Title: Relationship and its significance between VEGF, MMP-9 and microvessel density in progression of cervical carcinoma
Abstract: [Objective] To explore the correlation between the expression of vascular endothelial growth factor(VEGF), matrix metalloproteinase-9(MMP-9) and local microvessel angiogenesis and clinical pathologic features in the course of gradual progression in cervical carcinoma, in order to provide reliable theoretical foundation for the study of anti-angiogenesis drugs and matrix metalloproteinase inhibitors. [Methods] The expression of VEGF, MMP-9, and MVD labeled by CD34 in 40 cases of ICC, 52 cases of CIN Ⅰ, Ⅱ, Ⅲ and 15 cases of normal cervical epithelium(NCE) were detected by immunohistochemical streptavidin-biotin-peroxidase (SP) method. [Results] The values of MVD in NCE, CIN and ICC group were (12.31±3.82), (35.66±6.35), (48.19±10.82) respectively, showing a significant difference between any of the two groups(P 0.01). The positive rates of VEGF and MMP-9 expression in NCE, CIN, ICC group were 0%, 19.23%, 67.50% and 13.33%, 42.31%, 77.50% respectively, showing a significant difference between any of the two groups(P 0.05). In ICC, CIN group, the value of MVD was (50.33±11.22) in both high positive expression cases of VEGF, MMP-9, and was significantly higher than that in both negative expression cases of VEGF, MMP-9, its value of MVD was (25.06±7.63) (P 0.01). The expression of VEGF was positively correlated with the expression of MMP-9(rs =0.284, P 0.05). [Conclusions] Angiogenesis and VEGF, MMP-9 are involved in the development of cervical carcinoma. VEGF, MMP-9 play positive-regulation in the angiogenesis of cervical carcinoma. The increase of MVD indicates the increased potential of invasion and metastasis in cervical carcinoma. VEGF, MMP-9 may be used as prognostic indexes of metastasis of cervical carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot