Title: In <i>vitro</i> chemosensitivity of <i>Plasmodium falciparum</i> to four chloroquine derivatives
Abstract:The antimalarial activity of four chloroquine derivatives has been assessed in vitro by the Trager and Jensen technique against the strain of Plasmodium falciparum FCC, 2spp. Monodesethyl-chloroquine ...The antimalarial activity of four chloroquine derivatives has been assessed in vitro by the Trager and Jensen technique against the strain of Plasmodium falciparum FCC, 2spp. Monodesethyl-chloroquine possessed a significant activity, reducing the parasitaemia to 5% with 2 nM ml−1 (base). The hydroxy-metabolite showed a slight activity, reducing the parasitaemia to 39·5% with 2 nM ml−1 (base). No activity was found with the amino-metabolite and the pyrrolidinyl chemical derivative. The antimalarial activity of monodesethyl-chloroquine should be considered for pharmacokinetics and for optimizing chloroquine treatments.Read More
Publication Year: 1987
Publication Date: 1987-01-01
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 5
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot