Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2428079334', 'doi': 'https://doi.org/10.1152/ajpcell.1983.245.3.c203', 'title': 'Ca2+ regulation of tight-junction permeability and structure in Necturus gallbladder', 'display_name': 'Ca2+ regulation of tight-junction permeability and structure in Necturus gallbladder', 'publication_year': 1983, 'publication_date': '1983-09-01', 'ids': {'openalex': 'https://openalex.org/W2428079334', 'doi': 'https://doi.org/10.1152/ajpcell.1983.245.3.c203', 'mag': '2428079334', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6412561'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1983.245.3.c203', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050798679', 'display_name': 'Carlos E. Palant', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. E. Palant', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109332735', 'display_name': 'Michael E. Duffey', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M. E. Duffey', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027391505', 'display_name': 'Basab K. Mookerjee', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'B. K. Mookerjee', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076500780', 'display_name': 'Shu Cheow Ho', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S. Ho', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065192400', 'display_name': 'Carl J. Bentzel', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C. J. Bentzel', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.458, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 118, 'citation_normalized_percentile': {'value': 0.975688, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '245', 'issue': '3', 'first_page': 'C203', 'last_page': 'C212'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11872', 'display_name': 'Barrier Structure and Function Studies', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11480', 'display_name': 'Connexins and lens biology', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9769, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/necturus', 'display_name': 'Necturus', 'score': 0.96715367}, {'id': 'https://openalex.org/keywords/paracellular-transport', 'display_name': 'Paracellular transport', 'score': 0.8864684}, {'id': 'https://openalex.org/keywords/transcellular', 'display_name': 'Transcellular', 'score': 0.8344593}, {'id': 'https://openalex.org/keywords/transepithelial-potential-difference', 'display_name': 'Transepithelial potential difference', 'score': 0.59638584}, {'id': 'https://openalex.org/keywords/hyperpolarization', 'display_name': 'Hyperpolarization', 'score': 0.42882147}], 'concepts': [{'id': 'https://openalex.org/C2777144155', 'wikidata': 'https://www.wikidata.org/wiki/Q641652', 'display_name': 'Necturus', 'level': 3, 'score': 0.96715367}, {'id': 'https://openalex.org/C60903277', 'wikidata': 'https://www.wikidata.org/wiki/Q2051926', 'display_name': 'Paracellular transport', 'level': 4, 'score': 0.8864684}, {'id': 'https://openalex.org/C176285220', 'wikidata': 'https://www.wikidata.org/wiki/Q7833830', 'display_name': 'Transcellular', 'level': 2, 'score': 0.8344593}, {'id': 'https://openalex.org/C177779419', 'wikidata': 'https://www.wikidata.org/wiki/Q1053832', 'display_name': 'Tight junction', 'level': 2, 'score': 0.8216351}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.6525744}, {'id': 'https://openalex.org/C28938303', 'wikidata': 'https://www.wikidata.org/wiki/Q17122952', 'display_name': 'Transepithelial potential difference', 'level': 4, 'score': 0.59638584}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50995386}, {'id': 'https://openalex.org/C120882062', 'wikidata': 'https://www.wikidata.org/wiki/Q28352', 'display_name': 'Permeability (electromagnetism)', 'level': 3, 'score': 0.5013573}, {'id': 'https://openalex.org/C87555872', 'wikidata': 'https://www.wikidata.org/wiki/Q3141316', 'display_name': 'Ultrastructure', 'level': 2, 'score': 0.48549798}, {'id': 'https://openalex.org/C181911157', 'wikidata': 'https://www.wikidata.org/wiki/Q389844', 'display_name': 'Membrane potential', 'level': 2, 'score': 0.46113268}, {'id': 'https://openalex.org/C29350253', 'wikidata': 'https://www.wikidata.org/wiki/Q189073', 'display_name': 'Cell junction', 'level': 3, 'score': 0.45100135}, {'id': 'https://openalex.org/C131453863', 'wikidata': 'https://www.wikidata.org/wiki/Q1641079', 'display_name': 'Hyperpolarization (physics)', 'level': 3, 'score': 0.42882147}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.33113515}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3247553}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27756956}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.25147265}, {'id': 'https://openalex.org/C99975950', 'wikidata': 'https://www.wikidata.org/wiki/Q911011', 'display_name': 'Ion transporter', 'level': 3, 'score': 0.24724123}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.16626492}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1559582}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C66974803', 'wikidata': 'https://www.wikidata.org/wiki/Q10359898', 