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'neurogastrointestinal': [27], 'encephalomyopathy': [28], '(MNGIE)': [29], 'やmtDNA複製酵素': [30], '(POLG)': [31], '異常症のような,': [32], '核DNAの異常が原因で二次的にmtDNA変異が蓄積し,': [33], '全身性の様々な臓器障害を呈するヒトミトコンドリア病が相次いで報告されている.': [34], '特に': [35], 'MNGIE': [36], 'は,': [37], '全身のmtDNAに多様な変異,': [38], '多重欠失': [39], '(multiple': [40], 'deletions),': [41], '量的枯渇': [42], '(depletion),': [43], 'さらに配列特異的な点変異': [44], '(site-specific': [45], 'point': [46], 'が蓄積し,': [48], '特徴的な臨床像を示す.': [49], 'これらの疾患におけるmtDNA損傷の蓄積メカニズムを検討することは,': [50], 'ヒトの加齢に伴う臓器障害や老化機構を解き明かす上で,': [51], '極めて重要な鍵になると考えられる.': [52]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2433011597', 'counts_by_year': [], 'updated_date': '2024-09-10T02:04:17.868143', 'created_date': '2016-06-24'}