Title: Low Dose Arginine Vasopressin Increase Spatial Learning and Memory Ability in Rats
Abstract: Objective To study the effect of multiple low dose of arginine vasopressin(AVP) on the spatial learning and memory ability in rats. Methods Wistar male rats were treated with different doses of AVP(0.5 and 1.0 μg·kg-1) or saline(0.12 mL) by subcutaneous injection 30 min before training,then the ability of their spatial learning and memory and dose-effect relationship were measured by Morris water maze method. Results No evident difference of the latent period and distance in the hidden platform test was observed between rats administrated with 0.5 and 1.0 μg·kg-1AVP.In the probe test,however,the swimming durance and distance in the quadrant for rats treated with AVP(0.5 and 1.0 μg·kg-1) were significantly longer than those in control group,moreover,no significant difference between three groups of rats on the motive to find the platform and visual acuity. Conclusion Multiple low dose of periphery AVP could increase long term memory of the rats.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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