The Effect of Amiloride on Sodium Transport in the Normal and Moulting Frog Skin

Name: Work Video:
Duration: 3 min 30 s
Description: Abstract It is shown that amiloride is a potent inhibitor for the active sodium transport across tht‐isolated frog skin. The percentage inhibition produced by various amiloride concentrations was not dependent on the initial short‐circuit current but rather on the phase of the moulting cycle at which the skin was tested.
Robert Nielsen; R. W. S. Tomilson
{'id': 'https://openalex.org/W2032157459', 'doi': 'https://doi.org/10.1111/j.1748-1716.1970.tb04723.x', 'title': 'The Effect of Amiloride on Sodium Transport in the Normal and Moulting Frog Skin', 'display_name': 'The Effect of Amiloride on Sodium Transport in the Normal and Moulting Frog Skin', 'publication_year': 1970, 'publication_date': '1970-06-01', 'ids': {'openalex': 'https://openalex.org/W2032157459', 'doi': 'https://doi.org/10.1111/j.1748-1716.1970.tb04723.x', 'mag': '2032157459', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/5454893'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1748-1716.1970.tb04723.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210232992', 'display_name': 'Acta Physiologica Scandinavica', 'issn_l': '0001-6772', 'issn': ['0001-6772', '1365-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022237350', 'display_name': 'Robert Nielsen', 'orcid': 'https://orcid.org/0000-0002-7673-1681'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Robert Nielsen', 'raw_affiliation_strings': ['Institute of Biological Chemistry, University of Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biological Chemistry, University of Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000490046', 'display_name': 'R. W. S. Tomilson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}, {'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK', 'GB'], 'is_corresponding': False, 'raw_author_name': 'R. W. S. Tomilson', 'raw_affiliation_strings': ["Department of Medicine King's College Hospital Medical School London, S.E.5.", 'Institute of Biological Chemistry, University of Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': "Department of Medicine King's College Hospital Medical School London, S.E.5.", 'institution_ids': ['https://openalex.org/I4210153400']}, {'raw_affiliation_string': 'Institute of Biological Chemistry, University of Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.387, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 28, 'citation_normalized_percentile': {'value': 0.757559, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '79', 'issue': '2', 'first_page': '238', 'last_page': '243'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10985', 'display_name': 'Sleep and Wakefulness Research', 'score': 0.8995, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10985', 'display_name': 'Sleep and Wakefulness Research', 'score': 0.8995, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10704', 'display_name': 'Advancements in Transdermal Drug Delivery', 'score': 0.8188, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13206', 'display_name': 'Neonatal skin health care', 'score': 0.8068, 'subfield': {'id': 'https://openalex.org/subfields/3616', 'display_name': 'Speech and Hearing'}, 'field': {'id': 'https://openalex.org/fields/36', 'display_name': 'Health Professions'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amiloride', 'display_name': 'Amiloride', 'score': 0.98761785}, {'id': 'https://openalex.org/keywords/frog-skin', 'display_name': 'Frog Skin', 'score': 0.9416141}, {'id': 'https://openalex.org/keywords/grenouille', 'display_name': 'GRENOUILLE', 'score': 0.4353081}], 'concepts': [{'id': 'https://openalex.org/C2779608910', 'wikidata': 'https://www.wikidata.org/wiki/Q419995', 'display_name': 'Amiloride', 'level': 3, 'score': 0.98761785}, {'id': 'https://openalex.org/C2777103240', 'wikidata': 'https://www.wikidata.org/wiki/Q18356482', 'display_name': 'Frog Skin', 'level': 3, 'score': 0.9416141}, {'id': 'https://openalex.org/C41905685', 'wikidata': 'https://www.wikidata.org/wiki/Q381084', 'display_name': 'Moulting', 'level': 3, 'score': 0.79179275}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.58293027}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49093273}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4603204}, {'id': 'https://openalex.org/C176704843', 'wikidata': 'https://www.wikidata.org/wiki/Q5514434', 'display_name': 'GRENOUILLE', 'level': 5, 'score': 0.4353081}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4171275}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34881842}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18311954}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16782635}, {'id': 'https://openalex.org/C2778935311', 'wikidata': 'https://www.wikidata.org/wiki/Q1746027', 'display_name': 'Salientia', 'level': 4, 'score': 0.16385517}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.106208146}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.10168636}, {'id': 'https://openalex.org/C2779535977', 'wikidata': 'https://www.wikidata.org/wiki/Q1342298', 'display_name': 'Xenopus', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001001', 'descriptor_name': 'Anura', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001693', 'descriptor_name': 'Biological Transport, Active', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001693', 'descriptor_name': 'Biological Transport, Active', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012867', 'descriptor_name': 'Skin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012964', 'descriptor_name': 'Sodium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1748-1716.1970.tb04723.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210232992', 'display_name': 'Acta Physiologica Scandinavica', 'issn_l': '0001-6772', 'issn': ['0001-6772', '1365-201X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/5454893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W2014359221', 'https://openalex.org/W2021778217', 'https://openalex.org/W2046600315', 'https://openalex.org/W2259177077', 'https://openalex.org/W2444326174'], 'related_works': ['https://openalex.org/W2424294941', 'https://openalex.org/W2258666746', 'https://openalex.org/W2084880426', 'https://openalex.org/W2055765138', 'https://openalex.org/W2045134416', 'https://openalex.org/W2032157459', 'https://openalex.org/W1993665401', 'https://openalex.org/W1969026572', 'https://openalex.org/W1964577038', 'https://openalex.org/W1952010291'], 'abstract_inverted_index': {'Abstract': [0], 'It': [1], 'is': [2, 6], 'shown': [3], 'that': [4], 'amiloride': [5, 25], 'a': [7], 'potent': [8], 'inhibitor': [9], 'for': [10], 'the': [11, 31, 38, 41, 46], 'active': [12], 'sodium': [13], 'transport': [14], 'across': [15], 'tht‐isolated': [16], 'frog': [17], 'skin.': [18], 'The': [19], 'percentage': [20], 'inhibition': [21], 'produced': [22], 'by': [23], 'various': [24], 'concentrations': [26], 'was': [27, 48], 'not': [28], 'dependent': [29], 'on': [30, 37], 'initial': [32], 'short‐circuit': [33], 'current': [34], 'but': [35], 'rather': [36], 'phase': [39], 'of': [40], 'moulting': [42], 'cycle': [43], 'at': [44], 'which': [45], 'skin': [47], 'tested.': [49]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2032157459', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-09T01:19:41.804785', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
