Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2414263157', 'doi': 'https://doi.org/10.1080/10837450.2016.1193192', 'title': 'Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration', 'display_name': 'Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration', 'publication_year': 2016, 'publication_date': '2016-06-07', 'ids': {'openalex': 'https://openalex.org/W2414263157', 'doi': 'https://doi.org/10.1080/10837450.2016.1193192', 'mag': '2414263157', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27269370'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10837450.2016.1193192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80622011', 'display_name': 'Pharmaceutical Development and Technology', 'issn_l': '1083-7450', 'issn': ['1083-7450', '1097-9867'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060874577', 'display_name': 'Yangyang Sun', 'orcid': 'https://orcid.org/0000-0001-5148-0954'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yangyang Sun', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101599361', 'display_name': 'Lili Jia', 'orcid': 'https://orcid.org/0000-0001-9855-1473'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lili Jia', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101760161', 'display_name': 'Hui Zhou', 'orcid': 'https://orcid.org/0000-0002-1578-590X'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui Zhou', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053819493', 'display_name': 'Mengqian Mao', 'orcid': 'https://orcid.org/0000-0002-2716-5257'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Mengqian Mao', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022979261', 'display_name': 'Xiaobo Wang', 'orcid': 'https://orcid.org/0000-0001-6754-7404'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaobo Wang', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073760040', 'display_name': 'Wei Lan', 'orcid': 'https://orcid.org/0000-0001-6194-4839'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lan Wei', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101796260', 'display_name': 'Lixin Sun', 'orcid': 'https://orcid.org/0000-0001-6197-259X'}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Lixin Sun', 'raw_affiliation_strings': ['School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China', 'institution_ids': ['https://openalex.org/I103890011']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5101796260'], 'corresponding_institution_ids': ['https://openalex.org/I103890011'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.147, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.458005, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 74, 'max': 77}, 'biblio': {'volume': '22', 'issue': '2', 'first_page': '218', 'last_page': '228'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10256', 'display_name': 'Drug Delivery Systems', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10256', 'display_name': 'Drug Delivery Systems', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/3003', 'display_name': 'Pharmaceutical Science'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11460', 'display_name': 'Green Analytical Chemistry in Pharmaceutical Analysis', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1602', 'display_name': 'Analytical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10908', 'display_name': 'Chiral Separation in Chromatography', 'score': 0.9722, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/drug-solubility', 'display_name': 'Drug Solubility', 'score': 0.534333}], 'concepts': [{'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.9064902}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.8904441}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.8333308}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.7659712}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.7559329}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.711854}, {'id': 'https://openalex.org/C2779422922', 'wikidata': 'https://www.wikidata.org/wiki/Q1029907', 'display_name': 'Stomach', 'level': 2, 'score': 0.5083813}, {'id': 'https://openalex.org/C110121322', 'wikidata': 'https://www.wikidata.org/wiki/Q865811', 'display_name': 'Distribution (mathematics)', 'level': 2, 'score': 0.50158525}, {'id': 'https://openalex.org/C2779433975', 'wikidata': 'https://www.wikidata.org/wiki/Q40417805', 'display_name': 'Cyclodextrin', 'level': 2, 'score': 0.45282584}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.22207361}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.22066522}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17033419}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.08782619}, {'id': 'https://openalex.org/C134306372', 'wikidata': 'https://www.wikidata.org/wiki/Q7754', 'display_name': 'Mathematical analysis', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004337', 'descriptor_name': 'Drug Carriers', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D047392', 'descriptor_name': 