Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4284967787', 'doi': 'https://doi.org/10.1089/cell.2022.0055', 'title': 'Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming', 'display_name': 'Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming', 'publication_year': 2022, 'publication_date': '2022-10-01', 'ids': {'openalex': 'https://openalex.org/W4284967787', 'doi': 'https://doi.org/10.1089/cell.2022.0055', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35802497'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/cell.2022.0055', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180034465', 'display_name': 'Cellular Reprogramming', 'issn_l': '2152-4971', 'issn': ['2152-4971', '2152-4998'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://digital.csic.es/bitstream/10261/296089/4/Modeling%20Mitochondrial%20Encephalomyopathy_Povea_Postprint_Art2022.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047037542', 'display_name': 'Suleva Povea-Cabello', 'orcid': 'https://orcid.org/0000-0003-3804-1724'}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I4210115082', 'display_name': 'Centro de Investigación Biomédica en Red', 'ror': 'https://ror.org/02g87qh62', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4210115082', 'https://openalex.org/I4387152914']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Suleva Povea-Cabello', 'raw_affiliation_strings': ['Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037732314', 'display_name': 'Marina Villanueva-Paz', 'orcid': 'https://orcid.org/0000-0003-4728-201X'}, 'institutions': [{'id': 'https://openalex.org/I4210164724', 'display_name': 'Instituto de Investigación Biomédica de Málaga', 'ror': 'https://ror.org/05n3asa33', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I4210164724']}, {'id': 'https://openalex.org/I82767444', 'display_name': 'Universidad de Málaga', 'ror': 'https://ror.org/036b2ww28', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I82767444']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Marina Villanueva-Paz', 'raw_affiliation_strings': ['Unidad de Gestión Clínica de Gastroenterología, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Unidad de Gestión Clínica de Gastroenterología, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.', 'institution_ids': ['https://openalex.org/I4210164724', 'https://openalex.org/I82767444']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031114658', 'display_name': 'Irene Villalón-García', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I4210115082', 'display_name': 'Centro de Investigación Biomédica en Red', 'ror': 'https://ror.org/02g87qh62', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4210115082', 'https://openalex.org/I4387152914']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Irene Villalón-García', 'raw_affiliation_strings': ['Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016220313', 'display_name': 'Marta Talaverón-Rey', 'orcid': 'https://orcid.org/0000-0002-5006-3814'}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I4210115082', 'display_name': 'Centro de Investigación Biomédica en Red', 'ror': 'https://ror.org/02g87qh62', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4210115082', 'https://openalex.org/I4387152914']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Marta Talaverón-Rey', 'raw_affiliation_strings': ['Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011675522', 'display_name': 'Mónica Álvarez-Córdoba', 'orcid': 'https://orcid.org/0000-0002-7596-8708'}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I4210115082', 'display_name': 'Centro de Investigación Biomédica en Red', 'ror': 'https://ror.org/02g87qh62', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4210115082', 'https://openalex.org/I4387152914']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Mónica Álvarez-Cordoba', 'raw_affiliation_strings': ['Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047814627', 'display_name': 'Juan M. Suárez-Rivero', 'orcid': 'https://orcid.org/0000-0002-6260-7284'}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I4210115082', 'display_name': 'Centro de Investigación Biomédica en Red', 'ror': 