Title: Bioequivalence study of ranitidine caps in healthy volunteers
Abstract: AIM: To study the pharmacokinetic activities and bioequivalence of ranitidine capsule after oral administration in healthy volunteers.METHODS: A single administration of 300 mg test and reference ranitidine were given to 20 healthy male volunteers in randomized crossover study respectively.The HPLC was developed to determine the concentration of ranitidine in human plasma.RESULTS: The pharmacokinetics parameters after a single oral administration of 300 mg test and reference products were as follows: C_(max) were(1.62)±(0.56) and(1.78)±(0.69)(μg·ml~(-1)),t_(max) were(2.8)±(1.1) and(2.6)±(0.8) h,AUC_(0-τ) were(6.69)±(1.46) and(6.67)±(1.86) (μg·h·ml~(-1)),AUC_(0-∞) were(7.06)±(1.56) and(7.06)±(1.86)(μg·h·ml~(-1)),respectively.The relative bioavailability of single oral administration group was(103.8)%±(19.1)%.CONCLUSION:The test and reference products were bioequivalent.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot