Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2031216366', 'doi': 'https://doi.org/10.1016/j.humpath.2007.10.017', 'title': 'Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis', 'display_name': 'Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis', 'publication_year': 2008, 'publication_date': '2008-06-01', 'ids': {'openalex': 'https://openalex.org/W2031216366', 'doi': 'https://doi.org/10.1016/j.humpath.2007.10.017', 'mag': '2031216366', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18440591', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2476209'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.humpath.2007.10.017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S63477337', 'display_name': 'Human Pathology', 'issn_l': '0046-8177', 'issn': ['0046-8177', '1532-8392'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2476209?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101814553', 'display_name': 'Xiaowei Xu', 'orcid': 'https://orcid.org/0000-0003-4098-7690'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiaowei Xu', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013962604', 'display_name': 'Phyllis A. Gimotty', 'orcid': 'https://orcid.org/0000-0002-3850-9799'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Phyllis A. Gimotty', 'raw_affiliation_strings': ['Department of Biostatistics and Epidemiology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics and Epidemiology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031076661', 'display_name': 'DuPont Guerry', 'orcid': 'https://orcid.org/0009-0000-4040-530X'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'DuPont Guerry', 'raw_affiliation_strings': ['Department of Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035929126', 'display_name': 'Giorgos C. Karakousis', 'orcid': 'https://orcid.org/0000-0002-9321-2795'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Giorgos Karakousis', 'raw_affiliation_strings': ['Department of Surgery, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090942832', 'display_name': 'Patricia Van Belle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patricia Van Belle', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046421290', 'display_name': 'Haohai Liang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Haohai Liang', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056584285', 'display_name': 'K. Montone', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katharine Montone', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086103646', 'display_name': 'Terry Pasha', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Terry Pasha', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073967328', 'display_name': 'Michael E. Ming', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael E. Ming', 'raw_affiliation_strings': ['Department of Dermatology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006632858', 'display_name': 'Géza Ács', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Geza Acs', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028140714', 'display_name': 'Michael D. Feldman', 'orcid': 'https://orcid.org/0000-0002-6661-4940'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Feldman', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029772978', 'display_name': 'Stephen Barth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stephen Barth', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015245457', 'display_name': 'Rachel Hammond', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rachel Hammond', 'raw_affiliation_strings': ['Department of Biostatistics and Epidemiology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics and Epidemiology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020426602', 'display_name': 'Rosalie Elenitsas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rosalie Elenitsas', 'raw_affiliation_strings': ['Department of Dermatology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Dermatology, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080639509', 'display_name': 'Paul J. Zhang', 'orcid': 'https://orcid.org/0000-0002-3615-9094'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul J. Zhang', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102733175', 'display_name': 'David E. Elder', 'orcid': 'https://orcid.org/0000-0001-5012-152X'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David E. Elder', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, and the Melanoma Program of the Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3460, 'currency': 'USD', 'value_usd': 3460, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.64, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 60, 'citation_normalized_percentile': {'value': 0.945935, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '39', 'issue': '6', 'first_page': '901', 'last_page': '909'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10392', 'display_name': 'Melanoma', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10392', 'display_name': 'Melanoma', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11469', 'display_name': 'Lymphangiogenesis in Cancer Metastasis and Disease', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11569', 'display_name': 'Optical Coherence Tomography Imaging', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lymphovascular-invasion', 'display_name': 'Lymphovascular invasion', 'score': 0.5890438}, {'id': 'https://openalex.org/keywords/podoplanin', 'display_name': 'Podoplanin', 'score': 0.57101357}, {'id': 'https://openalex.org/keywords/melanoma', 'display_name': 'Melanoma', 'score': 0.563647}, {'id': 'https://openalex.org/keywords/lymphatic-vessel', 'display_name': 'Lymphatic vessel', 'score': 0.5565768}, {'id': 'https://openalex.org/keywords/tumor-lymphatics', 'display_name': 'Tumor Lymphatics', 'score': 0.531175}, {'id': 'https://openalex.org/keywords/tumor-staging', 'display_name': 'Tumor Staging', 'score': 0.522422}, {'id': 'https://openalex.org/keywords/skin-cancers', 'display_name': 'Skin Cancers', 'score': 0.507777}, {'id': 'https://openalex.org/keywords/microvasculature-detection', 'display_name': 'Microvasculature Detection', 'score': 0.502042}], 'concepts': [{'id': 'https://openalex.org/C181152851', 'wikidata': 'https://www.wikidata.org/wiki/Q712604', 'display_name': 'Lymphatic system', 'level': 2, 'score': 0.88217664}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.8013381}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.7678225}, {'id': 