'https://ror.org/02g87qh62', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4210115082', 'https://openalex.org/I4387152914']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Juan M. Suárez-Rivero', 'raw_affiliation_strings': ['Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053749651', 'display_name': 'María Ángeles Montes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'María Ángeles Montes', 'raw_affiliation_strings': ['Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I95013407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070193575', 'display_name': 'Antonio Rodríguez Moreno', 'orcid': 'https://orcid.org/0000-0002-8078-6175'}, 'institutions': [{'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Antonio Rodríguez-Moreno', 'raw_affiliation_strings': ['Laboratorio de Neurociencia Celular y Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Neurociencia Celular y Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I95013407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029805660', 'display_name': 'Yuniesky Andrade‐Talavera', 'orcid': 'https://orcid.org/0000-0002-5295-0169'}, 'institutions': [{'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Yuniesky Andrade-Talavera', 'raw_affiliation_strings': ['Laboratorio de Neurociencia Celular y Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Laboratorio de Neurociencia Celular y Plasticidad, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I95013407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012284638', 'display_name': 'José Á. Armengol', 'orcid': 'https://orcid.org/0000-0002-9452-7828'}, 'institutions': [{'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'José A. Armengol', 'raw_affiliation_strings': ['Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I95013407']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005530192', 'display_name': 'José A. Sánchez‐Alcázar', 'orcid': 'https://orcid.org/0000-0001-9705-1469'}, 'institutions': [{'id': 'https://openalex.org/I4210111405', 'display_name': 'Centro Andaluz de Biología del Desarrollo', 'ror': 'https://ror.org/01v5e3436', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210111405', 'https://openalex.org/I918821925', 'https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I4210115082', 'display_name': 'Centro de Investigación Biomédica en Red', 'ror': 'https://ror.org/02g87qh62', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4210115082', 'https://openalex.org/I4387152914']}, {'id': 'https://openalex.org/I95013407', 'display_name': 'Universidad Pablo de Olavide', 'ror': 'https://ror.org/02z749649', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I95013407']}, {'id': 'https://openalex.org/I2801357902', 'display_name': 'Instituto de Salud Carlos III', 'ror': 'https://ror.org/00ca2c886', 'country_code': 'ES', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801357902', 'https://openalex.org/I4387152914']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'José A. Sánchez-Alcázar', 'raw_affiliation_strings': ['Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro Andaluz de Biología del Desarrollo (CABD-CSIC-Universidad Pablo de Olavide), and Centro de Investigación Biomédica en Red: Enfermedades Raras, Instituto de Salud Carlos III, Sevilla, Spain.', 'institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5005530192'], 'corresponding_institution_ids': ['https://openalex.org/I4210111405', 'https://openalex.org/I4210115082', 'https://openalex.org/I95013407', 'https://openalex.org/I2801357902'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.466, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.615055, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 81}, 'biblio': {'volume': '24', 'issue': '5', 'first_page': '294', 'last_page': '303'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase Function and Regulation', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mitochondrial-encephalomyopathy', 'display_name': 'Mitochondrial encephalomyopathy', 'score': 0.985625}, {'id': 'https://openalex.org/keywords/lactic-acidosis', 'display_name': 'Lactic acidosis', 'score': 0.8747989}, {'id': 'https://openalex.org/keywords/melas-syndrome', 'display_name': 'MELAS