Title: Quantitation of delta 4-reduced metabolite of norethindrone in human plasma by HPLC-RIA.
Abstract: An HPLC-RIA method for the measurement of the delta 4-reduced metabolite of norethindrone is described. The sensitivity of the method was such as to permit the quantitation of pg amounts (30 pg with an inter-assay CV of less than 7%). Nineteen volunteers received a single oral dose of 1 mg of norethindrone and, blood samples withdrawn at timed intervals, were pooled for each time period and assayed. The plasma concentrations of the dihydro metabolite ranged from 460 pg/ml at 30 min to 20 pg/ml at 24h.
Publication Year: 1984
Publication Date: 1984-05-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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