Publication Information

{'id': 'https://openalex.org/W2416409425', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-4271', 'title': 'Abstract 4271: Lack of CD47 membrane mobility contributes to the poor erythrocyte binding of SIRPαFc, a novel CD47-blocking cancer immunotherapeutic', 'display_name': 'Abstract 4271: Lack of CD47 membrane mobility contributes to the poor erythrocyte binding of SIRPαFc, a novel CD47-blocking cancer immunotherapeutic', 'publication_year': 2015, 'publication_date': '2015-08-01', 'ids': {'openalex': 'https://openalex.org/W2416409425', 'doi': 'https://doi.org/10.1158/1538-7445.am2015-4271', 'mag': '2416409425'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-4271', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086142649', 'display_name': 'Penka S. Petrova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144024', 'display_name': 'Trillium Therapeutics (Canada)', 'ror': 'https://ror.org/0529f2p24', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210144024']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Penka S. Petrova', 'raw_affiliation_strings': ['Trillium Therapeutics Inc., Toronto, Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Trillium Therapeutics Inc., Toronto, Ontario, Canada.', 'institution_ids': ['https://openalex.org/I4210144024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076109602', 'display_name': 'Karen Dodge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144024', 'display_name': 'Trillium Therapeutics (Canada)', 'ror': 'https://ror.org/0529f2p24', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210144024']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Karen Dodge', 'raw_affiliation_strings': ['Trillium Therapeutics Inc., Toronto, Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Trillium Therapeutics Inc., Toronto, Ontario, Canada.', 'institution_ids': ['https://openalex.org/I4210144024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078533696', 'display_name': 'Tanya Prasolava', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144024', 'display_name': 'Trillium Therapeutics (Canada)', 'ror': 'https://ror.org/0529f2p24', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210144024']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Tanya Prasolava', 'raw_affiliation_strings': ['Trillium Therapeutics Inc., Toronto, Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Trillium Therapeutics Inc., Toronto, Ontario, Canada.', 'institution_ids': ['https://openalex.org/I4210144024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077499465', 'display_name': 'Vien Chai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144024', 'display_name': 'Trillium Therapeutics (Canada)', 'ror': 'https://ror.org/0529f2p24', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210144024']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Vien Chai', 'raw_affiliation_strings': ['Trillium Therapeutics Inc., Toronto, Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Trillium Therapeutics Inc., Toronto, Ontario, Canada.', 'institution_ids': ['https://openalex.org/I4210144024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056607617', 'display_name': 'Xinli Pang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144024', 'display_name': 'Trillium Therapeutics (Canada)', 'ror': 'https://ror.org/0529f2p24', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210144024']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Xinli Pang', 'raw_affiliation_strings': ['Trillium Therapeutics Inc., Toronto, Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Trillium Therapeutics Inc., Toronto, Ontario, Canada.', 'institution_ids': ['https://openalex.org/I4210144024']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5054420141', 'display_name': 'Robert A. Uger', 'orcid': 'https://orcid.org/0000-0002-0569-3307'}, 'institutions': [{'id': 'https://openalex.org/I4210144024', 'display_name': 'Trillium Therapeutics (Canada)', 'ror': 'https://ror.org/0529f2p24', 'country_code': 'CA', 'type': 'company', 