Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2424294941', 'doi': 'https://doi.org/10.1152/ajpcell.1981.241.5.c250', 'title': 'Isoproterenol-induced current changes in glands of frog skin', 'display_name': 'Isoproterenol-induced current changes in glands of frog skin', 'publication_year': 1981, 'publication_date': '1981-11-01', 'ids': {'openalex': 'https://openalex.org/W2424294941', 'doi': 'https://doi.org/10.1152/ajpcell.1981.241.5.c250', 'mag': '2424294941', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6975574'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1981.241.5.c250', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089238504', 'display_name': 'Ian G. Thompson', 'orcid': 'https://orcid.org/0000-0003-3445-8696'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'I. G. Thompson', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103541064', 'display_name': 'John W. Mills', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J. W. Mills', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.361, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.772244, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '241', 'issue': '5', 'first_page': 'C250', 'last_page': 'C257'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10971', 'display_name': 'Olfactory and Sensory Function Studies', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10704', 'display_name': 'Advancements in Transdermal Drug Delivery', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amiloride', 'display_name': 'Amiloride', 'score': 0.98417866}, {'id': 'https://openalex.org/keywords/frog-skin', 'display_name': 'Frog Skin', 'score': 0.8498744}, {'id': 'https://openalex.org/keywords/isoprenaline', 'display_name': 'Isoprenaline', 'score': 0.47327825}, {'id': 'https://openalex.org/keywords/choline-chloride', 'display_name': 'Choline chloride', 'score': 0.46849567}], 'concepts': [{'id': 'https://openalex.org/C2779608910', 'wikidata': 'https://www.wikidata.org/wiki/Q419995', 'display_name': 'Amiloride', 'level': 3, 'score': 0.98417866}, {'id': 'https://openalex.org/C2777103240', 'wikidata': 'https://www.wikidata.org/wiki/Q18356482', 'display_name': 'Frog Skin', 'level': 3, 'score': 0.8498744}, {'id': 'https://openalex.org/C2779133857', 'wikidata': 'https://www.wikidata.org/wiki/Q285911', 'display_name': 'Ouabain', 'level': 3, 'score': 0.76281583}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.68031865}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.65179974}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6396195}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.6027224}, {'id': 'https://openalex.org/C2778151854', 'wikidata': 'https://www.wikidata.org/wiki/Q423364', 'display_name': 'Propranolol', 'level': 2, 'score': 0.5917002}, {'id': 'https://openalex.org/C2776090920', 'wikidata': 'https://www.wikidata.org/wiki/Q415550', 'display_name': 'Isoprenaline', 'level': 3, 'score': 0.47327825}, {'id': 'https://openalex.org/C2778375661', 'wikidata': 'https://www.wikidata.org/wiki/Q2964153', 'display_name': 'Choline chloride', 'level': 2, 'score': 0.46849567}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.3620264}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21655682}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19029322}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.14197448}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007545', 'descriptor_name': 'Isoproterenol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012627', 'descriptor_name': 'Sebaceous Glands', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D012879', 'descriptor_name': 'Skin Physiological Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000584', 'descriptor_name': 'Amiloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004553', 'descriptor_name': 'Electric Conductivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007545', 'descriptor_name': 'Isoproterenol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010042', 'descriptor_name': 'Ouabain', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010042', 'descriptor_name': 'Ouabain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011433', 'descriptor_name': 'Propranolol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011433', 'descriptor_name': 'Propranolol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011892', 'descriptor_name': 'Rana catesbeiana', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012627', 'descriptor_name': 'Sebaceous Glands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012627', 'descriptor_name': 'Sebaceous Glands', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajpcell.1981.241.5.c250', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S62704344', 'display_name': 'AJP Cell Physiology', 'issn_l': '0363-6143', 'issn': ['0363-6143', '1522-1563'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320261', 'host_organization_name': 'American Physical Society', 'host_organization_lineage': ['https://openalex.org/P4310320261'], 'host_organization_lineage_names': ['American Physical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6975574', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.57, 'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1969235529', 'https://openalex.org/W1976973677', 'https://openalex.org/W1983484335', 'https://openalex.org/W1987515485', 'https://openalex.org/W1997193345', 'https://openalex.org/W2034671136', 'https://openalex.org/W2062651371', 'https://openalex.org/W2083596354', 'https://openalex.org/W2091200387', 'https://openalex.org/W2163394937', 'https://openalex.org/W2432909714', 'https://openalex.org/W2442335212'], 'related_works': ['https://openalex.org/W2473697620', 'https://openalex.org/W2400282263', 'https://openalex.org/W2258666746', 'https://openalex.org/W2084880426', 'https://openalex.org/W2081743932', 'https://openalex.org/W2078137434', 'https://openalex.org/W2063415948', 'https://openalex.org/W2045134416', 'https://openalex.org/W2032157459', 'https://openalex.org/W1964577038'], 'abstract_inverted_index': {'In': [0, 81, 111], 'this': [1, 129], 'study': [2], 'we': [3], 'report': [4], 'on': [5, 142], 'isoproterenol-induced': [6], 'changes': [7], 'in': [8, 15, 51, 85, 108, 136, 147, 188, 206], 'short-circuit': [9], 'current': [10, 94, 130, 134], '(SCC)': [11], 'that': [12, 102, 178, 195], 'are': [13, 73, 89], 'located': [14], 'the': [16, 19, 26, 32, 41, 45, 77, 82, 103, 109, 112, 121, 125, 143, 148, 153, 165, 170, 189, 193, 199, 202, 207], 'glands': [17, 88, 191], 'of': [18, 25, 34, 44, 116, 145, 152, 167, 192, 201, 209], 'frog': [20, 194], 'skin.': [21], 'Following': [22], 'complete': [23], 'inhibition': [24], 'SCC': [27, 52, 106, 204], 'with': [28, 76, 156], 'amiloride': [29], '(10(-4)': [30, 158], 'M),': [31], 'addition': [33, 166], 'isoproterenol': [35, 97, 168, 171], '(9.0': [36], 'X': [37], '10(-7)': [38], 'M)': [39, 159], 'to': [40, 57, 96, 164], 'serosal': [42, 122, 149], 'side': [43], 'skin': [46, 155, 190], 'elicits': [47], 'a': [48, 181], 'significant': [49], 'increase': [50], 'from': [53, 120], '0.6': [54], '+/-': [55, 59], '0.1': [56], '3.9': [58], '0.5': [60], 'microA/cm2': [61], '(p': [62], 'less': [63], 'than': [64], '0.001).': [65], 'The': [66, 132], 'conductance': [67], 'is': [68, 92, 139, 180, 196], 'doubled,': [69], 'and': [70, 183], 'both': [71], 'effects': [72], 'blocked': [74], 'completely': [75], 'beta-blocking': [78], 'agent': [79], 'propranolol.': [80], 'split-skin': [83], 'preparation,': [84], 'which': [86], 'no': [87, 93], 'present,': [90], 'there': [91, 179], 'response': [95, 172], 'following': [98], 'amiloride.': [99, 210], 'This': [100], 'indicates': [101], 'amiloride-insensitive': [104], 'isoproterenol-stimulated': [105, 203], 'resides': [107], 'glands.': [110], 'intact': [113], 'skin,': [114], 'removal': [115], 'sodium': [117], '(choline': [118], 'replacement)': [119], '(but': [123], 'not': [124], 'mucosal)': [126], 'medium': [127], 'abolishes': [128], 'change.': [131], 'postisoproterenol': [133], 'change': [135], 'amiloride-inhibited': [137, 154], 'skins': [138], 'also': [140], 'dependent': [141], 'presence': [144, 208], 'chloride': [146], 'bath.': [150], 'Preincubation': [151], 'ouabain': [157], 'for': [160, 198], '10': [161], 'min': [162], 'prior': [163], 'reduces': [169], 'by': [173], '50%.': [174], 'These': [175], 'results': [176], 'indicate': [177], 'sodium-': [182], 'chloride-dependent': [184], 'ouabain-sensitive': [185], 'secretory': [186], 'mechanism': [187], 'responsible': [197], 'development': [200], 'observed': [205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2424294941', 'counts_by_year': [], 'updated_date': '2024-12-09T05:00:03.429442', 'created_date': '2016-06-24'}