Publication Information

{'id': 'https://openalex.org/W2400910219', 'doi': None, 'title': 'Expression and implication of osteopontin in renal cortex of diabetic rats', 'display_name': 'Expression and implication of osteopontin in renal cortex of diabetic rats', 'publication_year': 2008, 'publication_date': '2008-05-01', 'ids': {'openalex': 'https://openalex.org/W2400910219', 'mag': '2400910219', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18471361'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://europepmc.org/article/MED/18471361', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046826953', 'display_name': 'Yanping Cao', 'orcid': 'https://orcid.org/0000-0003-4787-9748'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan-ping Cao', 'raw_affiliation_strings': ['Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China', 'institution_ids': ['https://openalex.org/I111381250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103238121', 'display_name': 'Feng Gao', 'orcid': 'https://orcid.org/0000-0002-6188-081X'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Feng Gao', 'raw_affiliation_strings': ['Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China', 'institution_ids': ['https://openalex.org/I111381250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026806225', 'display_name': 'Jun Hao', 'orcid': 'https://orcid.org/0000-0002-1213-0449'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Hao', 'raw_affiliation_strings': ['Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China', 'institution_ids': ['https://openalex.org/I111381250']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101111349', 'display_name': 'Yunzhuo Ren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yun-zhuo Ren', 'raw_affiliation_strings': ['Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China', 'institution_ids': ['https://openalex.org/I111381250']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101571635', 'display_name': 'Huijun Duan', 'orcid': 'https://orcid.org/0000-0002-1344-3551'}, 'institutions': [{'id': 'https://openalex.org/I111381250', 'display_name': 'Hebei Medical University', 'ror': 'https://ror.org/04eymdx19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I111381250']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hui-jun Duan', 'raw_affiliation_strings': ['Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology,Hebei Medical University,Shijiazhuang 050017,Hebei,China', 'institution_ids': ['https://openalex.org/I111381250']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '20', 'issue': '5', 'first_page': '287', 'last_page': '290'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12110', 'display_name': 'Bone and Dental Protein Studies', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12110', 'display_name': 'Bone and Dental Protein Studies', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9673, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11919', 'display_name': 'dental development and anomalies', 'score': 0.9224, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/osteopontin', 'display_name': 'Osteopontin', 'score': 0.90669864}, {'id': 'https://openalex.org/keywords/cd68', 'display_name': 'CD68', 'score': 0.71372163}, {'id': 'https://openalex.org/keywords/renal-cortex', 'display_name': 'Renal cortex', 'score': 0.55749667}, {'id': 'https://openalex.org/keywords/blood-urea-nitrogen', 'display_name': 'Blood urea nitrogen', 'score': 0.48942462}], 'concepts': [{'id': 'https://openalex.org/C2780804394', 'wikidata': 'https://www.wikidata.org/wiki/Q411994', 'display_name': 'Osteopontin', 'level': 2, 'score': 0.90669864}, {'id': 'https://openalex.org/C2779922275', 'wikidata': 'https://www.wikidata.org/wiki/Q1129105', 'display_name': 'Diabetic nephropathy', 'level': 3, 'score': 0.7820236}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.7512144}, {'id': 'https://openalex.org/C2776460901', 'wikidata': 'https://www.wikidata.org/wiki/Q21109693', 'display_name': 'CD68', 'level': 3, 'score': 0.71372163}, {'id': 'https://openalex.org/C34688535', 'wikidata': 'https://www.wikidata.org/wiki/Q418732', 'display_name': 'Proliferating cell nuclear antigen', 'level': 3, 'score': 0.71290976}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6858634}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6220778}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.58455884}, {'id': 'https://openalex.org/C2778577996', 'wikidata': 'https://www.wikidata.org/wiki/Q2307492', 'display_name': 'Renal cortex', 'level': 3, 'score': 0.55749667}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.5332422}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.49821448}, {'id': 'https://openalex.org/C2778176769', 'wikidata': 'https://www.wikidata.org/wiki/Q764079', 'display_name': 'Blood urea nitrogen', 'level': 3, 'score': 0.48942462}, {'id': 'https://openalex.org/C85265743', 'wikidata': 'https://www.wikidata.org/wiki/Q885458', 'display_name': 'Blot', 'level': 3, 'score': 0.46631962}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.46253067}, {'id': 'https://openalex.org/C81439078', 'wikidata': 'https://www.wikidata.org/wiki/Q2304142', 'display_name': 'In situ hybridization', 'level': 4, 'score': 0.44243228}, {'id': 'https://openalex.org/C2780306776', 'wikidata': 'https://www.wikidata.org/wiki/Q426660', 'display_name': 'Creatinine', 'level': 2, 'score': 0.42446604}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.28816125}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1613836}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.06258324}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053495', 'descriptor_name': 'Osteopontin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015703', 'descriptor_name': 'Antigens, CD', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015214', 'descriptor_name': 'Antigens, Differentiation, Myelomonocytic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015214', 'descriptor_name': 'Antigens, Differentiation, Myelomonocytic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053495', 'descriptor_name': 'Osteopontin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053495', 'descriptor_name': 'Osteopontin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018809', 'descriptor_name': 'Proliferating Cell Nuclear Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018809', 'descriptor_name': 'Proliferating Cell Nuclear Antigen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://europepmc.org/article/MED/18471361', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18471361', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W75837176', 'https://openalex.org/W3032474110', 'https://openalex.org/W3031762173', 'https://openalex.org/W3031294448', 'https://openalex.org/W3031290628', 'https://openalex.org/W3030082748', 'https://openalex.org/W3006106246', 'https://openalex.org/W2589594885', 'https://openalex.org/W2414525925', 'https://openalex.org/W2384686617', 'https://openalex.org/W2379188792', 'https://openalex.org/W2370296765', 'https://openalex.org/W2368075704', 'https://openalex.org/W2365262720', 'https://openalex.org/W2365000987', 'https://openalex.org/W2357999832', 'https://openalex.org/W2357435997', 'https://openalex.org/W2349137022', 'https://openalex.org/W2272708046', 'https://openalex.org/W1979790422'], 'abstract_inverted_index': {'Objective': [0], 'To': [1], 'investigate': [2], 'the': [3, 50, 62, 65, 143, 163, 176], 'expression': [4, 52, 67], 'and': [5, 37, 43, 55, 92, 114, 133, 142, 152, 174], 'implication': [6], 'of': [7, 13, 53, 68, 94, 122, 129, 157, 165, 171, 178], 'osteopontin': [8], '(OPN)': [9], 'in': [10, 21, 73, 107, 145], 'renal': [11], 'cortex': [12], 'diabetic': [14, 38, 108, 172], 'rats.': [15], 'Methods': [16], 'Experimental': [17], 'diabetes': [18], 'was': [19, 70, 104, 147], 'reproduced': [20], 'uninephrectomized': [22], 'rats': [23], 'by': [24, 72], 'giving': [25], 'streptozotocin': [26], '(STZ).': [27], 'The': [28, 120], 'animals': [29], 'were': [30, 46, 124], 'divided': [31], 'into': [32], 'two': [33], 'groups:': [34], 'control': [35, 79, 130], 'group': [36, 39, 110, 131], '(each': [40], 'n=24).': [41], 'Immunohistochemistry': [42], 'Western': [44], 'blotting': [45], 'used': [47], 'to': [48], 'detect': [49], 'protein': [51, 90, 96, 121], 'OPN,CD68,': [54], 'proliferating': [56], 'cell': [57, 186], 'nuclear': [58, 187], 'antigen': [59, 188], '(PCNA).': [60], 'At': [61], 'same': [63], 'time': [64], 'mRNA': [66], 'OPN': [69, 95, 158], 'detected': [71], 'situ': [74], 'hybridization.': [75], 'Results': [76], 'Compared': [77], 'with': [78], 'group,': [80], 'blood': [81, 83], 'glucose,': [82], 'urea': [84], 'nitrogen': [85], '(BUN)': [86], ',': [87], '24-hour': [88], 'urine': [89], 'quantum': [91], 'quantification': [93], 'significantly': [97, 105], 'increased': [98], 'while': [99], 'creatinine': [100], 'clearance': [101], 'rate': [102], '(CCr)': [103], 'decreased': [106], 'rat': [109], '1,': [111], '2,': [112], '4': [113, 151], '8': [115], 'weeks': [116, 135], 'after': [117, 136], 'STZ': [118, 137], 'injection.': [119], 'PCNA': [123], 'also': [125], 'higher': [126], 'than': [127], 'that': [128], '1': [132], '2': [134], 'injection': [138], '(all': [139], 'P＜0.': [140], '05),': [141], 'increase': [144], 'CD68': [146], 'observed': [148], 'at': [149, 168, 180], 'week': [150, 153], '8.': [154], 'Conclusion': [155], 'Overexpression': [156], 'may': [159], 'be': [160], 'responsible': [161], 'for': [162, 175], 'proliferation': [164], 'tubular': [166], 'cells': [167], 'early': [169], 'stage': [170], 'nephropathy': [173], 'accumulation': [177], 'macrophage': [179], 'later': [181], 'stage.\r\n\r\nKey': [182], 'words:': [183], '\r\ndiabetic': [184], 'nephropathy;\xa0osteopontin;\xa0macrophage;\xa0proliferating': [185]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2400910219', 'counts_by_year': [], 'updated_date': '2024-12-16T22:52:52.364523', 'created_date': '2016-06-24'}