Title: Expression of the P-glycoprotein gene in multidrug-resistant Chinese hamster ovary cells.
Abstract: A series of multidrug-resistant (MDR) Chinese hamster ovary (CHO) cells was established to survive in stepwise increasing concentrations of vincristine. These MDR cells contained amplified P-glycoprotein (mdr) genes. Using monoclonal antibody against the P-glycoprotein, we present here results showing that the levels of P-glycoprotein and its phosphorylation and glycosylation did not correlate with those of drug resistance. Our results suggest that overproduction of the P-glycoprotein cannot account for the differences in drug resistance in these MDR cells, and that multiple modalities are involved in multiple drug resistance in mammalian cells.
Publication Year: 1989
Publication Date: 1989-05-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 4
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