'lineage': ['https://openalex.org/I4210144024']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Robert A. Uger', 'raw_affiliation_strings': ['Trillium Therapeutics Inc., Toronto, Ontario, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Trillium Therapeutics Inc., Toronto, Ontario, Canada.', 'institution_ids': ['https://openalex.org/I4210144024']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.568273, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': '75', 'issue': '15_Supplement', 'first_page': '4271', 'last_page': '4271'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cd47', 'display_name': 'CD47', 'score': 0.9903102}], 'concepts': [{'id': 'https://openalex.org/C2780104668', 'wikidata': 'https://www.wikidata.org/wiki/Q21108354', 'display_name': 'CD47', 'level': 3, 'score': 0.9903102}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.55748254}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5070944}, {'id': 'https://openalex.org/C51639874', 'wikidata': 'https://www.wikidata.org/wiki/Q167149', 'display_name': 'Plasma protein binding', 'level': 2, 'score': 0.48108384}, {'id': 'https://openalex.org/C160448771', 'wikidata': 'https://www.wikidata.org/wiki/Q184726', 'display_name': 'Phagocytosis', 'level': 2, 'score': 0.4781707}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45730925}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.33379346}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2015-4271', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1', 'score': 0.63}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W74828802', 'https://openalex.org/W3112679617', 'https://openalex.org/W2135974397', 'https://openalex.org/W2092705900', 'https://openalex.org/W2090257541', 'https://openalex.org/W2045887353', 'https://openalex.org/W2017715435', 'https://openalex.org/W1966649467', 'https://openalex.org/W1964791394', 'https://openalex.org/W1964738368'], 'abstract_inverted_index': {'Abstract': [0], 'CD47': [1, 40, 60, 96, 181, 219, 239, 245, 289, 308, 402, 417, 466], 'binds': [2, 77, 133, 194, 377], 'to': [3, 34, 54, 79, 85, 136, 156, 178, 189, 196, 209, 248, 262, 277, 293, 352, 362, 380, 418, 437, 470], 'SIRPα': [4], 'on': [5, 97, 122], 'the': [6, 31, 56, 63, 172, 187, 190, 207, 216, 221, 234, 252, 263, 321, 471, 486, 491], 'surface': [7, 93], 'of': [8, 39, 59, 65, 95, 125, 140, 159, 175, 218, 228, 238, 323, 333, 340, 393, 465, 475, 485, 490], 'macrophages': [9], 'and': [10, 27, 61, 99, 112, 231, 242, 300, 405], 'delivers': [11], 'a': [12, 42, 51, 123, 225, 285, 310, 368, 409, 477], '“do': [13], 'not': [14, 205, 366, 435], 'eat”': [15], 'signal': [16], 'that': [17, 24, 74, 131, 201, 215, 306, 347, 360, 425], 'suppresses': [18], 'phagocytosis.': [19], 'There': [20], 'is': [21, 182, 224, 282, 291, 350, 384, 406, 434, 446], 'strong': [22, 100, 317], 'evidence': [23], 'many': [25], 'liquid': [26], 'solid': [28], 'tumors': [29], 'exploit': [30], 'CD47-SIRPα': [32], 'pathway': [33], 'escape': [35], 'macrophage-mediated': [36], 'destruction.': [37], 'Blockade': [38], 'using': [41], 'soluble': [43], 'SIRPα-Fc': [44], 'fusion': [45], 'protein': [46], '(SIRPαFc)': [47], 'has': [48], 'emerged': [49], 'as': [50], 'promising': [52], 'strategy': [53], 'neutralize': [55], 'suppressive': [57], 'effects': [58], 'promote': [62], 'eradication': [64], 'tumor': [66, 80], 'cells.': [67], 'We': [68, 345, 423], 'have': [69, 303], 'previously': [70, 304], 'reported': [71], 'data': [72], 'demonstrating': [73], 'human': [75, 86, 127, 137, 176, 191, 241, 268, 278, 314, 363, 375, 381, 440], 'SIRPαFc': [76, 132, 153, 177, 229, 318, 341, 371, 376, 413, 432], 'strongly': [78, 195], 'cells': [81, 89], 'but': [82, 258, 365, 383], 'very': [83, 134, 378], 'poorly': [84, 135, 379], 'red': [87], 'blood': [88, 143], '(RBCs),': [90], 'despite': [91], 'abundant': [92], 'expression': [94], 'RBCs': [98, 138, 160, 315, 334, 382], 'reactivity': [101], 'with': [102, 150, 284, 298, 309, 357, 367, 387, 408], 'CD47-specific': [103], 'antibodies.': [104, 169], 'Here': [105], 'we': [106, 213, 302], 'expand': [107], 'upon': [108], 'these': [109], 