Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2126797993', 'doi': 'https://doi.org/10.1530/acta.0.1220369', 'title': 'Effects of angiotensin II, ACTH, and KCl on the adrenal renin-angiotensin system in the rat', 'display_name': 'Effects of angiotensin II, ACTH, and KCl on the adrenal renin-angiotensin system in the rat', 'publication_year': 1990, 'publication_date': '1990-03-01', 'ids': {'openalex': 'https://openalex.org/W2126797993', 'doi': 'https://doi.org/10.1530/acta.0.1220369', 'mag': '2126797993', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2158196'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1530/acta.0.1220369', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210218062', 'display_name': 'European Journal of Endocrinology', 'issn_l': '0804-4643', 'issn': ['0804-4643', '1479-683X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083752938', 'display_name': 'Hiroyuki Sasamura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroyuki Sasamura', 'raw_affiliation_strings': ['Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078175026', 'display_name': 'Hiromichi Suzuki', 'orcid': 'https://orcid.org/0000-0003-1434-7104'}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiromichi Suzuki', 'raw_affiliation_strings': ['Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108250211', 'display_name': 'Ryuichi Kato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryuichi Kato', 'raw_affiliation_strings': ['Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan', 'Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}, {'raw_affiliation_string': 'Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013203308', 'display_name': 'Takao Saruta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Takao Saruta', 'raw_affiliation_strings': ['Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I203951103']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5013203308'], 'corresponding_institution_ids': ['https://openalex.org/I203951103'], 'apc_list': {'value': 3478, 'currency': 'EUR', 'value_usd': 3751, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.775, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.673187, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 75, 'max': 76}, 'biblio': {'volume': '122', 'issue': '3', 'first_page': '369', 'last_page': '373'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System Studies', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 0.9927, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/angiotensin-iii', 'display_name': 'Angiotensin III', 'score': 0.6603407}, {'id': 'https://openalex.org/keywords/plasma-renin-activity', 'display_name': 'Plasma renin activity', 'score': 0.52681565}, {'id': 'https://openalex.org/keywords/captopril', 'display_name': 'Captopril', 'score': 0.44842225}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.90075433}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.89448774}, {'id': 'https://openalex.org/C198710026', 'wikidata': 'https://www.wikidata.org/wiki/Q898218', 'display_name': 'Renin–angiotensin system', 'level': 3, 'score': 0.83717704}, {'id': 'https://openalex.org/C2778525890', 'wikidata': 'https://www.wikidata.org/wiki/Q184564', 'display_name': 'Aldosterone', 'level': 2, 'score': 0.796049}, {'id': 'https://openalex.org/C2908929049', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin II', 'level': 3, 'score': 0.7352976}, {'id': 'https://openalex.org/C2908560794', 'wikidata': 'https://www.wikidata.org/wiki/Q65963433', 'display_name': 'Angiotensin III', 'level': 5, 'score': 0.6603407}, {'id': 'https://openalex.org/C2780694816', 'wikidata': 'https://www.wikidata.org/wiki/Q712294', 'display_name': 'Adrenal gland', 'level': 2, 'score': 0.5462113}, {'id': 'https://openalex.org/C138976137', 'wikidata': 'https://www.wikidata.org/wiki/Q7201790', 'display_name': 'Plasma renin activity', 'level': 4, 'score': 0.52681565}, {'id': 'https://openalex.org/C2780178468', 'wikidata': 'https://www.wikidata.org/wiki/Q3551060', 'display_name': 'Zona glomerulosa', 'level': 4, 'score': 0.52285486}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5151905}, {'id': 'https://openalex.org/C2777977426', 'wikidata': 'https://www.wikidata.org/wiki/Q19065', 'display_name': 'Adrenal cortex', 'level': 2, 'score': 0.46262145}, {'id': 'https://openalex.org/C2779479957', 'wikidata': 'https://www.wikidata.org/wiki/Q421119', 'display_name': 'Captopril', 'level': 3, 'score': 0.44842225}, {'id': 