Title: [Expression and prognostic significance of cyclooxygenase-2 in supraglottic laryngeal squamous cell carcinomas].
Abstract: Objective:To study the expression and prognostic significance of cyclooxygenase-2(Cox-2) in supraglottic laryngeal squamous cell carcinomas(SGLSCC) and identify the relationship between Cox-2 and angiogenesis and the roles of Cox-2 in SGLSCC as a biological marker.Method:Eighty-eight primary SGLSCC patients received surgical treatment were studied by immunohistochemical staining,and reverse transcription-polymerase chain reaction(RT-PCR) technique.Result:The percentage of Cox-2-positive cells was 94.3%(83/88)in SGLSCC whereas there was no immunostaining in the all cells of normalmucosas of paracarcinoma.Cox-2 expression was higher in well-differentiated tumors compared with poorly-differentiated SGLSCC.The relative concentration of Cox-2 mRNA was 141.871±20.543 5 in SGLSCC and 17.031±2.259 7 in normal paracarcinoma mucosas(P0.01).It was significantly higher in SGLSCC than in normal paracarcinoma mucosas.In SGLSCC,only pathological grading and the percentage of Cox-2-positive cells had significant correlation(P0.01).And not only the percentage of Cox-2-positive cells but also Cox-2 intensity had significant correlation with microvessel density(MVD)(P0.01).Kaplan-Meier survival analysis showed there had significant relationship between Cox-2 intensity and cumulative survival rate of SGLSCC patients(P0.05).But the percentage of Cox-2-positive cells was different(P0.05).Cox′s regression analysis indicated that Cox-2 intensity were significantly independent prognostic factors(P0.01).Conclusion:Cox-2 expression maybe relate to the carcinogenesis and progress in tumors especially in well-differentiated ones;The changes of Cox-2 expression are synchronous with MVD.Cox-2 intensity is a significantly independent prognostic factor.So Cox-2 may be an effective target of prevention,therapy and prognostic evaluation for laryngeal carcinoma and other head and neck squamous cell carcinomas(HNSCC).
Publication Year: 2007
Publication Date: 2007-12-01
Language: en
Type: article
Indexed In: ['pubmed']
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