Title: Determination of nifedipine in plasma by high-performance liquid chromatography.
Abstract: A simple high-performance liquid chromatographic method for the determination of nifedipine, dimethyl 1, 4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3, 5-pyridinedicarboxylate, in plasma is described. The method permits the accurate determination of the drug in plasma at concentrations as low as 2 ng/ml and is suitable for drug monitoring and for investigation of the bioavailabilities of drug preparations.