'https://openalex.org/C104849204', 'wikidata': 'https://www.wikidata.org/wiki/Q24778533', 'display_name': 'Angiotensin receptor', 'level': 4, 'score': 0.39280257}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26765916}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.11069262}], 'mesh': [{'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000324', 'descriptor_name': 'Adrenocorticotropic Hormone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011189', 'descriptor_name': 'Potassium Chloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000311', 'descriptor_name': 'Adrenal Glands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000324', 'descriptor_name': 'Adrenocorticotropic Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000450', 'descriptor_name': 'Aldosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000804', 'descriptor_name': 'Angiotensin II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000805', 'descriptor_name': 'Angiotensin III', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000805', 'descriptor_name': 'Angiotensin III', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000805', 'descriptor_name': 'Angiotensin III', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002216', 'descriptor_name': 'Captopril', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002216', 'descriptor_name': 'Captopril', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011189', 'descriptor_name': 'Potassium Chloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011919', 'descriptor_name': 'Rats, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012083', 'descriptor_name': 'Renin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1530/acta.0.1220369', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210218062', 'display_name': 'European Journal of Endocrinology', 'issn_l': '0804-4643', 'issn': ['0804-4643', '1479-683X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2158196', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4231079515', 'https://openalex.org/W3145681292', 'https://openalex.org/W2572767566', 'https://openalex.org/W2400851159', 'https://openalex.org/W2141215121', 'https://openalex.org/W2026478029', 'https://openalex.org/W2023063360', 'https://openalex.org/W2010171695', 'https://openalex.org/W2009549069', 'https://openalex.org/W1987998575'], 'abstract_inverted_index': {'Angiotensin': [0], 'II,': [1, 143], 'ACTH': [2, 89, 144], 'and': [3, 13, 20, 49, 135, 145], 'potassium': [4], 'chloride': [5], 'were': [6, 25], 'administered': [7, 166], 'to': [8], 'rats': [9, 69, 86], 'for': [10], '6': [11], 'days': [12], 'the': [14, 154, 161], 'effects': [15, 159], 'on': [16, 160], 'adrenal': [17, 21, 41, 61, 98, 110, 128, 131, 155, 162], 'renin-like': [18, 62, 99, 129], 'activity': [19, 100], 'angiotensin': [22, 30, 42, 67, 75, 111, 132, 142], 'II/III': [23, 43, 76, 112, 133], 'immunoreactivity': [24, 44, 77], 'investigated.': [26], 'Rats': [27, 114], 'infused': [28], 'with': [29, 88, 116], 'II': [31], '(140': [32], 'pmol/min)': [33], 'either': [34], 'ip': [35], 'or': [36], 'sc': [37], 'showed': [38, 94, 121], 'increases': [39, 122], 'in': [40, 60, 74, 97, 109, 118, 127, 167], '(p': [45, 53, 101, 123], 'less': [46, 54, 102, 124], 'than': [47, 55, 103, 125], '0.05)': [48, 126], 'plasma': [50, 136], 'aldosterone': [51, 151], 'concentration': [52], '0.05),': [56], 'but': [57, 105], 'no': [58, 106], 'change': [59, 108], 'activity.': [63], 'Captopril': [64], 'treatment': [65], 'of': [66, 150], 'II-infused': [68], 'caused': [70], 'a': [71], 'slight': [72], 'decrease': [73], 'which': [78], 'did': [79], 'not': [80], 'reach': [81], 'statistical': [82], 'significance.': [83], 'In': [84], 'contrast,': [85], 'treated': [87, 115], '(Cortrosyn-Z,': [90], '3': [91], 'IU/day,': [92], 'sc)': [93], 'an': [95], 'increase': [96], '0.01),': [104], 'significant': [107], 'immunoreactivity.': [113], 'KCl': [117], 'drinking': [119], 'water': [120], 'activity,': [130], 'immunoreactivity,': [134], 'aldosterone.': [137], 'These': [138], 'results': [139], 'suggest': [140], 'that': [141], 'potassium,': [146], 'three': [147], 'major': [148], 'regulators': [149], 'secretion': [152], 'by': [153], 'gland,': [156], 'have': [157], 'different': [158], 'renin-angiotensin': [163], 'system': [164], 'when': [165], 'vivo.': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2126797993', 'counts_by_year': [], 'updated_date': '2024-12-10T03:02:51.408147', 'created_date': '2016-06-24'}