Title: Detection of Mutations in Insulin Receptor Gene in Hypertensive Patients
Abstract: Aim To study the role of insulin receptor gene mutations in the pathogenesis of hypertension. Methods The polymorphism of exon 17 and 18 of insulin gene were detected in 46 hypertension patients and 39 normal controls using PCR and single strand conformation polymorphism. Results The mutations in exon 17 were found. The mutation frequency of exon 17 were 8.12% and 6.88% in patients and controls, respectively(χ 2=4.9082, P 0.05). Based on direct sequence analysis of exon 17, homozygous and heterozygous nonsense mutations were found silent polymorphism at position 1058(CAC→CAT). The mutations in exon 18 were not found. Conclusion The result suggests that codon 1058(CAC) may be a genetic marker of susceptibility for hypertension in Chinese.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot