Title: Research on Relationship between Insulin Receptor Gene Defection and Hypertension with Insulin Resistance
Abstract: Objective:Research on insulin receptor(INSR)gene defection in primary hypertension with insulin resistance.Me thods: Using PCR SSCP,we detected the mutation of INSR tyrosine kinase domain exon 17 and exon 18 in 33 primary hypertension patients and 28 normal persons.Exon with mutation was detected by direct sequence analysis.Results:9 INSR exon 17 mutations were detected in 33 primary hypertension with insulin resistance.Based on direct sequence analysis of exon 17,nonsense mutations were found at position 1058 (CAC→CAT).2 were homozygous muation and 7 were heterozygous mutation.Conclusion:The frequency of sense mutation of INSR tyrosine kinase domain in hypertension with insulin resistance is relatively lower,but nonsense mutation may be regarded as one type of gene markers for hypertension patients who are of insulin resistance.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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