syndrome', 'score': 0.8018172}, {'id': 'https://openalex.org/keywords/mitochondrial-disease', 'display_name': 'Mitochondrial disease', 'score': 0.7282573}, {'id': 'https://openalex.org/keywords/mitochondria', 'display_name': 'Mitochondria', 'score': 0.524607}, {'id': 'https://openalex.org/keywords/metabolic-regulation', 'display_name': 'Metabolic Regulation', 'score': 0.519742}, {'id': 'https://openalex.org/keywords/mitochondrial-dysfunction', 'display_name': 'Mitochondrial Dysfunction', 'score': 0.519369}, {'id': 'https://openalex.org/keywords/mitochondrial-fission', 'display_name': 'Mitochondrial Fission', 'score': 0.503116}, {'id': 'https://openalex.org/keywords/reprogramming', 'display_name': 'Reprogramming', 'score': 0.4197843}], 'concepts': [{'id': 'https://openalex.org/C2779799828', 'wikidata': 'https://www.wikidata.org/wiki/Q6881866', 'display_name': 'Mitochondrial encephalomyopathy', 'level': 4, 'score': 0.985625}, {'id': 'https://openalex.org/C2780317664', 'wikidata': 'https://www.wikidata.org/wiki/Q1500373', 'display_name': 'Lactic acidosis', 'level': 2, 'score': 0.8747989}, {'id': 'https://openalex.org/C2776287708', 'wikidata': 'https://www.wikidata.org/wiki/Q2666433', 'display_name': 'MELAS syndrome', 'level': 5, 'score': 0.8018172}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7981677}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.7397809}, {'id': 'https://openalex.org/C2777614518', 'wikidata': 'https://www.wikidata.org/wiki/Q935710', 'display_name': 'Mitochondrial disease', 'level': 4, 'score': 0.7282573}, {'id': 'https://openalex.org/C2775833069', 'wikidata': 'https://www.wikidata.org/wiki/Q6881881', 'display_name': 'Mitochondrial myopathy', 'level': 4, 'score': 0.619405}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.5579323}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.52610594}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4268458}, {'id': 'https://openalex.org/C77255625', 'wikidata': 'https://www.wikidata.org/wiki/Q402093', 'display_name': 'Reprogramming', 'level': 3, 'score': 0.4197843}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19101462}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.17405668}], 'mesh': [{'descriptor_ui': 'D000140', 'descriptor_name': 'Acidosis, Lactic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017241', 'descriptor_name': 'MELAS Syndrome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000140', 'descriptor_name': 'Acidosis, Lactic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017241', 'descriptor_name': 'MELAS Syndrome', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020521', 'descriptor_name': 'Stroke', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1089/cell.2022.0055', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180034465', 'display_name': 'Cellular Reprogramming', 'issn_l': '2152-4971', 'issn': ['2152-4971', '2152-4998'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320443', 'host_organization_name': 'Mary Ann Liebert, Inc.', 'host_organization_lineage': ['https://openalex.org/P4310320443'], 'host_organization_lineage_names': ['Mary Ann Liebert, Inc.'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10261/296089', 'pdf_url': 'https://digital.csic.es/bitstream/10261/296089/4/Modeling%20Mitochondrial%20Encephalomyopathy_Povea_Postprint_Art2022.pdf', 'source': {'id': 'https://openalex.org/S4306400616', 'display_name': 'DIGITAL.CSIC (Spanish National Research Council (CSIC))', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I134820265', 'host_organization_name': 'Consejo Superior de Investigaciones Científicas', 'host_organization_lineage': ['https://openalex.org/I134820265'], 'host_organization_lineage_names': ['Consejo Superior de Investigaciones Científicas'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35802497', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/10261/296089', 'pdf_url': 'https://digital.csic.es/bitstream/10261/296089/4/Modeling%20Mitochondrial%20Encephalomyopathy_Povea_Postprint_Art2022.pdf', 'source': {'id': 'https://openalex.org/S4306400616', 'display_name': 'DIGITAL.CSIC (Spanish National Research Council (CSIC))', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I134820265', 