Title: Effect of amiodarone on severe ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy
Abstract: Objectives To investigate the effects of amiodarone on non-sustained ventricular tachycardia(VT) and sudden cardiac death in patients with idiopathic dilated cardiomyopathy(DCM). Methods Sixty-five patients with DCM treated with diurctics,digitalis and angiotensin-converting enzyme inhibitors were assigned to receive minidose amiodarone(n=33) or not(n=32),Mean follow-up was 12 months. The echocardiographic indices of cardiac funtion,the incidence of non-sustained VT on Holter monitoring electrocardiograms,and sudden cardiac death rate were compared between the 2 groups. Results Comparable improvement in cardiac function on echocardiographic was found in the 2 treatment groups. The patient group treated with minidose amiodarone showed a significant reduction in the prevalence of VT and reduced the development of new episodes of VT compared to the group without minidose amiodarone. The sudden cardiac death rate did not differ between two groups. Conclusions Amiodarone is effective and safe in treatment of DCM with arrhythmia and reduct the development of new episodes of VT.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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