'https://openalex.org/C2778740770', 'wikidata': 'https://www.wikidata.org/wiki/Q6708283', 'display_name': 'Lymphovascular invasion', 'level': 4, 'score': 0.5890438}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.5851822}, {'id': 'https://openalex.org/C2909316934', 'wikidata': 'https://www.wikidata.org/wiki/Q2100344', 'display_name': 'Podoplanin', 'level': 3, 'score': 0.57101357}, {'id': 'https://openalex.org/C2780965494', 'wikidata': 'https://www.wikidata.org/wiki/Q11238641', 'display_name': 'Lymphatic vessel', 'level': 4, 'score': 0.5565768}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.55626327}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.52595806}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.25980842}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.11303389}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.094617605}], 'mesh': [{'descriptor_ui': 'D008198', 'descriptor_name': 'Lymph Nodes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D042601', 'descriptor_name': 'Lymphatic Vessels', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019085', 'descriptor_name': 'Fluorescent Antibody Technique, Direct', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008198', 'descriptor_name': 'Lymph Nodes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042583', 'descriptor_name': 'Lymphangiogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042601', 'descriptor_name': 'Lymphatic Vessels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042601', 'descriptor_name': 'Lymphatic Vessels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D008545', 'descriptor_name': 'Melanoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009418', 'descriptor_name': 'S100 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009418', 'descriptor_name': 'S100 Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012878', 'descriptor_name': 'Skin Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.humpath.2007.10.017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S63477337', 'display_name': 'Human Pathology', 'issn_l': '0046-8177', 'issn': ['0046-8177', '1532-8392'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2476209', 'pdf_url': 'https://europepmc.org/articles/pmc2476209?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2476209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18440591', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2476209', 'pdf_url': 'https://europepmc.org/articles/pmc2476209?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.73, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1951046932', 'https://openalex.org/W1988061758', 'https://openalex.org/W2001320779', 'https://openalex.org/W2008483037', 'https://openalex.org/W2010679818', 'https://openalex.org/W2011032800', 'https://openalex.org/W2013317185', 'https://openalex.org/W2013673884', 'https://openalex.org/W2016427872', 'https://openalex.org/W2031563062', 'https://openalex.org/W2037033894', 'https://openalex.org/W2047096720', 'https://openalex.org/W2048249167', 'https://openalex.org/W2074110731', 'https://openalex.org/W2077261769', 'https://openalex.org/W2101347382', 'https://openalex.org/W2110217908', 'https://openalex.org/W2110613088', 'https://openalex.org/W2114611119', 'https://openalex.org/W2115867454', 'https://openalex.org/W2117226152', 'https://openalex.org/W2136927379', 'https://openalex.org/W71022479'], 'related_works': ['https://openalex.org/W2547822128', 'https://openalex.org/W24481840', 'https://openalex.org/W2379330222', 'https://openalex.org/W2379048772', 'https://openalex.org/W2361076087', 'https://openalex.org/W2139810530', 'https://openalex.org/W2127431746', 'https://openalex.org/W2017828562', 'https://openalex.org/W1968237864', 'https://openalex.org/W1819192711'], 'abstract_inverted_index': {'Lymphatic': [0, 80, 93, 123, 169], 'invasion': [1, 32, 36, 81, 94, 124, 170, 190], 'by': [2, 84, 89, 97, 110, 146, 183], 'tumor': [3, 25], 'cells': [4, 26], 'has': [5], 'been': [6], 'noted': [7], 'infrequently': [8], 'in': [9, 100, 104, 175], 'primary': [10, 13, 176], 'melanomas.': [11], 'Our': [12], 'hypotheses': [14], 'were': [15, 50, 118], 'that': [16, 34, 178], 'using': [17], 'immunohistochemical': [18, 68, 107, 184], 'markers': [19], 'of': [20, 24, 30, 63, 156, 167, 188, 197], 'lymphatic': [21, 31, 35, 73, 148, 189], 'vessels': [22], 'and': [23, 33, 54, 56, 75, 87, 140], 'would': [27, 37], 'improve': [28], 'detection': [29], 'correlate': [38], 'with': [39, 128], 'regional': [40, 131, 160], 'nodal': [41, 132, 161], 'metastatic': [42, 133, 162, 199], 'disease.': [43, 200], 'This': [44], 'study': [45], 'included': [46], '106': [47], 'patients': [48], 'who': [49, 57, 158], 'diagnosed': [51], 'between': [52], '1972': [53], '1991': [55], 'had': [58, 159], '10': [59], 'years': [60, 166], 'or': [61, 151], 'more': [62], 'follow-up.': [64], 'We': [65], 'performed': [66], 'dual': [67], 'stains': [69], 'for': [70], 'podoplanin': [71], '(for': [72, 77], 'vessels)': [74], 'S-100': [76], 'melanoma': [78], 'cells).': [79], 'was': [82, 95, 125], 'identified': [83, 119, 154], 'light': [85], 'microscopy': [86], 'confirmed': [88], 'multispectral': [90, 111], 'imaging': [91, 112], 'analysis.': [92], 'detected': [96, 182], 'morphology': [98], 'alone': [99], '5': [101, 165], 'cases': [102, 116], '(4.7%)': [103], 'contrast': [105], 'to': [106, 130], 'staining': [108], 'augmented': [109], 'analysis': [113], 'where': [114], '35': [115], '(33%)': [117], '(P': [120], '<': [121], '.0001).': [122], 'significantly': [126], 'associated': [127], 'time': [129], 'disease,': [134], 'as': [135, 137], 'well': [136], 'first': [138], 'metastasis': [139], 'melanoma-specific': [141], 'death.': [142], '"Local': [143], 'metastasis,"': [144], 'defined': [145], 'immunohistochemistry-detected': [147], 'invasion,': [149, 153], 'satellites,': [150], 'neural': [152], '64%': [155], 'those': [157], 'disease': [163], 'within': [164], 'diagnosis.': [168], 'is': [171], 'an': [172], 'underobserved': [173], 'phenomenon': [174], 'melanomas': [177], 'can': [179], 'be': [180, 192], 'better': [181], 'staining.': [185], 'The': [186], 'presence': [187], 'may': [191], 'a': [193], 'clinically': [194], 'useful': [195], 'predictor': [196], 'regionally': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031216366', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-08-23T20:16:49.964347', 'created_date': '2016-06-24'}