'display_name': 'Nuclear magnetic resonance spectroscopy', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005704', 'descriptor_name': 'Gallbladder', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D007365', 'descriptor_name': 'Intercellular Junctions', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000001', 'descriptor_name': 'Calcimycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000001', 'descriptor_name': 'Calcimycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005614', 'descriptor_name': 'Freeze Fracturing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005704', 'descriptor_name': 'Gallbladder', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007365', 'descriptor_name': 'Intercellular Junctions', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007365', 'descriptor_name': 'Intercellular Junctions', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D007365', 'descriptor_name': 'Intercellular Junctions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009092', 'descriptor_name': 'Mucous Membrane', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009092', 'descriptor_name': 'Mucous Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009337', 'descriptor_name': 'Necturus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1983.245.3.c203', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6412561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1500700435', 'https://openalex.org/W1946036006', 'https://openalex.org/W1968530847', 'https://openalex.org/W1972959382', 'https://openalex.org/W1973828738', 'https://openalex.org/W1978462371', 'https://openalex.org/W1983890950', 'https://openalex.org/W2012906347', 'https://openalex.org/W2016842546', 'https://openalex.org/W2027321089', 'https://openalex.org/W2029045868', 'https://openalex.org/W2035876533', 'https://openalex.org/W2037627249', 'https://openalex.org/W2045084108', 'https://openalex.org/W2047871421', 'https://openalex.org/W2050466991', 'https://openalex.org/W2065291819', 'https://openalex.org/W2065836489', 'https://openalex.org/W2075994960', 'https://openalex.org/W2086971581', 'https://openalex.org/W2087389581', 'https://openalex.org/W2138067074', 'https://openalex.org/W2155291985', 'https://openalex.org/W2314841077', 'https://openalex.org/W3185889544'], 'related_works': ['https://openalex.org/W4211180241', 'https://openalex.org/W39007305', 'https://openalex.org/W2428079334', 'https://openalex.org/W2418502380', 'https://openalex.org/W2171148360', 'https://openalex.org/W2138343267', 'https://openalex.org/W2089529797', 'https://openalex.org/W2077340378', 'https://openalex.org/W2071488647', 'https://openalex.org/W1994998441'], 'abstract_inverted_index': {'To': [0], 'explore': [1], 'the': [2, 9, 20, 26, 106, 137, 147, 157], 'role': [3], 'of': [4, 108, 136], 'Ca2+': [5, 16, 21, 69], 'in': [6, 40, 76, 83, 128, 146, 163], 'tight-junction': [7, 47], 'permeability,': [8], 'Necturus': [10], 'gallbladder': [11], 'was': [12], 'exposed': [13], 'to': [14, 19, 25, 32, 86, 96], 'varying': [15], 'concentrations': [17], 'and': [18, 61, 119, 143, 159], 'ionophore': [22], 'A23187': [23, 71, 154], 'added': [24], 'mucosal': [27, 138], 'side': [28], '(1.9': [29], 'X': [30, 34], '10(-6)': [31], '6.8': [33], '10(-5)': [35], 'M).': [36], 'Electrophysiological': [37], 'parameters': [38], 'measured': [39], 'an': [41, 73, 81], 'Ussing-type': [42], 'chamber': [43], 'were': [44, 122], 'correlated': [45], 'with': [46, 114, 132], 'morphology': [48], 'revealed': [49], 'by': [50, 80], 'freeze-fracture': [51], 'electron': [52], 'microscopy.': [53], 'In': [54, 66], 'Ca2+-free': [55], 'bathing': [56], 'media,': [57, 70], 'transepithelial': [58, 77, 84, 129, 167], 'resistance': [59, 85, 130, 151], 'decreases': [60], 'tight-junctional': [62], 'ultrastructure': [63], 'is': [64], 'fragmented.': [65], '1.8': [67], 'mM': [68], 'induces': [72], 'initial': [74, 126], 'drop': [75], 'resistance,': [78], 'followed': [79], 'increase': [82, 111], 'a': [87, 133, 144], 'value': [88], '20%': [89], 'above': [90], 'base': [91], 'line.': [92], 'At': [93], 'peak': [94], 'response': [95], 'A23187,': [97], 'NaCl': [98], 'diffusion': [99], 'potentials': [100], 'decrease.': [101], 'Freeze-fracture': [102], 'replicas': [103], 'reveal': [104], 'that': [105], 'number': [107], 'junctional': [109, 115], 'strands': [110], 'pari': [112], 'passu': [113], 'depth.': [116], 'Both': [117], 'physiological': [118], 'morphological': [120], 'changes': [121], 'partially': [123], 'reversible.': [124], 'The': [125], 'decrease': [127, 145], 'coincided': [131], 'persistent': [134], 'hyperpolarization': [135], 'cell': [139, 149], 'membrane': [140, 150], 'potential': [141], 'difference': [142], 'mucosal-to-serosal': [148], 'ratio.': [152], 'Thus': [153], 'alters': [155], 'both': [156], 'transcellular': [158], 'paracellular': [160], 'pathway,': [161], 'resulting': [162], 'opposing': [164], 'effects': [165], 'on': [166], 'resistance.': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2428079334', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T08:25:45.132742', 'created_date': '2016-06-24'}