'beta-Cyclodextrins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000073738', 'descriptor_name': '2-Hydroxypropyl-beta-cyclodextrin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001682', 'descriptor_name': 'Biological Availability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004337', 'descriptor_name': 'Drug Carriers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065546', 'descriptor_name': 'Drug Liberation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011284', 'descriptor_name': 'Pregnenolone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012995', 'descriptor_name': 'Solubility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014018', 'descriptor_name': 'Tissue Distribution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047392', 'descriptor_name': 'beta-Cyclodextrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10837450.2016.1193192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S80622011', 'display_name': 'Pharmaceutical Development and Technology', 'issn_l': '1083-7450', 'issn': ['1083-7450', '1097-9867'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27269370', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1007853786', 'https://openalex.org/W1595611980', 'https://openalex.org/W1899532244', 'https://openalex.org/W1980244493', 'https://openalex.org/W2013316400', 'https://openalex.org/W2022656408', 'https://openalex.org/W2024827120', 'https://openalex.org/W2030951340', 'https://openalex.org/W2033995489', 'https://openalex.org/W2037803874', 'https://openalex.org/W2055653035', 'https://openalex.org/W2058539083', 'https://openalex.org/W2068037258', 'https://openalex.org/W2077295356', 'https://openalex.org/W2080260078', 'https://openalex.org/W2080823953', 'https://openalex.org/W2091080458', 'https://openalex.org/W2102560874', 'https://openalex.org/W2130060973', 'https://openalex.org/W2141566507', 'https://openalex.org/W2173680579', 'https://openalex.org/W2177729771', 'https://openalex.org/W2213601522', 'https://openalex.org/W2235157532', 'https://openalex.org/W2236667527', 'https://openalex.org/W2277227732', 'https://openalex.org/W2315365549', 'https://openalex.org/W2337108207', 'https://openalex.org/W2355056412', 'https://openalex.org/W2361519801', 'https://openalex.org/W2363290276', 'https://openalex.org/W2409898702', 'https://openalex.org/W2781467391', 'https://openalex.org/W4247852925', 'https://openalex.org/W586906331'], 'related_works': ['https://openalex.org/W2437352158', 'https://openalex.org/W2391021644', 'https://openalex.org/W2373403320', 'https://openalex.org/W2365953299', 'https://openalex.org/W2314489661', 'https://openalex.org/W2143815486', 'https://openalex.org/W2086460393', 'https://openalex.org/W2081375274', 'https://openalex.org/W2073311134', 'https://openalex.org/W2022148560'], 'abstract_inverted_index': {'16-Dehydropregnenolone': [0], '(16-DHP)': [1], 'is': [2], 'an': [3, 7], 'active': [4], 'compound': [5], 'with': [6], 'unsatisfied': [8], 'in': [9, 23, 37, 62, 86, 111], 'vivo': [10, 24], 'behavior': [11, 25], 'and': [12, 26, 80, 162], 'poor': [13], 'water-solubility,': [14, 27], 'which': [15], 'limits': [16], 'its': [17, 22, 59], 'clinical': [18], 'application.': [19], 'To': [20], 'improve': [21, 143], 'a': [28, 121], 'Hydroxypropyl-beta-Cyclodextrin': [29], '(HP-β-CD)': [30], 'inclusion': [31, 139], 'complex': [32, 140], 'of': [33, 45, 49, 78, 91, 100, 108], '16-DHP': [34, 82], 'was': [35, 67, 113], 'prepared': [36], 'this': [38], 'paper.': [39], 'Pharmacokinetic': [40], 'studies': [41, 150], 'after': [42, 83, 102, 125], 'oral': [43, 84, 103], 'administration': [44, 85, 104, 127], '16-DHP-HP-β-CD': [46, 79, 101, 117, 153], 'at': [47, 88, 105, 131], 'doses': [48, 133], '37.5,': [50], '75,': [51], '150': [52], 'mg/kg': [53, 110], 'were': [54], 'carried': [55], 'out': [56], 'to': [57, 119, 128, 136, 155], 'investigate': [58], 'dose': [60, 90, 107], 'proportionality': [61], 'rats.': [63], 'The': [64], 'relative': [65, 145], 'bioavailability': [66, 146], 'researched': [68], 'by': [69], 'comparing': [70], 'the': [71, 74, 89, 95, 106, 129, 132, 144], 'area': [72], 'under': [73], 'plasma': [75], 'concentration-time': [76], 'curve': [77], 'free': [81, 137], 'rats': [87], '75': [92], 'mg/kg.': [93], 'At': [94], 'same': [96], 'time,': [97], 'tissue': [98], 'distribution': [99, 149], '240': [109], 'mice': [112], 'also': [114], 'investigated.': [115], 'Consequently,': [116], 'appeared': [118], 'be': [120], 'linear': [122], 'pharmacokinetic': [123], 'character': [124], 'peroral': [126], 'rat': [130], 'tested.': [134], 'Compared': [135], '16-DHP,': [138], 'could': [141], 'significantly': [142], '(467%).': [147], 'Tissue': [148], 'indicated': [151], 'that': [152], 'tended': [154], 'distribute': [156], 'into': [157], 'stomach,': [158], 'intestine,': [159], 'lung,': [160], 'brain': [161], 'liver.': [163]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2414263157', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-08-28T21:28:29.248075', 'created_date': '2016-06-24'}