Publication Information

{'id': 'https://openalex.org/W2436885537', 'doi': None, 'title': 'The effects of diazoxide on myocardium function and the expressions of ERK and JNK in isolated spontaneous hypertension rat hearts', 'display_name': 'The effects of diazoxide on myocardium function and the expressions of ERK and JNK in isolated spontaneous hypertension rat hearts', 'publication_year': 2006, 'publication_date': '2006-02-01', 'ids': {'openalex': 'https://openalex.org/W2436885537', 'mag': '2436885537', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21186579'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pubmed/21186579', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5084351619', 'display_name': 'Hongcui Cao', 'orcid': 'https://orcid.org/0000-0002-6604-6867'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hong Cao', 'raw_affiliation_strings': ['Department of Anesthesiology,The 2nd Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology,The 2nd Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,China)', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023372355', 'display_name': 'Xiuxia Chen', 'orcid': 'https://orcid.org/0009-0002-0173-5351'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiu-Xia Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019051886', 'display_name': 'Bo Gui', 'orcid': 'https://orcid.org/0000-0002-8208-5735'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bo Gui', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100612982', 'display_name': 'Jun Wang', 'orcid': 'https://orcid.org/0000-0002-1679-1922'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jun Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017946256', 'display_name': 'Duan Shi-ming', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shi-Ming Duan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083899603', 'display_name': 'Yin-Ming Zeng', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yin-Ming Zeng', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '22', 'issue': '1', 'first_page': '50', 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.8027, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.8027, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/diazoxide', 'display_name': 'Diazoxide', 'score': 0.9578135}, {'id': 'https://openalex.org/keywords/preload', 'display_name': 'Preload', 'score': 0.8148614}, {'id': 'https://openalex.org/keywords/ischemic-preconditioning', 'display_name': 'Ischemic Preconditioning', 'score': 0.56164336}, {'id': 'https://openalex.org/keywords/cardioprotection', 'display_name': 'Cardioprotection', 'score': 0.48022443}, {'id': 'https://openalex.org/keywords/potassium-channel-blocker', 'display_name': 'Potassium channel blocker', 'score': 0.44198933}], 'concepts': [{'id': 'https://openalex.org/C2779872217', 'wikidata': 'https://www.wikidata.org/wiki/Q420009', 'display_name': 'Diazoxide', 'level': 3, 'score': 0.9578135}, {'id': 'https://openalex.org/C48277249', 'wikidata': 'https://www.wikidata.org/wiki/Q1406926', 'display_name': 'Preload', 'level': 3, 'score': 0.8148614}, {'id': 'https://openalex.org/C2778921608', 'wikidata': 'https://www.wikidata.org/wiki/Q2002035', 'display_name': 'Ventricle', 'level': 2, 'score': 0.6896002}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.67273265}, {'id': 'https://openalex.org/C146957229', 'wikidata': 'https://www.wikidata.org/wiki/Q1266915', 'display_name': 'Perfusion', 'level': 2, 'score': 0.6661066}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5724252}, {'id': 'https://openalex.org/C2779311647', 'wikidata': 'https://www.wikidata.org/wiki/Q17148404', 'display_name': 'Ischemic preconditioning', 'level': 3, 'score': 0.56164336}, {'id': 'https://openalex.org/C83743174', 'wikidata': 'https://www.wikidata.org/wiki/Q423778', 'display_name': 'Potassium channel', 'level': 2, 'score': 0.54567325}, {'id': 'https://openalex.org/C2779676291', 'wikidata': 'https://www.wikidata.org/wiki/Q25325349', 'display_name': 'Cardioprotection', 'level': 3, 'score': 0.48022443}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4794575}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4713183}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45735943}, {'id': 'https://openalex.org/C2778457506', 'wikidata': 'https://www.wikidata.org/wiki/Q7234689', 'display_name': 'Potassium channel blocker', 'level': 3, 'score': 0.44198933}, {'id': 'https://openalex.org/C2780114680', 'wikidata': 'https://www.wikidata.org/wiki/Q1413991', 'display_name': 'Reperfusion injury', 'level': 3, 'score': 0.41750038}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.3763565}, {'id': 'https://openalex.org/C178853913', 'wikidata': 'https://www.wikidata.org/wiki/Q1642137', 'display_name': 'Hemodynamics', 'level': 2, 'score': 0.20973861}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003981', 'descriptor_name': 'Diazoxide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017202', 'descriptor_name': 'Myocardial Ischemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003981', 'descriptor_name': 'Diazoxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048670', 'descriptor_name': 'MAP Kinase Kinase 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048670', 'descriptor_name': 'MAP Kinase Kinase 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017202', 'descriptor_name': 'Myocardial Ischemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017202', 'descriptor_name': 'Myocardial Ischemia', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015428', 'descriptor_name': 'Myocardial Reperfusion Injury', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011918', 'descriptor_name': 'Rats, Inbred SHR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pubmed/21186579', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21186579', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032873295', 'https://openalex.org/W3032165069', 'https://openalex.org/W3031769436', 'https://openalex.org/W3031642309', 'https://openalex.org/W3030517493', 'https://openalex.org/W3030413861', 'https://openalex.org/W3029448007', 'https://openalex.org/W3029176078', 'https://openalex.org/W3028888158', 'https://openalex.org/W3028703100', 'https://openalex.org/W2752275381', 'https://openalex.org/W2588148232', 'https://openalex.org/W2414566809', 'https://openalex.org/W2393625805', 'https://openalex.org/W2384738281', 'https://openalex.org/W2384024204', 'https://openalex.org/W2366853764', 'https://openalex.org/W2365989048', 'https://openalex.org/W2362317748', 'https://openalex.org/W2352518072'], 'abstract_inverted_index': {'AIM': [0], 'To': [1], 'investigate': [2], 'the': [3, 9, 55, 69, 90, 172, 204, 212, 243, 285, 291], 'effect': [4, 268], 'of': [5, 11, 76, 97, 174, 206, 214, 245, 253, 287, 293], 'diazoxide': [6, 19, 107, 163, 249, 279, 298], 'preconditioning': [7, 20, 280, 299], 'and': [8, 13, 37, 80, 108, 184, 195, 222, 236, 257, 290], 'role': [10], 'ERK': [12, 215, 246, 288], 'JNK': [14, 254, 294], 'in': [15, 22, 193, 216, 220, 255, 297, 300], 'cellular': [16], 'signaling': [17], 'during': [18], 'protection': [21], 'isolated': [23, 32, 301], 'spontaneous': [24], 'hypertension': [25], 'rat': [26], '(SHR)': [27], 'hearts.': [28, 303], 'METHODS': [29], 'Hearts': [30], 'were': [31, 45, 57, 71, 92, 191, 218, 260], 'from': [33], 'male': [34], 'SHR': [35, 302], 'rats,': [36], 'perfused': [38], 'on': [39], 'a': [40], 'Langendorff': [41], 'apparatus.': [42], 'Five': [43], 'groups': [44, 197, 224, 259], 'considered': [46], '(n': [47], '=': [48], '6).': [49], 'Con:': [50], 'after': [51], '40': [52], 'min': [53, 61, 66, 78, 82, 87, 99, 110, 117, 137, 141, 147, 161], 'perfusion': [54, 144], 'hearts': [56, 70, 91], 'submitted': [58], 'to': [59, 85, 115], '25': [60, 86, 116, 146], 'ischemia': [62, 79], 'followed': [63, 138], 'by': [64, 139, 248, 272], '30': [65, 140], 'reperfusion.': [67], 'IP:': [68], 'preconditioned': [72, 93], 'with': [73, 94, 102, 121, 169, 209], '2': [74, 95], 'periods': [75, 96], '5': [77, 109], '10': [81, 98, 136, 160], 'reperfusion': [83, 113], 'prior': [84, 114], 'ischemia.': [88, 118, 148], 'DP:': [89, 151], 'K-H': [100, 111, 142], 'solution': [101, 112, 143], '50': [103], 'micromol': [104, 123, 153], 'x': [105, 124, 154], 'L(-1)': [106, 125, 155], '5-HD:': [119], 'perfuse': [120], '100': [122, 152], '5-HD': [126, 149, 156, 235, 240], '(a': [127], 'special': [128], 'mitochondrial': [129], 'ATP': [130], 'sensitive': [131], 'potassium': [132], 'channel': [133], 'blocker)': [134], 'for': [135, 159], 'before': [145, 162], '+': [150, 180], 'was': [157, 231], 'given': [158], 'preconditioning.': [164, 250], 'RESULTS': [165], 'During': [166], 'reperfusion,': [167, 207], 'comparing': [168], 'Con': [170, 210, 237], 'group,': [171, 211, 238], 'recoveries': [173], 'left': [175, 185], 'ventricle': [176, 186], 'developed': [177], 'pressure': [178, 189], '(LVDP),': [179], 'dP/dt(max),': [181], '-': [182], 'dP/dt(max)': [183], 'end': [187, 205], 'diastolic': [188], '(LVEDP)': [190], 'improved': [192], 'IP': [194, 221, 256], 'DP': [196, 223, 258], '(P': [198, 225, 262], '<': [199, 226, 263], '0.01': [200, 227], 'vs': [201, 228, 265], 'Con).': [202], 'At': [203], 'compared': [208], 'expression': [213, 244, 252, 289, 295], 'myocardium': [217], 'higher': [219], 'Con),': [229, 266], 'there': [230], 'no': [232], 'significance': [233], 'between': [234], 'but': [239], "couldn't": [241], 'inhibit': [242], 'induced': [247], 'The': [251], 'decreased': [261], '0.05': [264], 'this': [267], 'could': [269, 281], 'been': [270], 'inhibited': [271], '5-HD.': [273], 'CONCLUSION': [274], 'These': [275], 'results': [276], 'indicated': [277], 'that': [278], 'mimic': [282], 'ischemic': [283], 'preconditioning,': [284], 'activation': [286], 'declining': [292], 'involved': [296]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2436885537', 'counts_by_year': [], 'updated_date': '2024-12-12T15:41:33.081333', 'created_date': '2016-06-24'}