Publication Information

{'id': 'https://openalex.org/W2398322618', 'doi': None, 'title': 'Effective combination therapy of bortezomib and dexamethasone for two patients with refractory multiple myeloma', 'display_name': 'Effective combination therapy of bortezomib and dexamethasone for two patients with refractory multiple myeloma', 'publication_year': 2005, 'publication_date': '2005-04-01', 'ids': {'openalex': 'https://openalex.org/W2398322618', 'mag': '2398322618', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16444959'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://europepmc.org/abstract/MED/16444959', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057460944', 'display_name': 'Hiroshi Ikeda', 'orcid': 'https://orcid.org/0000-0002-7187-1722'}, 'institutions': [{'id': 'https://openalex.org/I141882310', 'display_name': 'Sapporo Medical University', 'ror': 'https://ror.org/01h7cca57', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I141882310']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Ikeda', 'raw_affiliation_strings': ['First Department of Internal Medicine, Sapporo Medical University School of Medicine'], 'affiliations': [{'raw_affiliation_string': 'First Department of Internal Medicine, Sapporo Medical University School of Medicine', 'institution_ids': ['https://openalex.org/I141882310']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102769387', 'display_name': 'Toshiaki Hayashi', 'orcid': 'https://orcid.org/0000-0002-9606-2542'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Toshiaki Hayashi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075596579', 'display_name': 'Masanori Nojima', 'orcid': 'https://orcid.org/0000-0002-8788-2522'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masahiro Nojima', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045095062', 'display_name': 'Hiroshi Yasui', 'orcid': 'https://orcid.org/0000-0003-0905-6855'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Yasui', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110022058', 'display_name': 'Yukiho Ikeda', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yukiho Ikeda', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078839273', 'display_name': 'Tadao Ishida', 'orcid': 'https://orcid.org/0000-0003-3219-3292'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Tadao Ishida', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110519662', 'display_name': 'Masaaki Adachi', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Masaaki Adachi', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5106182754', 'display_name': 'Kohzoh Imai', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kohzoh Imai', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '46', 'issue': '4', 'first_page': '269', 'last_page': '273'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Cancer Treatment and Pharmacology', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/melphalan', 'display_name': 'Melphalan', 'score': 0.67480826}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.93021566}, {'id': 'https://openalex.org/C2777478702', 'wikidata': 'https://www.wikidata.org/wiki/Q419319', 'display_name': 'Bortezomib', 'level': 3, 'score': 0.8927514}, {'id': 'https://openalex.org/C2780401358', 'wikidata': 'https://www.wikidata.org/wiki/Q422252', 'display_name': 'Dexamethasone', 'level': 2, 'score': 0.8456694}, {'id': 'https://openalex.org/C2776364478', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Multiple myeloma', 'level': 2, 'score': 0.70581985}, {'id': 'https://openalex.org/C2779609412', 'wikidata': 'https://www.wikidata.org/wiki/Q203174', 'display_name': 'Thalidomide', 'level': 3, 'score': 0.68639654}, {'id': 'https://openalex.org/C2778684742', 'wikidata': 'https://www.wikidata.org/wiki/Q2298283', 'display_name': 'Melphalan', 'level': 3, 'score': 0.67480826}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.54972535}, {'id': 'https://openalex.org/C2778570526', 'wikidata': 'https://www.wikidata.org/wiki/Q653197', 'display_name': 'Rash', 'level': 2, 'score': 0.4840395}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.4798688}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.44535428}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.43189445}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.39127943}], 