'early': [110], 'findings': [111], 'assess': [113], 'inter-species': [114], 'differences': [115, 400], 'in': [116, 161, 220, 240, 255, 267, 274, 287, 329, 342, 354, 401, 411, 429, 439], 'RBC': [117, 222, 325, 444], 'binding.': [118], 'Our': [119], 'results,': [120], 'based': [121], 'panel': [124], '43': [126], 'donors,': [128], 'clearly': [129], 'show': [130], 'regardless': [139], 'gender,': [141], 'ABO': [142], 'group': [144], 'or': [145], 'Rh': [146], 'antigen': [147], 'status.': [148], 'Consistent': [149], 'this': [151], 'finding,': [152], 'was': [154, 165, 246, 259, 335], 'unable': [155], 'induce': [157], 'agglutination': [158], 'vitro,': [162], 'although': [163, 171], 'hemagglutination': [164], 'triggered': [166], 'by': [167], 'CD47-blocking': [168, 358, 479], 'Curiously,': [170], 'binding': [173, 188, 230, 326, 414, 445, 474], 'affinity': [174, 202, 296, 421], 'cynomolgus': [179], 'macaque': [180], 'approximately': [183], '10-fold': [184], 'lower': [185], 'than': [186], 'target,': [192], 'it': [193], 'cyno': [197, 243, 275, 324, 343, 388], 'RBCs.': [198, 244, 279], 'This': [199, 280, 390], 'indicates': [200], 'alone': [203], 'does': [204], 'predict': [206, 424], 'ability': [208], 'bind': [210, 361], 'erythrocytes.': [211, 389], 'Instead,': [212], 'hypothesized': [214], 'mobility': [217, 273, 290, 404, 468], 'membrane': [223, 272, 403, 467], 'key': [226], 'determinant': [227], 'thus': [232], 'compared': [233, 276], 'detergent': [235], 'solubilization': [236], 'profile': [237], 'observed': [247, 305], 'segregate': [249], 'largely': [250], 'into': [251, 316], 'detergent-soluble': [253], 'fraction': [254, 266], 'monkey': [256], 'erythrocytes': [257], 'localized': [260], 'primarily': [261], 'insoluble': [264], 'pellet': [265], 'RBCs,': [269], 'suggesting': [270], 'greater': [271], 'finding': [281], 'consistent': [283, 407], 'model': [286, 410], 'which': [288, 412, 427], 'required': [292], 'form': [294, 419], 'high': [295, 420], 'clusters': [297], 'SIRPαFc,': [299, 476], 'indeed': [301], 'pre-clustering': [307], 'non-blocking': [311], 'antibody': [312], 'converts': [313], 'binders.': [319], 'Finally,': [320], 'consequences': [322], 'were': [327], 'assessed': [328], 'vivo.': [330], 'Significant': [331], 'depletion': [332], 'evident': [336], 'following': [337, 431], 'intravenous': [338], 'infusions': [339], 'monkeys.': [344], 'speculate': [346], 'similar': [348], 'anemia': [349], 'likely': [351, 436], 'occur': [353, 438], 'humans': [355], 'treated': [356], 'antibodies': [359], 'erythrocytes,': [364], 'low': [369], 'RBC-binding': [370], 'therapeutic.': [372], 'In': [373], 'conclusion,': [374], 'highly': [385], 'reactive': [386], 'unusual': [391], 'pattern': [392], 'species': [394], 'cross-reactivity': [395], 'may': [396], 'result': [397], 'from': [398], 'species-specific': [399], 'requires': [415], 'mobile': [416], 'clusters.': [422], 'anemia,': [426], 'occurs': [428], 'monkeys': [430], 'administration,': [433], 'patients': [441], 'where': [442], 'significant': [443], 'absent.': [447], 'Citation': [448], 'Format:': [449], 'Penka': [450], 'S.': [451], 'Petrova,': [452], 'Karen': [453], 'Dodge,': [454], 'Tanya': [455], 'Prasolava,': [456], 'Vien': [457], 'Chai,': [458], 'Xinli': [459], 'Pang,': [460], 'Robert': [461], 'A.': [462], 'Uger.': [463], 'Lack': [464], 'contributes': [469], 'poor': [472], 'erythrocyte': [473], 'novel': [478], 'cancer': [480], 'immunotherapeutic.': [481], '[abstract].': [482], 'In:': [483], 'Proceedings': [484], '106th': [487], 'Annual': [488], 'Meeting': [489], 'American': [492], 'Association': [493], 'for': [494], 'Cancer': [495, 505], 'Research;': [496], '2015': [497], 'Apr': [498], '18-22;': [499], 'Philadelphia,': [500], 'PA.': [501], 'Philadelphia': [502], '(PA):': [503], 'AACR;': [504], 'Res': [506], '2015;75(15': [507], 'Suppl):Abstract': [508], 'nr': [509], '4271.': [510], 'doi:10.1158/1538-7445.AM2015-4271': [511]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2416409425', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-12T04:43:22.630289', 'created_date': '2016-06-24'}