Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2400746123', 'doi': 'https://doi.org/10.1152/ajplegacy.1971.221.6.1733', 'title': 'Renin in dog brain', 'display_name': 'Renin in dog brain', 'publication_year': 1971, 'publication_date': '1971-12-01', 'ids': {'openalex': 'https://openalex.org/W2400746123', 'doi': 'https://doi.org/10.1152/ajplegacy.1971.221.6.1733', 'mag': '2400746123', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4330904'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajplegacy.1971.221.6.1733', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S204210209', 'display_name': 'American Journal of Physiology-Legacy Content', 'issn_l': '0002-9513', 'issn': ['0002-9513', '2163-5773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008231286', 'display_name': 'Detlev Ganten', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D Ganten', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024702786', 'display_name': 'A. Marquez-Julio', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A Marquez-Julio', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003441889', 'display_name': 'Pierre Granger', 'orcid': 'https://orcid.org/0000-0002-8333-4393'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P Granger', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019595253', 'display_name': 'K. Hayduk', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Hayduk', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085737555', 'display_name': 'K. -P. Karsunky', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'KP Karsunky', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004101754', 'display_name': 'R. Boucher', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R Boucher', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022102417', 'display_name': 'Jacques Genest', 'orcid': 'https://orcid.org/0000-0003-2248-9663'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Genest', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.891, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 300, 'citation_normalized_percentile': {'value': 0.994897, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '221', 'issue': '6', 'first_page': '1733', 'last_page': '1737'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.988, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9106, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/diabetes', 'display_name': 'Diabetes', 'score': 0.489861}], 'concepts': [{'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.5239913}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.5194451}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4400258}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41339806}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.38214573}, {'id': 'https://openalex.org/C42407357', 'wikidata': 'https://www.wikidata.org/wiki/Q521', 'display_name': 'Physiology', 'level': 1, 'score': 0.34761173}], 'mesh': [{'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004285', 'descriptor_name': 'Dogs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006706', 'descriptor_name': 'Homeostasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009392', 'descriptor_name': 'Nephrectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010530', 'descriptor_name': 'Peritoneal Dialysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000134', 'qualifier_name': 'cerebrospinal fluid', 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/ajplegacy.1971.221.6.1733', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S204210209', 'display_name': 'American Journal of Physiology-Legacy Content', 'issn_l': '0002-9513', 'issn': ['0002-9513', '2163-5773'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4330904', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2418574610', 'https://openalex.org/W2139586963', 'https://openalex.org/W2126797993', 'https://openalex.org/W2117060894', 'https://openalex.org/W2088924510', 'https://openalex.org/W2077998387', 'https://openalex.org/W2068374317', 'https://openalex.org/W2047608102', 'https://openalex.org/W2044747643', 'https://openalex.org/W1977123261'], 'abstract_inverted_index': {'ARTICLESRenin': [0], 'in': [1, 134, 216, 250, 366, 420], 'dog': [2], 'brainD': [3], 'Ganten,': [4, 18], 'A': [5, 19], 'Marquez-Julio,': [6, 20], 'P': [7, 21], 'Granger,': [8, 22], 'K': [9, 23], 'Hayduk,': [10, 24], 'KP': [11, 25], 'Karsunky,': [12, 26], 'R': [13, 27], 'Boucher,': [14, 28], 'and': [15, 29, 59, 70, 75, 86, 98, 114, 126, 144, 155, 201, 234, 268, 297, 327, 335, 350, 378, 389], 'J': [16, 30], 'GenestD': [17], 'GenestPublished': [31], 'Online:01': [32], 'Dec': [33], '1971https://doi.org/10.1152/ajplegacy.1971.221.6.1733MoreSectionsPDF': [34], '(1': [35], 'MB)Download': [36], 'PDF': [37, 52], 'ToolsExport': [38], 'citationAdd': [39], 'to': [40, 48], 'favoritesGet': [41], 'permissionsTrack': [42], 'citations': [43], 'ShareShare': [44], 'onFacebookTwitterLinkedInWeChat': [45], 'Previous': [46], 'Back': [47], 'Top': [49], 'Next': [50], 'Download': [51], 'FiguresReferencesRelatedInformation': [53], 'Cited': [54], 'ByMultifaceted': [55], 'interplay': [56], 'among': [57], 'mediators': [58], 'regulators': [60], 'of': [61, 84, 92, 102, 123, 139, 152, 165, 214, 226, 246, 255, 282, 312, 324, 387], 'intestinal': [62], 'glucose': [63], 'absorption:': [64], 'potential': [65], 'impacts': [66], 'on': [67], 'diabetes': [68], 'research': [69], 'treatmentLeo': [71], 'Ka': [72], 'Yu': [73], 'Chan': [74], 'Po': [76], 'Sing': [77], 'Leung1': [78], 'December': [79, 417, 423], '2015': [80, 119], '|': [81, 120, 149, 207, 239, 274, 303, 321, 342, 357, 384], 'American': [82, 121, 150, 322, 385, 411], 'Journal': [83, 122, 151, 323, 386], 'Physiology-Endocrinology': [85, 388], 'Metabolism,': [87, 390], 'Vol.': [88, 129, 158, 210, 222, 242, 277, 306, 330, 345, 360, 391], '309,': [89], 'No.': [90, 131, 160, 212, 224, 244, 279, 308, 332, 347, 362, 393], '11Mechanisms': [91], 'brain': [93, 314], 'renin': [94, 167, 247, 365], 'angiotensin': [95], 'system-induced': [96], 'drinking': [97], 'blood': [99], 'pressure:': [100], 'importance': [101], 'the': [103, 135, 137, 217, 251, 313], 'subfornical': [104], 'organJeffrey': [105], 'P.': [106], 'Coble,': [107], 'Justin': [108, 198], 'L.': [109, 199, 260, 291, 317, 380], 'Grobe,': [110, 200], 'Alan': [111], 'Kim': [112], 'Johnson,': [113], 'Curt': [115, 202, 269], 'D.': [116, 196, 203, 263, 270], 'Sigmund15': [117, 271], 'February': [118], 'Physiology-Regulatory,': [124, 153, 325], 'Integrative': [125, 154, 326], 'Comparative': [127, 156, 328], 'Physiology,': [128, 157, 329], '308,': [130], '4ACE2/ANG-(1–7)/Mas': [132], 'pathway': [133], 'brain:': [136, 368], 'axis': [138], 'goodPing': [140], 'Xu,': [141, 178], 'Srinivas': [142], 'Sriramula,': [143], 'Eric': [145], 'Lazartigues1': [146], 'April': [147], '2011': [148, 206], '300,': [159], '4Neuron-': [161], 'or': [162, 176], 'glial-specific': [163], 'ablation': [164], 'secreted': [166], 'does': [168], 'not': [169], 'affect': [170], 'renal': [171], 'renin,': [172], 'baseline': [173], 'arterial': [174], 'pressure,': [175], 'metabolismDi': [177], 'Giulianna': [179], 'R.': [180, 183, 192], 'Borges,': [181], 'Deborah': [182], 'Davis,': [184], 'Khristofor': [185], 'Agassandian,': [186], 'Maria': [187], 'Luisa': [188], 'S.': [189], 'Sequeira': [190], 'Lopez,': [191], 'Ariel': [193], 'Gomez,': [194], 'Martin': [195, 262], 'Cassell,': [197, 264], 'Sigmund1': [204], 'March': [205], 'Physiological': [208, 240, 275, 304, 343, 358, 412], 'Genomics,': [209, 276], '43,': [211], '6Mechanisms': [213], 'Hypertension': [215], 'Central': [218], 'Nervous': [219], 'SystemYAKUGAKU': [220], 'ZASSHI,': [221], '126,': [223], '9Physiology': [225], 'Local': [227], 'Renin-Angiotensin': [228], 'SystemsMartin': [229], 'Paul,': [230], 'Ali': [231], 'Poyan': [232], 'Mehr,': [233], 'Reinhold': [235], 'Kreutz1': [236], 'July': [237], '2006': [238], 'Reviews,': [241, 305, 344, 359], '86,': [243], '3Localization': [245], 'expressing': [248], 'cells': [249], 'brain,': [252], 'by': [253, 410], 'use': [254], 'a': [256], 'REN-eGFP': [257], 'transgenic': [258], 'modelJulie': [259], 'Lavoie,': [261], 'Kenneth': [265], 'W.': [266], 'Gross,': [267], 'January': [272, 301, 340, 355], '2004': [273, 302], '16,': [278], '2Neuroendocrine': [280], 'Control': [281], 'Body': [283], 'Fluid': [284], 'MetabolismJOSÉ': [285], 'ANTUNES-RODRIGUES,': [286], 'MARGARET': [287], 'DE': [288], 'CASTRO,': [289], 'LUCILA': [290], 'K.': [292], 'ELIAS,': [293], 'MARCELO': [294], 'M.': [295, 299], 'VALENÇA,': [296], 'SAMUEL': [298], 'McCANN1': [300], '84,': [307], '1Physiological': [309], 'genomic': [310], 'analysis': [311], 'renin-angiotensin': [315], 'systemRobin': [316], 'Davisson1': [318], 'September': [319], '2003': [320], '285,': [331], '3The': [333], 'Hypothalamus': [334], 'HypertensionH.': [336], 'E.': [337], 'De': [338], 'Wardener10': [339], '2001': [341], '81,': [346], '4Angiotensin,': [348], 'Thirst,': [349], 'Sodium': [351], 'AppetiteJ.': [352], 'T.': [353], 'FITZSIMONS7': [354], '1998': [356], '78,': [361], '3Evidence': [363], 'for': [364], 'rat': [367], 'differentiation': [369], 'from': [370, 396], 'other': [371], 'reninlike': [372], 'enzymesV.': [373], 'J.': [374], 'Dzau,': [375], 'A.': [376], 'Brenner,': [377], 'N.': [379], 'Emmett1': [381], 'May': [382], '1982': [383], '242,': [392], '5': [394], 'More': [395], 'this': [397], 'issue': [398], '>': [399], 'Volume': [400], '221Issue': [401], '6December': [402], '1971Pages': [403], '1733-1737': [404], 'Copyright': [405], '&': [406], 'PermissionsCopyright': [407], '©': [408], '1971': [409, 418, 424], 'Societyhttps://doi.org/10.1152/ajplegacy.1971.221.6.1733PubMed4330904History': [413], 'Published': [414, 419], 'online': [415], '1': [416, 422], 'print': [421], 'Metrics': [425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2400746123', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-18T02:47:00.591491', 'created_date': '2016-06-24'}