'mesh': [{'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000893', 'descriptor_name': 'Anti-Inflammatory Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001897', 'descriptor_name': 'Boronic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069286', 'descriptor_name': 'Bortezomib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003907', 'descriptor_name': 'Dexamethasone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011719', 'descriptor_name': 'Pyrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'http://europepmc.org/abstract/MED/16444959', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16444959', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W32729895', 'https://openalex.org/W3213165682', 'https://openalex.org/W3203462410', 'https://openalex.org/W3030437974', 'https://openalex.org/W2570221604', 'https://openalex.org/W2531713994', 'https://openalex.org/W2411542114', 'https://openalex.org/W2393087217', 'https://openalex.org/W2369399966', 'https://openalex.org/W2356030701', 'https://openalex.org/W2304017568', 'https://openalex.org/W2124996642', 'https://openalex.org/W2079167171', 'https://openalex.org/W2067463209', 'https://openalex.org/W2056236957', 'https://openalex.org/W2017303578', 'https://openalex.org/W2011412724', 'https://openalex.org/W1976592407', 'https://openalex.org/W1956430368', 'https://openalex.org/W1699374300'], 'abstract_inverted_index': {'We': [0], 'describe': [1], '2': [2, 53], 'cases': [3], 'of': [4, 55, 93, 199, 208, 219], 'conventional': [5, 140], 'therapy-resistant': [6], 'multiple': [7], 'myeloma': [8], '(MM)': [9], 'that': [10, 196, 212], 'responded': [11], 'to': [12, 29, 87, 139, 169], 'bortezomib': [13, 56, 62, 72, 154, 200], 'and': [14, 50, 66, 90, 109, 141, 156, 180, 201, 211], 'dexamethasone': [15, 202, 213], 'therapy.': [16], 'Case': [17, 127], '1:': [18], 'A': [19, 129], '62-year-old': [20], 'woman': [21], 'with': [22, 42, 77, 125, 132, 144, 153, 160], 'MM': [23, 133, 210], '(IgG,': [24], 'kappa-type,': [25], 'stage': [26, 136], 'IIIA)': [27], 'resistant': [28, 138], 'DMVM-IFN': [30], '(dexamethasone,': [31], 'ranimustine,': [32], 'vincristine,': [33], 'melphalan,': [34], 'interferon-a),': [35], 'VAD': [36], '(vincristine,': [37], 'doxorubicin,': [38], 'dexamethasone),': [39], 'high-dose': [40, 142], 'melphalan': [41], 'autologous': [43], 'peripheral': [44], 'blood': [45], 'stem': [46], 'cell': [47], 'transplantation': [48], '(PBSCT)': [49], 'thalidomide,': [51], 'received': [52, 151], 'courses': [54], 'treatment.': [57], 'In': [58], 'the': [59, 69, 91, 102, 113, 121, 183, 190, 197, 206, 216], 'first': [60, 114, 184], 'course,': [61, 185], 'alone': [63, 155], 'was': [64, 73, 99], 'administered': [65], 'then': [67, 157], 'in': [68, 75, 96, 112, 120, 158, 182, 189, 205], 'second': [70, 122, 191], 'course': [71, 123], 'given': [74], 'combination': [76, 159, 198], 'dexamethasone.': [78, 126, 161], 'The': [79], "patient's": [80], 'serum': [81, 163], 'IgG': [82], 'level': [83, 92, 165], 'decreased': [84, 166], 'from': [85, 167], '8040': [86], '1020': [88], 'mg/dl': [89], 'plasma': [94], 'cells': [95], 'bone': [97], 'marrow': [98], '1.2%': [100], 'after': [101], 'treatments.': [103], 'Adverse': [104], 'reactions': [105, 175, 218], 'including': [106], 'rash,': [107], 'anemia,': [108, 179], 'thrombocytopenia': [110, 181], 'occurred': [111], 'course;': [115], 'however,': [116], 'they': [117], 'were': [118, 187], 'milder': [119], 'combined': [124], '2:': [128], '43-year-old': [130], 'man': [131], '(IgD,': [134], 'gamma-type,': [135], 'IIA)': [137], 'chemotherapy': [143], 'PBSCT': [145], 'as': [146, 148, 177], 'well': [147], 'thalidomide': [149], 'therapy,': [150], 'treatment': [152, 207], 'His': [162], 'IgD': [164], '2140': [168], '623': [170], 'mg/dl.': [171], 'He': [172], 'suffered': [173], 'adverse': [174, 217], 'such': [176], 'fatigue,': [178], 'which': [186], 'relieved': [188], 'course.': [192], 'These': [193], 'results': [194], 'indicate': [195], 'is': [203], 'effective': [204], 'refractory': [209], 'can': [214], 'reduce': [215], 'bortezomib.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2398322618', 'counts_by_year': [], 'updated_date': '2024-12-08T14:14:37.713105', 'created_date': '2016-06-24'}