', 'https://openalex.org/W2294478386', 'https://openalex.org/W2423592745', 'https://openalex.org/W253487864', 'https://openalex.org/W2583160517', 'https://openalex.org/W4298287252'], 'related_works': ['https://openalex.org/W4295095065', 'https://openalex.org/W3144044208', 'https://openalex.org/W3140077495', 'https://openalex.org/W2981114495', 'https://openalex.org/W2884140292', 'https://openalex.org/W2289304380', 'https://openalex.org/W2139684752', 'https://openalex.org/W2119212619', 'https://openalex.org/W2073840770', 'https://openalex.org/W153428622'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1, 57, 175], 'voltage-gated': [2], 'sodium': [3, 68], 'ion': [4, 13, 69], 'channel': [5, 70], '(VGSC)': [6], 'belongs': [7], 'to': [8, 36, 46, 48, 66, 102, 191], 'the': [9, 61, 67, 186], 'largest': [10], 'superfamily': [11], 'of': [12, 63, 84, 90, 106, 147, 152, 172, 177, 197], 'channels.': [14], 'Since': [15], 'VGSCs': [16], 'play': [17], 'key': [18], 'roles': [19], 'in': [20, 77, 116, 129, 166], 'physiological': [21], 'processes': [22], 'they': [23], 'are': [24], 'major': [25], 'targets': [26], 'for': [27, 51, 138, 202], 'effective': [28], 'insecticides.': [29], 'RNA': [30], 'interference': [31], '(RNAi)': [32], 'is': [33], 'widely': [34], 'used': [35], 'analyse': [37], 'gene': [38, 76, 117, 167], 'function,': [39], 'but': [40], 'recently,': [41], 'it': [42], 'has': [43], 'shown': [44], 'potential': [45], 'contribute': [47], 'novel': [49], 'strategies': [50], 'selectively': [52], 'controlling': [53, 85], 'agricultural': [54], 'insect': [55, 87, 203], 'pests.': [56], 'current': [58], 'study': [59], 'evaluates': [60], 'delivery': [62, 146], 'dsRNA': [64, 93, 148, 183], 'targeted': [65], 'paralytic': [71], 'A': [72], '(TcNa': [73], 'v': [74, 92], ')': [75], 'Tribolium': [78], 'castaneum': [79], 'as': [80], 'a': [81, 198], 'viable': [82, 199], 'means': [83], 'this': [86, 157], 'pest.': [88], 'Delivery': [89], 'TcNa': [91], 'caused': [94, 149], 'severe': [95], 'developmental': [96], 'arrest': [97], 'with': [98], 'larval': [99, 188], 'mortalities': [100, 151], 'up': [101], '73%': [103], 'post': [104], 'injection': [105, 132], 'dsRNA.': [107], 'Injected': [108], 'larvae': [109, 178], 'showed': [110], 'significant': [111, 161], '(p': [112, 125, 162], '<': [113, 126, 163], '0.05)': [114, 127, 164], 'knockdown': [115, 137, 165], 'expression': [118, 168], 'between': [119, 153], '30–60%.': [120], 'Expression': [121], 'was': [122, 158], 'also': [123], 'significantly': [124], 'reduced': [128], 'pupae': [130], 'following': [131, 169], 'causing': [133], '30%': [134], 'and': [135, 140, 155], '42%': [136], 'early': [139], 'late': [141], 'pupal': [142], 'stages,': [143], 'respectively.': [144], 'Oral': [145], 'dose-dependant': [150], '19': [154], '51.34%;': [156], 'accompanied': [159], 'by': [160], '3': [170], 'days': [171], 'continuous': [173], 'feeding.': [174], 'majority': [176], 'injected': [179], 'with,': [180], 'or': [181], 'fed,': [182], 'died': [184], 'during': [185], 'final': [187], 'stage': [189], 'prior': [190], 'pupation.': [192], 'This': [193], 'work': [194], 'provides': [195], 'evidence': [196], 'RNAi-based': [200], 'strategy': [201], 'control.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2471583489', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-09-01T06:13:16.630295', 'created_date': '2016-07-22'}