'host_organization_name': 'Consejo Superior de Investigaciones Científicas', 'host_organization_lineage': ['https://openalex.org/I134820265'], 'host_organization_lineage_names': ['Consejo Superior de Investigaciones Científicas'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1484678674', 'https://openalex.org/W1806909159', 'https://openalex.org/W1967729506', 'https://openalex.org/W1976690565', 'https://openalex.org/W1977049211', 'https://openalex.org/W2002739600', 'https://openalex.org/W2013255748', 'https://openalex.org/W2031552158', 'https://openalex.org/W2045997356', 'https://openalex.org/W2062840593', 'https://openalex.org/W2067091330', 'https://openalex.org/W2095546080', 'https://openalex.org/W2136541538', 'https://openalex.org/W2186745986', 'https://openalex.org/W2254992479', 'https://openalex.org/W2398660216', 'https://openalex.org/W2521543069', 'https://openalex.org/W2560353941', 'https://openalex.org/W2686521530', 'https://openalex.org/W2750975167', 'https://openalex.org/W2783396730', 'https://openalex.org/W2805679083', 'https://openalex.org/W2916632364', 'https://openalex.org/W2946400231', 'https://openalex.org/W2971391883', 'https://openalex.org/W3005686642', 'https://openalex.org/W3016385000', 'https://openalex.org/W3089218617', 'https://openalex.org/W3120595412', 'https://openalex.org/W3186531232', 'https://openalex.org/W3197212023', 'https://openalex.org/W4244588350'], 'related_works': ['https://openalex.org/W4322723156', 'https://openalex.org/W4296051312', 'https://openalex.org/W4284967787', 'https://openalex.org/W3095420847', 'https://openalex.org/W251901857', 'https://openalex.org/W2411853324', 'https://openalex.org/W2400138124', 'https://openalex.org/W2170279871', 'https://openalex.org/W2067109565', 'https://openalex.org/W188647187'], 'abstract_inverted_index': {'Mitochondrial': [0, 58], 'diseases': [1, 20], 'are': [2, 21], 'a': [3, 110], 'heterogeneous': [4], 'group': [5], 'of': [6, 32, 83, 103, 114, 132, 147, 154], 'rare': [7], 'genetic': [8], 'disorders': [9], 'caused': [10, 69], 'by': [11, 70], 'mutations': [12], 'in': [13, 39, 47, 74, 99, 150], 'nuclear': [14], 'or': [15, 54], 'mitochondrial': [16, 40], 'DNA': [17], '(mtDNA).': [18], 'These': [19], 'frequently': [22], 'multisystemic,': [23], 'although': [24], 'mainly': [25, 68], 'affect': [26], 'tissues': [27], 'that': [28, 50], 'require': [29], 'large': [30], 'amounts': [31], 'energy': [33], 'such': [34], 'as': [35, 126, 128], 'the': [36, 71, 75, 81, 95, 100, 123, 145], 'brain.': [37], 'Mutations': [38], 'transfer': [41], 'RNA': [42], '(mt-tRNA)': [43], 'lead': [44], 'to': [45, 80, 93, 143], 'defects': [46], 'protein': [48], 'translation': [49], 'may': [51], 'compromise': [52], 'some': [53], 'all': [55], 'mtDNA-encoded': [56], 'proteins.': [57], 'Encephalomyopathy,': [59], 'Lactic': [60], 'Acidosis': [61], 'and': [62], 'Stroke-like': [63], 'episodes': [64], '(MELAS)': [65], 'syndrome': [66], 'is': [67], 'm.3243A>G': [72, 148], 'mutation': [73, 149], 'mt-tRNALeu(UUR)': [76], '(MT-TL1)': [77], 'gene.': [78], 'Owing': [79], 'lack': [82], 'proper': [84], 'animal': [85], 'models,': [86], 'several': [87], 'cellular': [88], 'models': [89], 'have': [90], 'been': [91], 'developed': [92], 'study': [94, 144], 'disease,': [96], 'providing': [97], 'insight': [98], 'pathophysiological': [101], 'mechanisms': [102], 'MELAS.': [104], 'In': [105, 137], 'this': [106, 151], 'study,': [107], 'we': [108, 139], 'show': [109], 'successful': [111], 'direct': [112], 'conversion': [113], 'MELAS': [115, 155], 'patient-derived': [116], 'fibroblasts': [117], 'into': [118], 'induced': [119], 'neurons': [120], '(iNs)': [121], 'for': [122], 'first': [124], 'time,': [125], 'well': [127], 'an': [129], 'electrophysiological': [130], 'characterization': [131], 'iNs': [133], 'cocultured': [134], 'with': [135], 'astrocytes.': [136], 'addition,': [138], 'performed': [140], 'bioenergetics': [141], 'analysis': [142], 'consequences': [146], 'neuronal': [152], 'model': [153], 'syndrome.': [156]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4284967787', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-09-13T16:52:12.191880', 'created_date': '2022-07-10'}