Title: A study of the impact on spatial learning and memory of a bilateral intraventricular infusion of AF64A in rats
Abstract: ObjectiveTo investigate the impacts on spatial learning and memory of a bilateral intraventricular infusion of AF64A in rats. MethodsAF64A was infused bilaterally into the dorsal lateral ventricles of adult rats. The spatial learning and memory of the rats was observed with Morris water-maze procedure in the 2 nd wk,4 th wk and 6 th wk after the AF64A-treatment. And the differences of the ability of spatial learning and memory in the rats between the sham-infused rats and AF64A-treated ones were evaluated in those times above. ResultsBeing compared with that of the sham-infused group, the escape latency of place navigation of Morris water-maze of the AF64A-treated group was significantly longer in all times.( P 0.01);Being compared with that of the sham-infused group, the time of passing through the platform of Morris water-maze of the AF64A-treated group was significantly decreased in all times.( P 0.01);And there was not differences of the escape latency of cue navigation between the sham-infused group and the AF64A-treated group( P 0.05). Conclusions The ability of spatial learning and memory of AF64A-treated rats is changed obviously in a long times, And these features are similar with that of behavioral disorders related with the cholinergic deficit in AD patient. AF64A-treated rat can be used as a animal mode to study the cholinergic hypofuntion in AD.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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